1. Cytotoxic cycloartanes from aglaia argentea
- Author
-
Mary Païs, Thierry Sevenet, O. R. Omobuwajo, Marie Thérèse Martin, Khalijah Awang, and G. Perromat
- Subjects
Magnetic Resonance Spectroscopy ,Cell Survival ,Stereochemistry ,Aglaia argentea ,Plant Science ,Spectrometry, Mass, Fast Atom Bombardment ,Horticulture ,Biochemistry ,KB Cells ,Terpene ,Triterpenoid ,Triterpene ,Humans ,Cytotoxic T cell ,Molecular Biology ,chemistry.chemical_classification ,Meliaceae ,Molecular Structure ,biology ,Cytotoxins ,Plant Extracts ,Chemistry ,Biological activity ,General Medicine ,Nuclear magnetic resonance spectroscopy ,Saponins ,biology.organism_classification ,Triterpenes - Abstract
Aglaia argentea leaves yielded three new cycloartanes: argenteanones A and B, and argenteanol. The first two possess cytotoxic activity against KB cells (IC50 7.5 micrograms ml-1 and 6.5 micrograms ml-1 respectively). Structural elucidation was done by two-dimensional NMR spectroscopy.
- Published
- 1996
- Full Text
- View/download PDF