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The ErbB family of receptor tyrosine kinases is a primary target for small molecules and antibodies for pancreatic cancer treatment. Nonetheless, the current treatments for this tumor are not optimal due to lack of efficacy, resistance, or toxicity. Here, using the novel BiXAb™ tetravalent format platform, we generated bispecific antibodies against EGFR, HER2, or HER3 by considering rational epitope combinations. We then screened these bispecific antibodies and compared them with the parental single antibodies and antibody pair combinations. The screen readouts included measuring binding to the cognate receptors (mono and bispecificity), intracellular phosphorylation signaling, cell proliferation, apoptosis and receptor expression, and also immune system engagement assays (antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity). Among the 30 BiXAbs™ tested, we selected 3Patri-1Cetu-Fc, 3Patri-1Matu-Fc and 3Patri-2Trastu-Fc as lead candidates. The in vivo testing of these three highly efficient bispecific antibodies against EGFR and HER2 or HER3 in pre-clinical mouse models of pancreatic cancer showed deep antibody penetration in these dense tumors and robust tumor growth reduction. Application of such semi-rational/semi-empirical approach, which includes various immunological assays to compare pre-selected antibodies and their combinations with bispecific antibodies, represents the first attempt to identify potent bispecific antibodies against ErbB family members in pancreatic cancer.

In this paper, we study the recovery of onmembrane semiconductor components, such as N-type Field-Effect Transistors (FETs) available in two different channel widths and a Complementary Metal-Oxide-Semiconductor (CMOS) inverter, after the exposure to high dose of proton radiation. Due to the ionizing effect, the electrical characteristics of the components established remarkable shifts, where the threshold voltages showed an average shift of -480 mV and -280 mV respectively for 6 μm and 24 μm N-channel transistors, likewise the inversion point of the inverter showed an important shift of -690 mV. The recovery concept is based mainly on a micro-hotplate, fabricated with backside MEMS micromachining structure and a Silicon-On-Insulator (SOI) technology, ensuring rapid, low power and in situ annealing technique, this method proved its reliability in recent works. Annealing the N-channel transistors and the inverter for 16 min with a temperature of the heater up to 385 °C, guaranteed a partial recovery of the semiconductor based components with a maximum power consumption of 66 mW.

La polymerisation du 1,3-dioxolane a ete effectuee avec des initiateurs cationiques metalliques produits electrochimiquement par dissolution de V, Hg, Cr, Al.

International audience; Epoxy resins are widely used in the design of fibre composite materials. This increasing use finds its reason in the fact that these materials have excellent mechanical and thermal properties. Playing on its chemical composition and curing speed, it's possible to vary the mechanical properties from the extreme flexibility to high rigidity. However, the inherent toughness of a highly crosslinked epoxy is relatively low. It therefore seems desirable for high impact resistance applications, to improve the toughness, without affecting the other usual properties of this polymer. Recent studies have shown a significant improvement in impact resistance of epoxy in the presence of block copolymers. Our work aims to investigate the effect of triblock copolymer-based acrylate (Nanostrength) on the impact resistance of glass / epoxy composite. An experimental device, called "drop tower" is used to perform impact tests on composites with or without Nanostrength. Dynamic mechanical analyses (DMA) were conducted, first to characterize the effect of addition of Nanostrength on the thermomechanical properties, but also to establish a correlation between thermomechanical properties and impact resistance. Different observation tools, such as optical observation, scanning electron microscopy (SEM) and atomic force microscopy (AFM) were used to visualize the material damages. Adding Nanostrength in epoxy leads to the improvement of impact resistance of the composite material. A slight decrease in the storage modulus and glass transition temperature have been observed. Microscopic observations shown that the different failure modes of the composite are mainly delamination, fibres breakage and matrix cracking. It was also observed that the presence of Nanostrength role as cracks deflect.

The polymerization of ϵ-caprolactone is carried out with metallic cationic initiators generated electrochemically. V, Ti, Cr, Al and Hg cations gave rise to polymers with molecular weights in the range 1 000–13 000. Better yields and higher degrees of polymerization are obtained in the presence of [SbF6]− and [ClO4]− as anion of the supporting electrolyte, which is in accordance with the stability and the poor nucleophilicity of these anions.

Since the popular protests that led to the flight of Jean-Claude Duvalier, Haiti has been the scene of important social and political confrontations. On one hand, the forces of the ancien regime, allied with the military and the National Government Council (CNG), are trying to conserve the status quo; on the other hand, almost every other social group in Haiti is demanding "de-Duvalierization" and democracy. This state of conflict has prevailed in Haiti since February 7, 1986. Little impact was felt, however, at the international level until the bloody events that accompanied the elections that were first scheduled for and then brutally canceled on November 29, 1987. These events received worldwide attention and resulted in greater awareness of the situation in Haiti, since they took place in the context of a display of violence that was covered by dozens of journalists who witnessed the machine-gunning of the electoral offices in Port-au-Prince by armed civilians and soldiers in civilian attire. The result was 34 deaths and dozens of injuries. Thus the methods of Duvalierism, as well as its character, were exposed for all to see. It is an authoritarian project of the military, the heirs of the dictatorship, which belies their commitment at the national and international level to assuring the democratic transition and bringing free elections to the country. In order to understand these events and the contradictions between the promises of those that govern and their fascistic actions, as well as between the people and the military government, it is necessary to look

L’etude rapportee ici de la regeneration fonctionnelle, de la selectivite ionique et de la conductivite electrique des membranes semi-permeables echangeuses d’ions baignant dans des solutions aqueuses ou organiques d’electrolytes de concentration variable, constitue un travail preliminaire a la mise en œuvre d’une methode nouvelle d’electrodialyse des solvants polaires en vue de leur desionisation complete.

Le procede d’electrodialyse des solvants polaires decrit precedemment (1) ayant permis de mesurer la conductibilite propre de l’eau, est applicable au cas du methanol et de l’ethanol. Les resultats presentes en montrent la tres grande efficacite et permettent de donner, a partir des resistivites limites mesurees dans le methanol entre 15 et 30 °C, une valeur de l’enthalpie d’ionisation a partir des lois etablies a propos de l’eau pure.

In this project, I developed a browser based interface for prototyping real-time processing algorithms using embedded multi channel audio acquisition platforms. The interface allows to interact in an easy manner with a GNU/Linux enabled single board computer and to run algorithms in real-time on distant audio streams from a host computer. It creates a bridge between the user’s computer and the audio acquisition board. More precisely, the interface let us to: - change the board configuration; - write Python code; - execute it in real-time on the audio streams; - visualize data (typically outputs of the algorithm). The project is composed of three main components, communicating together using WebSockets: - daemons in C running on the board: they transmit the audio streams and listen for configuration changes; - a Python daemon: it executes Python code sent by the interface; - the interface itself. Finally, a Python module helps the user to access the audio streams, the configuration, and to create data visualizations. This module connects to the C daemons (to receive the streams and the configuration) and to the browser to send data in real-time for visualizations. The technical documentation is included in the Appendix of this report. It is also available online: https://lcav.github.io/easy-dsp/, as well as the code repository: https: //github.com/LCAV/easy-dsp.