Search

Your search keyword '"Friedrichs, Kay"' showing total 2 results
Start Over Author "Friedrichs, Kay" Language undetermined
2 results on '"Friedrichs, Kay"'

1. Trends in axillary lymph node dissection for early-stage breast cancer in Europe: Impact of evidence on practice

Author

Garcia-Etienne, Carlos A., Mansel, Robert E., Tomatis, Mariano, Heil, Joerg, Biganzoli, Laura, Ferrari, Alberta, Marotti, Lorenza, Sgarella, Adele, Ponti, Antonio, Danaei, Mahmoud, Stickeler, Elmar, Sarlos, Dimitri, Prové, Annemie, Pagani, Olivia, Berclaz, Gilles, Taffurelli, Mario, Cretella, Elisabetta, Verhoeven, Didier, Denk, Andreas, Carly, Birgit, Ballardini, Bettina, van Riet, Yvonne, Kimmig, Rainer, Reinisch, Mattea, Angiolini, Catia, Möbus, Volker, Emons, Gunter, Friedrichs, Kay, Schneeweiss, Andreas, Tinterri, Corrado, Egle, Daniel, Staelens, Gracienne, Kiechle, Marion, Harbeck, Nadia, Corsi, Fabio, Menghini, Lorenzo, Lombardi, Augusto, Fortunato, Lucio, Bortul, Marina, Huober, Jens, Badbanchi, Farzaneh, Tausch, Christoph, EUSOMA Working Group, EUSOMA Working Grp, Garcia-Etienne, C. A., Mansel, R. E., Tomatis, M., Heil, J., Biganzoli, L., Ferrari, A., Marotti, L., Sgarella, A., Ponti, A., Danaei, M., Stickeler, E., Sarlos, D., Prove, A., Pagani, O., Berclaz, G., Taffurelli, M., Cretella, E., Verhoeven, D., Denk, A., Carly, B., Ballardini, B., van Riet, Y., Kimmig, R., Reinisch, M., Angiolini, C., Mobus, V., Emons, G., Friedrichs, K., Schneeweiss, A., Tinterri, C., Egle, D., Staelens, G., Kiechle, M., Harbeck, N., Corsi, F., Menghini, L., Lombardi, A., Fortunato, L., Bortul, M., Huober, J., Badbanchi, F., and Tausch, C.

Subjects
axillary lymph node dissection, axillary dissection, axillary surgery, axillary lymphadenectomy, positive sentinel node, Z0011, surgery for breast cancer, Medizin, Practice Patterns, Axillary dissection, 0302 clinical medicine, Axillary lymph node dissection, Breast, 030212 general & internal medicine, Practice Patterns, Physicians', Stage (cooking), Surgical approach, Lymph Node, Axillary lymphadenectomy, General Medicine, Middle Aged, 3. Good health, Europe, medicine.anatomical_structure, Homogeneous, 030220 oncology & carcinogenesis, Female, Axillary surgery, Positive sentinel node, Surgery for breast cancer, Adult, Aged, Axilla, Breast Neoplasms, Humans, Lymph Node Excision, Lymph Nodes, Breast Neoplasm, Human, medicine.medical_specialty, 03 medical and health sciences, Breast cancer, medicine, Physicians', Breast conservation, business.industry, General surgery, Background data, Axillary Lymph Node Dissection, medicine.disease, Surgery, Human medicine, business
Abstract

Background: Data from recently published trials have provided practice-changing recommendations for the surgical approach to the axilla in breast cancer. Patients with T1-2 lesions, treated with breast conservation, who have not received neoadjuvant chemotherapy and have 1-2 positive sentinel nodes (Z0011-criteria) may avoid axillary lymph node dissection (ALND). We aim to describe the dissemination of this practice in Europe over an extended period of time. Methods: Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified cases fulfilling Z0011-criteria from 2005 to 2016 from 34 European breast centers and report trends in ALND. Data derived from Germany, Italy, Belgium, Switzerland, Austria, and Netherlands. Results: 6671 patients fulfilled Z0011-criteria. Rates of ALND showed a statistically significant decrease from 2010 (89%) to 2011 (73%), reaching 46% in 2016 (p < 0.001). After multivariable analysis, factors associated with higher probability of ALND were earlier year of surgery, younger age, increasing tumor size and grade, and being operated in Italy (p < 0.001). The minimum and maximal rates of ALND in the most recent two-year period (2015-2016) were 0% and 83% in two centers located in different countries (p < 0.001). Conclusion: Our study demonstrates, a decrease in rates of ALND that started after year 2010 through the end of the study period. Wide differences were observed among centers and countries indicating the need to spread unified clinical guidelines in Europe to allow for homogeneous evidence-based practice patterns. (C) 2019 Elsevier Ltd. All rights reserved.

Published
2019
Full Text
View/download PDF

2. Mastectomy trends for early-stage breast cancer: a report from the EUSOMA multi-institutional European database

Author

Garcia-Etienne, Carlos A., Tomatis, Mariano, Heil, Joerg, Friedrichs, Kay, Kreienberg, Rolf, Denk, Andreas, Kiechle, Marion, Lorenz-Salehi, Fatemeh, Kimmig, Rainer, Emons, Günter, Danaei, Mahmoud, Heyl, Volker, Heindrichs, Uwe, Rageth, Christoph J., Janni, Wolfgang, Marotti, Lorenza, Del Turco, Marco Rosselli, Ponti, Antonio, Cataliotti, Luigi, Cretella, Elisabetta, Van Dam, Peter, Emons, Adelgund, Gyr, Thomas, Hils, Rita, Kern, Peter, Koehler, Uwe, Kuemmel, Sherko, Liedtke, Doris, Luini, Alberto, Moebus, Volker, Neumann, Monika, Paepke, Stefan, Pagani, Olivia, Pavesi, Lorenzo, Sarlos, Dimitri, Schlotfeldt, Tim, Sohn, Cristof, Spelsberg, Angela, Staelens, Gracienne, Taffurelli, Mario, Tinterri, Corrado, Vergin, Iris B., Zemmler, Thomas, Wagner, Dominik, and Turco, Marco Rosselli del

Subjects
Adult, Cancer Research, medicine.medical_specialty, Databases, Factual, Breast surgery, medicine.medical_treatment, Population, Medizin, Breast Neoplasms, computer.software_genre, Mastectomy, Segmental, Young Adult, Breast cancer, medicine, Humans, Stage (cooking), Young adult, education, Survival rate, Radical mastectomy, Mastectomy, Aged, Aged, 80 and over, education.field_of_study, Database, business.industry, General surgery, Middle Aged, medicine.disease, Europe, Survival Rate, Oncology, Lymphatic Metastasis, Female, business, computer
Abstract

Recent single-institution reports have shown increased mastectomy rates during the last decade. Further studies aiming to determine if these reports could be reflecting a national trend in the United States of America (US) have shown conflicting results. We report these trends from a multi-institutional European database.Our source of data was the eusomaDB, a central data warehouse of prospectively collected information of the European Society of Breast Cancer Specialists (EUSOMA). We identified patients with newly diagnosed unilateral early-stage breast cancer (stages 0, I or II) to examine rates and trends in surgical treatment.A total of 15,369 early-stage breast cancer cases underwent surgery in 13 Breast Units from 2003 to 2010. Breast conservation was successful in 11,263 cases (73.3%). Adjusted trend by year showed a statistically significant decrease in mastectomy rates from 2005 to 2010 (p = 0.003) with a progressive reduction of 4.24% per year. A multivariate model showed a statistically significant association of the following factors with mastectomy: age40 or ≥ 70 years, pTis, pT1mi, positive axillary nodes, lobular histology, tumour grade II and III, negative progesterone receptors and multiple lesions.Our study demonstrates that a high proportion of patients with newly diagnosed unilateral early-stage breast cancer from the eusomaDB underwent breast-conserving surgery. It also shows a significant trend of decreasing mastectomy rates from 2005 to 2010. Moreover, our study suggests mastectomy rates in the population from the eusomaDB are lower than those reported in the US.

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results