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1. Coupling of Wideband Impulses Generated by Granular Chains into Liquids

Author

Harput, S., Freear, S., Gelat, P., Saffari, N., Yang, J., Akanji, O., Thomas, P. J., and Hutchins, D. A.

Subjects
FOS: Physical sciences, Physics - Applied Physics, sense organs, Medical Physics (physics.med-ph), Applied Physics (physics.app-ph), physics.med-ph, physics.app-ph, Physics - Medical Physics
Abstract

An ultrasonic transducer technology to generate wideband impulses using a one-dimensional chain of spheres was previously presented. The Hertzian contact between the spheres causes the nonlinearity of the system to increase, which transforms high amplitude narrowband sinusoidal input into a train of wideband impulses. Generation of short duration ultrasonic pulses is desirable both in diagnostic and therapeutic ultrasound. Nevertheless, the biggest challenge in terms of adaptation to biomedical ultrasound is the coupling of the ultrasonic energy into biological tissue. An analytical model was created to address the coupling issue. Effect of the matching layer was modelled as a flexible thin plate clamped from the edges. Model was verified against hydrophone measurements. Different coupling materials, such as glass, aluminium, acrylic, silicon rubber, and vitreous carbon, was analysed with this model. Results showed that soft matching layers such as acrylic and rubber inhibit the generation of higher order harmonics. Between the hard matching materials, vitreous carbon achieved the best results due to its acoustic impedance.

Published
2019
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2. Wideband Excitation of Microbubbles to Maximize the Sonoporation Efficiency and Contrast in Ultrasound Imaging

Author

Harput, S, McLaughlan, J, Cowell, DMJ, and Freear, S

Subjects
physics.med-ph
Abstract

The importance of the excitation bandwidth is well known in diagnostic ultrasound imaging. However, the effect of excitation bandwidth in therapeutic applications of microbubbles has been mostly overlooked. A majority of contrast agent production techniques generate polydisperse microbubble populations, so a wide range of resonance frequencies exist. Therefore, wideband excitation is necessary to fully utilize microbubble resonance behavior and maximize the reradiated energy from a microbubble population, both for imaging and therapy. Oscillations of sixty SonoVue microbubbles in proximity of a rigid boundary were captured on a high speed camera at 3 Mfps, excited with a peak negative pressure of 50 kPa at 1 MHz. Measurements were analyzed according to their peak radiated pressure, radial oscillations, root mean squared pressure, and shear stress generated by microbubbles. Results showed that long duration and wideband excitation at low intensity levels was preferable for sonoporation, where microbubbles can be driven in a stable oscillation state without experiencing inertial cavitation or destruction.

Published
2018

5. WCE 2010 - World Congress on Engineering 2010: Preface

Author

Ahmad, M., Alexandrou, I., Al-Nuaimy, W., Amavasai, B. P., An, Y. -Y, Ariwa, E., Arteche, J., Audrino, F., Ayesh, A., Baber, C., Bailey, C., Balkan, N., Barria, J., Bartosova, J., Benkrid, K., Bleijs, H., Bluck, M., Bose, I., Bouzas, P. R., Braiden, P. M., Brdys, M., Burriesci, G., Cannataro, M., Carvalho, A., Chang, C. -C, Chen, D., Chen, G. G., Chen, Y. -S, Chiclana, F., Cooke, A., Das, D. B., Davis, D. N., Dayoub, I., Deb, S., Demetriou, I. C., Devai, F., Dilmaghani, R. S., Dini, D., Drikakis, D., Durkan, C., Durodola, J., Etebar, K., Fenn, P., Figueiredo, A., Florou, G., Freear, S., Gabrys, B., Galbraith, G. H., Gaskell, P. H., elena gaura, Ge, Z. -Q, Ghafouri-Shiraz, H., Ghavami, M., Giannopoulos, K., Gonzalez, R. E. P., Gracia, A. M., Grecos, C., Guan, L., Gulpinar, N., Guo, R., Guo, Y., Hardalupas, Y., He, L., Herrero, J. R., Hicks, B. J., Hines, E. L., Hodgson, S., Horsfall, A., Hosein, P., Hu, F., Hu, H., Ijomah, W., Ming, J., James, A., Jancovic, P., Jhumka, A., Kamareddine, F., Kannan, R., Karsligil, M. E., Katircioglu, S. T., Khalid, A., Kokossis, A., Kontis, K., Kulekci, M. O., Laukaitis, A., Leeson, M., Limbachiya, M. C., Li, L., Lin, P., Ling, W. -K, Macias Lopez, E. M., Lovas, T., Luglio, M., Mainardi, S., Mahanti, P. K., Marinos, I., Maropoulos, P., Mativenga, P., Mavrommatis, G., Meintanis, S. G., Meisel, Y. D., Mekid, S., Mias, C., Morin, A., Musliu, N., Nabhani, F., Naguib, R., Olatunbosun, O., Olsen, S., Ozalp, A. A., Pang, A. -C, Pao, W. K. -S, Piera, M. A., Pinciroli, F., Popescu, T. D., Power, H., Prewett, P. D., Putrus, G. A., Railton, C., Raja, V., Resta, M., Ristic, M., Roy, R., Russo, A., Sadri, F., Sahinkaya, M. N., Sakata, T., Salous, S., Sazhin, S., Scepi, G., Seneviratne, L., Seng, Q. T., Shammas, N., Shepherd, D. E. T., Short, T., Siddique, M. N. H., Singh, R., Sirlantzis, K., Solanas, A., Stathaki, T., Todd-Pokropek, A., Velez, F. J., Vicent, A. M. P., Virdee, B., Walters, R. J., Wang, C. H. -T, Wang, J., Wang, W., Wang, X. -Z, Ware, M., Webb, P., Wen, D., Wen, J., Wood, A., Woodhead, R., Woods, J., Wu, Q. H., Utyuzhnikov, S. V., Xu, H., Xu, Y., Yan, Y., Yang, G. -C, Yang, W., Yang, X. -S, Yu, H. -F, Zhao, Y., Zharkova, V., Zhong, Q. -C, and Zopounidis, C.

6. WCE 2010 - World Congress on Engineering 2010: Preface

Author

Korsunsky, A. M., Hunter, A., Hukins, D. W. L., Gelman, L., Hogger, C. J., Ceglarek, D. J., Payne, S., Ao, S. I., Ahmad, M., Alexandrou, I., Al-Nuaimy, W., Amavasai, B. P., An, Y. -Y, Ariwa, E., Arteche, J., Audrino, F., Ayesh, A., Baber, C., Bailey, C., Balkan, N., Barria, J., Bartosova, J., Benkrid, K., Bleijs, H., Bluck, M., Bose, I., Bouzas, P. R., Braiden, P. M., Brdys, M., Burriesci, G., Cannataro, M., Carvalho, A., Chang, C. -C, Chen, D., Chen, G. G., Chen, Y. -S, Chiclana, F., Cooke, A., Das, D. B., Davis, D. N., Dayoub, I., Raman, S. D. C. V., Demetriou, I. C., Devai, F., Dilmaghani, R. S., Dini, D., Drikakis, D., Durkan, C., Durodola, J., Etebar, K., Fenn, P., Figueiredo, A., Florou, G., Freear, S., Gabrys, B., Galbraith, G. H., Gaskell, P. H., Gaura, E., Ge, Z. -Q, Ghafouri-Shiraz, H., Ghavami, M., Giannopoulos, K., Pruneda Gonzalez, R. E., Gracia, A. M., Grecos, C., Guan, L., Gulpinar, N., Guo, R., Guo, Y., Hardalupas, Y., He, L., Herrero, J. R., Hicks, B. J., Hines, E. L., Hodgson, S., Horsfall, A., Hosein, P., Hu, F., Hu, O., Ijomah, W., Ming, J., James, A., Jancovic, P., Jhumka, A., Kamareddine, F., Kannan, R., Karsligil, M. E., Katircioglu, S. T., Khalid, A., Kokossis, A., Kontis, K., Kulekci, M. O., Laukaitis, A., Leeson, M., Limbachiya, M. C., Li, L., Lin, P., Ling, W. -K, Macias Lopez, E. M., Lovas, T., Luglio, M., Mainardi, S., Mahanti, P. K., Marinos, I., Maropoulos, P., Mativenga, P., Mavrommatis, G., Meintanis, S. G., Meisel, Y. D., Mekid, S., Mias, C., Morin, A., Musliu, N., Nabhani, F., Naguib, R., Olatunbosun, O., Olsen, S., Ozalp, A. A., Pang, A. -C, Pao, W. K. -S, Piera, M. A., Pinciroli, F., Popescu, T. D., Power, H., Prewett, P. D., Putrus, G. A., Railton, C., Raja, V., Resta, M., Ristic, M., Roy, R., Alessandra Russo, Sadri, F., Sahinkaya, M. N., Sakata, T., Salous, S., Sazhin, S., Scepi, G., Seneviratne, L., Seng, Q. T., Shammas, N., Shepherd, D. E. T., Short, T., Siddique, M. N. H., Singh, R., Sirlantzis, K., Solanas, A., Stathaki, T., Todd-Pokropek, A., Velez, F. J., Vicent, A. M. P., Virdee, B., Walters, R. J., Wang, C. H. -T, Wang, J., Wang, W., Wang, X. -Z, Ware, M., Webb, P., Wen, D., Wen, J., Wood, A., Woodhead, R., Woods, J., Wu, Q. H., Utyuzhnikov, S. V., Xu, H., Xu, Y., Yan, Y., Yang, G. -C, Yang, W., Yang, X. -S, Yu, H. -F, Zhao, Y., Zharkova, V., Zhong, Q. -C, and Zopounidis, C.

7. WCE 2010 - World Congress on Engineering 2010: Preface

Author

Korsunsky, A. M., Hunter, A., Hukins, D. W. L., Gelman, L., Hogger, C. J., Ceglarek, D. J., Payne, S., Ao, S. I., Ahmad, M., Alexandrou, I., Al-Nuaimy, W., Amavasai, B. P., An, Y. -Y, Ariwa, E., Arteche, J., Audrino, F., Ayesh, A., Baber, C., Bailey, C., Balkan, N., Barria, J., Bartosova, J., Benkrid, K., Bleijs, H., Bluck, M., Bose, I., Bouzas, P. R., Braiden, P. M., Brdys, M., Burriesci, G., Cannataro, M., Carvalho, A., Chang, C. -C, Chen, D., Chen, G. G., Chen, Y. -S, Chiclana, F., Cooke, A., Das, D. B., Davis, D. N., Dayoub, I., Raman, S. D. C. V., Demetriou, I. C., Devai, F., Dilmaghani, R. S., Dini, D., Drikakis, D., Durkan, C., Durodola, J., Etebar, K., Fenn, P., Figueiredo, A., Florou, G., Freear, S., Gabrys, B., Galbraith, G. H., Gaskell, P. H., Gaura, E., Ge, Z. -Q, Ghafouri-Shiraz, H., Ghavami, M., Giannopoulos, K., Pruneda Gonzalez, R. E., Gracia, A. M., Grecos, C., Guan, L., Gulpinar, N., Guo, R., Guo, Y., Hardalupas, Y., He, L., Herrero, J. R., Hicks, B. J., Hines, E. L., Hodgson, S., Horsfall, A., Hosein, P., Hu, F., Hu, O., Ijomah, W., Ming, J., James, A., Jancovic, P., Jhumka, A., Kamareddine, F., Kannan, R., Karsligil, M. E., Katircioglu, S. T., Khalid, A., Kokossis, A., Kontis, K., Kulekci, M. O., Laukaitis, A., Leeson, M., Limbachiya, M. C., Li, L., Lin, P., Ling, W. -K, Macias Lopez, E. M., Lovas, T., Luglio, M., Mainardi, S., Mahanti, P. K., Marinos, I., Maropoulos, P., Mativenga, P., Mavrommatis, G., Meintanis, S. G., Meisel, Y. D., Mekid, S., Mias, C., Morin, A., Musliu, N., Nabhani, F., Naguib, R., Olatunbosun, O., Olsen, S., Ozalp, A. A., Pang, A. -C, Pao, W. K. -S, Piera, M. A., Pinciroli, F., Popescu, T. D., Power, H., Prewett, P. D., Putrus, G. A., Railton, C., Raja, V., Resta, M., Ristic, M., Roy, R., Alessandra Russo, Sadri, F., Sahinkaya, M. N., Sakata, T., Salous, S., Sazhin, S., Scepi, G., Seneviratne, L., Seng, Q. T., Shammas, N., Shepherd, D. E. T., Short, T., Siddique, M. N. H., Singh, R., Sirlantzis, K., Solanas, A., Stathaki, T., Todd-Pokropek, A., Velez, F. J., Vicent, A. M. P., Virdee, B., Walters, R. J., Wang, C. H. -T, Wang, J., Wang, W., Wang, X. -Z, Ware, M., Webb, P., Wen, D., Wen, J., Wood, A., Woodhead, R., Woods, J., Wu, Q. H., Utyuzhnikov, S. V., Xu, H., Xu, Y., Yan, Y., Yang, G. -C, Yang, W., Yang, X. -S, Yu, H. -F, Zhao, Y., Zharkova, V., Zhong, Q. -C, and Zopounidis, C.

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