1. Long-term impact of joint bleeds in von Willebrand disease: a nested case-control study
- Author
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Galen, K.P.M. van, Kleijn, P. de, Foppen, W., Eikenboom, J., Meijer, K., Schutgens, R.E.G., Fischer, K., Cnossen, M.H., Meris, J. de, Fijnvandraat, K., Bom, J.G. van der, Laros-van Gorkom, B.A.P., Leebeek, F.W.G., Mauser-Bunschoten, E.P., Win Study Grp, ACS - Amsterdam Cardiovascular Sciences, Paediatric Infectious Diseases / Rheumatology / Immunology, ACS - Pulmonary hypertension & thrombosis, General Practice, Pediatrics, Hematology, Vascular Ageing Programme (VAP), and Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET)
- Subjects
Male ,Pediatrics ,Time Factors ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,030204 cardiovascular system & hematology ,PROPHYLAXIS ,0302 clinical medicine ,Surveys and Questionnaires ,hemic and lymphatic diseases ,Health score ,Aged, 80 and over ,Hematology ,Middle Aged ,HEMOPHILIA ACTIVITIES LIST ,von Willebrand Diseases ,AGREEMENT ,Joint pain ,RELIABILITY ,Female ,Joint Diseases ,medicine.symptom ,Adult ,medicine.medical_specialty ,Adolescent ,Visual analogue scale ,Hemorrhage ,Article ,03 medical and health sciences ,Internal medicine ,Arthropathy ,medicine ,Von Willebrand disease ,Journal Article ,Humans ,VALIDITY ,Aged ,ARTHROPATHY ,HEALTH SCORE ,business.industry ,Coagulation & its Disorders ,Case-control study ,ADULTS ,medicine.disease ,Case-Control Studies ,Nested case-control study ,MODERATE ,Joints ,EPISODES ,business ,030215 immunology - Abstract
Contains fulltext : 177213.pdf (Publisher’s version ) (Open Access) Patients with severe von Willebrand disease (VWD) may develop arthropathy after joint bleeds. Information on its prevalence and severity is limited. We aimed to assess the occurrence and severity of arthropathy in VWD and its impact on daily life. VWD patients with and without verified joint bleeds were matched for age, sex and Factor VIII level or von Willebrand Factor activity in a nested case-control study within the Willebrand in the Netherlands study. Assessments included the Hemophilia Joint Health Score (0-124), Pettersson score (0-13 per joint X-ray), Hemophilia Activity List score (0-100), joint pain (Visual Analog Scale 0-10), and the Impact on Participation and Autonomy questionnaire (0-20). Arthropathy was defined as a Hemophilia Joint Health Score of 10 or higher, or a Pettersson score over 3 of at least one joint. We included 48 patients with verified joint bleeds (cases) and 48 controls: 60% males, mean age 46 years (range 18-80), median von Willebrand Factor activity 5 versus 8 IU/dL and Factor VIII 24 versus 36 IU/dL. Arthropathy occurred in 40% of the cases versus 10% of the controls (P3: 13 of 19 vs. 3 of 28, P
- Published
- 2017