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Your search keyword '"FitzGerald, Garret A"' showing total 7 results
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2. Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples

Author

O'Donnell, Valerie, Schebb, Nils H, Milne, Ginger L, Murphy, Michael P, Thomas, Christopher P, Steinhilber, Dieter, Wendell, Stacy G, K��hn, Hartmut, Per-Johan Jakobsson, Blair, Ian, Murphy, Robert C, Freeman, Bruce A, Brash, Alan R, and FitzGerald, Garret

Subjects
fungi, lipids, specialized proresolving mediators, immunology, inflammation, resolution
Abstract

Specialized pro-resolving mediators (SPM) derived from oxygenation of long chain polyunsaturated fatty acids (PUFA) were originally described by Serhan and colleagues and have been proposed as mediators of inflammation resolution. Families of SPM described in the literature include lipoxins, resolvins, maresins, protectins and their peptide conjugates. In this article Gomez and co-authors report that levels of plasma SPM from patients with early rheumatoid arthritis predict response to biologic therapy after 6 months. SPM were measured in this study using liquid chromatography tandem mass spectrometry (LC-MS/MS). On reviewing the methods, supplementary analytical data and the online peer review file, we note several concerns, regarding both analytical methods and experimental conclusions. Specifically, quantifications of multiple SPM are based on weak or absent peaks in ion chromatograms, and mass spectra extracted from the recordings do not concord with authentic standards of SPM molecules presented. Indeed, applying their methodology, it is possible to infer the presence of lipids in clean methanol and buffer blanks. The LC-MS/MS analyses described, which are widely applied to the analysis of SPM, fail to meet the standards of accepted practices in the small molecule and lipidomics field or those endorsed by professional bodies for analytical chemistry. Application of this flawed methodology to SPM analysis brings into question the very occurrence of many of these lipids in biological samples, their proposed impact on inflammatory processes, and biomarker claims.

Published
2021
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3. sj-pdf-1-jbr-10.1177_07487304211054408 ��� Supplemental material for Nitecap: An Exploratory Circadian Analysis Web Application

Author

Brooks, Thomas G., Mr��ela, Antonijo, Lahens, Nicholas F., Paschos, Georgios K., Grosser, Tilo, Skarke, Carsten, FitzGerald, Garret A., and Grant, Gregory R.

Subjects
FOS: Clinical medicine, FOS: Biological sciences, 110306 Endocrinology, 69999 Biological Sciences not elsewhere classified, Neuroscience
Abstract

Supplemental material, sj-pdf-1-jbr-10.1177_07487304211054408 for Nitecap: An Exploratory Circadian Analysis Web Application by Thomas G. Brooks, Antonijo Mr��ela, Nicholas F. Lahens, Georgios K. Paschos, Tilo Grosser, Carsten Skarke, Garret A. FitzGerald and Gregory R. Grant in Journal of Biological Rhythms

Published
2021
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4. Genetic and pharmacological analysis of prostanoid receptor function

Author

Narumiya, Shuh and FitzGerald, Garret A.

Subjects
Fever, Prostaglandin Antagonists, Placenta, Receptors, Prostaglandin, Receptors, Thromboxane, Pain, Mice, GTP-Binding Proteins, Ischemia, Pregnancy, Hypersensitivity, Animals, Humans, Cyclooxygenase Inhibitors, Bone Resorption, Cell Nucleus, Inflammation, Mice, Knockout, Aspirin, Neovascularization, Pathologic, Thromboxanes, Biological Transport, General Medicine, Protein Structure, Tertiary, Vasodilation, Drug Design, Perspective, Colonic Neoplasms, Prostaglandins, Female, Signal Transduction
Published
2001

5. Reply

Author

Violi, Francesco, Iuliano, Luigi, and FitzGerald, Garret A

Subjects
Cardiology and Cardiovascular Medicine
Published
2002
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6. Gene-centric Meta-analysis in 87,736 Individuals of European Ancestry Identifies Multiple Blood-Pressure-Related Loci

Author

Tragante, Vinicius, Barnes, Michael R., Ganesh, Santhi K., Lanktree, Matthew B., Guo, Wei, Franceschini, Nora, Smith, Erin N., Johnson, Toby, Holmes, Michael V., Padmanabhan, Sandosh, Karczewski, Konrad J., Almoguera, Berta, Barnard, John, Baumert, Jens, Chang, Yen-Pei Christy, Elbers, Clara C., Farrall, Martin, Fischer, Mary E., Gaunt, Tom R., Gho, Johannes M. I. H., Gieger, Christian, Goel, Anuj, Gong, Yan, Isaacs, Aaron, Kleber, Marcus E., Leach, Irene Mateo, McDonough, Caitrin W., Meijs, Matthijs F. L., Melander, Olle, Nelson, Christopher P., Nolte, Ilja M., Pankratz, Nathan, Price, Tom S., Shaffer, Jonathan, Shah, Sonia, Tomaszewski, Maciej, Van Der Most, Peter J., Van Iperen, Erik P. A., Vonk, Judith M., Witkowska, Kate, Wong, Caroline O. L., Zhang, Li, Beitelshees, Amber L., Berenson, Gerald S., Bhatt, Deepak L., Brown, Morris, Burt, Amber, Cooper-DeHoff, Rhonda M., Connell, John M., Cruickshanks, Karen J., Curtis, Sean P., Davey-Smith, George, Delles, Christian, Gansevoort, Ron T., Guo, Xiuqing, Haiqing, Shen, Hastie, Claire E., Hofker, Marten H., Hovingh, G. Kees, Kim, Daniel S., Kirkland, Susan A., Klein, Barbara E., Klein, Ronald, Li, Yun R., Maiwald, Steffi, Newton-Cheh, Christopher, O’Brien, Eoin T., Onland-Moret, N. Charlotte, Palmas, Walter R., Parsa, Afshin, Penninx, Brenda W., Pettinger, Mary, Vasan, Ramachandran S., Ranchalis, Jane E., Ridker, Paul M., Rose, Lynda M., Sever, Peter, Shimbo, Daichi, Steele, Laura, Stolk, Ronald P., Thorand, Barbara, Trip, Mieke D., Van Duijn, Cornelia M., Verschuren, W. Monique, Wijmenga, Cisca, Wyatt, Sharon, Young, J. Hunter, Zwinderman, Aeilko H., Bezzina, Connie R., Boerwinkle, Eric, Casas, Juan P., Caulfield, Mark J., Chakravarti, Aravinda, Chasman, Daniel I., Davidson, Karina W., Doevendans, Pieter A., Dominiczak, Anna F., FitzGerald, Garret A., Gums, John G., Fornage, Myriam, Hakonarson, Hakon, Halder, Indrani, Hillege, Hans L., Illig, Thomas, Jarvik, Gail P., Johnson, Julie A., Kastelein, John J. P., Koenig, Wolfgang, Kumari, Meena, Marz, Winfried, Murray, Sarah S., O’Connell, Jeffrey R., Oldehinkel, Albertine J., Pankow, James S., Rader, Daniel J., Redline, Susan, Reilly, Muredach P., Schadt, Eric E., Kottke-Marchant, Kandice, Snieder, Harold, Snyder, Michael, Stanton, Alice V., Tobin, Martin D., Uitterlinden, Andre G., Van Der Harst, Pim, Van Der Schouw, Yvonne T., Samani, Nilesh J., Watkins, Hugh, Johnson, Andrew D., Reiner, Alex P., Zhu, Xiaofeng, De Bakker, Paul I. W., Levy, Daniel, Asselbergs, Folkert W., Munroe, Patricia B., and Keating, Brendan J.

Subjects
Meta-analysis, Epidemiology, Molecular biology, FOS: Biological sciences, Blood pressure, Genetics, Human genetics--Research, 3. Good health
Abstract

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10−7) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.

7. Loci influencing blood pressure identified using a cardiovascular gene-centric array

Author

Ganesh, Santhi K., Tragante, Vinicius, Guo, Wei, Guo, Yiran, Lanktree, Matthew B., Smith, Erin N., Johnson, Toby, Almoguera Castillo, Berta, Barnard, John, Baumer, Jens, Chang, Yen-Pei Christy, Elbers, Clara C., Farrall, Martin, Fischer, Mary E., Franceschini, Nora, Gaunt, Tom R., Gho, Johannes M. I. H., Gieger, Christian, Gong, Yan, Isaacs, Aaron, Kleber, Marcus E., Leach, Irene Mateo, McDonough, Caitrin W., Meijs, Matthijs F. L., Mellander, Olle, Molony, Cliona M., Nolte, Ilja M., Padmanabhan, Sandosh, Price, Tom S., Rajagopalan, Ramakrishnan, Shaffer, Jonathan, Shah, Sonia, Shen, Haiqing, Soranzo, Nicole, Van Der Most, Peter J., Van Iperen, Erik P. A., Van Setten, Jessic A., Vonk, Judith M., Zhang, Li, Beitelshees, Amber L., Berenson, Gerald S., Bhatt, Deepak L., Boer, Jolanda M. A., Boerwinkle, Eric, Burkley, Ben, Burt, Amber, Chakravarti, Aravinda, Chen, Wei, Cooper-DeHoff, Rhonda M., Curtis, Sean P., Dreisbach, Albert, Duggan, David, Ehret, Georg B., Fabsitz, Richard R., Fornage, Myriam, Fox, Ervin, Furlong, Clement E., Gansevoort, Ron T., Hofker, Marten H., Hovingh, G. Kees, Kirkland, Susan A., Kutlar, Abdullah, Kottke-Marchant, Kandice, LaCroix, Andrea Z., Langaee, Taimour Y., Li, Yun R., Lin, Honghuang, Liu, Kiang, Maiwald, Steffi, Malik, Rainer, Murugesan, Gurunathan, Newton-Cheh, Christopher, O’Connell, Jeffery R., Onland-Moret, N. Charlotte, Ouwehand, Willem H., Palmas, Walter R., Penninx, Brenda W., Pepine, Carl J., Pettinger, Mary, Polak, Joseph F., Ramachandran, Vasan S., Ranchalis, Jane, Redline, Susan, Ridker, Paul M., Rose, Lynda M., Scharnag, Hubert, Schork, Nicholas J., Shimbo, Daichi, Shuldiner, Alan R., Srinivasan, Sathanur R., Stolk, Ronald P., Taylor, Herman A., Thorand, Barbara, Trip, Mieke D., Van Duijn, Cornelia M., Verschuren, W. Monique, Wijmenga, Cisca, Winkelmann, Bernhard R., Wyatt, Sharon, Young, J. Hunter, Boehm, Bernhard O., Caulfield, Mark J., Chasman, Daniel I., Davidson, Karina W., Doevendans, Pieter A., FitzGerald, Garret A., Gums, John G., Hakonarson, Hakon, Hillege, Hans L., Illig, Thomas, Jarvik, Gail P., Johnson, Julie A., Kastelein, John J. P., Koenig, Wolfgang, Marz, Winfried, Mitchell, Braxton D., Murray, Sarah S., Oldehinkel, Albertine J., Rader, Daniel J., Reilly, Muredach P., Reiner, Alex P., Schadt, Eric E., Silverstein, Roy L., Snieder, Harold, Stanton, Alice V., Uitterlinden, Andre G., Van Der Harst, Pim, Van Der Schouw, Yvonne T., Samani, Nilesh J., Johnson, Andrew D., Munroe, Patricia B., De Bakker, Paul I. W., Zhu, Xiaofeng, Levy, Daniel, Keating, Brendan J., Asselbergs, Folkert W., CARDIOGRAM, METASTROKE, and LifeLines Cohort Study

Subjects
Human genetics, Molecular biology, Blood pressure, cardiovascular diseases, Medical sciences, 3. Good health, Blood pressure--Regulation
Abstract

Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped ∼50 000 single-nucleotide polymorphisms (SNPs) that capture variation in ∼2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P < 2.4 × 10−6). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.

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