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Water loss due to persistent leakages in water distribution networks remains a substantive problem around the world, all the more so given noticeable trends of increasing global water scarcities. In this paper, we present a data-driven leak localization approach leveraging a connected Geographical Information System together with an autoencoder to perform anomaly detection on time-variable sensor data. Data-driven approaches are able to circumvent many of the uncertainty issues associated with model-based approaches, but they usually require significant amounts of high-quality data, reflecting many different leak scenarios, to perform well. Our approach obviates this requirement by relying only on leakless data during model training. We examine the efficacy of this approach on 19 realistic leak experiments conducted in the field. Based on these evaluations, we were able to achieve average search costs as low as 2.2 kilometers, for a total network length of 215 kilometers.

We study market-consistent valuation of liability cash flows motivated by current regulatory frameworks for the insurance industry. Building on the theory on multiple-prior optimal stopping we propose a valuation functional with sound economic properties that applies to any liability cash flow. Whereas a replicable cash flow is assigned the market value of the replicating portfolio, a cash flow that is not fully replicable is assigned a value which is the sum of the market value of a replicating portfolio and a positive margin. The margin is a direct consequence of considering a hypothetical transfer of the liability cash flow from an insurance company to an empty corporate entity set up with the sole purpose to manage the liability run-off, subject to repeated capital requirements, and considering the valuation of this entity from the owner's perspective taking model uncertainty into account. Aiming for applicability, we consider a detailed insurance application and explain how the optimisation problems over sets of probability measures can be cast as simpler optimisation problems over parameter sets corresponding to parameterised density processes appearing in applications., 1 figure

10 Pág. Centro de Investigación Forestal (CIFOR), Riparian vegetation supports high biodiversity providing many services and is, therefore, an important landscape element. Riparian ecosystems are subject to numerous pressures leading to population decline and genetic erosion of riparian plants. This may have cascading effects at various ecosystem levels, including decreasing ecosystem services, so identifying the current status of genetic diversity of riparian tree species is vital to improve the effectiveness of restoration efforts. We aimed to elicit expert views on the status and importance of genetic diversity of tree species, and conservation needs across European riparian ecosystems. Sharing of such information among researchers, managers and policymakers has the potential to enhance ecological restoration and management of riparian ecosystems. We identified experts in riparian genetic resources conservation and management across Europe. These included stakeholders with different perspectives, ranging from researchers to practitioners. We designed a set of questionnaires where our identified experts were asked to answer questions related to the status and conservation of genetic diversity of riparian tree species in their respective countries. Specifically, we asked about societal awareness, legislative tools, good practices and conservation or restoration projects accounting for intraspecific genetic diversity and differentiation of tree species in riparian ecosystems. Questionnaire responses were analysed and discussed in light of the scientific literature to define needs and priorities related to the management and conservation of genetic diversity of riparian tree species. The experts recognized that a combination of in situ and ex situ measures and/or integrative conservation of riparian ecosystems is the most appropriate option for conserving the genetic diversity of riparian tree species. Simultaneous application of conservation measures at the level of priority species, identified by experts, and protection of riparian areas are required. Synthesis and applications. This study revealed the importance of recognizing the ecological processes that shape the genetic diversity of riparian tree species in hydrographic networks (dendritic spatial configuration, specific patterns of gene flow among riparian populations, fragmentation of river by dams) but also the need to overcome socio-economic barriers, such as lack of policy priority, deficiency in funding and weak legislation framework., The work leading to this paper was developed within the COST Action (CA16208)—CONVERGES (Knowledge Conversion for Enhancing Management of European Riparian Ecosystems and Services), supported by COST (European Cooperation in Science and Technology; www.cost.eu) and by the Horizon 2020 Framework Programme of the European Union. We thank three anonymous reviewers for comments and suggestions that greatly improved the paper. JM was supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia, according to the agreement No. 0801-417/1. PMRG was supported by the Portuguese Foundation for Science and Technology (FCT) through the 2020.03356.CEECIND grant, and through PTDC/ASP-SIL/28593/2017 grant; and Forest Research Centre by the FCT (UIDB/00239/2020) grant. RP was supported by the grant from the National Science Centre, Poland (2019/35/B/NZ8/01901).

Correction to Lancet Gastroenterol Hepatol 2022; 7: 627-47. Lancet Gastroenterol Hepatol. 2022 Aug;7(8):704. doi: 10.1016/S2468-1253(22)00210-2. PMID: 35809605. Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990-2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408-868 574) to 2·17 million (2·00-2·34), and deaths increased from 518 126 (493 682-537 877) to 1·09 million (1·02-1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3-23·0) per 100 000 to 26·7 (24·6-28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5-14·9) per 100 000 to 13·7 (12·6-14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7-320·7) per 100 000 to 295·5 (275·2-313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9-80·0] per 100 000), Monaco (60·7 [48·5-73·6] per 100 000), and Andorra (56·6 [42·8-71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0-37·1] per 100 000), Brunei (30·3 [26·6-34·1] per 100 000), and Hungary (28·6 [23·6-34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age

Different topographical support bases are used to solve the problems of raising and tracing underground mining works. These are frequently used on polygonal path with two fixed points, where the coordinates of the end points are given, and the measured quantities are angles and distances. Depending on the errors of the quantities measured before processing and the errors after processing, the coordinates of the points of the polygonal route and the orientations of the sides are determined with the precision, that fundamentally, technically and economically determines the execution of the designed mining works.

Background & Aims: HEV genotype (gt) 3 infections are prevalent in high-income countries and display a wide spectrum of clinical presentations. Host - but not viral - factors are reported to be associated with worse clinical outcomes.Methods: Demographic, clinical, and biochemical data laboratory-confirmed HEV infections (by PCR and/or a combination of IgM and IgG serology) at the Belgian National Reference Centre between January 2010 and June 2018 were collected using stand-ardised case report forms. Genotyping was based on HEV open reading frame 2 sequences. Serum CXCL10 levels were measured by a magnetic bead-based assay. H&E staining was performed on liver biopsies.Results: A total of 274 HEV-infected individuals were included. Subtype assignment was possible for 179/218 viraemic cases, confirming gt3 as dominant with an almost equal representation of clades abchijklm and efg. An increased hospitalisation rate and higher peak serum levels of alanine aminotransferase, bilirubin, and alkaline phosphatase were found in clade efg-infected in-dividuals in univariate analyses. In multivariable analyses, clade efg infections remained more strongly associated with severe disease presentation than any of the previously identified host risk factors, being associated with a 2.1-fold higher risk of hos-pitalisation (95% CI 1.1-4.4, p = 0.034) and a 68.2% higher peak of bilirubin levels (95% CI 13.3-149.9, p = 0.010), independently of other factors included in the model. In addition, acute clade efg infections were characterised by higher serum CXCL10 levels (p = 0.0005) and a more pronounced liver necro-inflammatory activity (p = 0.022). Conclusions: In symptomatic HEV gt3 infections, clade efg is associated with a more severe disease presentation, higher serum CXCL10 levels, and liver necro-inflammatory activity, irrespective of known host risk factors.Clinical Trial Registration: The protocol was submitted to clinicaltrials.gov (NCT04670419).(c) 2022 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. This study is a retrospective analysis of routinely collected data, within the Belgian National Reference Centre (NRC) programme funded by the National Institute for Health and Disability Insurance (RIZIV-INAMI, Belgium). TV is supported by a senior clinical investigator grant of the Research Foundation Flanders (FWO) (number 18B2821N, Belgium). JS and NH acknowledge funding from the European Research Council (ERC) Horizon 2020 research and innovation program (grant agreement 682540 — TransMID, European Union). The funding sources did not have any role in study design, in the collection, analysis, and interpretation of data, in the manuscript writing, or in the decision to submit the paper for publication. We thank Harry Dalton for helpful discussions on the national data collection and clinical outcome analysis and Christophe Conrad for his help in collecting patients data. The authors also especially thank all physicians from the following centres who participated in the study: Algemeen Ziekenhuis Alma, Eeklo; Algemeen Medisch Laboratorium, Antwerpen; Algemeen Stedelijk Ziekenhuis, Aalst; Algemeen Ziekenhuis Delta, Roeselare; Algemeen Ziekenhuis Delta, Torhout; Algemeen Ziekenhuis Nikolaas, Sint-Niklaas; Algemeen Ziekenhuis Sint-Elisabeth, Zottegem; Algemeen Ziekenhuis, Turnhout; Centre Hospitalier Universitaire Brugmann, Brussels; Centre Hospitalier de l’Ardenne, Libramont; Hôpital de Braine-l’Alleud-Waterloo, Braine-l’Alleud; Hôpital Delta, Brussels; Centre Hospitalier de Mouscron, Mouscron; Centre Hospitalier Régional Haute Senne, Soignies; Centre Hospitalier Epicura, Hornu; Centre Hospitalier Universitaire de Liège, Liège; Centre Hospitalier de la Wallonie Picarde, Tournai; Clinique CHC, Waremme; Grand Hôpital de Charleroi, Charleroi; Gasthuiszusters Antwerpen, Antwerpen; Hôpital Princesse Paola, Marche-en-Famenne; Hôpital Iris Sud, Brussels; Instituut voor Tropische Geneeskunde, Antwerpen; Hôpital de Jolimont, La Louvière; Centre Hospitalier de Jolimont, Lobbes; Centre Hospitalier de Jolimont, Nivelles; Centre Hospitalier de Jolimont, Tubize; Eurofins Labo Van Poucke, Kortrijk; Medisch Labo Medina, Dendermonde; Algemeen Ziekenhuis Maria Middelares, Gent; Ziekenhuis Netwerk Antwerpen Middelheim, Antwerpen; Cliniques Universitaires Saint-Luc, Brussels; Centre Hospitalier Universitaire UCL, Dinant; Centre Hospitalier Universitaire UCL, Namur; Centre Hospitalier Universitaire de MontGodinne, Yvoir; Clinique Saint-Luc, Bouge; Clinique Notre-Dame de Grâce, Gosselies; Sint-Andriesziekenhuis, Tielt; Algemeen Ziekenhuis West, Veurne; Algemeen Ziekenhuis Sint Blasius, Dendermonde; Algemeen Ziekenhuis SintJan, Brugge; Klinik Sankt-Joseph, Sankt-Vith; Algemeen Ziekenhuis SintLucas, Gent; Algemeen Ziekenhuis Sint-Maarten, Mechelen; Centre Hospitalier Universitaire Saint-Pierre, Brussels; Sint-Trudo Ziekenhuis, Sint-Truiden; Centre Hospitalier Universitaire Tivoli, La Louvière; Hôpital Erasme – Cliniques Universitaires de Bruxelles, Brussels; Universitair Ziekenhuis Antwerpen, Antwerpen; Universitair Ziekenhuis Gent, Gent; Cassiman David, Laleman Wim, Van Malenstein Hannah, Verslype Chris and Van der Merwe Schalk from Universitair Ziekenhuis Leuven, Leuven; Virga Jesse Ziekenhuis, Hasselt; Universitair Ziekenhuis Brussel, Brussels; Jan Yperman Ziekenhuis, Ieper.

Police administrators are looking for concrete pathways to fight the phenomenon of (ethnic) prejudice among members of the police force. Surprisingly, few studies have assessed the effectiveness of existing police ethics training programs on prejudice and social dominance orientation. Therefore, we assessed the impact of a 1-day training called the Holocaust, Police, and Human Rights (HPH) program on the attitudes related to ethnic prejudice and social dominance orientation of 223 members of the Belgian police. Analyses of three-wave panel data indicate that HPH training reduced ethnic prejudice and social dominance orientation. For ethnic prejudice, the reduced effects were maintained after 1 month in the follow-up study. However, the effect of training on prejudice was weaker for police officers who were more often exposed to victims and perpetrators of crime. No lasting effect of HPH training was found for social dominance orientation.

Dupuytren's disease (DD) is a chronic benign fibroproliferative disorder of the palmar and digital fasciae. It is characterized by formation of nodules and fibrous cords that may eventually lead to contractures with permanent flexion of the finger joints. Correction of the flexion contractures in advanced disease is still performed by open limited fasciectomy; ultrasonography (US)-guided minimally invasive treatment is preferred for early disease.We provide an overview of the detailed anatomy of the palmar aponeurosis and the structures that may be involved in DD. Although magnetic resonance imaging is used as the gold standard, these small anatomical structures are often better visible on US. We describe two new morphological signs due to thickening of these small structures in patients with DD: the tardigrade sign and the manifold sign. Familiarity with detailed imaging anatomy and these new imaging signs of DD will help confirm a correct and early diagnosis and distinguish this disease from various other entities.

Purpose: SYNB1891 is a live, modified strain of the probiotic Escherichia coli Nissle 1917 (EcN) engineered to produce cyclic dinucleotides under hypoxia, leading to STimulator of INterferon Genes (STING) activation in phagocytic antigen-presenting cells in tumors and activating complementary innate immune pathways. Patients and Methods: This first-in-human study (NCT04167137) enrolled participants with refractory advanced cancers to receive repeat intratumoral injections of SYNB1891 either alone or in combination with atezolizumab, with the primary objective of evaluating the safety and tolerability of both regimens. Results: Twenty-four participants received monotherapy across six cohorts, and 8 participants received combination therapy in two cohorts. Five cytokine release syndrome events occurred with monotherapy, including one that met the criteria for dose-limiting toxicity at the highest dose; no other SYNB1891-related serious adverse events occurred, and no SYNB1891-related infections were observed. SYNB1891 was not detected in the blood at 6 or 24 hours after the first intratumoral dose or in tumor tissue 7 days following the first dose. Treatment with SYNB1891 resulted in activation of the STING pathway and target engagement as assessed by upregulation of IFN-stimulated genes, chemokines/cytokines, and T-cell response genes in core biopsies obtained predose and 7 days following the third weekly dose. In addition, a dose-related increase in serum cytokines was observed, as well as stable disease in 4 participants refractory to prior PD-1/L1 antibodies. Conclusions: Repeat intratumoral injection of SYNB1891 as monotherapy and in combination with atezolizumab was safe and well tolerated, and evidence of STING pathway target engagement was observed.

Biventricular pacing (Biv) and left bundle branch area pacing (LBBAP) are methods of cardiac resynchronization therapy (CRT). Currently, little is known about how they differ in terms of ventricular activation. This study compared ventricular activation patterns in left bundle branch block (LBBB) heart failure patients using an ultra-high-frequency electrocardiography (UHF-ECG). This was a retrospective analysis including 80 CRT patients from two centres. UHF-ECG data were obtained during LBBB, LBBAP, and Biv. Left bundle branch area pacing patients were divided into non-selective left bundle branch pacing (NSLBBP) or left ventricular septal pacing (LVSP) and into groups with V6 R-wave peak times (V6RWPT) < 90 ms and ≥ 90 ms. Calculated parameters were: e-DYS (time difference between the first and last activation in V1–V8 leads) and Vdmean (average of V1–V8 local depolarization durations). In LBBB patients (n = 80) indicated for CRT, spontaneous rhythms were compared with Biv (39) and LBBAP rhythms (64). Although both Biv and LBBAP significantly reduced QRS duration (QRSd) compared with LBBB (from 172 to 148 and 152 ms, respectively, both P < 0.001), the difference between them was not significant (P = 0.2). Left bundle branch area pacing led to shorter e-DYS (24 ms) than Biv (33 ms; P = 0.008) and shorter Vdmean (53 vs. 59 ms; P = 0.003). No differences in QRSd, e-DYS, or Vdmean were found between NSLBBP, LVSP, and LBBAP with paced V6RWPTs < 90 and ≥ 90 ms. Both Biv CRT and LBBAP significantly reduce ventricular dyssynchrony in CRT patients with LBBB. Left bundle branch area pacing is associated with more physiological ventricular activation.

When radon is taken out of the scientific context in order to be understood by the public, the way the media approaches radon is prone to sensationalising. Communicating risk in a clear and effective manner was never easy and communication of radon risk poses serious challenges because radon is not widely known and specialists need to be more involved in engagement activities and campaigns to inform about radon exposure. This paper presents the results of the continuous radon measurements performed in workplaces for raising awareness among occupationally exposed workers. Radon measurements were made using Airthings monitors for up to 9 months of monitoring. Measured data correlated to real-time visualisation of the maximum radon levels provided convincing evidence that led to increased interest for radon exposure among exposed workers, raise awareness and empowered their own understanding of radon exposure.

Background: Acute kidney injury occurs commonly in the Neonatal Intensive Care Unit and is associated with increased mortality and morbidity. We report a case of a neonate with congenital heart disease who developed acute kidney injury after cardiac surgery, administration of iodinated contrast media for cardiac catheterization, and a combination of nephrotoxic drugs. Case report: A term neonate without a prenatal diagnosis of congenital heart disease and with a good postnatal transition was transferred at 13 days of life to the MS Curie Emergency Hospital for Children, Newborn Intensive Care Unit, from a regional hospital where he was admitted at 10 days of life with severe general status, respiratory distress, cyanosis, and arterial hypotension. The cardiac ultrasound detected critical aortic valve stenosis, hypoplastic descending aorta, acute heart failure, and pulmonary hypertension. The patient was intubated and mechanically ventilated and received antibiotherapy (meropenem, vancomycin, and colistin), inotropic and vasoactive support (epinephrine, norepinephrine, dopamine, and milrinone), and diuretic support (furosemide, aminophylline, and ethacrynic acid). A balloon aortic valvuloplasty was performed several hours after admission, but after two days the patient required reintervention by open heart surgery due to relapsing severe aortic stenosis. He developed oligo-anuria, generalized edema, and altered renal function tests on the second postoperative and fourth day post-contrast media administration. Continuous renal replacement therapy was initiated for 75 h, leading to almost instant improvement in blood pressure, then diuresis and creatinine levels. The patient required long-term treatment for heart, respiratory, and liver failure. He was discharged at almost four months of age with normal renal function tests, blood pressure, and good urine output without diuretic support. The literature review indicates that contrast-associated acute kidney injury (CA-AKI) requiring continuous renal replacement therapy is rare. Conclusions: Our current case proves that iodinated contrast media administration in a neonate with concomitant insults, such as cardiac surgery for a specific pathology, aortic stenosis, coarctation, arch stenosis, arterial hypotension, and administration of nephrotoxic drugs, may lead to severe kidney injury.

The electrochemical oxidative coupling of methane (EOCM) is an emerging process through which methane can be converted into value-added products such as ethylene. However, this application is hampered by the fact that a stable and ethylene-selective anode material does not currently exist. In this study, we analyse a selection of titanate-based anode materials: SrTi0.3Fe0.63Co0.07O3, SrTi0.65Fe0.35O3 and La0.3Sr0.7TiO3. We analyse the stability of these materials under EOCM operating conditions using post-mortem characterisations involving XRD, XPS and EDS analyses. We also characterise the ethylene production of these anode materials at similar current densities. We find that Fe/Co-doped titanates are unstable under EOCM conditions and undergo significant phase decomposition while La0.3Sr0.7TiO3 remains stable over several weeks of operation.

State-of-the-art solid oxide fuel cell (SOFC) oxygen electrode materials such as La0.6Sr0.4Co0.2Fe0.8O3-δ (LSCF) continue to be plagued by degradation primarily through strontium (Sr) segregation to the electrode surface and subsequent passivating poisoning reactions with chromium- and sulfur-containing species. Surface infiltration of more oxidizable cations is of interest for LSCF electrodes in order to reduce the electrostatic driver of Sr segregation and due its reported success in reducing Sr segregation and electrochemical degradation on LSC electrodes. In this work, we investigate the thermal stability of Hf, Nd, and Pr infiltrated cations at porous LSCF electrode surfaces. These select cations are of interest as surface infiltrates due to their more oxidizable nature. We demonstrate that infiltrated Hf, Nd, and Pr cations are not thermally stable at the LSCF electrode surface at standard SOFC operating temperatures, diffusing substantially away from the surface above 800°C.

Purpose: This article reviews 43 adaptations of the MacArthur–Bates Communicative Development Inventories (MB-CDIs), a tool used for measuring children's communicative and language skills. The aim is to provide an overview of different approaches to develop local versions of the instrument (reflecting linguistic and cultural specifics) and to formulate recommendations and suggestions that expand the current guidelines of the MB-CDI Advisory Board. The article also discusses cross-linguistic differences in the structure of this tool, as well as the availability of sources for the language-specific MB-CDI adaptations. Conclusions: Strategies differ in the construction of the inventory contents and in the norming phase, as well as in documenting reliability and validity. The most frequent strategies in developing the item lists are translations of existing CDIs and pilot administrations; relatively recent strategies include consultations with child development experts. The norming approach varies in, for example, the number of participants and techniques of administrations. When establishing age-related norms, different methods of growth curve construction are used. We recommend methods that consider the complete data set and provide a code example. We suggest that the reliability of the tool should be documented not only as internal consistency but also using test–retest measures, ideally combined with interrater agreement. It is desirable that adaptations establish criterion validity against other measures of language development, such as structured tests, spontaneous language samples, or experimental methods. In summary, by critically reviewing the different adaptation strategies, the present review article provides guidance for teams that adapt the MB-CDI into new languages. Supplemental Material: https://doi.org/10.23641/asha.22661689

Relative populations of the four energy-lowest isolated-pentagon-rule (IPR) isomers of Y@C82 under the high-temperature synthetic conditions are computed using the Gibbs energy based on characteristics from the density functional theory calculations (B3LYP/6–31G*∼SDD entropy, B3LYP/6–31G*∼SDD and B2PLYPD/6–31 + G*∼SDD energetics). Two major species are predicted, Y@C2v;9-C82 and Y@Cs(c);6-C82, their calculated equilibrium relative populations agreeing with observations.

The adult healthy human pancreas has been poorly studied given the lack of indication to obtain tissue from the pancreas in the absence of disease and rapid postmortem degradation. We obtained pancreata from brain dead donors, thus avoiding any warm ischemia time. The 30 donors were diverse in age and race and had no known pancreas disease. Histopathologic analysis of the samples revealed pancreatic intraepithelial neoplasia (PanIN) lesions in most individuals irrespective of age. Using a combination of multiplex IHC, single-cell RNA sequencing, and spatial transcriptomics, we provide the first-ever characterization of the unique microenvironment of the adult human pancreas and of sporadic PanIN lesions. We compared healthy pancreata to pancreatic cancer and peritumoral tissue and observed distinct transcriptomic signatures in fibroblasts and, to a lesser extent, macrophages. PanIN epithelial cells from healthy pancreata were remarkably transcriptionally similar to cancer cells, suggesting that neoplastic pathways are initiated early in tumorigenesis. Significance: Precursor lesions to pancreatic cancer are poorly characterized. We analyzed donor pancreata and discovered that precursor lesions are detected at a much higher rate than the incidence of pancreatic cancer, setting the stage for efforts to elucidate the microenvironmental and cell-intrinsic factors that restrain or, conversely, promote malignant progression.

Countries around the world have imposed various counter-measures at national level, adjusting societal and economic activities to constrain the Covid-19 pandemic. Here we report the research results of assessment of adequacy and effectiveness of the Covid-19 pandemic counter-measures in the case study of the Republic of Croatia. Statistical analysis and inference methods are applied to identify the adequate national-level Covid-19 counter-measures, and their effective intensity levels, as a lessons-learnt evidence with potential use for policy and strategy development support, in potential similar future situations.

Od trenutačnog broja svjetskog stanovništva (7,9 milijardi), broj korisnika interneta dopolovice 2022. iznosio je oko 5,3 milijarde. Promatramo li detaljnije prevalenciju interneta u Hrvatskoj (4,1 milijun stanovnika), broj korisnika tog medija doseže brojku od 3.787.838. U radu se korištenjem standardizirane ankete ispituje ovisnost o internetu 588 srednjoškolaca s područja Virovitice. Prvi dio ankete predstavlja sociodemografske podatke ispitanika, a drugi dio sadrži ljestvicu ovisnosti prema autorici K. S. Young. Rezultati ispitivanja pokazuju da blagu ovisnost pokazuje 354 (60,8%) ispitanika, umjerenu 59 (10,1%), a tešku ovisnost 6 (1%) ispitanika. Rezultati na skali blage ovisnosti pokazuju da na rezultat statistički značajno utječu vrsta škole (gimnazija vs. tehnička škola), povećana frekvencija konzumacije alkohola i aktivno bavljenje slobodnim izvanškolskim aktivnostima. Rezultati skale srednje razine ovisnosti s obzirom na promatrane varijable ne pokazuju statistički značajan utjecaj na rezultat. Rezultati skale teške razine ovisnosti s obzirom na promatrane varijable pokazuju statistički značajan utjecaj na rezultat s obzirom na vrstu škole (tehnička vs. gimnazija) te mjesto stanovanja (selo). Logističkom regresijom dobiveno je da ispitanici koji su ovisni o internetu imaju 0,655 puta veću vjerojatnost konzumacije alkohola, u odnosu na one koji nisu ovisni o internetu. S obzirom na to da je prisutnost interneta u našem životu neizbježna, što uz brojne pozitivne, može donijetii negativne posljedice (zlostavljanje, krađa identiteta, govor mržnje, seksualno iskorištavanje maloljetnika i sl.), radi zaštite djece i mladih potrebna je multisektorska suradnja na edukaciji i prevenciji.

Nowadays, most design processes are computer-aided, but in the case of internal ballistics they are not generally available or are highly specialized and secret. On the other hand, an analytical solution of the system of nonlinear differential equations describing the phases of the phenomenon of a shot in a gun barrel does not exist. Therefore, in order to obtain more accurate solutions to the system of equations, it is worth to use numerical methods. The paper presents a theoretical description of the problem based on a review of analytical and numerical models solving the main problem of internal ballistics. Based on this analysis, it was assumed that a possible direction of development is to implement several models to solve the main problem of internal ballistics in numerical solution, so that the end user (designer) can choose different models and check which model works best in his conditions. In addition, using optimization techniques, an attempt can be made to implement algorithms that would be able to search for example, the smallest powder weight value at specific powder parameters and at given maximum pressure and projectile muzzle velocity. The utilitarian goal of further research is to create a new analytical tool supporting the design of barrel weapons.internal ballistics, Lagrange, pyrodynamics, pyrostatics

The research on the tree of heaven (Ailanthus altissima (Mill.) Swingle) distribution within the Osijek city area was carried out in the summer period of 2017. In total of 589 individuals of the tree of heaven on 130 locations were recorded. The trees grew individually or in groups, mostly on abandoned places, and were rarely found in well-maintained areas. In the vicinity of the tree of heaven, mostly perennial herbaceous weeds were found. These plants thrive in different types of habitats. In order to prevent the uncontrolled spread of this invasive plant in the urban environment, it is necessary to continuously monitor and timely remove the tree of heaven individuals. Moreover, it is important to continuously educate the general public about the adverse impact of this species on the environment and biological diversity., Istraživanje prisutnosti pajasena (Ailanthus altissima (Mill.) Swingle) na području grada Osijeka provedeno je u ljetnom razdoblju 2017. godine. Na 130 lokaliteta zabilježeno je ukupno 589 jedinki stabala pajasena. Pajasen je rastao pojedinačno ili u skupinama, uglavnom na napuštenim područjima, dok je na uređenim i održavanim površinama bio rijetko prisutan. U neposrednoj blizini pajasena zabilježene su korovne, višegodišnje zeljaste biljke koje uspijevaju na različitim tipovima staništa. U svrhu sprječavanja nekontroliranog širenja ove invazivne biljke u gradskoj sredini potrebno je kontinuirano provoditi praćenje i pravovremeno uklanjanje pajasena, kao i kontinuiranu edukaciju šire javnosti o nepovoljnom utjecaju ove vrste na okoliš i biološku raznolikost.

Sackett et al. (2022) identified previously unnoticed flaws in the way range restriction corrections have been applied in prior meta-analyses of personnel selection tools. They offered revised estimates of operational validity, which are often quite different from the prior estimates. The present paper attempts to draw out the applied implications of that work. We aim to a) present a conceptual overview of the critique of prior approaches to correction, b) outline the implications of this new perspective for the relative validity of different predictors and for the tradeoff between validity and diversity in selection system design, c) highlight the need to attend to variability in meta-analytic validity estimates, rather than just the mean, d) summarize reactions encountered to date to Sackett et al., and e) offer a series of recommendations regarding how to go about correcting validity estimates for unreliability in the criterion and for range restriction in applied work.

For a given quadratic irrational [Formula: see text], let us denote by [Formula: see text] the length of the periodic part of the continued fraction expansion of [Formula: see text]. We prove that for every positive integer [Formula: see text], which is not a perfect square, there are infinitely many even integers [Formula: see text], for which the equality [Formula: see text] holds for infinitely many integers [Formula: see text].

A retrospective analysis of urine culture results was conducted for adult patients treated between 1 January 2017 and 31 December 2021 at the Department of Gastroenterology in Rzeszow (southern Poland). A total of 102 patients were sampled for microbiological tests during the analyzed period, with microbial growth found in 30 samples. The purpose of our study was to determine the predominant bacterial species present in the urine of patients hospitalized in the Department of Gastroenterology, as well as their drug susceptibility. The data obtained from medical records included, for example, urine culture results and the antibiotic susceptibility of the isolated microorganisms. The material for the study was collected according to the current procedures. During the analyzed period, urine was collected from a total of 102 patients, and 30 positive samples were found. The predominant pathogen was Escherichia coli (n = 10 (33.33% of all positive results), p < 0.001); the second most common microorganism was Enterococcus faecalis (n = 5 (16.67% of all positive results), p < 0.001). In vitro susceptibility testing showed E. coli, ESBL (ESBL strain with extended-spectrum beta-lactamase) (n = 2 (6.67% of all positive results), p = 0.055) and Klebsiella pneumoniae, ESBL (n = 3 (10% of all positive results), p = 0.005). Urinary tract infection (UTI) was an extremely common problem.