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105 results on '"Ferrarini M."'

1. Cardiovascular manifestations of Erdheim-Chester disease

Author

Berti, A., Ferrarini, M., Elisabetta Ferrero, Dagna, L., Berti, A, Ferrarini, M, Ferrero, E., and Dagna, Lorenzo

Subjects
Erdheim-Chester Disease, Heart Diseases, Cardiovascular Diseases, Aortic Diseases, Humans, Magnetic Resonance Imaging, Cine, Pericardial Effusion
Abstract

Erdheim-Chester disease (ECD) is a rare inflammatory disorder of unknown etiology, characterised by diffuse organ infiltration of CD68-positive, CD1a-negative, S100-low/negative foamy histiocytes. It is a non-Langerhans cell histiocytosis which invariably involves bones (96% of cases). Extraskeletal involvement is observed in about 50% of cases. Cardiovascular involvement affects more than 20% of patients and associates with poor prognosis, conferring a reduced response to treatment. Frequent findings are pericardial effusion (24% of patients), "coated aorta", a perivascular circumferential thickening of the aorta, and pericardial thickening. Other typical features include right atrial mass with pseudo-tumoural appearance and histiocytes' infiltration of right atrial walls, atrioventricular sulcus and interatrial septum. After the recent introduction of cardiac cine MRI in the clinical assessment of patients affected by ECD, a growing body of case reports and retrospective data showed that cardiovascular involvement is present more frequently than previously thought and that it is relatively often asymptomatic. Hence, clinicians should systematically screen ECD patients for occult cardiovascular involvement by means of highly sensitive imaging tools. Despite these recent novelties, comprehensive literature reviews focusing on ECD cardiovascular involvement and its imaging assessment in the last decade are lacking.

Published
2014

2. A GLOBAL PROGRESSION RISK SCORE FOR EARLY STAGE CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: THE NEVER-ENDING STORY

Author

Gentile, M., Shanafelt, T. D., Giovanna Cutrona, Molica, S., Tripepi, G., Ilariucci, F., Mauro, F. R., Di Renzo, N., Di Raimondo, F., Vincelli, I., Todoerti, K., Matis, S., Musolino, C., Maura, F., Fabris, S., Lionetti, M., Levato, L., Zupo, S., Angrilli, F., Consoli, U., Festini, G., Longo, G., Cortelezzi, A., Musto, P., Federico, M., Mannina, D., Neri, A., Kay, N. E., Ferrarini, M., and Morabito, F.

Published
2015

4. Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia

Author

Damle, R. N., Wasil, T., Fais, F., Fabio Ghiotto, Valetto, A., Allen, S. L., Buchbinder, A., Budman, D., Dittmar, K., Kolitz, J., Lichtman, S. M., Schulman, P., Vinciguerra, V. P., Rai, K. R., Ferrarini, M., and Chiorazzi, N.

Subjects
Male, B-Lymphocytes, Time Factors, Genes, Immunoglobulin, Immunology, Immunoglobulin Variable Region, Cell Biology, Hematology, CD5 Antigens, Prognosis, Leukemia, Lymphocytic, Chronic, B-Cell, Survival Analysis, Biochemistry, Immunophenotyping, Cohort Studies, Antigens, CD, immune system diseases, hemic and lymphatic diseases, Mutation, Humans, Female, Immunoglobulin Light Chains, Follow-Up Studies
Abstract

Cellular immunophenotypic studies were performed on a cohort of randomly selected IgM+ B-chronic lymphocytic leukemia (B-CLL) cases for which Ig VH and VL gene sequences were available. The cases were categorized based on V gene mutation status and CD38 expression and analyzed for treatment history and survival. The B-CLL cases could be divided into 2 groups. Those patients with unmutated V genes displayed higher percentages of CD38+ B-CLL cells (≥30%) than those with mutated V genes that had lower percentages of CD38+ cells (

Published
1999

7. Pathologic findings in lymph nodes in a patient with autoimmune lymphoproliferative syndrome (ALPS) who developed a histiocyte-rich/T-cell-rich B cell lymphoma: Evolution during a 20-year follow-up

Author

DAGNA , LORENZO, PONZONI , MAURILIO, Tantardini F, Dianzani U, Dianzani I, Baldissera E, Sanvito F, Freschi M, Sabbadini MG, Rugarli C, Ferrarini M., Dagna, Lorenzo, Ponzoni, Maurilio, Tantardini, F, Dianzani, U, Dianzani, I, Baldissera, E, Sanvito, F, Freschi, M, Sabbadini, Mg, Rugarli, C, and Ferrarini, M.

Published
2002

8. Vascular endothelial growth factor helps differentiate neuropathies in rare plasma cell dyscrasias

Author

Briani, Chiara, Fabrizi, Gm, Ruggero, S, Torre, Cd, Ferrarini, M, Campagnolo, M, Cavallaro, T, Ferrari, S, Scarlato, M, Taioli, F, and Adami, Fausto

Subjects
Adult, Male, Vascular Endothelial Growth Factor A, POEMS Syndrome, Paraproteinemias, Humans, Female, Middle Aged, Statistics, Nonparametric, Aged
Abstract

POEMS syndrome and amyloidosis are rare plasma cell diseases that share common features, including polyneuropathy. The aim of this study was to investigate serum vascular endothelial growth factor (sVEGF) in patients with amyloidosis and to evaluate changes in response to treatment. Twenty-five patients [17 primary light-chain amyloidosis (AL-A), 7 transthyretin amyloidosis (TTR-A), 1 senile wild-type TTR-A] were studied. sVEGF was analyzed by ELISA. Sera from 8 myeloma and 7 POEMS patients were also evaluated. The median sVEGF level was 420 pg/ml in AL-A and 179 pg/ml in TTR-A patients; this was significantly lower than in POEMS syndrome (median 2580 pg/ml, P = 0.0002 and 0.001, respectively). sVEGF of AL-A patients showed no changes in response to treatment. sVEGF was not increased in amyloid patients regardless of neuropathy, and did not mirror the course of the disease. sVEGF should be tested in patients with overlapping and atypical clinical features.

Published
2010

11. Mycobacterium tuberculosis exploits the CD95/CD95 ligand system of gammadelta T cells to cause apoptosis

Author

MANFREDI , ANGELO ANDREA M. A., Heltai S, ROVERE QUERINI , PATRIZIA, Sciorati C, Paolucci C, Gelati G, Rugarli C, Vaiani R, Clementi E, Ferrarini M., Manfredi, ANGELO ANDREA M. A., Heltai, S, ROVERE QUERINI, Patrizia, Sciorati, C, Paolucci, C, Gelati, G, Rugarli, C, Vaiani, R, Clementi, E, and Ferrarini, M.

Subjects
Fas Ligand Protein, Membrane Glycoproteins, T-Lymphocytes, Humans, Apoptosis, Receptors, Antigen, T-Cell, gamma-delta, Mycobacterium tuberculosis, fas Receptor, Cell Line
Abstract

Vgamma9/Vdelta2+ T cells specifically recognize Mycobacterium tuberculosis in vitro and are precociously recruited in early mycobacterial lesions. Even if gammadelta T cells are only fortuitously detected in granulomas or bronchoalveolar lavages of patients with active pulmonary tuberculosis, a role in shaping the mature alphabeta T cell response against M. tuberculosis is substantiated. Here we provide a molecular explanation for this paradox: the engagement of the gammadelta TCR by mycobacterial antigens induced the expression of CD95 ligand (CD95L) by chronically activated CD95+/CD95L- gammadelta T lymphocytes. The receptor was functional, as CD95/CD95L interaction triggered the bystander death of CD95+ cells by apoptosis. Cell death was abolished by CD95-blocking antibodies. The transient accumulation at the site of infection of CD95L+ gammadelta lymphocytes, capable of interacting with CD95+ leukocytes attracted by the response towards the pathogen, may determine the characteristics of the ensuing granulomatous disease.

Published
1998

12. Functional and phenotypic analysis of T lymphocytes cloned from the skin of patients with systemic sclerosis

Author

T L Whiteside, V Steen, Ferrarini M, and Thomas A. Medsger

Subjects
Adult, CD4-Positive T-Lymphocytes, Male, Systemic disease, Pathology, medicine.medical_specialty, Necrosis, medicine.medical_treatment, Immunology, Biology, Lymphocyte Activation, Scleroderma, Dermis, medicine, Humans, Immunology and Allergy, Interferon gamma, Skin, Lymphokines, Scleroderma, Systemic, integumentary system, T lymphocyte, Middle Aged, medicine.disease, Clone Cells, medicine.anatomical_structure, Cytokine, Concanavalin A, biology.protein, Female, medicine.symptom, Research Article, medicine.drug
Abstract

SUMMARY Activated T lymphocytes often accumulate in the‘ower dermis of patients with systemic selerosis (seleroderma) any may play a role in the development of dermal libresis. We propagated and cloned these cells directly from skin biopsies in four of eight cases of early, antreated systemic selerosis with diffuse seleroderma. The cloning frequency estimates were f – 0.20 and f – 0.48 for T cells derived from the skin of two patients versus f - 0.68 and f - 0.96 for autologous blood T lymphocytes, All but one of 24 skin-derived selerederma clones were CD4+. Clonal analyses performed with CD4+ clones from patients and normal controls showed that all but one skin-derived clones synthesized either laterferon-gamma (60%), glycosantinolgycan-stimulatory factor (26%) or both (9%) when induced in vitro by a nitrogen, concanavalin A, but not by antologous dermal fibroblasts. In contrast, blood-derived clones had a different functional phenotype. All skin-derived clones produced tumour accrosis factor-alpha. Our results demonstrate that T lymphecytes obtained from the skin of patients with systemic selerois synthesized cytokoines which could modulale functions of human dermal fibroblasts.

Published
1990

17. TBI a basse dosi nella sclerosi multipla cronico-progressiva; razionale e risultati preliminari

Author

Fossati V, FILIPPI , MASSIMO, Colombo B, Martinelli V, Ciboddo G, Ferrarini M, Volterrani F, Fiorino C, Longobardi B, Signorotto P, Cattaneo GM, Beatrice S, COMI, GIANCARLO, Calandrino R, Canal N, Martinenghi C., Sannazzari GL, Fossati, V, Filippi, Massimo, Colombo, B, Martinelli, V, Ciboddo, G, Ferrarini, M, Volterrani, F, Fiorino, C, Longobardi, B, Signorotto, P, Cattaneo, Gm, Beatrice, S, Comi, Giancarlo, Calandrino, R, Canal, N, and Martinenghi, C.

Published
1991

18. Late Epstein-Barr virus infection of a hepatosplenic gamma delta T-cell lymphoma arising in a kidney transplant recipient

Author

Roncella, S., Giovanna Cutrona, Truini, M., Airoldi, I., Pezzolo, A., Valetto, A., Di Martino, D., Dadati, P., Rossi, A., Ulivi, M., Fontana, I., Nocera, A., Valente, U., Ferrarini, M., and Pistoia, V.

Subjects
Adult, Male, T Cell Lymphoma, Epstein-Barr Virus Infections, Leukosialin, CD3 Complex, Sialoglycoproteins, Splenic Neoplasms, Gene Rearrangement, delta-Chain T-Cell Antigen Receptor, Liver Neoplasms, Receptors, Antigen, T-Cell, gamma-delta, Epstein Barr Virus, Lymphoma, T-Cell, Kidney Transplantation, Antigens, CD, DNA, Viral, Humans, Leukocyte Common Antigens, Cell Lineage
Abstract

gd T-cell lymphomas are only exceptionally observed in transplanted patients. Aim of this study was the detailed characterization of one such case.The patient developed spontaneous splenic rupture six years after kidney transplantation. The splenic red pulp was infiltrated by medium-sized and large lymphoid cells with two or more nucleoli. At autopsy, similar lymphoid cells infiltrated the hepatic sinusoids. Histologic, immunologic and molecular studies were carried out.By immunohistochemistry, the atypical lymphoid cells were found to express CD3, CD45 and CD43, indicating their T-lineage origin. Approximately 99% of spleen mononuclear cells (MNC) were CD3(+), gammadelta TcR+, CD4-, CD8-, alphabeta TcR-. A clonal gammadelta TcR rearrangement (Vgamma1-Jgamma1.3/2.3-Cgamma2; Vdelta1-Ddelta2-Jdelta1) was detected. The final diagnosis was peripheral T-cell lymphoma, hepato-splenic gammadelta-type. EBV infection of spleen MNC was documented by molecular studies. However, in situ hybridization for EBER-1 (EBV-RNA) showed that only a minority of malignant lymphoid cells (5-7%) were EBV-infected.It is concluded that EBV infection was as a late event involving an already transformed gd T-cell clone.

Published
2000

19. Heterogeneous p53 mutations in a Burkitt lymphoma from an AIDS patient with monoclonal c-myc and VDJ rearrangements

Author

Campomenosi, P., Fronza, G., Ottaggio, L., Roncella, S., Inga, A., Massimo Bogliolo, Monti, P., Assereto, P., Moro, F., Cutrona, G., Bozzo, S., Chiorazzi, N., Abbondandolo, A., and Ferrarini, M.

Subjects
Gene Rearrangement, B-Lymphocytes, Heterozygote, Genes, Immunoglobulin, Genes, myc, Tumor Cells, Cultured, Humans, Female, Chromosome Deletion, Genes, p53, Burkitt Lymphoma, In Situ Hybridization, Fluorescence, Lymphoma, AIDS-Related
Abstract

This study investigates the timing of p53 mutations detected in the malignant cells of a Burkitt's lymphoma cell line (BRG-P) with respect to other maturation or transforming events. The BRG-P cell line, derived from an AIDS patient, was of special value since it displayed subclones that had undergone an isotype switch from IgM to IgA1 (BRG-M and BRG-A cells). BRG-M and BRG-A cells were characterized by the same monoclonal c-myc and VDJ rearrangements and by the expression of Ig receptors with specificity for a 45 kDa protein of human breast cells. Analysis of p53 mutations in the different BRG subclones showed that 1) BRG-M cells displayed 2 different p53 mutations in trans; since the original BL cells also showed the same mutations, this finding indicated that both occurred in vivo; 2) one of the p53 alleles of BRG-A cells was lost, while the other showed a mutation different from those seen in BRG-M cells; and 3) all 3 mutations observed in BRG-M or BRG-A cells resulted in the functional inactivation of the transcriptional activation function of p53. Together, our data demonstrate that p53 mutations were relatively late events during lymphomagenesis. Moreover, in view of the role of p53 in cell apoptosis, it is conceivable that BRG cells were subjected to a strong selective pressure that favored p53 inactivation. Such inactivation was possibly required to counterbalance other potentially apoptotic events, including the presence of a deregulated c-myc oncogene and signals delivered by the host environment in situ.

Published
1997

21. Chromogranin A is preferentially cleaved into pro-angiogenic peptides in the bone marrow of multiple myeloma patients

Author

Bianco M, Am, Gasparri, BARBARA COLOMBO, Curnis F, Girlanda S, Ponzoni M, Mt, Bertilaccio, Calcinotto A, Sacchi A, Ferrero E, Ferrarini M, Chesi M, Pl, Bergsagel, Bellone M, Tonon G, Ciceri F, Marcatti M, Caligaris Cappio F, Corti A, Bianco, M, Gasparri, Am, Colombo, B, Curnis, F, Girlanda, S, Ponzoni, M, Bertilaccio, Mt, Calcinotto, A, Sacchi, A, Ferrero, E, Ferrarini, M, Chesi, M, Bergsagel, Pl, Bellone, Tonon M, G., Ciceri, Fabio, Marcatti, M, Caligaris Cappio, F, and Corti, Angelo

22. A GENOMIC APPROACH TO IDENTIFY NEW GENES RESPONSIBLE FOR INHERITED MOTOR AND CMT2 NEUROPATHIES: A COLLABORATIVE STUDY

Author

Previtali, S. C., Fabrizi, G. M., Manganelli, F., Mazzeo, A., Davide Pareyson, Schenone, A., Taroni, F., Vita, G., Bellone, E., Ferrarini, M., Magri, S., Scarlato, M., Riva, N., Lunetta, C., Carrera, P., Bucci, G., Mandich, P., Penco, S., Lazarevic, D., Cittaro, D., Jordanova, A., Reilly, M. M., Casari, G., Ferrari, M., Comi, G., Bolino, A., Previtali, Sc, Fabrizi, Gm, Manganelli, F, Mazzeo, A, Pareyson, D, Schenone, A, Taroni, F, Vita, G, Bellone, E, Ferrarini, M, Magri, S, Scarlato, M, Riva, N, Lunetta, C, Carrera, P, Bucci, G, Mandich, P, Penco, S, Lazarevic, D, Cittaro, D, Jordanova, A, Reilly, Mm, Casari, GIORGIO NEVIO, Ferrari, M, Comi, Giancarlo, and Bolino, A.

24. Chronic lymphocytic leukemia: a proliferation of B cells at two distinct stages of differentiation

Author

Rn, Damle, FRANCO FAIS, Ghiotto F, Valetto A, Albesiano E, Wasil T, Fm, Batliwalla, Sl, Allen, Schulman P, Vp, Vinciguerra, Kr, Rai, Pk, Gregersen, Ferrarini M, and Chiorazzi N

Subjects
DNA Replication, Embryonal Carcinoma Stem Cells, B-Lymphocyte Subsets, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Immunoglobulin Variable Region, CD5 Antigens, Lymphocyte Activation, NAD+ Nucleosidase, Antigens, CD, Antigens, Neoplasm, Humans, ADP-ribosyl Cyclase, Membrane Glycoproteins, Genes, Immunoglobulin, Cell Differentiation, DNA, Neoplasm, Telomere, Germinal Center, ADP-ribosyl Cyclase 1, Antigens, Differentiation, Leukemia, Lymphocytic, Chronic, B-Cell, Cell Transformation, Neoplastic, Neoplastic Stem Cells, Immunoglobulin Joining Region, Immunoglobulin Heavy Chains, Cell Division

28. Morphological and phenotypical changes in EBV positive lymphoblastoid cells infected by HIV-1

Author

Rossi, A., Calabro, M. L., D Andrea, E., Panozzo, M., Saggiori, D., Fabrizio Mammano, Roncella, S., Ferrarini, M., and Chieco-Bianchi, L.

Subjects
Adenosine Triphosphatases, B-Lymphocytes, Herpesvirus 4, Human, Receptors, IgE, Apyrase, SYNDROME AIDS, HTLV-III, HIV Infections, RETROVIRUS, Receptors, Fc, Antigens, Differentiation, B-Lymphocyte, Tumor Virus Infections, Phenotype, Antigens, CD, HUMAN-IMMUNODEFICIENCY-VIRUS, LYMPHOMA-CELLS, DNA, Viral, HIV-1, EPSTEIN-BARR VIRUS, Humans, EPSTEIN-BARR VIRUS, HUMAN-IMMUNODEFICIENCY-VIRUS, LYMPHOMA-CELLS, SYNDROME AIDS, HTLV-III, RETROVIRUS, Virus Activation, Cells, Cultured
Abstract

Human Immunodeficiency Virus type 1 (HIV-1) infects CD4+ T lymphocytes and various other cell types, including B cells. Since HIV-1 seropositive individuals have high numbers of B cells carrying Epstein-Barr Virus (EBV), and are at high risk for development of EBV-associated lymphoproliferative diseases, we studied the mode of HIV-1 infection in four EBV-positive lymphoblastoid B-cell lines (LCLs) as well as some molecular and biological features of the B cells infected by both viruses. We found that LCL cells were successfully infected in vitro by HIV-1, despite the lack of CD4 antigen expression on the cell membrane. LCL cells displayed a persistent, productive, and non-cytopathic infection. Moreover, HIV-1 infection induced reactivation of EBV latent genomes in one cell line. Following HIV-1 infection, LCL cells showed a decrease in B-cell activation markers CD23 and CD39, and an increase in CD10 immature B-cell antigen. Not all cells in each LCL expressed HIV-1 antigens, but all CD10+ cells also co-expressed the HIV-1 envelope protein gp 120. Furthermore, HIV-1 infected LCL cells grew as disperse suspensions, and formed more agar colonies than control, non-HIV-1-infected LCLs. These findings raise the possibility that HIV-1 might play a role in EBV reactivation, and in B-cell lymphoma pathogenesis in AIDS patients.

33. GENOMIC APPROACH FOR INHERITED MOTOR AND CMT2 NEUROPATHIES: A COLLABORATIVE STUDY

Author

Previtali, S. C., Fabrizi, G. M., Schenone, A., Pareyson, D., Manganelli, F., Bellone, E., Lunetta, C., Penco, S., Mandich, P., Taroni, F., Corbo, M., Magri, S., Ferrarini, M., Piscosquito, G., Scarlato, M., Nilo Riva, Vigano, F., Carrera, P., Pisciotta, C., Santoro, L., Ferrari, M., Bucci, G., Lazarevic, D., Cittaro, D., Comi, G., Casari, G., and Bolino, A.

38. INCIDENCE OF CYTOGENETIC ABNORMALITIES IN NEWLY DIAGNOSED BINET STAGE A B-CLL AND RELATIONSHIP WITH PROGNOSTIC BIOMARKERS: UPDATED RESULTS ON 319 PATIENTS INCLUDED IN THE PROSPECTIVE O-CLL1 GISL STUDY

Author

Fabris, S., Giovanna Cutrona, Gentile, M., Matis, S., Pesce, E., Di Raimondo, F., Musolino, C., Gobbi, M., Di Renzo, N., Mauro, F., Cantaffa, R., Brugiatelli, M., Merli, F., Zupo, S., Mammi, C., Baldini, L., Angrilli, F., Quintana, G., Consoli, U., Bertoldero, G., Iannitto, E., Di Tonno, P., Fragasso, A., Molica, S., Musto, P., Cox, M. C., Festini, G., Callea, V., Sacchi, S., Cortelezzi, A., Deliliers, G. Lambertenghi, Foa, R., Federico, M., Morabito, F., Ferrarini, M., and Neri, A.

Subjects
B-CLL

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