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This study will investigate whether drinking from glasses displaying health warnings affects drink behaviour and other alcohol-related outcomes. In a human laboratory experiment we will manipulate the glassware (health warning glassware vs. control glassware) to examine the differences in alcohol consumption, alcohol urges and alcohol-related attitudes.

CANTAB Connect Research is a validated, precise and reliable research software providing sensitive digital measures of cognitive function for all areas of brain research. Currently, normative data only exists for adult participants. Before normative data can be collected from paediatric participants, the current tests may need to be adapted for paediatric use. Therefore, the aim of this study is to evaluate the user experience of various CANTAB tests in children between the ages of 7 to 11 years.

The aim of this study is to measure Advanced glycation end products (AGEs) and serum levels of Growth differentiation factor-15 (GDF-15) in regular smokers during ad-libitum (i.e., normal) smoking and following acute smoking abstinence (i.e., minimum 12 hours deprived).

This study will replicate a previous experiment, “Right is right”, by Zhu (unpublished data), as part of the Pipeline Project 2. This study will investigate if the location where a company profile is presented on a computer screen (left / right hand side) affects the amount of money individuals are willing to invest into that company.

A research project interested in how parents make decisions about feeding their children from infancy to toddlerhood. Researchers are also interested in understanding if parents' decisions and children's eating behaviour changed as a result of COVID-19 pandemic (i.e. closure of early years settings, home confinement).

The aim of this pilot study is to inform the design of study investigating effects of nicotine on appetite and food intake. First, the pilot study will assess the aversive effects of nicotine using two different doses. Second, the pilot study will assess the effectiveness (i.e., matching) of a non-matched placebo for nicotine buccal spray.

Recent work in rodents has identified that a mixture of long-chain aldehydes, which activate receptors within the OR37 sub-family of olfactory receptors (ORs), can reduce neuroendocrine correlates of stress reactivity by around 50%. OR37 receptors are highly preserved across mammals suggesting similar effects may occur in humans. The aim of this pilot study is to inform the design of a future study which will investigate if exposure to an OR37 ligand mixture will reduce subjective, physiological and behavioural measures of stress and anxiety in humans.

This is a pre-registration of an updated version of the detailed statistical analysis plan, before any analyses are conducted.

The aim of this study is to investigate the effects of nicotine on eating topography in non-dependent smokers. Participants will attend two sessions approximately one week apart. At one session participants will receive nicotine and at the other they will receive placebo via a buccal (mouth) spray before undergoing a test of food intake. We hypothesise that nicotine administration will result in reduced portion size and consumption rate compared to placebo administration.

This is a registration of an updated analysis plan, prior to the analyses being conducted. To better inform a UK government proposal to consult on an intention to make companies provide alcohol calorie labelling, as part of an obesity strategy, we have added calories selected and purchased as additional secondary outcomes.

The aim of this study is to investigate whether alcohol drinkers are familiar with the term “mindful drinking”, what their interpretation of this term is, if they currently engage in mindful drinking, and exploring the barriers and facilitators to engagement.

The aim of this study is to estimate the impact of increasing the proportion (i.e., the relative availability) of draught alcohol-free beer on alcohol consumption in bars and public houses. The study is a randomised four-period crossover trial where all participating sites (bars and public houses) will perform two intervention periods and two control periods. During the intervention periods, sites will remove one draught alcoholic beer and replace it with one draught alcohol-free beer. During the control periods, sites will have no alcohol-free beer on draught (i.e., usual practice).​ The primary outcome is the mean volume (in litres) of draught alcoholic beer (lager and ale combined) sold weekly.

BackgroundIncreasing the availability of non-alcoholic options is a promising population-level intervention to reduce alcohol consumption, currently unassessed in naturalistic settings. This study in an online retail context aimed to estimate the impact of increasing the proportion of non-alcoholic (relative to alcoholic) drinks, on selection and purchasing of alcohol.Methods and ResultsAdults (n=737) residing in England and Wales who regularly purchased alcohol online were recruited between March-July 2021. Participants were randomly assigned to one of three groups: ‘25% non-alcoholic/75% alcoholic’; ‘50% non-alcoholic/50% alcoholic’; ‘75% non-alcoholic/25% alcoholic’, then selected drinks in a simulated online supermarket, before purchasing them in an actual online supermarket. The primary outcome was the number of alcohol units selected (with intention to purchase); secondary outcomes included actual purchasing. 607 participants (60% female, mean age = 38 years [range: 18-76]) completed the study and were included in the primary analysis. In the first part of a hurdle model, a greater proportion of participants in the ‘75% non-alcoholic’ group did not select any alcohol (13.1%) compared to the ‘25% non-alcoholic’ group (3.4%; 95% confidence interval [CI] - 2.09, -0.63; p < 0.001). There was no evidence of a difference between the ‘75% non-alcoholic’ and the ‘50% non-alcoholic’ (7.2%) groups (95% CI 0.10, 1.34; p = 0.022) or between the ‘50% non-alcoholic’ and the ‘25% non-alcoholic’ groups (95% CI -1.44, 0.17; p = 0.121). In the second part of a hurdle model in participants (559/607) selecting any drinks containing alcohol, the ‘75% non-alcoholic’ group selected fewer alcohol units compared to the ‘50% non-alcoholic’ (95% CI -0.44, -0.14; p < 0.001) and ‘25% non-alcoholic’ (95% CI - 0.54, -0.24; p < 0.001) groups, with no evidence of a difference between the ‘50% non-alcoholic’ and ‘25% non-alcoholic’ groups (95% CI -0.24, 0.05; p = 0.178). Overall, across all participants, 17.46 units (95% CI 15.24, 19.68) were selected in the ‘75% non-alcoholic’ group; 25.51 units (95% CI 22.60, 28.43) in the ‘50% non-alcoholic’ group; and 29.40 units (95% CI 26.39, 32.42) in the ‘25% non-alcoholic’ group. This corresponds to 8.1 fewer units (a 32% reduction) in the ‘75% non-alcoholic’ compared to the ‘50% non-alcoholic’ group, and 11.9 fewer alcohol units (41% reduction) compared to the ‘25% non-alcoholic’ group; 3.9 fewer units (13% reduction) were selected in the ‘50% non-alcoholic’ group than in the ‘25% non-alcoholic’ group.For all other outcomes, alcohol selection and purchasing were consistently lowest in the ‘75% non-alcoholic’ group.Study limitations include the setting not being entirely naturalistic due to using a simulated online supermarket as well as an actual online supermarket, and that there was substantial dropout between selection and purchasing.ConclusionsThis study provides evidence that substantially increasing the proportion of non-alcoholic drinks – from 25% to 50% or 75% - meaningfully reduces alcohol selection and purchasing. Further studies are warranted to assess whether these effects are realised in a range of real-world settings.Trial registrationISRCTN:11004483; OSF:https://osf.io/qfupwAuthor summaryWhy was this study done?Excessive alcohol consumption contributes to the global burden of non-communicable diseases, including cancer, heart disease and stroke. Interventions that change physical and economic environments have the potential to reduce alcohol consumption.Interventions targeting physical environments include availability interventions that involve changing the proportion of healthier options that are available, relative to less healthy options.A previous online study found that increasing the availability of non-alcoholic compared to alcoholic drinks reduced the hypothetical selection of alcoholic drinks, but there is an absence of evidence from naturalistic settings.What did the researchers do and find?This study evaluated the impact of increasing the proportion of non-alcoholic (relative to alcoholic) drinks, on selection and actual purchasing of alcohol.In a randomised controlled trial, 737 participants were randomly assigned to one of three groups with varying proportions of alcoholic versus non-alcoholic drinks ‘25% non-alcoholic/75% alcoholic’; ‘50% non-alcoholic/50% alcoholic’; ‘75% non-alcoholic/25% alcoholic’).Participants selected drinks from 64 options in a simulated online supermarket which was designed to look and function similarly to an online supermarket. Participants were then required to immediately purchase the same drinks in an actual online supermarket.It was found that increasing the proportion of non-alcoholic drinks – from 25% to 50% or 75% – reduced the amount of alcohol selected and bought, in this online supermarket setting.What do these findings mean?This study provides evidence that increasing the proportion of non-alcoholic drinks could reduce alcohol selection and purchasing, highlighting the potential for availability interventions to reduce alcohol sales at population level.Further studies are warranted to assess whether these effects are realised in a range of real-world settings