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Supplemental material, sj-docx-1-psp-10.1177_01461672211034376 for Blindness, But Not HMHA Anosmia, Predicts Loneliness: A Psychophysical Study by Agnieszka Sorokowska, Anna Janczak, Camille Ferdenzi, Nicolas Baldovini and Anna Oleszkiewicz in Personality and Social Psychology Bulletin

Supplemental material, sj-docx-1-psp-10.1177_01461672211034376 for Blindness, But Not HMHA Anosmia, Predicts Loneliness: A Psychophysical Study by Agnieszka Sorokowska, Anna Janczak, Camille Ferdenzi, Nicolas Baldovini and Anna Oleszkiewicz in Personality and Social Psychology Bulletin

This is a correction notice for article bjaa041 (DOI: https:// doi.org/10.1093/chemse/bjaa041), published 20 June 2020. An incorrect version of the caption to Figure 5 was mistakenly included in the published paper. An updated version is given below. Neither the data nor the paper's conclusions were affected by this correction. The authors sincerely apologize for the error. (A) Correlations between the 3 principal components with respect to changes in 3 chemosensory modalities (i.e., taste, smell, and chemesthesis). Shades of gray indicate positive correlation, whereas shades of red indicate negative correlations. White denotes no correlation. (B) Clusters of participants identified by k-means clustering. The scatterplot shows each participant's loading on dimension 1 (degree of smell and taste loss, PC1 on x-Axis) and dimension 2 (degree of chemesthesis loss, PC2 on y-Axis). Based on the centroid of each cluster, participants in cluster 1 (blue, N = 1767; top left) are generally characterized by significant smell, taste and chemesthesis loss. Participants in cluster 2 (orange, N = 1724; bottom center) are generally characterized by ratings that reflect smell/taste loss with preserved chemesthesis. Loadings for participants in cluster 3 (green, N = 548; right side) are generally characterized by reduced smell and taste loss, and preserved chemesthesis.

Methods, Table S1, Figure S1, References

International audience; Background: Magnetic resonance imaging (MRI) is the gold standard in the etiological assessment of a persistent olfactory dysfunction (OD). While the utility of imaging in COVID-19-related OD has yet to be established, MRI is recommended in all patients with persistent OD. The high prevalence of the latter after SARS-CoV-2 infection means evaluating this strategy is an important public health matter.Methods:The main objective was to examine the impact of systematic MRI on the management of patients with OD. All adult patients consulting for persistent OD (>2 months) after primary SARS-COV-2 infection (PCR) between March 2020 and December 2021 were included (n = 67). The secondary objective was to evaluate the relationship between the severity of the OD as measured by psychophysical testing (ETOC) and the volume of the olfactory bulb (OB) measured by MRI.Results: All patients underwent MRI, and none led to a change in diagnosis or treatment. Among them, 82% (55/67) were considered normal by the radiologist on initial interpretation. There were no significant differences (visual analysis or OB volume) between groups (mild, moderate, and severe hyposmia).Conclusion: Systematic MRI may be unnecessary in patients whose persistent OD began soon (a few days) after confirmed SARS-CoV-2 infection.

International audience; Purpose: One of the long-term symptoms of COVID-19 is phantosmia, a type of Olfactory Disorder (OD) that has deleterious impacts on patients' quality of life. The aim of this article was to study how this poorly understood qualitative OD manifests itself in the COVID-19.Methods: 4691 patients with COVID-19 responded to our online questionnaire focusing on COVID-19-related OD. We first analyzed the prevalence of phantosmia in this population. Then, with the help of Natural Language Processing techniques, we investigated the qualitative descriptions of phantom smells by the 1723 respondents who reported phantosmia.Results: The prevalence of phantosmia was of 37%. Women were more likely to report phantosmia than men, as well as respondents for whom OD was described as fluctuating rather than permanent, lasted longer, was partial rather than total and appeared progressively rather than suddenly. The relationship between OD duration and phantosmia followed a logarithmic function, with a prevalence of phantosmia increasing strongly during the first 2 months of the disease before reaching a plateau and no decrease over the 15 months considered in this study. Qualitative analyses of phantosmia descriptions with a sentiment analysis revealed that the descriptions were negatively valenced for 78% of the respondents. Reference to "tobacco" was more frequent in non-smokers. Source names and odor characteristics were used differently according to age and OD duration.Conclusion: The results of this descriptive study of phantosmia contribute to the current efforts of the medical community to better understand and treat this rapidly increasing COVID-19-related OD.

International audience; Olfactory deficits can play a detrimental role in everyday social functioning. Perception of 3-hydroxy-3-methylhexanoic acid (HMHA)-a body odor component-could also be linked to this research area. However, no study so far has addressed the problem of HMHA perception in the context of the previously reported relationship between olfactory abilities and social difficulties. Here, we tested whether HMHA-specific anosmia predicted loneliness understood both as a cognitive evaluation of social participation and as one's social isolation, and we additionally analyzed the effects and correlates of HMHA perception in relation to sightedness. The study comprised 196 people, of whom 99 were blind. We found that subjects with blindness declared particularly high loneliness, but HMHA anosmia and the interaction of sightedness and HMHA anosmia predicted neither loneliness nor social withdrawal. In addition, HMHA pleasantness was positively associated with social withdrawal of the subjects with blindness and emotional loneliness correlated with HMHA familiarity regardless of sightedness.