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Exportin 1 (XPO1) is overexpressed in several solid tumors, and is associated with poor prognosis. Here, we aimed to evaluate the implication of XPO1 expression in solid tumors through a meta-analysis. PubMed, Web of Science, and Embase databases were searched for articles published until February 2023. Statistical data of the patients, odds ratios and hazard ratios (HRs), together with their corresponding 95% confidence intervals (CIs) were pooled to assess clinicopathological features and survival outcomes. Besides, the Cancer Genome Atlas (TCGA) was used to explore the prognostic significance of XPO1 in solid tumors. A total of 22 works, comprising 2595 patients were included in this study. The results suggested that increased XPO1 expression was associated with a higher tumor grade, more lymph node metastasis, advanced tumor stage, and progressively worse total clinical stage. Additionally, high XPO1 expression was associated with worse overall survival (OS) (HR = 1.43, 95% CI = 1.12–1.81, P = 0.004) and shorter progression-free survival (HR = 1.40, 95% CI = 1.07–1.84, P = 0.01). An analysis using the TCGA dataset showed that high XPO1 expression was associated with poor OS and disease-free survival. XPO1 is a promising prognostic biomarker and may constitute a therapeutic target for solid tumors. PROSPERO registration number: CRD42023399159

Additional file 6: Figure S1. Subcellular location of ZNF71 protein (downloaded from HPA website).

Additional file 2: Table S2. Specific information of included datasets collected from public resources.

Additional file 16: Table S4. Functional enrichment based on 632 overlapping genes of upregulated DEGs and CEGs positively related to COL8A1. Only the top four terms or pathways were exhibited. KEGG, Kyoto Encyclopedia of Genes and Genomes; DO, Disease Ontology; GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function; DEGs, differentially expressed genes; CEGs, co-expressed genes. Table S5. Functional enrichment based on 322 overlapping genes of downregulated DEGs and CEGs negatively related to COL8A1. Only the top two terms or pathways were exhibited. KEGG, Kyoto Encyclopedia of Genes and Genomes, GO, Gene Ontology; BP, biological process; CC, cellular component; MF, molecular function.

Additional file 14: Table S3. Mutation types of COL8A1 in breast cancer patients based on the Catalogue Of Somatic Mutations In Cancer (COSMIC).

Additional file 11: Table S1. The relevance between COL8A1 expression and clinicopathological parameters of breast cancer patients. Independent-samples t-test or one way analysis of variance (ANOVA) was used to compare the COL8A1 expression level between two groups or more groups, respectively. *A P-value

Additional file 12: Table S2. Clinical data of breast cancer samples used to perform immunohistochemistry.