1. Serum Contactin-1 in CIDP
- Author
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Wieske, Luuk, Martín-Aguilar, Lorena, Fehmi, Janev, Lleixà, Cinta, Koel-Simmelink, Marleen J. A., Chatterjee, Madhurima, van Lierop, Zoë, Killestein, Joep, Verhamme, Camiel, Querol, Luis, Rinaldi, Simon, Teunissen, Charlotte E., Eftimov, Filip, and Universitat Autònoma de Barcelona
- Abstract
To investigate whether serum levels of contactin-1, a paranodal protein, correlate with paranodal injury as seen in patients with CIDP with antibodies targeting the paranodal region. Serum contactin-1 levels were measured in 187 patients with CIDP and 222 healthy controls. Paranodal antibodies were investigated in all patients. Serum contactin-1 levels were lower in patients (N = 41) with paranodal antibodies compared with patients (N = 146) without paranodal antibodies (p < 0.01) and showed good discrimination between these groups (area under the curve 0.84; 95% CI: 0.76-0.93). These findings suggest that serum contactin-1 levels have the potential to serve as a possible diagnostic biomarker of paranodal injury in CIDP. This study provides class II evidence that serum contactin-1 levels can discriminate between patients with CIDP with or without paranodal antibodies with a sensitivity of 71% (95% CI: 56%-85%) and a specificity of 97% (95% CI: 83%-100%).
- Published
- 2021