1. Validation of the Rat Model of Prostate Cancer: Correlating Seminal Vesicle Lesions With Dorsolateral Prostate Lesions
- Author
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NASCIMENTO-GONÇALVES, ELISABETE, SEIXAS, FERNANDA, OLIVEIRA, BRUNO MIGUEL MAIO, TEIGA-TEIXEIRA, JOÃO EDUARDO, FAUSTINO-ROCHA, ANA I., COLAÇO, BRUNO, FERREIRA, RITA, and OLIVEIRA, PAULA A.
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Male ,Pharmacology ,Cancer Research ,Prostate ,Humans ,Animals ,Seminal Vesicles ,Prostatic Neoplasms ,Testosterone ,Rats, Wistar ,General Biochemistry, Genetics and Molecular Biology ,Research Article ,Rats - Abstract
Background/Aim: Lesions in the seminal vesicle are described in the most used protocols for prostate cancer (PCa) induction. This study aimed to characterize the lesions of seminal vesicles associated with a protocol of PCa induction in rats to contribute to better characterization of this model. Materials and Methods: Forty-five male Wistar Unilever rats were randomly divided into two control groups: CONT1 (n=10) and CONT2 (n=10); and two PCa-induced groups: IND1 (n=10) and IND2 (n=15), sacrificed at 35 and 61 weeks, respectively. Animals from the induced groups were exposed to a multistep protocol for PCa induction. Animals, seminal vesicles and dorsolateral prostate were weighed. Seminal vesicles and dorsolateral prostate were submitted to histopathological and immunohistochemical analysis. Results: Animals in which PCa was induced had a lower mean body weight when compared with the control animals (p
- Published
- 2022
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