1. Dinggui Oil Capsule in treating irritable bowel syndrome with stagnation of qi and cold: a prospective, multi-center, randomized, placebo-controlled, double-blind trial
- Author
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Jiang, Yu Z, Fan Zj, Li Tq, Zhang Hr, Qing Xia, Lei Wang, Yang Xn, Zhang Fx, and Rui-ming Zhang
- Subjects
Adult ,Male ,Abdominal pain ,medicine.medical_specialty ,Adolescent ,Capsules ,Placebo ,Placebo group ,Gastroenterology ,Diagnosis, Differential ,Irritable Bowel Syndrome ,Double blind ,Clinical study ,Young Adult ,Double-Blind Method ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Medicine, Chinese Traditional ,Adverse effect ,Irritable bowel syndrome ,Aged ,business.industry ,Capsule ,Middle Aged ,medicine.disease ,Complementary and alternative medicine ,Female ,medicine.symptom ,business ,Drugs, Chinese Herbal ,Phytotherapy - Abstract
OBJECTIVE To evaluate the efficacy and safety of Dinggui Oil Capsule in treating irritable bowel syndrome (IBS) with stagnation of qi and cold. METHODS A prospective, randomized, placebo-controlled, double-blind clinical study was undertaken. One hundred and ninety-eight patients with IBS and syndrome of stagnation of qi and cold were randomly divided into high-dose Dinggui Oil group (DGO-H, 1.2 g, 3 times daily; n=66), low-dose Dinggui Oil group (DGO-L, 0.8 g, 3 times daily, n=66), and placebo group (placebo, 5.0 g, 3 times daily, n=66). Patients in the three groups were all treated for 2 weeks. RESULTS The total significant effective rates for IBS were 54.1%, 28.8% and 21.9% in the DGO-H, DGO-L, and placebo groups, and the total effective rates for the syndrome of stagnation of qi and cold were 54.1%, 25.8% and 23.4% in the three groups, respectively. Dinggui Oil Capsule showed a higher efficacy than the placebo in relieving the abdominal pain (P
- Published
- 2007