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1. Secular trends of cardiorespiratory fitness in children and adolescents over a 35-year period: Chronicle of a predicted foretold

Author

Leone, Mario, Levesque, Patrick, Bourget-Gaudreault, Sabrina, Lemoyne, Jean, Kalinova, Emilia, Comtois, Alain Steve, Bui, Hung Tien, Léger, Luc, Frémont, Pierre, and Allisse, Maxime

Subjects
Public Health, Environmental and Occupational Health
Abstract

BackgroundIn the context of concerns regarding the cardiorespiratory fitness (CRF) of youth populations, the aims of this study were: (1) to update reference values for the VO2max for school-aged Canadians and (2) to document secular trends in CRF after a 35-year interval.MethodsBetween September 2014 and April 2017, the CRF of 3725 students (53.2% boys; 6.0 to 17.9 yrs) was determined using the 20-m shuttle run test. The sample was collected in 36 different schools from six cities of Québec (Canada).ResultsMedian values of VO2max decreased with age in both sexes (p ≤ 0.05). By the age of 10, more than 20% of boys showed VO2max values below the recommended value (42 ml·kg−1·min−1). At the age of 17, that proportion reached 56.8%. A similar proportion of 12 yrs girls (20%) were under the recommended minimal value (37 ml·kg−1·min−1) and that value reached 69.9% at the age of 17. Compared to 1982, the VO2max at age 17 has declined by 18% for boys and 12% for girls. The situation is worse in terms of functional capacity (number of stages completed) with an overall decrease of more than 30%.ConclusionThis study demonstrates that, compared to data obtained using the same methodology 35 years ago, the CRF and functional capacity of children and adolescents has declined to levels that should raise concerns from a public health perspective. Thus, the development of strategies to promote a physically active lifestyle in youth is more relevant than ever.

Published
2023

2. Moving from the clinic to telehealth during the COVID-19 pandemic – a pilot clinical trial comparing in-clinic rehabilitation versus telerehabilitation for persisting symptoms following a mild Traumatic brain injury

Author

Langevin, Pierre, Frémont, Pierre, Fait, Philippe, Dubé, Marc-Olivier, and Roy, Jean-Sébastien

Abstract

The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program (education, home exercises, manual techniques, sub-symptom threshold aerobic exercise [STAE] program) to a similar program (education, home-exercises, STAE program), but without manual techniques, provided in a telerehabilitation format in adults with persisting post-concussion symptoms (PCS). In this parallel-group non-randomized clinical trial, 41 adults with persisting PCS were allocated to the in-clinic (n = 30) or telerehabilitation (n = 11) program. The outcome measures, which included the Post-Concussion Symptom Scale (PCSS; primary outcome), Numerical Pain Rating Scale (NPRS) for neck pain and headache and three disability questionnaires, were collected at baseline, weeks 6, 12, and 26. Non-parametric analysis for longitudinal data (NparLD) was used. For the PCSS, there was a group-by-time interaction (p = 0.05) with significant between-group differences at week 6, 12, and 26 (p < 0.05) for the in-clinic group. There were also group-by-time interactions for NPRS neck pain and headache (p < 0.05) for the in-clinic group. The study suggests that a telehealth format failed to reach the efficiency of an in-clinic rehabilitation program in terms of symptoms reduction and functional improvement. These results must be interpreted with caution given the limited number of participants. ClinicalTrials.gov Identifier: NCT03677661.IMPLICATION FOR REHABILITATIONThe telerehabilitation format for adults with persisting post-concussion symptoms was widely implemented in the COVID-19 pandemic without any evidence of efficacy over the more traditional in-clinic rehabilitation format.The study suggests that a telerehabilitation format failed to reach the efficiency of an in-clinic rehabilitation program in terms of symptoms reduction and functional improvement.Clinicians should try to incorporate some in-clinic appointments when a telerehabilitation format is required such as for patients in underserved area. The telerehabilitation format for adults with persisting post-concussion symptoms was widely implemented in the COVID-19 pandemic without any evidence of efficacy over the more traditional in-clinic rehabilitation format. The study suggests that a telerehabilitation format failed to reach the efficiency of an in-clinic rehabilitation program in terms of symptoms reduction and functional improvement. Clinicians should try to incorporate some in-clinic appointments when a telerehabilitation format is required such as for patients in underserved area.

Published
2023
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3. A032 – Health, lifestyle and aging with Multiple Sclerosis: A qualitative study

Author

Arnold, Catherine M., Faulkner, Robert A., Ploughman, Michelle, Austin, Mark, Kearney, Anne, Murdoch, Michelle, Stefanelli, Mark, Godwin, Marshall, Muir, Susan W, Speechley, Mark, Borrie, Michael, Montero-Odasso, Manuel, MacKay-Lyons, M, Creaser, G, Macdonald, A, McKenna, J, Murphy, S, O'Neill, VR, Nilsson, T, Begley, L, Ikert, Kathy M., Long, Kristin M., Bittner, Darren R., Birmingham, Trevor B., Bryant, Dianne M., Richardson, Julie, Letts, Lori, Chan, David, Stratford, Paul, Hand, Carri, Price, David, Hilts, Linda, Coman, Liliana, Edwards, Mary, Baptiste, Sue, Law, Mary, Alexander, Elliot, Rosenthal, Stephanie, Guilcher, Sara, Evans, Cathy, Gattey, M, Hydomako, R, McLean, B, O'Leary, J, Shkopich, K, Klassen, L, Laprade, Judi, Roy, Marla, Laing, M, Di Nicolantonio, L, Goncharova, K, Pui, M, Vas, H, House, R, Switzer-McIntyre, S, Cheifetz, O, Serediuk, F, Park Dorsay, J, Hladysh, G, Woodhouse, L, Dalzell, MA, Shallwani, S, Preuss, RA, Patterson, Debbie, Ptak, Janice, Howe, JA, Brunton, K, Salisbury, K, Sharma, SK, Childerhose, DE, Sharma, S, WalkerJohnston, JA, Barnes, JL, Fisher, Megan E., Aristone, Martha N., Young, Katrina K., Waechter, Laurie E., Landry, Michel D., Taylor, Leslie A., Cooper, Nicole S., Wong, S, Hébert, Luc J., Rowe, Peter, Debouter, Kelly, Lai, Denise, Winn, CS, Chisholm, BA, Hummelbrunner, JA, Wasson, Pamela, Passalent, L, Soever, L, Kennedy, C, Warmington, K, Shupak, R, Thomas, R, Linekar, S, Lundon, K, Morgan, Dale, Kelly, Larry, Hastie, Robyn, Deber, Raisa B., Verrier, Molly C., O'Callaghan, L, Alexander, E, Titus, D, MacDougall, P, Hoens, AM, Garland, SJ, Tunnacliffe, R, Lineker, S, Varatharasan, N, Schneider, R, MacKay, C, Murphy, SM, Wu, Kenneth, Fox, Patricia, Tullis, Elizabeth, Stephenson, Anne L., Davis, AM, Mahomed, N, Badley, EM, Scott, Lisa, Carpenter, Christine, Brander, Rosemary R., Paterson, Margo L., Chan, Yolande E., Reinikka, KJE, French, E, Huijbregts, M, Cleaver, SR, Paulenko, T, Hebert, D, Creaser, GA, MacKenzie, D, Barkhouse-McKeen, C, Shrier, Ian, Freeman, K, Davidson, L, Pelland, L, Wilson, Nicole, Hopkins-Rosseel, Diana, Fraser, M, Wainwright, G, MacCormack, B, Basque Godin, C, Mori, B, Evans, C, Gibson, BE, Thornton, M, Dutton, T, King, J, Lawrence, PJ, Duggan, M, Hoens, A, Geddes, E Lynne, Gill, Caroline, Fong-Lee, Dianna, Lindsay, Jane, McPhail, Stacey, McIntosh, Karen, Marken, Suri L., Dutton, Tanya, Hopkins-Rosseel, DH, Kasdan, P, Fong-Lee, D., Marken, Siri, Moreside, JM, McGill, SM, Juma, S, Winter Di Cola, JL, Kennedy, DM, Dickson, P, Denis, S, Robarts, S, Gollish, J, Salbach, NM, Veinot, P, Jaglal, SB, Bayley, M, Rolfe, D, Dogra, M, Woodhouse, LJ, Spadoni, GF, Stratford, PW, Fox, P, Sessford, J, Beaton, D, Harniman, E, Inrig, T, Baxter, K, Portanova, A, Smuck, L, Connelly, DM, Shaw, J, Adkin, A, Jog, M, Hollway, D, Earl, M, Murphy, A, MacDonald, E, Overend, TJ, Brooks, D, Anderson, CM, Cicutto, L, Keim, M, McAuslan, D, Nonoyama, M, Levac, D., Pierrynowski, M., MacPherson, M, Glassman, L, Jadan, P, MacArthur, L, Landry, M, Frenette, J, Dumont, N, Moreland, JD, DePaul, VG, DeHueck, AL, Musselman, KE, Yang, JF, Tousignant, M, Moffet, H, Boissy, P, Corriveau, H, Cabana, F, Marquis, F, Towns, Megan, Barrett, Lauren, Darling, Catherine, Lee, Michelle, Aganon, Isabel, Hill, Kylie, Brooks, Dina, Robbins, Shawn, Alcock, Greg, Maly, Monica, Jones, Gareth, Birmingham, Trevor, Glazebrook, Cheryl M., Wright, F. Virginia, Martin, MBA, Norton, B, Ramsaran, KD, Street, ME, Syed, SN, Dang, MT, Barclay-Goddard, R, Stratford, P, Miller, P, Karam, J., Zettel, M., Green, K., Carter, D., Lam, F., Evans, C., Yeung, E., Lindquist, NJ, Magis, TF, Rispin, JE, Walton, PE, Kirby, RL, Manns, PJ, Haller, MK, Marler, K, Lore, S, Sottana, B, Crowley, A, Beaudin, V, Sloan, C, Landry, SC, Nigg, BM, Tecante, KE, Albers, Pamela, Devon, Heidi, Nairn, Lacey, Olenick, Betsy, Roach, Stephanie, Arnold, Cathy, Watts, Cathy, Wieler, M, Jones, CA, Allen, J, Haennel, R, Shaw, JA, Zecevic, A, Dal Bello-Haas, V, Harrision, L, Kanthan, R, Lawson, S, Zaluski, N, Petrie, A, Rohs, J, Parker, R, Roy, JS, MacDermid, JC, Roth, JH, Grewal, R, Officer, Alexis, DePaul, Vincent, Bosch, Jackie, Wilkins, Seanne, Wishart, Laurie, Inness, EL, Mansfield, A, Biasin, L, Prajapati, S, Lakhani, B, Mileris, R, McIlroy, WE, Henderson, RJ, Vanik, J, Alyoshkina, N, Diamond, C, Lee, J, Martinov, K, O'Brien, KK, Alexander, R, King, K, Murray, J, Tebeje, M, Bayoumi, AM, Bereket, T, Swinton, M, Norman, G, Solomon, P, Anstey, S, Bethune, M, Thomas, A, Wood-Salomon, E, Curwin, S, D'Amboise, SN, Héroux, ME, Pari, G, Norman, KE, Lee, Linda-Joy, Coppieters, Michel W., Hodges, Paul W., Perreault, Audrey, Tremblay, Louis E., Thibault-Gagnon, S, Gentilcore-Saulnier, E, McLean, L, Kay, JL, McNeely, ML, Campbell, KL, Peddle, CJ, Courneya, KS, Subramanian, SK, Levin, MF, Dechman, G, Tupper, SM, Levesque, L, Reese, H, Nailer, T, Walton, D, Schachter, CL, Stalker, CA, Teram, E, Lasiuk, G, Bartlett, Doreen, Chiarello, Lisa, Jacobs, Diane, Busch, Angela, Novak, Christine B., Anastakis, Dimitri J., Beaton, Dorcas E., Mackinnon, Susan E., Katz, Joel, Figueiredo, S, Finch, L, Jiali, M, Ahmed, S, Huang, A, Mayo, NE, Lochhead, Lois, MacMillan, Peter, DePaul, V, Burridge, H, Kwok, C, Rosario, J, Stogios, C, McKay, E, Moyer, E, Wishart, L, Holly, J, DYER, Joseph-Omer, MAUPAS, Éric, de ANDRADE MELO, Sibele, BOURBONNAIS, Daniel, FORGET, Robert, Shrier, I, Boudier-Reveret, M, Feldman, D, Mazer, B, Rege, SS, Soever, LJ, Fenety, Anne, Hoens, Alison, Harman, Katherine, Bassett, Raewyn, Byrne, Jeannette M., Prentice, Stephen D., Carlesso, Lisa, Cairney, John, Hoogenes, Jennifer, Gabison, S, Nussbaum, EL, Taillon-Hobson, A., McLean, L., Aaron, S., Bilodeau, M., Taillon-Hobson, Anne, McLean, Linda, Aaron, Shawn, Bilodeau, Martin, Zbarsky, Kathryn, Parsley, Dana, Clegg, Heather, Welch, Tyler, Fernandes, Catherine, Jaglal, Susan, Inness, Liz, Williams, Josh, McIlroy, William, Howe, Jo-Anne, Yardley, D, Benoit, M, Blake, T, Gillies, G, Ho, R, MacKinnon, M, Chesworth, BM, Busch, AJ, Dooley, A, Coons, S, Crockett, K, Mucha, J, Kean, CO, Birmingham, TB, King, LK, Giffin, JR, Lourenço, Christiane B., Subramanian, Sandeep, Sveistrup, Heidi, Levin, Mindy F., DESMEULES, FRANÇOIS, DIONNE, CLERMONT E., BELZILE, ÉTIENNE L., BOURBONNAIS, RENÉE, FRÉMONT, PIERRE, Richards, CL, Schneider, GM, Smith, AD, Bath, B, Bourassa, R, Lovo Grona, S, Schneider, KJ, Emery, Carolyn, Norman, Kathleen, Pearson, Neil, Woodhouse, Linda, Pelland, Lucie, Werstine, Rob, and Schneider, Kathryn

Subjects
active transfer strategies for informing clinical practice through information technologies, injury prevention, health human resources management strategies, Merging Research and Practice, implementation and management strategies, Abstracts, clinical experience, clinical skills and clinical reasoning modules in orthopaedic practice, Special Sessions, evolving physiotherapist roles, chronic disease prevention, neurological, basic science or clinically focused research on targeted physiotherapy interventions, Scientific sessions, fundamental scientific research, mobility, Newfoundland, Canadian Physiotherapy Association Congress 2010, population health services, advances in research related to neuromusculoskeletal practice, health system reform, patient and client preference, clinical research and the reciprocal transfer of knowledge between clinical practice and research, innovative service delivery models, post-operative management of acute care patients, promotion of research, practice and patient/client care in the neuromusculoskeletal area, Canada, assessment and treatment of disability that arises from both spinal and peripheral pathologies, Abstracts, CPA Congress 2010, role of physiotherapists in primary health care, exercise prescription, Physical Therapy, Sports Therapy and Rehabilitation, Health Promotion, clinical decision making, St. John's, evidence based practice model, informing the development of clinical research questions, determinants of health, innovative models of practice, physiotherapy leadership development, Physio10, Leadership in Action, public and patient education, musculoskeletal, benchmarking areas of practice, inter-professional collaboration and education strategies, Neuromusculoskeletal Practice, public, private and independent practice management of physiotherapy services, Merging Research with Practice, cardio-respiratory
Published
2010

4. Gold- and Platinum-Catalyzed Cycloisomerization of Enynyl Esters versus Allenenyl Esters: An Experimental and Theoretical Study

Author

Louis Fensterbank, Jean-Philippe Goddard, Steven P. Nolan, Denis Lesage, Alexandra Hours, Rubén S. Ramón, Rim Dahmane, Nicolas Marion, Xavier Moreau, Chiara Costabile, Vincent Gandon, Jean-Claude Tabet, Luigi Cavallo, Max Malacria, Gilles Lemière, Andrea Correa, Pierre de Frémont, Marion, Nicola, Lemière, Gille, Correa, Andrea, Costabile, Chiara, Ramón, Rubén S., Moreau, Xavier, De Frémont, Pierre, Dahmane, Rim, Hours, Alexandra, Lesage, Deni, Tabet, Jean-Claude, Goddard, Jean-Philippe, Gandon, Vincent, Cavallo, Luigi, Fensterbank, Loui, Malacria, Max, and Nolan, Steven P.

Subjects
Addition reaction, Allene, Bicyclic molecule, Organic Chemistry, Cycloisomerization, General Chemistry, Medicinal chemistry, Catalysis, Cyclopropane, Catalysi, chemistry.chemical_compound, chemistry, Hexene, Atom economy, Organic chemistry, Reactivity (chemistry), Gold, Density functional calculation, Carbene, Alkyne
Abstract

Ester-way to heaven: Unexpected formation of bicyclo[3.1.0]hexene 4 was the main focus of combined experimental and theoretical studies on the Au-catalyzed cycloisomerization of branched dienyne 1 (see scheme), which provided better understanding of the mechanistic details governing the cyclization of enynes bearing a propargylic ester group.Experimental and theoretical studies on Au- and Pt-catalyzed cycloisomerization of a branched dienyne with an acetate group at the propargylic position are presented. The peculiar architecture of the dienyne precursor, which has both a 1,6- and a 1,5-enyne skeleton, leads, in the presence of alkynophilic gold catalysts, to mixtures of bicyclic compounds 3, 4, and 5. Formation of unprecedented bicyclo[3.1.0]hexene 5 is the main focus of this study. The effect of the ancillary ligand on the gold center was examined and found to be crucial for formation of 5. Further mechanistic studies, involving cyclization of an enantioenriched dienyne precursor, (18)O-labeling experiments, and DFT calculations, allowed an unprecedented reaction pathway to be proposed. We show that bicyclo[3.1.0]hexene 5 is likely formed by a 1,3-OAc shift/allene-ene cyclization/1,2-OAc shift sequence, as calculated by DFT and supported by Au-catalyzed cyclization of isolated allenenyl acetate 7, which leads to improved selectivity in the formation of 5. Additionally, the possibility of OAc migration from allenyl acetates was supported by a trapping experiment with styrene that afforded the corresponding cyclopropane derivative. This unprecedented generation of a vinyl metal carbene from an allenyl ester supports a facile enynyl ester/allenenyl ester equilibrium. Further examination of the difference in reactivity between enynyl acetates and their corresponding [3,3]-rearranged allenenyl acetates toward Au- and Pt-catalyzed cycloisomerization is also presented.

Published
2009

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