Author: "FANTUZZI, G." / Language: undetermined - Searchworks@Jio Institute Digital Library Search Results

55 results on '"FANTUZZI, G."'

1. Rigorous scaling laws for internally heated convection at infinite Prandtl number

Author: Arslan, A, Fantuzzi, G, Craske, J, and Wynn, A
Subjects: Physics::Fluid Dynamics, physics.flu-dyn, math.MP, math-ph
Abstract: New bounds are proven on the mean vertical convective heat transport, ⟨wT⟩¯¯¯¯¯¯¯¯¯¯¯, for uniform internally heated (IH) convection in the limit of infinite Prandtl number. For fluid in a horizontally-periodic layer between isothermal boundaries, we show that ⟨wT⟩¯¯¯¯¯¯¯¯¯¯¯≤12−cR−2, where R is a nondimensional `flux' Rayleigh number quantifying the strength of internal heating and c=216. Then, ⟨wT⟩¯¯¯¯¯¯¯¯¯¯¯=0 corresponds to vertical heat transport by conduction alone, while ⟨wT⟩¯¯¯¯¯¯¯¯¯¯¯>0 represents the enhancement of vertical heat transport upwards due to convective motion. If, instead, the lower boundary is a thermal insulator, then we obtain ⟨wT⟩¯¯¯¯¯¯¯¯¯¯¯≤12−cR−4, with c≈0.0107. This result implies that the Nusselt number Nu, defined as the ratio of the total-to-conductive heat transport, satisfies Nu≲R4. Both bounds are obtained by combining the background method with a minimum principle for the fluid's temperature and with Hardy--Rellich inequalities to exploit the link between the vertical velocity and temperature. In both cases, power-law dependence on R improves the previously best-known bounds, which, although valid at both infinite and finite Prandtl numbers, approach the uniform bound exponentially with R.
Published: 2022

2. The background method: Theory and computations

Author: Fantuzzi, G, Arslan, A, and Wynn, A
Subjects: physics.flu-dyn, General Science & Technology, 76M30, 76F25, 90C22
Abstract: The background method is a widely used technique to bound mean properties of turbulent flows rigorously. This work reviews recent advances in the theoretical formulation and numerical implementation of the method. First, we describe how the background method can be formulated systematically within a broader "auxiliary function" framework for bounding mean quantities, and explain how symmetries of the flow and constraints such as maximum principles can be exploited. All ideas are presented in a general setting and are illustrated on Rayleigh-Bénard convection between stress-free isothermal plates. Second, we review a semidefinite programming approach and a timestepping approach to optimizing bounds computationally, revealing that they are related to each other through convex duality and low-rank matrix factorization. Open questions and promising directions for further numerical analysis of the background method are also outlined.
Published: 2021

3. Sum-of-squares chordal decomposition of polynomial matrix inequalities

Author: Zheng, Y and Fantuzzi, G
Subjects: eess.SY, math.AG, Operations Research, cs.DS, math.OC, 0102 Applied Mathematics, 0103 Numerical and Computational Mathematics, cs.SY, 0802 Computation Theory and Mathematics
Abstract: We prove decomposition theorems for sparse positive (semi)definite polynomial matrices that can be viewed as sparsity-exploiting versions of the Hilbert--Artin, Reznick, Putinar, and Putinar--Vasilescu Positivstellensätze. First, we establish that a polynomial matrix $P(x)$ with chordal sparsity is positive semidefinite for all $x\in \mathbb{R}^n$ if and only if there exists a sum-of-squares (SOS) polynomial $\sigma(x)$ such that $\sigma P$ is a sum of sparse SOS matrices. Second, we show that setting $\sigma(x)=(x_1^2 + \cdots + x_n^2)^\nu$ for some integer $\nu$ suffices if $P$ is homogeneous and positive definite globally. Third, we prove that if $P$ is positive definite on a compact semialgebraic set $\mathcal{K}=\{x:g_1(x)\geq 0,\ldots,g_m(x)\geq 0\}$ satisfying the Archimedean condition, then $P(x) = S_0(x) + g_1(x)S_1(x) + \cdots + g_m(x)S_m(x)$ for matrices $S_i(x)$ that are sums of sparse SOS matrices. Finally, if $\mathcal{K}$ is not compact or does not satisfy the Archimedean condition, we obtain a similar decomposition for $(x_1^2 + \cdots + x_n^2)^\nu P(x)$ with some integer $\nu\geq 0$ when $P$ and $g_1,\ldots,g_m$ are homogeneous of even degree. Using these results, we find sparse SOS representation theorems for polynomials that are quadratic and correlatively sparse in a subset of variables, and we construct new convergent hierarchies of sparsity-exploiting SOS reformulations for convex optimization problems with large and sparse polynomial matrix inequalities. Numerical examples demonstrate that these hierarchies can have a significantly lower computational complexity than traditional ones.
Published: 2021

4. Convex relaxations of integral variational problems: pointwise dual relaxation and sum-of-squares optimization

Author: Chernyavsky, A, Bramburger, JJ, Fantuzzi, G, and Goluskin, D
Subjects: math.OC
Abstract: We present a method for finding lower bounds on the global infima of integral variational problems, wherein $\int_\Omega f(x,u(x),\nabla u(x)){\rm d}x$ is minimized over functions $u\colon\Omega\subset\mathbb{R}^n\to\mathbb{R}^m$ satisfying given equality or inequality constraints. Each constraint may be imposed over $\Omega$ or its boundary, either pointwise or in an integral sense. These global minimizations are generally non-convex and intractable. We formulate a particular convex maximization, here called the pointwise dual relaxation (PDR), whose supremum is a lower bound on the infimum of the original problem. The PDR can be derived by dualizing and relaxing the original problem; its constraints are pointwise equalities or inequalities over finite-dimensional sets, rather than over infinite-dimensional function spaces. When the original minimization can be specified by polynomial functions of $(x,u,\nabla u)$, the PDR can be further relaxed by replacing pointwise inequalities with polynomial sum-of-squares (SOS) conditions. The resulting SOS program is computationally tractable when the dimensions $m,n$ and number of constraints are not too large. The framework presented here generalizes an approach of Valmorbida, Ahmadi, and Papachristodoulou (IEEE Trans. Automat. Contr., 61:1649--1654, 2016). We prove that the optimal lower bound given by the PDR is sharp for several classes of problems, whose special cases include leading eigenvalues of Sturm-Liouville problems and optimal constants of Poincar\'e inequalities. For these same classes, we prove that SOS relaxations of the PDR converge to the sharp lower bound as polynomial degrees are increased. Convergence of SOS computations in practice is illustrated for several examples.
Published: 2021

5. Bounds for internally heated convection with fixed boundary heat flux

Author: Arslan, A, Fantuzzi, G, Craske, J, Wynn, A, and Engineering and Physical Sciences Research Council
Subjects: physics.flu-dyn
Abstract: We prove a new rigorous bound for the mean vertical heat transport ⟨wT⟩ in internally heated convection with an insulating lower boundary and an upper boundary with fixed heat flux that balances the total internal heating. An analytical application of the background method, based on the construction of a quadratic auxiliary function, yields ⟨wT⟩≤12(12+13√)−1.6899R−1/3, where R is the Rayleigh number. Numerical optimisation of the auxiliary function suggests that the asymptotic value of this bound and the −1/3 exponent are optimal within our bounding framework. This new result halves the best existing (uniform) bound and the Rayleigh number dependence is consistent with previous conjectures and heuristic scaling arguments.
Published: 2021

6. Rigorous bounds on the heat transport of rotating convection with Ekman pumping

Author: Pachev, B, Whitehead, JP, Fantuzzi, G, and Grooms, I
Subjects: Physics::Fluid Dynamics, math.MP, physics.flu-dyn, 02 Physical Sciences, math-ph, 01 Mathematical Sciences, Mathematical Physics
Abstract: We establish rigorous upper bounds on the time-averaged heat transport for a model of rotating Rayleigh-Benard convection between no-slip boundaries at infinite Prandtl number and with Ekman pumping. The analysis is based on the asymptotically reduced equations derived for rotationally constrained dynamics with no-slip boundaries, and hence includes a lower order correction that accounts for the Ekman layer and corresponding Ekman pumping into the bulk. Using the auxiliary functional method we find that, to leading order, the temporally averaged heat transport is bounded above as a function of the Rayleigh and Ekman numbers Ra and Ek according to $Nu \leq 0.3704 Ra^2 Ek^2$. Dependent on the relative values of the thermal forcing represented by $Ra$ and the effects of rotation represented by $Ek$, this bound is both an improvement on earlier rigorous upper bounds, and provides a partial explanation of recent numerical and experimental results that were consistent yet surprising relative to the previously derived upper bound of $Nu \lesssim Ra^3 k^4$.
Published: 2019

7. Duality of convex relaxations for constrained variational problems

Author: Fantuzzi, G
Subjects: math.OC, 49N15, 49M20 (Primary), 35A15 (Secondary), math.AP
Abstract: We prove weak duality between two recent convex relaxation methods for bounding the optimal value of a constrained variational problem in which the objective is an integral functional. The first approach, proposed by Valmorbida et al. (IEEE Trans. Automat. Control 61(6):1649--1654, 2016), replaces the variational problem with a convex program over sufficiently smooth functions, subject to pointwise non-negativity constraints. The second approach, discussed by Korda et al. (arXiv:1804.07565v1 [math.OC]), relaxes the variational problem into a convex program over scaled probability measures. We also prove that the duality between these infinite-dimensional convex programs is strong, meaning that their optimal values coincide, when the range and gradients of admissible functions in the variational problem are constrained to bounded sets. For variational problems with polynomial data, the optimal values of each convex relaxation can be approximated by solving weakly dual hierarchies of finite-dimensional semidefinite programs (SDPs). These are strongly dual under standard constraint qualification conditions irrespective of whether strong duality holds at the infinite-dimensional level. Thus, the two relaxation approaches are equivalent for the purposes of computations.
Published: 2019

8. Bounds for Rayleigh-Bénard convection between free-slip boundaries with an imposed heat flux

Author: Fantuzzi, G and Engineering and Physical Sciences Research Council
Subjects: Technology, INCOMPRESSIBLE FLOWS, Science & Technology, Physics, Fluids & Plasmas, variational methods, Mechanics, turbulent convection, TRANSPORT, 09 Engineering, Physics::Fluid Dynamics, physics.flu-dyn, Physics, Fluids & Plasmas, ENERGY-DISSIPATION, VARIATIONAL BOUNDS, Physical Sciences, SUM-OF-SQUARES, Benard convection, DRIVEN SHEAR, OPTIMIZATION, 01 Mathematical Sciences
Abstract: We prove the first rigorous bound on the heat transfer for three-dimensional Rayleigh-Bénard convection of finite-Prandtl-number fluids between free-slip boundaries with an imposed heat flux. Using the auxiliary functional method with a quadratic functional, which is equivalent to the background method, we prove that the Nusselt number $Nu$ is bounded by $Nu \leq 0.5999 R^{1/3}$ uniformly in the Prandtl number, where $R$ is the Rayleigh number based on the imposed heat flux. In terms of the Rayleigh number based on the mean vertical temperature drop, $Ra$, we obtain $Nu \leq 0.4646 Ra^{1/2}$. The scaling with Rayleigh number is the same as that of bounds obtained with no-slip isothermal, free-slip isothermal, and no-slip fixed flux boundaries, and numerical optimisation of the bound suggests that it cannot be improved within our bounding framework. Contrary to the two-dimensional case, therefore, the $Ra$-dependence of rigorous upper bounds on the heat transfer obtained with the background method for three-dimensional Rayleigh-Bénard convection is insensitive to both the thermal and the velocity boundary conditions.
Published: 2017

9. Bounds on heat transfer for Bénard-Marangoni convection at infinite Prandtl number

Author: Fantuzzi, G, Pershin, A, Wynn, A, Engineering and Physical Sciences Research Council, and Engineering & Physical Science Research Council (EPSRC)
Subjects: Technology, INCOMPRESSIBLE FLOWS, CONIC OPTIMIZATION, Science & Technology, Marangoni convection, Physics, Fluids & Plasmas, variational methods, Mechanics, turbulent convection, TRANSPORT, 09 Engineering, physics.flu-dyn, Physics, Fluids & Plasmas, ENERGY-DISSIPATION, VARIATIONAL BOUNDS, Physical Sciences, 01 Mathematical Sciences
Abstract: The vertical heat transfer in Bénard–Marangoni convection of a fluid layer with infinite Prandtl number is studied by means of upper bounds on the Nusselt number 𝑁𝑢 as a function of the Marangoni number 𝑀𝑎 . Using the background method for the temperature field, it has recently been proved by Hagstrom & Doering (Phys. Rev. E, vol. 81, 2010, art. 047301) that 𝑁𝑢⩽0.838𝑀𝑎2/7 . In this work we extend previous background method analysis to include balance parameters and derive a variational principle for the bound on 𝑁𝑢 , expressed in terms of a scaled background field, that yields a better bound than Hagstrom & Doering’s formulation at a given 𝑀𝑎 . Using a piecewise-linear, monotonically decreasing profile we then show that 𝑁𝑢⩽0.803𝑀𝑎2/7 , lowering the previous prefactor by 4.2 %. However, we also demonstrate that optimisation of the balance parameters does not affect the asymptotic scaling of the optimal bound achievable with Hagstrom & Doering’s original formulation. We subsequently utilise convex optimisation to optimise the bound on 𝑁𝑢 over all admissible background fields, as well as over two smaller families of profiles constrained by monotonicity and convexity. The results show that 𝑁𝑢⩽𝑂(𝑀𝑎2/7(ln𝑀𝑎)−1/2) when the background field has a non-monotonic boundary layer near the surface, while a power-law bound with exponent 2/7 is optimal within the class of monotonic background fields. Further analysis of our upper-bounding principle reveals the role of non-monotonicity, and how it may be exploited in a rigorous mathematical argument.
Published: 2017

10. Fast ADMM for homogeneous self-dual embeddings of sparse SDPs

Author: Zheng, Y, Fantuzzi, G, Papachristodoulou, A, Goulart, Paul, and Wynn, A
Subjects: MathematicsofComputing_NUMERICALANALYSIS
Abstract: We propose an efficient first-order method, based on the alternating direction method of multipliers (ADMM), to solve the homogeneous self-dual embedding problem for a primal-dual pair of semidefinite programs (SDPs) with chordal sparsity. Using a series of block eliminations, the per-iteration cost of our method is the same as applying a splitting method to the primal or dual alone. Moreover, our approach is more efficient than other first-order methods for generic sparse conic programs since we work with smaller semidefinite cones. In contrast to previous first-order methods that exploit chordal sparsity, our algorithm returns both primal and dual solutions when available, and it provides a certificate of infeasibility otherwise. Our techniques are implemented in the open-source MATLAB solver CDCS. Numerical experiments on three sets of benchmark problems from the library SDPLIB show speed-ups compared to some common state-of-the-art software packages.
Published: 2017

11. Optimization with affine homogeneous quadratic integral inequality constraints

Author: Fantuzzi, G, Wynn, A, Goulart, P, Papachristodoulou, A, and Engineering and Physical Sciences Research Council
Subjects: Technology, INCOMPRESSIBLE FLOWS, Science & Technology, math.OC, Engineering, Electrical & Electronic, semidefinite programming, 0906 Electrical and Electronic Engineering, Automation & Control Systems, Engineering, Industrial Engineering & Automation, PROGRAMS, ENERGY-DISSIPATION, VARIATIONAL BOUNDS, SYSTEMS, Optimization and Control (math.OC), 0102 Applied Mathematics, sum-of-squares optimization, partial differential equations (PDEs), FOS: Mathematics, 35A23, 90C22, Integral inequalities, Mathematics - Optimization and Control, 0913 Mechanical Engineering
Abstract: We introduce a new technique to optimize a linear cost function subject to a one-dimensional affine homogeneous quadratic integral inequality, i.e., the requirement that a homogeneous quadratic integral functional, affine in the optimization variables, is non-negative over a space of functions defined by homogeneous boundary conditions. Such problems arise in stability analysis, input-to-state/output analysis, and control of many systems governed by partial differential equations (PDEs), in particular fluid dynamical systems. First, we derive outer approximations for the feasible set of a homogeneous quadratic integral inequality in terms of linear matrix inequalities (LMIs), and show that under mild assumptions a convergent, non-decreasing sequence of lower bounds for the optimal cost can be computed with a sequence of semidefinite programs (SDPs). Second, we obtain inner approximations in terms of LMIs and sum-of-squares constraints, so upper bounds for the optimal cost and strictly feasible points for the integral inequality can also be computed with SDPs. To aid the formulation and solution of our SDP relaxations, we implement our techniques in QUINOPT, an open-source add-on to YALMIP. We demonstrate our techniques by solving problems arising from the stability analysis of PDEs., 31 pages, 3 figures. Codes available from https://github.com/aeroimperial-optimization/QUINOPT/. Latest version: improved exposition, fixed proof of Theorem 1, added comparison to other method, added discussion on scalability, corrected typos
Published: 2016

12. Effetti dell’attività fisica in gravidanza sulla nascita per termine

Author: FANTUZZI G, RIGHI E, MORANDI M, MASTROIANNI K, GIACOBAZZI P, KANITZ S, BARBONE F, SANSEBASTIANO G, BATTAGLIA MA, LEONI V, FABIANI L, SCIACCA S, AGGAZZOTTI G, TRIASSI, MARIA, Fantuzzi, G, Righi, E, Morandi, M, Mastroianni, K, Giacobazzi, P, Kanitz, S, Barbone, F, Sansebastiano, G, Battaglia, Ma, Leoni, V, Fabiani, L, Sciacca, S, Aggazzotti, G, and Triassi, Maria
Published: 2008

13. Composti organoalogenati nelle acque potabili di 9 Province italiane: indagine sulla presenza di cloriti, clorati, trialometani, trielina e tetracloroetilene

Author: TRIASSI, MARIA, FANTUZZI G, AGGAZZOTTI G, RIGHI E, PREDIERI G, GIACOBAZZI P, KANITZ S, BARBONE F, SANSEBASTIANO G, BATTAGLIA M, LEONI V, FABIANI L, SCIACCA S., Triassi, Maria, Fantuzzi, G, Aggazzotti, G, Righi, E, Predieri, G, Giacobazzi, P, Kanitz, S, Barbone, F, Sansebastiano, G, Battaglia, M, Leoni, V, Fabiani, L, and Sciacca, S.
Published: 2007

14. Suppression of endotoxin-inducible cytokines in whole blood from human subjects following single dose of recombinant human interleukin-11

Author: Reznikov, L. L., Adrian Puren, Fantuzzi, G., Hamner, G. R., Schwertschlag, U. S., Ryan, J. L., and Dinarello, C. A.
Subjects: Infectious Diseases, Immunology, Cell Biology, Molecular Biology, Microbiology
Published: 1999
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15. L’INSEGNAMENTO DI EDUCAZIONE FISICA NELLE SCUOLE ITALIANE: INDAGINE MULTICENTRICA DEL GRUPPO DI LAVORO 'SCIENZE MOTORIE PER LA SALUTE'

Author: Liguori, G., Arpesella, M., Brandi, G., Bruno, S., Capelli, G., Carraro, E., Di Onofrio, V., Fabiani, L., Fantuzzi, G., Gallè, F., Grasso, G. M., Grillo, O. C., Guida, M., Izzotti, A., Leoni, E., Mammina, C., Manzoli, L., Minelli, L., Napoli, C., Nobile, C., Parpinel, M., Pasquarella, C., Prato, R., Privitera, Gp, Signorelli, C., Romano Spica, V., and Tardivo, Stefano
Subjects: indagine multicentrica, Educazione fisica, scuole italiane
Published: 2014

16. Physical education in Italian school: a multicenter investigation about experiences and opinions of undergraduate students

Author: Liguori, Giorgio, Galle', Francesca, DI ONOFRIO, Valeria, Arpesella, M, Brandi, G, Bruno, S, Capelli, G, Carraro, E, Fabiani, L, Fantuzzi, G, Grasso, Gm, Grillo, Oc, Guida, M, Izzotti, A, Leoni, E, Mammina, C, Manzoli, L, Minelli, L, Napoli, C, Nobile, C, Parpinel, M, Pasquarella, C, Prato, R, Privitera, Gp, Signorelli, C, Nullv, Nullromano Spica, Tardivo, S, and Siti Working Group ‘‘movement Sciences For Health’’
Published: 2014

17. Gold Nanoparticles Protected with Triethyleneglycol-functionalized Thiolates: Acid Induced Clustering of the Aggregates and Solvent Dependent Optical Properties

Author: Pengo, Paolo, Fantuzzi, G., Pasquato, Lucia, Scrimin, P., Pengo, Paolo, Fantuzzi, G., Pasquato, Lucia, and Scrimin, P.
Published: 2002

18. Water safety in buildings 2011

Author: Romano Spica, V, Boadonna, L, Fantuzzi, G, Liguori, Giorgio, Vitali, M, Gurnari, Gb, and Pedullà, S.
Published: 2012

19. Fumo attivo e passivo, consumo di caffé ed effetti sulla gravidanza: uno studio caso-controllo in Italia

Author: Fantuzzi, G., Aggazzotti, G., Righi, E., Biasotti, B., Ravera, G., Kanitz, S., Barbone, F., Sansebastiano, G., Battaglia, MARIO ALBERTO, Leoni, V., Fabiani, L., Triassi, M., Sciacca, S., and Gravidanza, Gruppo di studio su acque potabili clorate e.
Published: 2003

20. Role of the hypothalamus-pituitary-adrenal axis in the regulation of TNF production in mice. Effect of stress and inhibition of endogenous glucocorticoids

Author: Fantuzzi G, Di Santo E, Silvano Sacco, Benigni F, and Ghezzi P
Subjects: Lipopolysaccharides, Male, Hypothalamo-Hypophyseal System, Mice, Adrenocorticotropic Hormone, Stress, Physiological, Tumor Necrosis Factor-alpha, Immunology, Immunology and Allergy, Animals, Pituitary-Adrenal System, Glucocorticoids, Antibodies
Abstract: Glucocorticoids (GC) are known inhibitors of TNF production and are increased by endotoxin (LPS) through a stimulation of the hypothalamus-pituitary-adrenal axis (HPAA), suggesting a feedback mechanism. We tried different approaches to study the role of the HPAA and endogenous GC in the regulation of TNF production. Cyanoketone, a GC synthesis inhibitor, inhibited corticosterone (CS) induction by LPS and increased LPS-induced serum TNF levels. Similar results were obtained by pretreating mice with anticorticotropin-releasing hormone Abs. Administration of adrenocorticotropic hormone increased blood CS and inhibited LPS-induced serum TNF. TNF production by mouse blood stimulated in vitro with LPS was inhibited by addition of CS. Blood from stressed or adrenocorticotropic-releasing hormone-treated mice (in which CS levels are elevated) stimulated ex vivo with LPS produced significantly less TNF than blood from control mice. Normal TNF production was restored by the addition of the GC receptor antagonist RU 38486, indicating a role for the elevated endogenous CS levels in the inhibition of TNF production. These data indicate that the HPAA is a major regulator of TNF production.
Published: 1995

21. Chlorpromazine specifically inhibits peripheral and brain TNF production, and up-regulates IL-10 production, in mice

Author: Mengozzi, M., Fantuzzi, G., Faggioni, R., Marchant, A., Goldman, M., Orencole, S., Clark, B. D., Marina Sironi, Benigni, F., and Ghezzi, P.
Subjects: Lipopolysaccharides, Male, Antigens, Bacterial, Chlorpromazine, Interleukin-6, Tumor Necrosis Factor-alpha, Brain, Mice, Inbred Strains, Dexamethasone, Interleukin-10, Up-Regulation, Kinetics, Mice, Staphylococcus epidermidis, Animals, Interleukin-1, Research Article
Abstract: We have previously shown that chlorpromazine (CPZ) inhibits tumour necrosis factor (TNF) production and protects against endotoxic shock in mice. In this paper we investigated the effect of pretreatment with CPZ, 4 mg/kg i.p. 30 min before, compared with dexamethasone (DEX; 3 mg/kg) on the induction of other endotoxin (lipopolysaccharide; LPS)-induced cytokines in the serum of mice, i.e. interleukin-1 alpha (IL-1 alpha), IL-6 and IL-10, and TNF. We also studied the effect of CPZ on serum and spleen-associated TNF. Both DEX and CPZ inhibited TNF production, whereas induction of IL-1 and IL-6 was inhibited by DEX but not by CPZ. DEX did not affect IL-10, while CPZ potentiated its induction. CPZ also inhibited spleen-associated TNF induction in LPS-treated mice, suggesting an effect on the synthesis of TNF. CPZ inhibited TNF induction by Gram-positive bacteria (heat-killed Staphylococcus epidermidis) and by anti-CD3 monoclonal antibodies. Intraperitoneal administration of CPZ also inhibited the induction of brain-associated TNF induced by intra-cerebroventricular injection of LPS. Therefore, CPZ is a more specific inhibitor of TNF production than DEX; in particular, CPZ increased the induction of IL-10, which is a 'protective' cytokine known to inhibit LPS toxicity and TNF production. CPZ inhibited TNF production in vivo, irrespective of the TNF stimulus used to induce TNF. Finally, CPZ did not induce the 'rebound' effect of DEX that, when given 24 hr before LPS, potentiates TNF production, but it did inhibit TNF production after 24 hr.
Published: 1994

22. How to assess exposure to chlorination by-products(CBPS) in drinking water during the last trimester of pregnancy

Author: Aggazzotti, G., Fantuzzi, G., Elena Righi, Triassi, M., Di Lieto, A., Scognamiglio, G., Barbone, F., Valent, F., Brussi, V., Tomasella, L., Aggazzotti, G, Fantuzzi, G, Righi, E, Triassi, Maria, Di Lieto, A, Scognamiglio, G, Barbone, F, Valent, F, Brussi, V, and Tomasella, L.
Subjects: Chlorination by-products
Abstract: Exposure assessment to chlorination by-products(CBPS) in drinking water during the last trimester of pregnancy

23. HEAVY-METAL CONTAMINATION IN MILK FOR INFANTILE NUTRITION .1. LEAD CONTENT IN MATERNAL MILK AND PASTEURIZED MILK

Author: Amore, F., Bergomi, M., Paola Borella, Fantuzzi, G., Vivoli, G., Lauriola, P., and Goldoni, C. A.

24. Epidemiology of work related injuries in young people: results of a survey carried out in Modena (Italy) between January and June 2000 | Epidemiologia degli infortuni lavorativi in minori: risultatidi una indagine condotta nella città di Modena nel periodo gennaio-giugno 2000

Author: Righi, E., Gatti, G., Marcheselli, R., Fantuzzi, G., and Gabriella Aggazzotti

25. Blood, teeth and hair: 3 different materials used to evaluate exposure to lead and cadmium in children living in an industrial zone | Sangue, denti e capelli: tre diverse matrici utilizzate per valutare l'esposizione al piombo e al cadmio in bambini residenti in zona industriale

Author: Bergomi, M., Paola Borella, and Fantuzzi, G.

26. Evaluation of a questionnaire for measuring individual environmental exposure to disinfection byproducts found in drinking water,La valutazione di un questionario sull'esposizione personale a fattori di rischio ambientali: sottoprodotti della disinfezione nelle acque potabili ed effetti sulla salute

Author: Righi, E., Fantuzzi, G., Bargellini, A., Casolari, L., and Gabriella Aggazzotti

27. Behavior during the work week of biological indicators of exposure to lead | Comportamento nella settimana lavorativa degli indicatori biologici di esposizione al piombo

Author: Vivoli, G., Berlin, A., Bergomi, M., Paola Borella, Caselgrandi, E., and Fantuzzi, G.

28. EXPOSURE TO DISINFECTION BY-PRODUCTS IN DRINKING WATER DURING PREGNANCY AND CONGENITAL ANOMALIES. A CASE-CONTROL STUDY IN THE EMILIA-ROMAGNA REGION (NORTHERN ITALY)

Author: Elena Righi, Bechtold, P., Mariosa, D., Mastroianni, K., Giacobazzi, P., Predieri, G., Calzolari, E., Astolfi, G., Lauriola, P., Tortorici, D., Fantuzzi, G., and Aggazzotti, G.
Subjects: trihalomethanes, chlorite, congenital anomalies, disinfection by products, drinking water disinfection, chlorate

29. Early down-regulation of TNF production by LPS tolerance in human monocytes: comparison with IL-1 beta, IL-6, and IL-8

Author: Manuela Mengozzi, Fantuzzi G, Sironi M, Bianchi M, Fratelli M, Peri G, Bernasconi S, and Ghezzi P
Subjects: Lipopolysaccharides, Time Factors, Interleukin-6, Tumor Necrosis Factor-alpha, Interleukin-8, Lipopolysaccharide Receptors, Zymosan, Antigens, Differentiation, Myelomonocytic, Cell Separation, In Vitro Techniques, Monocytes, Kinetics, Antigens, CD, Cyclic AMP, Humans
Abstract: We studied the effect of a 4-hr preexposure to LPS on the ability of human monocytes to respond to a subsequent stimulation with LPS in terms of cytokine production. LPS-preexposed monocytes did not produce TNF on LPS restimulation, but they retained the ability to produce IL-1 beta, IL-6, and IL-8. LPS-tolerant monocytes were still capable of producing TNF when restimulated with zymosan. Down-regulation of TNF by LPS tolerance was also evident at the mRNA level. To investigate the possible mechanisms underlying this phenomenon, we also studied the effect of LPS preexposure on membrane CD14, which was suggested to be an LPS receptor, and on intracellular cAMP, an inhibitor of TNF production. LPS induced a 50% decrease in CD14 expression. On the other hand, the increase in cAMP levels by LPS was not affected by preexposure to LPS. In conclusion, (a) TNF is more rapidly down-regulated than IL-1 beta, IL-6, and IL-8 during LPS tolerance in vitro; (b) early LPS tolerance is associated with decreased CD14, which might partially explain the decreased LPS response; and (c) a feedback mechanism controlling TNF synthesis, cAMP elevation, is not down-regulated in LPS tolerance.

30. Early down-regulation of TNF production by LPS tolerance in human monocytes: Comparison with IL-1β, IL-6, and IL-8

Author: Mengozzi, M., Fantuzzi, G., Sironi, M., Bianchi, M., Maddalena Fratelli, Peri, G., Bernasconi, S., and Ghezzi, P.

31. Colour vision loss in perchloroethylene exposed dry-cleaning workers

Author: Gobba, F., Elena Righi, Fantuzzi, G., Predieri, G., and Aggazzotti, G.
Subjects: Colour vision loss perchloroethylene dry-cleaning workers

32. [Epidemiology of work related injuries in young people: results of a survey carried out in Modena (Italy) between January and June 2000]

Author: Righi E, Gatti G, Raffaella Marcheselli, Fantuzzi G, and Aggazzotti G
Subjects: Male, Adolescent, Italy, Age Factors, Accidents, Occupational, Humans, Female
Abstract: Work related injuries, above all those involving young people, are an important health and social issue, even though up to now small attention has been deserved in spite of the presence of about 68 workers per 1000 young people and the occurrence of 27400 injures in young people in 2000 in Italy. This study was aimed at improving the knowledge on work related injures occurring in Modena in 14-17 year old subjects in the period January-June 2000. A descriptive epidemiological study was carried out. Information was collected at the two emergency departments operating in Modena by checking hospital and INAIL records. Injures were defined as events caused by a violent external cause producing one or more lesions. Injuries were defined as work related when occurring during working activities or "in itinere". Work related injures and other injures were compared using the different statistical methods. Work related injuries occurring in young people during January-June 2000 in Modena were 76 (6-month incidence: 1.5 per 100 subjects of the same age) and represent 8.5% of all injuries. The most involved subjects were 17 year old males working in the industrial field, and in most cases prognoses were lasting less than 8 days. A Cluster Analysis identified two types of injures: the "in itinere" ones which resulted similar to the road accidents, both for body sites involved and for the way of occurrence and the injuries occurring at the working place characterised by a high frequency of lesions concerning hand, head, above all eyes. The study showed a remarkable incidence of work related injuries among 14-17 year old subjects in Modena in the first 6 months of 2000. Nevertheless many difficulties in finding information raised during the survey: a higher accuracy and completeness in collecting and recording of the data is needed to better define the epidemiological aspects of this issue.

33. TNF Receptor p55 Plays a Major Role in Centrally Mediated Increases of Serum IL-6 and Corticosterone after Intracerebroventricular Injection of TNF

Author: Benigni F, Faggioni R, Sironi M, Fantuzzi G, Vandenabeele P, Takahashi N, Sacco S, Fiers W, Wa, Buurman, Pietro Ghezzi, Algemene Heelkunde, and RS: NUTRIM School of Nutrition and Translational Research in Metabolism
Subjects: Male, musculoskeletal diseases, Interleukin-6, Tumor Necrosis Factor-alpha, Immunology, Mice, Inbred Strains, hemic and immune systems, Receptors, Tumor Necrosis Factor, Recombinant Proteins, biological factors, Cerebral Ventricles, Mice, Blood-Brain Barrier, Animals, Humans, Immunology and Allergy, Endothelium, Vascular, Corticosterone, Cells, Cultured
Abstract: The aim of this work was to study the relative role of the two TNF receptors (p55 and p75) in the central actions of TNF, studying the elevation of serum corticosterone (CS) and IL-6 levels after injection of recombinant murine (rm)TNF (intracerebroventricularly (i.c.v.)) in normal or p55-deficient (p55 -/-) mice. rmTNF induced high serum IL-6 levels and doubled serum CS in normal mice, whereas no elevation of serum IL-6 or CS was induced in p55 -/- mice. However, a normal CS response was observed in p55 -/- mice after LPS (2.5 microg, i.c.v.). p55 -/- mice also responded, although to a lesser extent than p55 +/+, in terms of LPS-induced IL-6 production. We also injected two agonist Abs specific for the two receptors, alpha p55 and alpha p75. While alpha p55 injected i.c.v. induced a marked elevation in CS and IL-6, alpha p75 induced CS (although less than alpha p55) but no IL-6. rmTNF, which binds both receptors, was more potent in inducing IL-6 and CS than injection of rhTNF, which in mice binds only p55. Finally, we investigated the role of p55 and p75 in IL-6 induction by TNF in a murine brain endothelioma. The results resembled closely those obtained in vivo: rmTNF was more potent than rhTNF and only alpha p55, and not alpha p75, induced IL-6 production. These data indicate that p55 plays a major role in TNF activation of the hypothalamus-pituitary-adrenal axis and in the centrally mediated induction of peripheral IL-6 by TNF, but p75, despite having little IL-6 inductive properties by itself, seems to potentiate p55 induction of IL-6.

34. Work-related injuries among minors. Italian multicenter study, 1994-1998 | Infortuni sul lavoro nei minori. Studio multicentrico italiano, anni 1994-1998

Author: Fabiani, L., Anna Rita Giuliani, Scatigna, M., Righi, E., Fantuzzi, G., and Aggazzotti, G.

35. [Environmental surveillance of a sample of indoor swimming pools from Emilia Romagna region: microclimate characteristics and chemical parameters, particularly disinfection by products, in pool waters]. | Aspetti igienico-ambientali di un campione di piscine coperte della Regione Emilia Romagna: valutazione delle condizio- ni microclimatiche e dei principali parametri chimici delle acque, con particolare riferimento alla presenza di sottopro- dotti della disinfezione

Author: Fantuzzi, G., Righi, E., Predieri, G., Giacobazzi, P., Mastroianni, K., and Gabriella Aggazzotti

36. Effect of endotoxin in IL-1 beta-deficient mice

Author: Fantuzzi G, Zheng H, Faggioni R, Benigni F, Pietro Ghezzi, Jd, Sipe, Ar, Shaw, and Ca, Dinarello
Subjects: Blood Glucose, Lipopolysaccharides, Male, Serum Amyloid A Protein, Macrophages, Immunology, Mice, Mutant Strains, Lethal Dose 50, Mice, Inbred C57BL, Mice, Immunology and Allergy, Animals, Cytokines, Female, Corticosterone, Cells, Cultured, Injections, Intraperitoneal, Interleukin-1
Abstract: IL-1 plays an important role in the pathophysiologic responses to infection and inflammation, in part by mediating its own production and that of other proinflammatory cytokines. However, the relative contribution of IL-1 alpha and IL-1 beta to the inflammatory response has not been well clarified. Using IL-1 beta-deficient (IL-1 beta -/-) mice, we investigated the specific role of IL-1 beta in the in vivo and in vitro response to LPS. No differences between IL-1 beta +/+ and IL-1 beta -/- mice were observed in circulating levels for IL-1 alpha, IL-6, or TNF-alpha after the systemic administration of either a low (5 micrograms/kg) or high (5 mg/kg) dose of LPS. IL-1 beta -/- mice also had a normal response to LPS in terms of activation of the hypothalamus-pituitary-adrenal axis, hypoglycemia, serum amyloid A production, and anorexia. IL-1 beta -/- mice were normally sensitive to the lethal effect of LPS and were protected against LPS toxicity when pretreated with low-dose LPS. However, in vitro, peritoneal macrophages from IL-1 beta -/- mice stimulated with LPS produced significantly less IL-1 alpha than macrophages from IL-1 beta +/+ mice (p < 0.05). No differences in IL-6 or TNF-alpha synthesis were observed between macrophages from IL-1 beta +/+ and IL-1 beta -/- mice. In summary, our results suggest that either IL-1 beta is not essential for the in vivo systemic response to LPS or that its role can be fulfilled by other cytokines with overlapping activities.

37. Two-year evolution of perchloroethylene-induced color-vision loss

Author: Fabriziomaria Gobba, Righi, E., Fantuzzi, G., Predieri, G., Cavazzuti, L., and Aggazzotti, G.

38. Cytokines in acute myocardial infarction: selective increase in circulating tumor necrosis factor, its soluble receptor, and interleukin-1 receptor antagonist

Author: Latini R, Bianchi M, Correale E, Ca, Dinarello, Fantuzzi G, Fresco C, Aldo Pietro Maggioni, Mengozzi M, Romano S, and Shapiro L
Subjects: Aged, 80 and over, Male, Tumor Necrosis Factor-alpha, Sialoglycoproteins, Interleukin-8, Myocardial Infarction, Middle Aged, Receptors, Tumor Necrosis Factor, Recombinant Proteins, Interleukin 1 Receptor Antagonist Protein, Tissue Plasminogen Activator, Humans, Female, Streptokinase, Aged, Interleukin-1
Abstract: Cytokines play a pathogenetic role in a variety of infective and inflammatory diseases. In the present study, we had two objectives: (a) to define the kinetics of tumor necrosis factor (TNF) in plasma after acute myocardial infarction (AMI) in patients treated with early thrombolysis, and (b) to measure other cytokines, interleukin-1 (IL-1) and TNF receptor antagonists, in plasma. TNF-alpha, but not IL-1 beta or IL-8, was present in plasma of 6 of 7 patients with severe AMI (Killip class 3 or 4). No TNF (50 pg/ml) was detected in a group of 11 patients with uncomplicated myocardial infarction (Killip class 1) or in control patients without AMI. Soluble TNF receptor type I and IL-1 receptor antagonist (IL-1Ra) were also significantly increased in the group with severe AMI compared with those with uncomplicated AMI. Circulating TNF is increased only in AMI complicated by heart failure at hospital admission. This finding may have diagnostic and therapeutic relevance.

39. Evaluation of fluoride content in Modena water | Valutazione del contenuto in fluoro nelle acque del modenese

Author: Gabriella Aggazzotti, Vernole, B., Dottorini, R., Caprioglio, D., and Fantuzzi, G.

40. Differential regulation of cytokine production in lipopolysaccharide tolerance in mice

Author: Erroi, A., Fantuzzi, G., Mengozzi, M., Sironi, M., Orencole, S. F., Clark, B. D., Dinarello, C. A., Isetta, A., Gnocchi, P., Mirella Giovarelli, and Ghezzi, P.

41. Endogenous nitric oxide production by human monocytic cells regulates LPS-induced TNF production

Author: Zinetti, M., Fantuzzi, G., Delgado, R., Di Santo, E., Ghezzi, P., and Maddalena Fratelli
Subjects: Lipopolysaccharides, omega-N-Methylarginine, Tumor Necrosis Factor-alpha, Leukocytes, Mononuclear, Humans, In Vitro Techniques, Arginine, Nitric Oxide, Cell Division, Monocytes, Cell Line
Abstract: The ability to produce nitric oxide (NO) of human monocytes macrophages is object of debate. While studying the regulation of tumor necrosis factor (TNF) synthesis induced by endotoxin (LPS) in a human cell line of monocyte origin (THP-1) and in human peripheral blood mononuclear cells (PBMC) we found an indirect evidence of such production. We showed that L-N-monomethyl-arginine (L-NMMA), an inhibitor of NO synthase, and hemoglobin, a chelator of NO, are able to significantly reduce TNF synthesis, indicating that NO production is induced by LPS and contributes to the induction of TNF. Since NO is a known cytostatic agent, we also studied the cytostatic effect of LPS, and demonstrated that it is reverted by L-NMMA. Although we were unable to show any nitrites/nitrates accumulation in the culture media, taken together our data give an indirect evidence of a physiologically relevant LPS-induced NO production in human monocytes-macrophages.

42. [World Health Organization (WHO) Guidelines for coastal and fresh waters: Italian translation by the Society of Hygiene, Preventive Medicine and Public Health (SItI) Working Group 'Movement Sciences for Health'].,Linee Guida dell'Organizzazione Mondiale della Sanità per acque costiere ed acque dolci: traduzione a cura del Gruppo di Lavoro SItI - 'Scienze Motorie per la Salute'

Author: Napoli, C., Amagliani, G., Arpesella, M., Bonadonna, L., Giorgio Brandi, Briancesco, R., Capelli, G., Di Onofrio, V., Fantuzzi, G., Frangella, C., Gallè, F., Leoni, E., and Liguori, G.

43. [Environmental surveillance of a sample of indoor swimming pools from Emilia Romagna region: microclimate characteristics and chemical parameters, particularly disinfection by products, in pool waters].,Aspetti igienico-ambientali di un campione di piscine coperte della Regione Emilia Romagna: valutazione delle condizio- ni microclimatiche e dei principali parametri chimici delle acque, con particolare riferimento alla presenza di sottopro- dotti della disinfezione

Author: Fantuzzi, G., Elena Righi, Predieri, G., Giacobazzi, P., Mastroianni, K., and Aggazzotti, G.

44. Cadmium in blood, urine and hair related to human hypertension

Author: Vivoli, G., Bergomi, M., Paola Borella, Fantuzzi, G., and Caselgrandi, E.
Subjects: Adult, Male, hypertension, cadmium, case-control study, zinc, copper, Middle Aged, Zinc, Case-Control Studies, Hypertension, Humans, Copper, Cadmium, Hair
Abstract: A case-control study was performed to assess whether cadmium is related to hypertension in a non-occupationally exposed population. 63 male subjects affected by mild stable hypertension, pharmacologically untreated, were investigated together with 63 male normotensive controls individually matched for sex, age, body mass index, smoking habits and work activities. Cadmium in blood, zinc and copper in serum, the three elements in urine and hair, together with some biological parameters involved in pathogenesis of hypertension, were investigated. The mean Cd blood value in hypertensives (H) was 0.58 micrograms/L vs 0.44 micrograms/L in normotensives (N) (t = 2.03; p less than 0.05) with a greater difference in non-smokers (0.41 micrograms/L vs 0.25 micrograms/L) (t = 2.69, p less than 0.01). Furthermore, both systolic and diastolic blood pressure were significantly related to cadmium blood levels (r = 0.20 and 0.19 respectively, p less than 0.05). Smoking habit affected cadmium levels only in the blood, not in the other biological matrices examined. No significant difference of cadmium content in urine and hair was found between normotensives and hypertensives but Cd/Cu ratio in urine was significantly lowered in the second group.

45. [Exposure to organic halogen compounds in drinking water of 9 Italian regions: exposure to chlorites, chlorates, thrihalomethanes, trichloroethylene and tetrachloroethylene]

Author: Fantuzzi, G., Aggazzotti, G., Elena Righi, Predieri, G., Giacobazzi, P., Kanitz, S., Barbone, F., Sansebastiano, G., Ricci, C., Leoni, V., Fabiani, L., Triassi, M., and Collsborative Group for the Study of Chlorinated Drinking Waters and Pregnancy

46. INTERACTION BETWEEN CADMIUM AND SOME BIOCHEMICAL PARAMETERS INVOLVED WITH HUMAN HYPERTENSION

Author: Vivoli, G., Bergomi, M., Paola Borella, Fantuzzi, G., and Caselgrandi, E.
Subjects: heavy metals, cadmium, hypertension

47. Exposure to chloroform in persons frequenting an indoor swimming pool | L'esposizione al cloroformio dei frequentatori di piscine coperte

Author: Olivo, R., Gabriella Aggazzotti, Fantuzzi, G., Predieri, G., and Tamburi, M.

48. Relationship between stressful work, personality and catecholamine excretion | Studio dei rapporti tra attività lavorative stressanti, personalità ed escrezione catecolaminica

Author: Vivoli, G., Bergomi, M., Paola Borella, and Fantuzzi, G.

49. 35th Annual Meeting of the European Association for the Study of Diabetes : Brussels, Belgium, 28 September-2 October 1999

Author: Melander, A., Olsson, J., Lindberg, G., Salzman, A., Howard, T., Stang, P., Lydick, E., Emslie-Smith, A., Boyle, D. I. R., Evans, J. M. M., Macdonald, T. M., Bain, J., Sullivan, F., Ad Darts Memo, Morris For The Collaboration, Juhl, C., Porksen, N., Sturis, J., Hollingdal, M., Pincus, S., Veldhuis, J., Dejgaard, A., Schmitz, O., Kristensen, J. S., Frandsen, K. B., Bayer, Th, Muller, P., Dunning, B. E., Paladini, S., Gutierrez, C., Deacon, R., Valentin, M., Grunberger, G., Weston, W. M., Patwardhan, R., Rappaport, E. B., Sargeant, L. A., Wareham, N. J., Khaw, K. T., Zethelius, Bjorn, Lithell, Hans, Hales, C. Nicholas, Berne, Christian, Lakka, H-M, Oksanen, L., Tuomainen, T-P, Kontula, K., Salonen, J. T., Dekker, J. M., Boks, P., Vegt, F., Stehouwer, C. D. A., Nijpels, G., Bouter, L. M., Heine, R. J., Bruno, G., Cavallo-Perin, P., Bargero, G., D Errico, N., Borra, M., Macchia, G., Pagano, G., Newton, R. W., Ruta, D. A., New, J. P., Wallace, C., Roxburgh, M. A., Young, R. J., Vaughan, N. J. A., Elliott, P., Brennan, G., Devers, M., Macalpine, R., Steinke, D., Lawson, D. H., Decallonne, B., Casteels, K., Gysemans, C., Bouillon, R., Mathieu, C., Linn, Thomas, Strate, Christine, Schneider, Kerstin, Funda, D. P., Jirsa, M. Jr, Kozakova, H., Kaas, A., Kofronova, O., Tlaskalova-Hogenova, H., Buschard, K., Wanka, H., Hartmann, A., Kuttler, B., Rasmussen, S. B., Sorensen, T. S., Markholst, H., Petersen, J. S., Karounos, D., Dyrberg, T., Mabley, J. G., Hasko, G., Szabo, C., Seissler, J., Nguyen, T. B. T., Steinbrenner, H., Scherbaum, W. A., Cipriani, R., Gabriele, A., Sensi, M., Guidobaldi, L., Pantellini, F., Cerrito, M. G., Scarpa, S., Di Mario, U., Morano, S., Ceolotto, G., Iori, E., Baritono, E., Del Prato, S., Semplicini, A., Trevisan, R., Zerbini, G., Meregalli, G., Asnaghi, V., Tentori, F., Maestroni, A., Mangili, R., Marescotti, C., Vedovato, M., Tiengo, A., Tadjieva, J., Mankovsky, B. N., Aken, S., Raes, A., Vande Walle, J., Matthys, D., Craen, M., Hansen, H. P., Lund, S. S., Rossing, P., Jensen, T., Parving, H-H, Genediab, Study Group, Andersen, S., Tarnow, L., Hansen, B. V., Trautner, C., Haastert, B., Ennenbach, N., Willich, S., Tabak, A. Gy, Orchard, T. J., Spranger, J., Preissner, K. T., Schatz, H., Pfeiffer, A., Canton, A., Burgos, R., Hernandez, C., Lecube, A., Mesa, J., Segura, R. M., Mateo, C., Simo, R., Fathallah, L., Greene, D. A., Obrosova, I., Gilbert, R. E., Kelly, D. J., Cox, A. J., Berka-Wilkinson, J. L., Taylor, H. R., Panagiotopoulos, S., Lee, V., Jerums, G., Cooper, M. E., Hitman, G. A., Aganna, E., Ogunkolade, W. B., Rema, M., Deepa, R., Shanthi-Rani, C. S., Barakat, K., Kumarajeewa, T. R., Cassell, P. G., Mcdermott, M. F., Mohan, V., Ways, K., Bursell, S., Devries, T., Woodworth, J., Alatorre, C., King, G., Aiello, L. P., Karisen, A. E., Pavlovic, D., Nielsen, K., Jensen, J., Andersen, H. U., Pociot, F., Mandrup-Poulsen, T., Eizirik, D. L., Nerup, J., Lortz, S., Tiedge, M., Lenzen, S., Lally, F. J., Bone, A. J., Darville, M. I., Ho, Y-S, Sternesjo, J., Sandler, S., Chen, M-C, Schuit, F., Pipeleers, D. G., Merezak, S., Hardikar, A., Hoet, J. J., Remacle, C., Reusens, B., Breant, B., Garofano, A., Czernichow, P., Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Nakano, R., Komeda, K., Eto, K., Tobe, K., Kimura, S., Kadowaki, T., Ide, T., Murakami, K., Tsunoda, M., Mochizuki, T., Ozanne, S. E., Nave, B. T., Wang, C. L., Dorling, M. W., Petry, C. J., Koopmans, S. J., Bent, C., Que, I., Radder, J. K., Sebokova, E., Sana, A. K., Klimes, I., Ruderman, N., Morviducci, L., Pastore, L., Morelli, S., Sagratella, E., Zorretta, D., Buongiomo, A., Tamburrano, G., Giaccari, A., Martinenghi, Sabina, Angelis, Gabriella Cusella, Ravasi, Flavio, Bifari, Francesco, Bordignon, Claudio, Falqui, Luca, Kessler, A., Dransfeld, O., Sasson, S., Tomas, E., Zorzano, A., Eckel, J., Thorsby, P., Rosenfalck, A. M., Kjems, L., Hanssen, K. F., Madsbad, S., Birkeland, K. I., Hamilton-Wessler, M., Markussen, J., Bergman, R. N., Melki, V., Hanaire-Broutin, H., Bessieres-Lacombe, S., Gedec, Study Group, Tauber, J-P, Home, P. D., Lindholm, A., Riis, A., European Insulin Aspart Study Group, Rosenstock, J., Schwartz, S., Clark, C., Edwards, M., Donley, D., Us Dm, Study Group Of Insulin Glargine In Type, Swift, P., Mortensen, H. B., Lynggaard, H., Hougaard, P., Hvidore Study group on Childhood Diabetes, Cull, C. A., Neil, H. A. W., Frighi, V., Manley, S. E., Holman, R. R., Turner, R. C., Ukpds, Group, Steiner, G., Dais, Project Group, Davis, W. A., Weeraratna, T., Bruce, D. G., Davis, T. M. E., Verges, B., Duvillard, L., Pont, F., Florentin, E., Gambert, Ph, Benko, B., Ljubic, S., Turk, Z., Granic, M., Marz, W., Wollschlager, H., Klein, G., Neiss, A., Wehling, M., Huxtable, S. J., Saker, P. J., Walker, M., Frayling, T. M., Levy, J. C., O Rahilly, S., Hattersley, A. T., Mccarthy, M. I., Orecchio, A., Giacchini, A., Dominici, R., Canettieri, G., Trinti, B., Zani, M., Andreoli, M., Sciacchitano, S., Silva, A. M., Whitecross, K., Pasco, J., Kotowicz, M., Nicholson, G., Zimmet, P., Boyko, E. J., Collier, G. R., Frittitta, L., Pizzuti, A., Argiolas, A., Graci, S., Goldfine, I. D., Bozzali, M., Ercolino, T., Costanzo, B., Iacoviello, L., Tassi, V., Trischitta, V., Wauters, M., Rankinen, T., Mertens, I., Chagnon, M., Bouchard, C., Gaal, L., Sivenius, K., Valve, R., Hakkarainen, V., Niskanen, L., Laakso, M., Uusitupa, M., Beridze, N., Japaridze, M., Kurashvili, R., Dundua, M., Kebuladze, G., Kazakhashvili, N., Offley-Shore, B., Thomas, B., Ghebremeskel, K., Crawford, M., Lowy, C., Eriksson, Ulf J., Martin Siman, C., Wisse, Bert, Gittenberger-De Groot, Adriana C., Wentzel, P., Eriksson, U. J., Wender-Ozegowska, E., Drews, K., Biczysko, R., Bronisz, A., Rosc, D., Graczykowska-Koczorowska, A., Kotschy, M., Sokup, A., Kohnert, K. D., Besch, W., Strese, J., Frick, U., Zander, E., Kemer, W., Skrha, J., Kvasnicka, J., Kalvodova, B., Hilgertova, J., Schatteman, K., Goossens, F., Scharpe, S., Leeuw, I., Hendriks, D., Legakis, I. N., Panayiotou, D., Mountokalakis, Th D., Enderle, M. D., Beckmann, P., Balletshofer, B., Rittig, K., Maerker, E., Volk, A., Meisner, C., Jacob, S., Matthaei, S., Haring, H. U., Rett, K., Ueda, K., Nakagawa, T., Shimajiri, Y., Kokawa, M., Matsumoto, E., Sasaki, H., Sanke, T., Nanjo, K., Mckinnon, Caroline M., Macfarlane, Wendy M., Docherty, Kevin, Furukawa, N., Shirotani, T., Kishikawa, H., Kaneko, K., Araki, E., Shichiri, M., Prentki, M., Roduit, R., Susini, S., Buteau, J., Ejrnas, A. M., Andersen, N. Aa, Osterhoff, M., Mohlig, M., Ortmann, J., Bikashaghi, F., Mayer, C., Bikashagi, F., Ackermans, M. T., Pereira Arias, A. M., Bisschop, P. H. L. T., Endert, E., Sauerwein, H. P., Romijn, J. A., Gastaldelli, A., Baldi, S., Pettiti, M., Natali, A., Frascerra, S., Camastra, S., Toschi, E., Ferrannini, E., Stingl, H., Krssak, M., Bischof, M. G., Krebs, M., Furnsinn, C., Nowotny, P., Waldhausl, W., Roden, M., Neeft, M., Meijer, A. J., Bavenholm, P., Pigon, J., Efendic, S., Kastenbauer, T., Sauseng, S., Sokol, G., Auinger, M., Irsigler, K., Abbott, C. A., Carrington, A. L., Faragher, B., Kulkarni, J., Ross, E. R. E., Boulton, A. J. M., Armstrong, D. G., Hadi, S., Nguyen, H. C., Harkless, L. B., Jirkovska, A., Kasalicky, P., Hosova, J., Skibova, J., Uccioli, L., Caselli, A., Giacomozzi, C., Macellari, V., Giurato, L., Lardieri, L., Menzinger, G., Pham, H. T., Rosenblum, B. I., Lyons, T. E., Giurini, J. M., Smakowski, P., Chrzan, J. S., Habershaw, G. M., Veves, A., Foster, A. M., Bates, M., Doxford, M., Edmonds, M. E., Kecha, O., Winkler, R., Martens, H., Collette, J., Lefebvre, P. J., Greiner, D., Geenen, V., Atlan-Gepner, C., Naspetti, M., Valero, R., Barad, M., Lepault, F., Vialettes, B., Naquet, P., Galan, B., Netea, M. G., Hancu, N., Smits, P., Meer, J. W. M., Osterbye, T., Jorgensen, K. H., Tranum-Jensen, J., Fredman, P., Hoy, M., Bokvist, K., Olsen, H. L., Horn, T., Gromada, J., Laub, R., Lohmann, T., Hahn, H. J., Adler, T., Emmrich, F., Rabuazzo, A. M., Lupi, R., Dotta, F., Patane, G., Marselli, L., Realacci, M., Piro, S., Del Guerra, S., Santangelo, C., Navalesi, R., Purrello, F., Marchetti, P., Vos, P., Visser, L., Haan, B. J., Klok, P., Schilfgaarde, R., Poppema, S., Juang, J-H, Kuo, C-H, Hsu, B. R-S, Nacher, V., Perez, M., Biarnes, M., Raurell, M., Soler, J., Montanya, E., Ritzel, R., Maubach, J., Busing, M., Becker, T., Klempnauer, J., Hucking, K., Schmiegel, W. H., Nauck, M. A., Boucek, P., Saudek, F., Adamec, M., Kozitarova, R., Jedinakova, T., Vlasakova, Z., Bartos, V., Maffi, P., Bertuzzi, F., Aldrighetti, L., Taglietti, M. V., Castelnuovo, A., Pozza, G., Di Carlo, V., Secchi, A., Renier, G., Mamputu, J-C, Gillespie, J. S., Mcmaster, D., Mercer, C., Trimble, E. R., Lecomte, M., Vericel, E., Paget, C., Ruggiero, D., Lagarde, M., Wiernsperger, N., Pricci, F., Leto, G., Amadio, L., Cordone, S., Iacobini, C., Catalano, S., Violi, F., Rotella, C. M., Pugliese, G., Zicari, A., Gradini, R., Sale, P., Pala, L., Cresci, B., Giannini, S., Manuelli, C., Dahlfors, G., Arnqvist, H. J., Gonelle-Gispert, C., Halnan, P. A., Sadoul, K., Wolter, S., Lang, J., Niwa, T., Yu, W., Hidaka, H., Senda, T., Niki, I., Fukasawa, T., Renstrom, E., Barg, S., Seward, E., Rorsman, P., Rutter, G. A., Molinete, M., Lilla, V., Ravazzola, M., Halban, P. A., Efanov, A. M., Bertorello, A. M., Zaitsev, S. V., Zwiller, J., Berggren, P-O, Msengul, A., Salman, F., Sargrn, M., Ozer, E., Karsidaǧ, K., Salman, S., Gedik, S., Satman, I., Dinccaǧ, N., Yilmaz, M. T., Lloyd, A., Hopkinson, P. K., Testa, M. A., Blonde, L., Turner, R. 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50. Exposure to water disinfection by-products and adverse pregnancy outcomes: results of a case-control study carried out in Modena (Italy),Esposizione a sottoprodotti della disinfezione delle acque potabili ed effetti sul neonato: studio caso-controllo presso l'azienda ospedaliera Policlinico di Modena

Author: Righi, E., Fantuzzi, G., Montanari, M., Annalisa Bargellini, Predieri, G., and Aggazzotti, G.

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