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More than 50% of solar-mass stars form in multiple systems. It is therefore crucial to investigate how multiplicity affects the star and planet formation processes at the protostellar stage. We report continuum and C$^{18}$O (2-1) observations of the VLA 1623-2417 protostellar system at 50 au angular resolution as part of the ALMA Large Program FAUST. The 1.3 mm continuum probes the disks of VLA 1623A, B, and W, and the circumbinary disk of the A1+A2 binary. The C$^{18}$O emission reveals, for the first time, the gas in the disk-envelope of VLA 1623W. We estimate the dynamical mass of VLA 1623W, $M_{\rm dyn}=0.45\pm0.08$ M$_{\odot}$, and the mass of its disk, $M_{\rm disk}\sim6\times10^{-3}$ M$_{\odot}$. C$^{18}$O also reveals streamers that extend up to 1000 au, spatially and kinematically connecting the envelope and outflow cavities of the A1+A2+B system with the disk of VLA 1623W. The presence of the streamers, as well as the spatial ($\sim$1300 au) and velocity ($\sim$2.2 km/s) offset of VLA 1623W suggest that either sources W and A+B formed in different cores, interacting between them, or that source W has been ejected from the VLA 1623 multiple system during its formation. In the latter case, the streamers may funnel material from the envelope and cavities of VLA 1623AB onto VLA 1623W, thus concurring to set its final mass and chemical content., Comment: 10 pages, 5 figures, accepted by MNRAS

4 Pág., Cetacean morbillivirus (CeMV) causes illness and death in cetaceans worldwide; the CeMV strains circulating in the Southern Hemisphere are poorly known. We detected a pilot whale CeMV strain in 3 short-finned pilot whales (Globicephala macrorhynchus) stranded in Brazil during July-October 2020. Our results confirm this virus circulates in this species., The Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Technological and Scientific Development (CNPq), and São Paulo Research Foundation (FAPESP) provided financial support. S.C.S. and A.C.E. received PhD fellowships by FAPESP (process nos. 2020/12434-9 and 2016/20956-0). L.B.K. received financial support from FAPESP (no. 2020/12434-9). J.L.C.-D., L.B.K. and M.J.C. are recipients of research productivity fellowships from CNPq (nos.304999-18, 315619/2021-0, and 313577/2020-0, respectively),C.S. is a recipient of a Juan de la Cierva incorporación fellowship (no. IJC2020-046019-I) and received a postdoctoral grant by FAPESP (no. 2018/25069-7)

One possible consequence of dentoalveolar trauma is the development of external inflammatory root resorption (EIRR), which represents an anatomic and microbiologic challenge for clinicians. This case report describes different strategies implemented for successful endodontic management of teeth with multiple EIRR lesions, highlighting the orthograde root canal filling using a tricalcium silicate-based material (Biodentine, Septodont, Saint-Maur-des-Fossés, France). A 17-year-old female patient presented with severe pain in the anterior maxillary teeth and a history of trauma. Two- and three-dimensional radiographic exams confirmed EIRR in three teeth, with a total of 11 EIRR lesions, three exhibiting communication with the root canal. Therefore, chemo-mechanical preparation complemented by ultrasonic activation of irrigants and some changes of intra-canal dressing with calcium hydroxide were performed to reduce the microbiologic load of the affected teeth as much as possible. Then, the canals were entirely filled with Biodentine to interrupt the root resorption process and strengthen the remaining root structure. A 60-month follow-up showed the disappearance of bone rarefactions and the complete repair of the 11 EIRR lesions. The favorable long-term response indicates the feasibility of using tricalcium silicate-based putty as part of orthograde endodontic treatment of teeth with EIRR and root perforations.

Purpose Primary Health Care (PHC) is the coordinator of health care in Brazil and needs to be strengthened in the diagnostic field to increase health care quality. Aiming to improve the diagnostic tools currently available in PHC, this work describes the process of development and validation of two point-of-care biomedical devices for screening patients with syphilis or different kinds of cancer. Methods The development of these devices followed nine stages of action based on the requirements established by the Ministry of Health. During development, both systems followed the stages of circuit planning, software simulation to verify the components used, cost assessment for the acquisition of features, simulation in contact matrix, development of the embedded system, and planning of the printed circuit board and storage box. Results Both devices underwent preliminary functionality tests to assess their quality. The performance tests applied on the device to diagnose syphilis performed 8,733,194 requests, with a flow of 2426 requests/second, reaching the desired parameters of robustness, integrity, durability, and stability. In addition, functioning tests on the cancer-screening device indicated the ability to detect standard fluorescence in a minimal (150 uL) sample volume. Conclusions Together, the methodology used for developing the devices resulted in promising equipment to improve the diagnosis and meet the requirements for executing technologies for testing and triaging patients in PHC.

This study compared the shaping ability of four new reciprocating and rotary nickel-titanium instruments, with triangular or S-shaped cross-section, in the mesial canals of mandibular molars using micro-computed tomographic (micro-CT) evaluation.Twenty-four extracted mandibular molars with Vertucci's class IV configuration in the mesial root were selected for this study. The teeth were matched in fours according to anatomic similarities as revealed by micro-CT and then distributed into four groups of 12 mesial canals each according to the instrumentation technique: Reciproc Blue, R-motion, VDW.Rotate and RaCe EVO. The final apical size of instrumentation was 30/0.04 for three systems and 25/08 for the Reciproc Blue instrument. Micro-CT scans were taken before and after preparation to evaluate the canal volume, area and unprepared surface areas, as well as the centring ability, and the canal: root width ratio.Preparation with all systems significantly increased the volume and area of the canals (p .05). There were no significant differences between groups regarding the amount of unprepared areas in both the apical and full canal lengths (p .05). Variation in the centre of gravity showed no significant difference between groups either (p .05). The canal: root width ratio at levels 0 and 4 mm apically to the coronal canal opening was significantly increased by all systems (p .01), with no significant differences between groups (p .05). The canal width never exceeded 40% of the root width.Reciprocating or rotary instruments, with a triangular or an S-shaped cross-section, performed equally in shaping Vertucci's class IV mesial canals of mandibular molars.

Radiography is a common imaging method for non-destructive object inspection. Processing radiographs to detect defects is, however, challenging, especially if the defect type and location are unknown. In other fields, autoencoders (AE) have been largely studied for anomaly detection. While their performance for defect detection has shown promise, many solutions are not demonstrated to be defect-independent. In this work, we introduce a radiography-based anomaly detection method that first computes the AE prediction error from an input radiograph to enhance the detectability of defects. Subsequently, the probability of the imaged object being defective is predicted by a convolutional classification network. Results on simulated data demonstrate that this method succeeds in distinguishing between defective and nondefective objects, with accuracy (which calculates how often the predictions are equal to the labels) >94% and precision (which is the ratio between the true positives and the total predicted positive) >90%, even for defects unseen during the training stage. Our classification network showed high robustness to noise (with signal-to-noise-ratio (SNR) of 20 dB), and accuracy on noisy data >90% and precision >86%. Since our network workflow does not require image registration for defect detection, the proposed solution is therefore independent of the orientation and position of the object during the scan.

Objective: To assess the centralization and dentin thickness of mesial root canals by microcomputed tomography (micro-CT). Methods: Ninety-nine mandibular molars Vertucci’s type IV mesial canals were scanned by micro-CT. The mesiodistal deviation; and the centroid were calculated for mesiobuccal (MB) and mesiolingual (ML) canals (apical 4 mm and full canal). Results: The centroid was deviated in MB and ML canals in full canal (MB=0.83 mm, 0.02-2.30 mm, and ML=0.83 mm, 0.05-3.99 mm), and in 4mm (MB=0.18mm,0.01-1.01 mm and ML=0.21 mm, 0.01-1.01 mm). In the full canal, both MV (69%) e ML (57%) deviated to mesial (M). In 4 mm, the deviation was M in 51% for MB canals and 52% of ML to distal (D). The dentin thickness was similar for MB and ML canals and their walls. Distal wall was lower for MB canal (0.07 mm) and M wall the higher in the MB canal (2.46 mm). Conclusions: There is no centrality of mesial canals in mandibular first molars. The M deviation was frequent in the full canal. Dentin thickness were similar between mesial canals.

Objective The effects of brushing on shaping with different instruments was assessed in oval canals. Design Mandibular incisors were assigned to 6 groups (n = 12/group) according to the system, each one with or without brushing: Reciproc Blue, VDW.Rotate, and Race EVO. Micro-computed tomography was performed before and after preparation. Results Brushing strokes caused no increase in canal volume, surface area, and structure model index independently of the system (p > 0.05), except RaCe in full canal surface area (p 0.05), except for Reciproc in apical canal (p

Functionally graded cellular materials, which combine cellular materials with a gradient of properties, have been recently investigated as cores of sandwich panels. The present work aims to evaluate the flexural properties of functionally graded cellular structures with a gradient of cell thickness on configurations recently proposed. The structures hexagonal honeycomb (Hr), lotus (Lt), and hexagonal honeycomb with Plateau borders (Pt) were designed with three different gradients of cell thickness. The parts were manufactured by material extrusion using FFF (Fused Filament Fabrication). To evaluate the mechanical properties, three-point bending tests were conducted, both experimentally and by numerical modelling, by means of the finite element method. The materials used were polylactic acid (PLA) and aluminum. Although experimental and numerical results exhibited some deviations, they revealed the same trends. The results showed that the stiffness and the absorbed energy of the graded Hr, Lt and Pt structures, made of PLA, are higher than such values for the regular hexagonal honeycombs. For the same gradient of cell thickness, the lotus structure tends to exhibit the highest stiffness and absorbed energy, while the hexagonal honeycomb arrangement achieves the largest value of strength. Graded aluminum specimens also attain higher values of stiffness, strength and absorbed energy in comparison with non-graded hexagonal honeycomb configurations. Thus, the use of gradients of cell thickness can promote structures with higher stiffness and absorbed energy, which may compete with the conventional structures of sandwich panel cores.

Ferritin, the iron storage protein, is composed of light and heavy chain subunits, encoded byFTLandFTH1, respectively. Heterozygous variants inFTLcause hereditary neuroferritinopathy, a type of neurodegeneration with brain iron accumulation (NBIA). Variants inFTH1have not been previously associated with neurologic disease. We describe the clinical, neuroimaging, and neuropathology findings of five unrelated pediatric patients withde novoheterozygousFTH1variants. Children presented with developmental delay, epilepsy, and progressive neurologic decline. NonsenseFTH1variants were identified using whole exome sequencing, with a recurrentde novovariant (p.F171*) identified in three unrelated individuals. Neuroimaging revealed diffuse volume loss, features of pontocerebellar hypoplasia and iron accumulation in the basal ganglia. Neuropathology demonstrated widespread ferritin inclusions in the brain. Patient-derived fibroblasts were assayed for ferritin expression, susceptibility to iron accumulation, and oxidative stress. VariantFTH1mRNA transcripts escape nonsense-mediated decay (NMD), and fibroblasts show elevated ferritin protein levels, markers of oxidative stress, and increased susceptibility to iron accumulation. C-terminus variants inFTH1truncate ferritin’s E-helix, altering the four-fold symmetric pores of the heteropolymer and likely diminish iron-storage capacity.FTH1pathogenic variants appear to act by a dominant, toxic gain-of-function mechanism. The data support the conclusion that truncating variants in the last exon ofFTH1cause a novel disorder in the spectrum of NBIA. Targeted knock-down of mutantFTH1transcript with antisense oligonucleotides rescues cellular phenotypes and suggests a potential therapeutic strategy for this novel pediatric neurodegenerative disorder.

Os bioindicadores ambientais são espécies de organismos que podem ser utilizados para monitorar a qualidade do meio ambiente e dessa forma monitorar o impacto das ações antrópicas sobre os ecossistemas. O objetivo deste trabalho foi identificar a contribuição brasileira nos últimos 5 anos sobre as pesquisas à respeito de bioindicadores ambientais. Para possibilitar tal identificação foram realizadas buscas no portal de Periódicos da CAPES no período de 2018 a 2023, selecionando as contribuições mais recentes referentes ao tema. Foram identificados 29 trabalhos, observando os critérios de inclusão e exclusão estabelecidos como artigos duplicados; artigos que estivessem disponíveis para download; artigos do tipo estudo de caso de algum bioindicador ambiental e artigos que apresentassem estudos de caso em território brasileiro. Destaca-se grande contribuição de pesquisas desenvolvidas no estado de Minas Gerais, além de maior incidência de resultados em invertebrados bentônicos como bioindicadores de qualidade da água.

In recent years, the use of Public Service Obligations (PSOs) in air transport policy has substantially increased. In remote regions, where air transport services are not profitable, the application of this subsidy program is crucial for the economic and social development of these regions. However, there is a great diversity in the provision of PSO services among different regions in Europe. Therefore, it is essential to assess the performances of the air carriers operating in different PSO routes. The present study uses Data Envelopment Analysis (DEA) to assess the efficiency of PSO routes within the European Union and compares them with the performances of the operating airlines, both when operating under this subsidy program and when operating their regular flights. First, DEA was applied to the annual data of several European airlines, and then applied to the data of their PSO routes, so that a comparison can be made between the performance obtained on regular flights and flights under the PSO regime. The results identify which airlines had the best and worst performances, as well as the routes and respective regions of Europe where the airlines tend to score higher and lower in terms of efficiency. Results suggest that the Nordic European countries and the United Kingdom were the regions where air carriers obtained the lowest results, and thus, this empirical evidence should support the public authorities to consider revisiting their PSO contracts, in order to improve their operation. info:eu-repo/semantics/acceptedVersion

Made available in DSpace on 2022-05-01T08:45:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 We investigate several notions related to pseudotrajectories, including chain recurrence and shadowing properties, for a special class of diffeomorphisms on euclidean spheres, known as spherical linear transformations, and for bounded linear operators on Banach spaces. Our main results are complete characterizations of chain recurrence for spherical linear transformations on euclidean spheres and for weighted shifts on the classical Banach sequence spaces c and ℓp. Another main result is a characterization of hyperbolicity for invertible operators on Banach spaces by means of average expansivity and the average shadowing property. Instituto Federal de Educação Ciência e Tecnologia de São Paulo Campus Presidente Epitácio, Rua José Ramos Junior, 27-50 Departamento de Matemática Aplicada Instituto de Matemática Universidade Federal do Rio de Janeiro, Caixa Postal 68530 Departamento de Matemática Universidade Estadual Paulista, Rua Cristóvão Colombo, 2265, Jardim Nazareth Departamento de Matemática Universidade Estadual Paulista, Rua Cristóvão Colombo, 2265, Jardim Nazareth

Observando o cenário atual das escolas, nota-se a permanência dos meios tradicionais de ensino, fato que torna o aprendizado de determinadas matérias massivo e desinteressante ao aluno. Visto isso, o presente artigo teve como objetivo realizar uma exploração e análise de estudos que discorrem sobre o uso da gamificação no processo de ensino-aprendizagem do ensino médio, utilizando do método da Revisão Sistemática da Literatura (RSL), que foi desenvolvido por meio de um protocolo previamente elaborado. Concluiu-se que existem estudos relatando a usabilidade da gamificação no ensino médio, com diferentes técnicas, e todos demonstram um impacto positivo no aprendizado.

Introduction The WHO Prison Health Framework was developed to assess prison health system performance and support Member States (MS) in improving their prison health systems. Moreover, it shall enhance MS capacity to evaluate: the impact of changes in governance models, progress in service provision and improvements of the health status of people in prison (PiP). Methods The framework informed the 2021 data collection round of the Health In Prisons European Database Survey. Invitations were sent to all 53 MS of the WHO European Region. Those MS nominating a focal point and providing valid answers were included in the analysis. Results Answers were obtained from 36 MS, representing a total of 613,497 PiP. Access to immunization was very good across all MS, with the highest for COVID-19 (90% of MS provide it in all prisons). Vaccination against HBV was only available in all prisons of 25 MS. Access in all prisons to HIV post and PrEP were reported, respectively, by 78% and 58% of MS. Screening for diseases at entrance was common for HIV, HCV and HBV. In all prisons of 35 MS soap was provided for free, while needles & syringes and lubricants were only provided free of charge, respectively, in 3 and 4 MS. 5 MS did not have therapeutic spaces to tackle drug problems in any prison, in 73% of those having, accessibility was restricted to some prisons. HIV prevalence ranged from 0-16% and treatment was accessible to 55-100% of those diagnosed. Prevalence of HCV ranged from 0-34%, with access to treatment ranging from 0-91%. The most common format of health records in European prisons was paper based (44%). Conclusions Prison-based data collection systems resulted in limited capacity for extraction so that some countries were unable to provide any data on disease prevalence or treatments offered. Given the scarcity of data on this topic obtained from real-world and not from ad-hoc studies, this snapshot provides an important contribution to public health.

Given the potential of acid-activated clays in adsorptive and catalytic processes, several studies focusing on acid matrices have grown over the years, making it possible to study vermiculite, a mineral composed of a type 2:1 unit cell with tetrahedral and octahedral sheets. Therefore, this work aimed to study vermiculite treated with acids for the production of matrices. In this work, the treatment of natural vermiculite-hydrobiotite, with nitric acid in concentrations of 0.25, 0.50, 0.75, and 1 mol.L-1, followed by the dealumination process with sulfuric acid 25% v/v, aiming the production of acid matrices for applications as support for biocatalysts, chemical adsorbents, among others. The produced materials were characterized using different techniques, including X-ray fluorescence spectroscopy, X-ray diffraction, scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis, and isotherm adsorption using the BET method. The results showed that after acid leaching the vermiculite showed a high SiO2 content, high Brønsted and Lewis surface acidity, good adsorption/desorption performance, and significant growth of the specific surface area, qualifying the vermiculite as a promising material for future applications in catalytic and biocatalytic processes. The acid concentration had a considerable influence on the compositional and textural modification of vermiculite-hydrobiotite.

The 3D musculoskeletal motion of animals is of interest for various biological studies and can be derived from X-ray fluoroscopy acquisitions by means of image matching or manual landmark annotation and mapping. While the image matching method requires a robust similarity measure (intensity-based) or an expensive computation (tomographic reconstruction-based), the manual annotation method depends on the experience of operators. In this paper, we tackle these challenges by a strategic approach that consists of two building blocks: an automated 3D landmark extraction technique and a deep neural network for 2D landmarks detection. For 3D landmark extraction, we propose a technique based on the shortest voxel coordinate variance to extract the 3D landmarks from the 3D tomographic reconstruction of an object. For 2D landmark detection, we propose a customized ResNet18-based neural network, BoneNet, to automatically detect geometrical landmarks on X-ray fluoroscopy images. With a deeper network architecture in comparison to the original ResNet18 model, BoneNet can extract and propagate feature vectors for accurate 2D landmark inference. The 3D poses of the animal are then reconstructed by aligning the extracted 2D landmarks from X-ray radiographs and the corresponding 3D landmarks in a 3D object reference model. Our proposed method is validated on X-ray images, simulated from a real piglet hindlimb 3D computed tomography scan and does not require manual annotation of landmark positions. The simulation results show that BoneNet is able to accurately detect the 2D landmarks in simulated, noisy 2D X-ray images, resulting in promising rigid and articulated parameter estimations.

For many years, methods for detecting violence in video data used features designed by humans to extract visual information from input frames for composing feature vectors and then applied machine learning techniques to assign labels to them. Recently, Deep Learning methods are highly evidenced for this task since they can automatically learn image features. Furthermore, they usually overcome the accuracy rates obtained by classical methods based on handcrafted features. This work evaluates learned and handcrafted features for classifying video frames as 'violence' or 'non-violence'. Our results showed that learned features can not always be claimed superior since some violent scenes are only detected by handcrafted features.

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attri- bution 4.0 International License, which permits use, sharing, adapta- tion, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/., Purpose: There is limited data concerning neuroimaging findings and longitudinal evaluation of familial cerebral cavernous malformations (FCCM) in children. Our aim was to study the natural history of pediatric FCCM, with an emphasis on symptomatic hemorrhagic events and associated clinical and imaging risk factors. Methods: We retrospectively reviewed all children diagnosed with FCCM in four tertiary pediatric hospitals between January 2010 and March 2022. Subjects with first available brain MRI and [Formula: see text] 3 months of clinical follow-up were included. Neuroimaging studies were reviewed, and clinical data collected. Annual symptomatic hemorrhage risk rates and cumulative risks were calculated using survival analysis and predictors of symptomatic hemorrhagic identified using regression analysis. Results: Forty-one children (53.7% males) were included, of whom 15 (36.3%) presenting with symptomatic hemorrhage. Seven symptomatic hemorrhages occurred during 140.5 person-years of follow-up, yielding a 5-year annual hemorrhage rate of 5.0% per person-year. The 1-, 2-, and 5-year cumulative risks of symptomatic hemorrhage were 7.3%, 14.6%, and 17.1%, respectively. The latter was higher in children with prior symptomatic hemorrhage (33.3%), CCM2 genotype (33.3%), and positive family history (20.7%). Number of brainstem (adjusted hazard ratio [HR] = 1.37, P = 0.005) and posterior fossa (adjusted HR = 1.64, P = 0.004) CCM at first brain MRI were significant independent predictors of prospective symptomatic hemorrhage. Conclusion: The 5-year annual and cumulative symptomatic hemorrhagic risk in our pediatric FCCM cohort equals the overall risk described in children and adults with all types of CCM. Imaging features at first brain MRI may help to predict potential symptomatic hemorrhage at 5-year follow-up.

The invasion of Ukraine by Russia in February 2022 has resulted in destruction of healthcare infrastructure and triggered the largest wave of internally displaced populations and refugees since World War Two. Conflicts in transitioned countries such as Ukraine create new non-communicable disease (NCD) challenges, especially for cancer care for refugees and humanitarian assistance in host countries. In the early days, rapid attempts were made to model possible impacts. By evaluating open source intelligence used in the first three months of the conflict through snowball search methods, we aimed to address: (i) burden of cancer in Ukrainian population, specifically considering translating to the refugees population, and its cancer care capacity; ii) baseline capacity/strengths of cancer systems in initial host countries. Moreover, using a baseline scenario based on crude cancer incidence in Ukraine, and considering data from UNHCR, we estimated how cancer cases would be distributed across host countries. Finally, a surveillance assessment instrument was created, intersecting health system's capacity and influx of internally displaced populations and refugees. The total new cancer patients per month in pre-conflict Ukraine was estimated as 13,106, of which < 1 % are paediatric cases. The estimated cancer cases in the refugee population (combining prevalent and incident), assuming 7.5 million refugees by July 2022 and a female:male ratio of 9:1, was 33,121 individuals (Poland: 19284; Hungary: 3484; Moldova: 2651; Slovakia: 2421; Romania: 5281). According to our assessments, Poland is the only neighbouring country classified as green/yellow for cancer capacity, i.e. sufficient ablility to absorb additional burden into national health system; Slovakia we graded as yellow, Hungary and Romania as yellow/red and Moldova as red.

Funder: Agua Salud Project, Funder: U.S. Department of Energy; Id: http://dx.doi.org/10.13039/100000015, Funder: CAPES; Id: http://dx.doi.org/10.13039/501100002322, Data capturing multiple axes of tree size and shape, such as a tree's stem diameter, height and crown size, underpin a wide range of ecological research-from developing and testing theory on forest structure and dynamics, to estimating forest carbon stocks and their uncertainties, and integrating remote sensing imagery into forest monitoring programmes. However, these data can be surprisingly hard to come by, particularly for certain regions of the world and for specific taxonomic groups, posing a real barrier to progress in these fields. To overcome this challenge, we developed the Tallo database, a collection of 498,838 georeferenced and taxonomically standardized records of individual trees for which stem diameter, height and/or crown radius have been measured. These data were collected at 61,856 globally distributed sites, spanning all major forested and non-forested biomes. The majority of trees in the database are identified to species (88%), and collectively Tallo includes data for 5163 species distributed across 1453 genera and 187 plant families. The database is publicly archived under a CC-BY 4.0 licence and can be access from: https://doi.org/10.5281/zenodo.6637599. To demonstrate its value, here we present three case studies that highlight how the Tallo database can be used to address a range of theoretical and applied questions in ecology-from testing the predictions of metabolic scaling theory, to exploring the limits of tree allometric plasticity along environmental gradients and modelling global variation in maximum attainable tree height. In doing so, we provide a key resource for field ecologists, remote sensing researchers and the modelling community working together to better understand the role that trees play in regulating the terrestrial carbon cycle.

Made available in DSpace on 2021-06-25T10:56:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 Animal models are widely used for studying diabetes in translational research. However, methods for induction of diabetes are conflicting with regards to their efficacy, reproducibility and cost. A comparison of outcomes between the diabetic models is still unknown, especially full-term pregnancy.To understand the comparison, we analyzed the streptozotocin (STZ)-induced diabetes at three life-different moments during the neonatal period in Sprague–Dawley female rats: at the first (D1), second (D2) and fifth (D5) day of postnatal life. At adulthood (90 days; D90), the animals were submitted to an oral glucose tolerance test (OGTT) for diabetic status confirmation. The diabetic and control rats were mated and sacrificed at full-term pregnancy for different analyses. Group D1 presented a higher mortality percentage after STZ administration than groups D2 and D5. All diabetic groups presented higher blood glucose levels as compared to those of the control group, while group D5 had higher levels of glycemia compared with other groups during OGTT. The diabetic groups showed impaired reproductive outcomes compared with the control group. Group D1 had lower percentages of mated rats and D5 showed a lower percentage of a full-term pregnancy. Besides that, these two groups also showed the highest percentages of inadequate fetal weight. In summary, although all groups fulfill the diagnosis criteria for diabetes in adult life, in our investigation diabetes induced on D5 presents lower costs and higher efficacy and reproducibility for studies involving diabetes-complicated pregnancy. Laboratory of Experimental Research on Gynecology and Obstetrics São Paulo State University (UNESP) DNA Repair Laboratory University of São Paulo (USP) Joslin Diabetes Center Harvard Medical School Department of Physiology Charles University Laboratory of System Physiology and Reproductive Toxicology Federal University of Mato Grosso (UFMT) Laboratory of Experimental Research on Gynecology and Obstetrics São Paulo State University (UNESP)

TheCrónica Geral de Espanha de 1344is one of the most important historical works of the Iberian Middle Ages, but it presents also a complex and lacunar manuscript tradition. This work presents two new manuscripts of this chronicle, tracing its history and establishing its place in the manuscript tradition. The text of theCrónica de 1344copied in these two manuscripts, although fragmentary, is of great importance, since it covers the final part of the chronicle, precisely the least well known. The analysis of its text and the comparison with the other manuscripts of the chronicle and its sources reveals that these new testimonies contain a copy of the original version, of which, until now, no copies were known.