4 results on '"Er-Nan Liu"'
Search Results
2. Blood and urinary biomarkers of prenatal exposure to disinfection byproducts and oxidative stress: A repeated measurement analysis
- Author
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Li-Li Huang, Carmen Messerlian, Wen-Qing Lu, Er-Nan Liu, Chong Liu, Yi-Xin Wang, Yang Sun, Ying-Hui Cheng, and Ying-Jun Chen
- Subjects
Haloacetic acids ,010504 meteorology & atmospheric sciences ,Urinary system ,Dibromochloromethane ,Physiology ,Dichloroacetic acid ,Urine ,010501 environmental sciences ,Bromodichloromethane ,medicine.disease_cause ,01 natural sciences ,chemistry.chemical_compound ,Pregnancy ,Medicine ,Humans ,Trichloroacetic Acid ,lcsh:Environmental sciences ,0105 earth and related environmental sciences ,General Environmental Science ,lcsh:GE1-350 ,business.industry ,medicine.disease ,Disinfection ,Oxidative Stress ,chemistry ,Prenatal Exposure Delayed Effects ,Female ,business ,Oxidative stress ,Biomarkers ,Water Pollutants, Chemical ,medicine.drug ,Disinfectants ,Trihalomethanes - Abstract
Background: Toxicological studies have demonstrated that disinfection by-products (DBPs) can induce oxidative stress, a proposed mechanism that is relevant to adverse birth outcomes. Objective: To examine the associations of blood trihalomethanes (THMs) and urinary haloacetic acids (HAAs) with urinary biomarkers of oxidative stress among pregnant women. Methods: From 2015 to 2017, a total of 4150 blood and 4232 urine samples were collected from 1748 Chinese women during pregnancy. We determined concentrations of 4 blood THMs [chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and 2 urinary HAAs [dichloroacetic acid (DCAA) and trichloroacetic acid (TCAA)]. The summary measures of exposure for brominated THMs (Br-THMs; a molar sum of BDCM, DBCM, and TBM) and total THMs (TTHMs; a molar sum of TCM and Br-THMs) were also calculated. Associations of categorical (i.e., tertiles) and continuous measures of DBPs with urinary concentrations of oxidative stress (OS) biomarkers, 8-hydroxy-2-deoxyguanosine (8-OHdG), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), and 8-iso-prostaglandin F2α (8-isoPGF2α), were assessed using linear mixed regression models. Results: After adjusting for relevant confounding factors, we observed positive dose-response relationships between blood Br-THM tertiles and urinary HNE-MA (P for trend
- Published
- 2019
3. Mediation of the relationship between phthalate exposure and semen quality by oxidative stress among 1034 reproductive-aged Chinese men
- Author
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Yi-Kai Zhou, Chong Liu, Wen-Qing Lu, Yan-Ling Deng, Qiong Luo, Qi Wang, Jorge E. Chavarro, Liang Wang, Yu Miao, Peng Duan, Er-Nan Liu, Shu-Heng Cui, Yi-Xin Wang, and Ying-Jun Chen
- Subjects
Adult ,Male ,Mediation (statistics) ,China ,Chinese men ,Urinary system ,Phthalic Acids ,Physiology ,Phthalate metabolite ,Urine ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,Biochemistry ,03 medical and health sciences ,Semen quality ,chemistry.chemical_compound ,0302 clinical medicine ,Semen ,Medicine ,Animals ,Humans ,030212 general & internal medicine ,0105 earth and related environmental sciences ,General Environmental Science ,Sperm Count ,business.industry ,Reproduction ,Phthalate ,Environmental Exposure ,Semen Analysis ,Oxidative Stress ,chemistry ,Environmental Pollutants ,business ,Oxidative stress - Abstract
Background Emerging evidence from animals indicates that oxidative stress plays a crucial role in the effects of phthalate exposure on male reproductive dysfunctions, which has never been thoroughly explored in humans. Objective To explore the potential mediating role of oxidative stress in the association of phthalate exposure with semen quality among 1034 Chinese men. Method Repeated urine samples gathered from the male partners of sub-fertile couples were analyzed for 3 oxidative stress markers [8-hydroxy-2-deoxyguanosine (8-OHdG), 8-iso-prostaglandin F2α (8-isoPGF2α) and 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA)], using a liquid chromatography-tandem mass spectrometry. Multivariate regression models were constructed to evaluate the associations of urinary oxidative stress markers with urinary phthalate metabolites and semen quality. We also explored the potential mediation effects by oxidative stress markers. Results Significantly positive dose-dependent relationships were observed between each individual phthalate metabolite and all analyzed oxidative stress markers (all p for trend Conclusions Although further investigations are required, our results suggest that oxidative stress may play a mediating role in the effects of phthalate exposure on impaired semen quality.
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- 2019
4. Urinary biomarkers of phthalates exposure and risks of thyroid cancer and benign nodule
- Author
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Yan-Ling Deng, Chong Liu, Ming Jiang, Long-Qiang Wang, Pan Yang, Qiang Zeng, Xiaoping Miao, Xue-Qing Jiang, Er-Nan Liu, and Tong-Zhang Zheng
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Adult ,Male ,China ,endocrine system ,Environmental Engineering ,Health, Toxicology and Mutagenesis ,Urinary system ,Phthalic Acids ,0211 other engineering and technologies ,Physiology ,02 engineering and technology ,010501 environmental sciences ,medicine.disease_cause ,01 natural sciences ,chemistry.chemical_compound ,medicine ,Humans ,Environmental Chemistry ,Thyroid Neoplasms ,Waste Management and Disposal ,Thyroid cancer ,0105 earth and related environmental sciences ,021110 strategic, defence & security studies ,business.industry ,Thyroid ,Phthalate ,Case-control study ,Nodule (medicine) ,Environmental Exposure ,Odds ratio ,medicine.disease ,Pollution ,medicine.anatomical_structure ,chemistry ,Environmental Pollutants ,medicine.symptom ,Carcinogenesis ,business ,Biomarkers - Abstract
Phthalates have been reported to affect the function and growth of thyroid. However, there is little data on the effect of phthalates on thyroid oncogenesis. Here we explored the associations between phthalates exposure and the risks of thyroid cancer and benign nodule. We sex-matched 144 thyroid cancer, 138 benign nodule patients and 144 healthy adults from Wuhan, China. Eight phthalate metabolites in spot urine samples were quantified using high-performance liquid chromatography and tandem mass spectrometry. The associations of creatinine-corrected urinary phthalate metabolites with the risks of thyroid cancer and benign nodule were assessed using multivariable logistic regression models. We found that urinary monomethyl phthalate (MMP), mono(2-ethyl-5hydroxyhexyl) phthalate (MEHHP) and mono(2-ethylhexyl) phthalate (MEHP) associated with increased risks of thyroid cancer and nodule, with adjusted odds ratios (ORs) ranging from 1.74 to 4.78 comparing the extreme tertiles, and urinary monobutyl phthalate (MBP) was associated with decreased risks of thyroid cancer and benign nodule (all P for trends 0.05). Male-specific positive associations of urinary monoethyl phthalate (MEP) with thyroid cancer and nodule as well as urinary mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) with thyroid cancer were also observed. Our results suggest that exposure to certain phthalates may contribute to increased risks of thyroid cancer and benign nodule.
- Published
- 2020
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