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Additional file 1. Supplementary material.

Supplemental material, sj-pdf-1-jso-10.1177_23971983231175213 for Nailfold capillaroscopy and candidate-biomarker levels in systemic sclerosis-associated pulmonary hypertension: A cross-sectional study by Jacqueline MJ Lemmers, Arjan PM van Caam, Brigit Kersten, Cornelia HM van den Ende, Hanneke Knaapen, Arie PJ van Dijk, Wanda Hagmolen of ten Have, Frank HJ van den Hoogen, Hans Koenen, Sander I van Leuven, Wynand Alkema, Ruben L Smeets and Madelon C Vonk in Journal of Scleroderma and Related Disorders

Additional file 1: Appendix 1. Screenshots of the dr. Bart app. Appendix 2. Baseline characteristics of participants in the study per indicator of use and non-users. Appendix 3. The 5 most and least often read paragraphs. Appendix 4. Median and interquartile range of the number of cumulative completed goals over time of the active users (n = 151). Appendix 5. Median and interquartile range of the number of cumulative logins over time of the active users (n = 151). Appendix 6. The 5 relatively most and least often completed goals (i.e., times completed / times chosen). Appendix 7. The 5 relatively most and least often chosen goals (i.e., times chosen / times proposed). Appendix 8. Some responses to the free-text option of the SUS. Appendix 9. Regression coefficient and 95% confidence interval of the relation between baseline characteristics and different parameters of use. Appendix 10. Spearman rank correlation coefficients between different indicators of use and beliefs regarding 5 treatment modalities in knee/hip OA as measured with the treatment beliefs in osteoarthritis questionnaire (TOA) (relative difference between baseline and six month follow-up).

Additional file 1. Example search terms – for PubMed.

Additional file 3. Additional background information about selected definitions.

Additional file 2. Definitions of poor outcome after primary TKA.

A detailed description of the process of inventory and prioritising of FAQs. (DOCX 18 kb)

Background: Significant functional impairment of the hands is nearly universal in systemic sclerosis (SSc, scleroderma). Hand exercises may improve hand function, but developing, testing and disseminating rehabilitation interventions in SSc is challenging. The Scleroderma Patient-centered Intervention Network (SPIN) was established to address this issue and has developed an online hand exercise program to improve hand function for SSc patients (SPIN-HAND). The aim of the proposed feasibility trial is to evaluate the feasibility of conducting a full-scale randomized controlled trial (RCT) of the SPIN-HAND intervention. Design and methods: The SPIN-HAND feasibility trial will be conducted via the SPIN Cohort. The SPIN Cohort was developed as a framework for embedded pragmatic trials using the cohort multiple RCT design. In total, 40 English-speaking SPIN Cohort participants with at least mild hand function limitations (Cochin Hand Function Scale ≥3) and an indicated interest in using an online hand-exercise intervention will be randomized with a 1:1 ratio to be offered to use the SPIN-HAND program or usual care for 3 months. The primary aim is to evaluate the trial implementation processes, required resources and management, scientific aspects, and participant acceptability and usage of the SPIN-HAND program. Discussion: The SPIN-HAND exercise program is a self-help tool that may improve hand function in patients with SSc. The SPIN-HAND feasibility trial will ensure that trial methodology is robust, feasible, and consistent with trial participant expectations. The results will guide adjustments that need to be implemented before undertaking a full-scale RCT of the SPIN-HAND program. Trial registration: ClinicalTrials.gov Identifier: NCT03092024., Canadian Institutes of Health Research(undefined)

Procedure that was used for selecting a representative set of items from statements resulting from interviews. Description: Procedure that was used for selecting a representative set of items from statements resulting from interviews. (DOCX 22Â kb)

Development of the search strategy and full electronic search. Full electronic search (MEDLINE). (DOCX 17Â kb)

Best evidence synthesis: sensitivity analysis. Sensitivity analysis with regard to the impact of large trials with high risk of bias on every individual outcome measure in the best evidence synthesis. (DOCX 20Â kb)

Data not shown in the results section of the main text of the manuscript. Table S1. Effect of medication review on mortality. Figure S1. Meta-analysis of the studies assessing the effect of medication review on mortality. Table S3. Effect of medication review on the number of patients with hospital admissions. Figure S2. Meta-analysis of the studies assessing the effect of medication review on the number of patients with hospital admissions. Table S4. Effect of medication review on time to first hospital (re)admission. Table S6. Effect of medication review on the number of emergency admissions/visits. Table S7. Effect of medication review on the number of GP visits. Table S8. Effect of medication review on the number of outpatient visits. Table S9. Effect of medication review on the number of patients admitted to residential homes. Figure S3. Meta-analysis of the studies assessing the effect of medication review on the number of patients admitted to residential homes. Table S10. Effect of medication review on the number of falls per patient. Table S11. Effect of medication review on the number of patients falling. Figure S4. Meta-analysis of the studies assessing the effect of medication review on the number of patients falling. Table S12. Effect of medication review on the Barthel index. Table S13. Effect of medication review on the Standard Mini Mental State Examination. Table S14. Effect of medication review on the quality of life. Table S15. Effect of medication review on the number of drug-related problems. Table S16. Effect of medication review on the number of drug changes. Table S17. Effect of medication review on the number of drugs with a dosage decrease. Table S18. Effect of medication review on the number of drugs with a dosage increase. Table S19. Effect of medication review on the number of drugs. Table S20. Effect of medication review on drug costs. (DOCX 124Â kb)

Risk of bias assessment: sensitivity analysis. Sensitivity analysis regarding a more stringent cut-off point for risk of bias. (DOCX 19Â kb)

Initial factor loadings for items in the Treatment beliefs in OsteoArthritis Questionnaire in patients with knee and hip osteoarthritis (N = 351). Description: Initial factor loadings for items in the Treatment beliefs in OsteoArthritis Questionnaire. (DOCX 42 kb)

The RA care booklet - Information about the development and content of the RA Care booklet and an estimation of costs for each distribution strategy. (DOCX 21Â kb)

The RA care booklet - Information about the development and content of the RA Care booklet and an estimation of costs for each distribution strategy. (DOCX 21Â kb)