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3. MOESM2 of Differential genome-wide DNA methylation patterns in childhood obesity

Author

Cao-Lei, Lei, Elgbeili, Guillaume, Szyf, Moshe, Laplante, David, and King, Suzanne

Subjects
bacterial infections and mycoses, skin and connective tissue diseases, respiratory tract diseases, 3. Good health
Abstract

Additional file 2: Table S2. 52 canonical pathways classified with IPA. IPA classified and revealed 52 canonical pathways based on the 143 genes differentially methylated between obese and non-obese groups. The biological functions of these pathways were predominantly involved in immune system.

4. MOESM2 of Differential genome-wide DNA methylation patterns in childhood obesity

Author

Cao-Lei, Lei, Elgbeili, Guillaume, Szyf, Moshe, Laplante, David, and King, Suzanne

Subjects
bacterial infections and mycoses, skin and connective tissue diseases, respiratory tract diseases, 3. Good health
Abstract

Additional file 2: Table S2. 52 canonical pathways classified with IPA. IPA classified and revealed 52 canonical pathways based on the 143 genes differentially methylated between obese and non-obese groups. The biological functions of these pathways were predominantly involved in immune system.

5. Epigenetic Modifications Associated with Maternal Anxiety during Pregnancy and Children's Behavioral Measures

Author

Matthias Schwab, Renee A Otte, Bea Van den Bergh, Guillaume Elgbeili, Klaus Huse, Marion I. van den Heuvel, Marijke A. K. A. Braeken, Lei Cao-Lei, Otto W. Witte, Matthias Platzer, Cao-Lei, Lei, van den Heuvel, Marion I., Huse, Klaus, Platzer, Matthias, Elgbeili, Guillaume, BRAEKEN, Marijke, Otte, Renee A., Witte, Otto W., Schwab, Matthias, van den Bergh, Bea R. H., and Cognitive Neuropsychology

Subjects
DISORDER, Male, Physiology, Anxiety, NR3C1, Epigenesis, Genetic, PRENATAL STRESS, Pregnancy, IGF2/H19, Biology (General), DNA methylation, Depression, IGF2, General Medicine, Methylation, PREVALENCE, DEPRESSIVE SYMPTOMS, Child, Preschool, Prenatal Exposure Delayed Effects, SEX, Female, RNA, Long Noncoding, sex-specific effects, Life Sciences & Biomedicine, mediation, Mediation (statistics), Offspring, QH301-705.5, Mothers, interaction, Article, Sex Factors, Insulin-Like Growth Factor II, medicine, LINE1, Humans, EXPOSURE, Epigenetics, H19, maternal anxiety, Problem Behavior, Fetus, Science & Technology, business.industry, Mechanism (biology), CORTISOL, Mouth Mucosa, Infant, Cell Biology, medicine.disease, Long Interspersed Nucleotide Elements, RECEPTOR GENE NR3C1, CENTRAL ADIPOSITY, business
Abstract

Epigenetic changes are associated with altered behavior and neuropsychiatric disorders and they modify the trajectory of aging. Maternal anxiety during pregnancy is a common environmental challenge for the fetus, causing changes in DNA methylation. Here, we determined the mediating role of DNA methylation and the moderating role of offspring sex on the association between maternal anxiety and children's behavioral measures. In 83 mother-child dyads, maternal anxiety was assessed in each trimester of pregnancy when the child was four years of age. Children's behavioral measures and children's buccal DNA methylation levels (NR3C1, IGF2/H19 ICR, and LINE1) were examined. Higher maternal anxiety during the third trimester was associated with more methylation levels of the NR3C1. Moderating effects of sex on the association between maternal anxiety and methylation were found for IGF2/H19 and LINE1 CpGs. Mediation analysis showed that methylation of NR3C1 could buffer the effects of maternal anxiety on children's behavioral measures, but this effect did not remain significant after controlling for covariates. In conclusion, our data support an association between maternal anxiety during pregnancy and DNA methylation. The results also underscore the importance of sex differences and timing effects. However, DNA methylation as underlying mechanism of the effect of maternal anxiety during pregnancy on offspring's behavioral measures was not supported. European Science Foundation (ESF) European Commission EuroSTRESS-PELS-99930AB6-0CAC-423B-9527-7487B33085F3 European Commission European Commission Joint Research Centre 279281 Erasmus+ travel grant

Published
2021

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