Search

Summary Objective To summarize recent scientific advances in protein-derived soluble biomarkers of osteoarthritis. Design A systematic search on the PubMed electronic database of clinical studies on protein-derived soluble biochemical markers of osteoarthritis in humans that were published between between January 1st 2020 and Maarch 31th 2021. The studies were selected on the basis of objective criteria and summarized in a table. Then they were described in a narrative review. Results Out of 1971 publications, 48 fulfilled all selection criteria and 16 were selected by the author for the narrative review. The papers were classified according their clinical significance as defined in the BIPEDS classification. Two papers investigated the “burden of disease”, two were dedicated to “investigative biomarkers”, four papers question the “prognosis”, three the “efficacy of treatment” and five the “diagnosis and phenotyping” value of protein-derived biomarkers. Conclusions Currently, biomarkers research is focused on their use as tools to identify molecular endotypes and clinical phenotypes and to facilitate patient screening and monitoring in clinical trials. This approach should allow a more targeted management of patients suffering from osteoarthritis.

Background: Psychotic symptoms are highly frequent in Parkinson’s disease (PD) patients and are associated with poor prognosis. They include hallucinations, delusions, and minor psychotic phenomena, including sense of presence, passage hallucinations, and illusions. Objective: To evaluate the frequency of psychosis in PD patients. Methods: A systematic review and meta-analysis of clinical trials, prospective and retrospective cohort studies, case-control studies, and cross-sectional studies reporting the frequency of psychosis, hallucinations, and delusions in PD. Results: Electronic database search wielded 3536 articles, an additional 91 were identified through citation chaining. Of these, 163 were fully inspected, 57 removed, and 106 included as relevant for neuropsychiatric events frequency, with 32 meeting our inclusion criteria (psychosis and/or specific psychotic phenomena). The pooled frequency of psychosis was 20.7% (95% CI 14.5 to 28.6; I2 = 94%, 15 studies; combined n = 2919). None of the pre-defined meta-regressions or subgroup analyses were statistically significant or helped explain the statistical heterogeneity. The pooled frequency of any form of hallucination was 21.6% (95% CI 14.7 to 30.6; I2 = 95%; 18 studies; combined n = 3161). Duration of PD at baseline and mean baseline Hoehn & Yahr stage helped explain the statistical heterogeneity in the meta-analysis of hallucinations. Conclusion: Based on the available evidence, around a fifth of PD patients experience psychosis or hallucinations. The risk of developing hallucinations is likely moderated by the disease duration, Hoehn & Yahr stage, and the cognitive status.

Objective The development and evaluation of new employees in air medical transport has historically lacked standardization and competency-based learning goals. Here we discuss the development, implementation, and assessment of a new competency-based education and evaluation method at Geisinger's Life Flight air medical transport service. Methods Using Bloom's taxonomy of learning, 14 competencies for flight employees were identified. An electronic database was created to track progress across competencies and serve as an information repository for the identification of goals and the development of individualized learning plans. Ten months after implementation of the new method, 11 preceptors and education team members were surveyed to understand their views on the new program. Results At the time of survey administration, 20 orientees had completed orientation under the new education and evaluation program in an average of 6.45 weeks, with a range of 3 to 10 weeks. Of the 11 surveyed instructors, 81.1% definitely agree that the new method adequately assesses performance compared with 45.5% with the previous unstandardized method; 81.8% of the instructors rated the overall change as very helpful. Conclusion The adoption of a competency-based learning model for air medical transport employee education and evaluation improves the assessment of performance and allows for the development of customized learning plans.

Писцовые описания Перми Великой, выполненные под руководством И.И. Яхонтова (1579 г.) и М.Ф. Касарова (1623–24 гг.), сохранились лишь в виде разновременных списков и для разных районов. Часть этих списков уже изучалась, но полученные результаты не могут считаться исчерпывающими. Представляется, что систематический источниковедческий и статистический анализ их сведений поможет лучше понять степень достоверности этих источников и повысит их информационную ценность. С этой целью к рассмотрению впервые привлечён широкий круг неопубликованных списков, на основе которых создана электронная база данных писцовых описаний. В статье исследуются слабо или вовсе не изученные фундаментальные характеристики пицовых книг, а именно: а) структура сошного письма; б) соотношение между «живущим» и «пустым»; в) точность писцовых итогов и г) итоги основных показателей, полученные сплошным подсчётом. Результаты, в частности, показывают, что писцы могли искусственно подгонять или округлять количество дворов или пашни для их выражения в удобных цифрах сошного письма. Соотношение между «живущим» и «пустым» в описании Кайсарова, в отличие от описания Яхонтова, заметно варьируется между разными территориями. При этом для Верхне-Чусовской вотчины Строгановых в описании Кайсарова выявляются две редакции, одна из которых могла быть получена путём подделки ряда показателей (в частности, соотношения между «живущим» и «пустым») из первоначальной редакции с целью снижения платежей. Сравнительно высокая доля абсолютно точных писцовых итогов (порядка 50%), небольшие относительные ошибки (в большинстве случаев не превышающие 3%) позволяют говорить об удовлетворительном умении писцов производить арифметические вычисления. Тщательный учёт источниковедческих особенностей списков позволил сделать итоги сплошного подсчёта показателей писцовых книг более точными и полными, чем в предыдущих работах. Исследование сопровождается таблицами, которые могут использоваться в качестве справки и для верификации результатов автора., Only copies of two early cadastral registers of Great Perm created under the direction of the government clerks I. Yakhontov (1579) and M. Kaisarov (1623–24) have survived to today. The primary goal of the study is to check reliability and to increase the information potential of those documents by means of source criticism and statistical analysis. Only few of the copies were examined in previous works, which could therefore lead to inaccurate and insufficient results. To overcome the problem a wider variety of extant unpublished sources was reviewed and an electronic database with information extracted from them was created. The following fundamental issues of cadastral surveys are considered: (i) the system of taxation units (so-called soshnoe pismo), (ii) the relation between taxable and non-taxable lands, (iii) the accuracy of the clerk's totals, and finally (iv) the total sums of various cadastral values. The results in particular show that the clerks could artificially adapt their data to the convenient number of taxation units. A closer inspection of the sources reveals that two versions of the Kaisarov's register for one of the Stroganov estates exist and some data in one of the versions are presumably falsified to reduce the Stroganov taxes. This was particularly done by distorting the relation between taxable and non-taxable lands. A quite high fraction of absolutely accurate clerk's totals (approximately 50%) and small relative errors (in most cases, no more than 3%) allow to conclude that the clerks could perform arithmetic calculations rather satisfactorily. The summarized cadastral data seem more complete and accurate than in previous works because of larger source base and careful inspection of the copies. The extensive tables of the paper's results are provided and can be used for reference purposes or to verify the author's conclusions.

The formal description of the languages has become more and more practical; however, it should be noted that the full formal description of the Armenian language has not yet been done. However, the fact that certain attempts have been made is undeniable. The Electronic database of the Armenian word-formation (https://formlang.am/) is the first stage of the complex project in the full formal description of the Armenian language. In the current article, we want to present the advantages of the electronic database of the Armenian word-formation. The electronic database containing the word-formation analysis of thousands of words can search for words and morphemes within them. It means that searching for any root or affix appears all the simple, compound, derived and derived-compound words made up of them. It enables us to reveal the regular structures and the variative forms, deflections, and irregularities with frequency data with their automatic analysis and the possibility of derivation. The database gives a great opportunity to study the Armenian word-formation on synchronic and diachronic points, to discover the basic patterns of the formation of new words, by the thousands of examples to find out the principles and ways of word-formation in the Armenian language, to have the full list of the distinguished simple, compound, derived and derived-compound Armenian words. The current database has not only practical great value to involve the Armenian language in the domain of the modern informational technologies as the communicative mean, but also significant theoretical value to present the accurate description of the vocabulary structure. Thus, it will give an excellent perspective for solving the problems of theoretical linguistics and the practical -applied tasks. It can be significant for the further development of Armenology.

AIM To determine the effectiveness of two instructional guides to obtain video recordings for the General Movements Assessment (GMA). METHODS A cross-sectional study of a community sample of family participants with low-risk term newborn infants recruited via social media and randomly allocated to receive one of two instructional guides (detailed or quick versions) to film their infant's movements at home. Participants returned videos via a secure Research Electronic Database Capture link and videos were scored for quality across 10 criteria, along with scoring the GMA. Participants were surveyed about their perceptions of the instructional guides and electronic file transmission. RESULTS Seventy-six parents of infants were enrolled and randomly allocated to receive detailed (n = 38) and quick (n = 38) instructions to film their infant for a GMA. Videos were returned by 87% (95% confidence interval (CI) 72%, 96%) of detailed instruction users and 84% (95% CI 69%, 94%) of quick instruction users. The GMA could be conducted on all returned videos. The mean score for video quality was 9.9/10 (standard deviation 0.4, 95% CI 9.7, 10.0) for detailed instructions and 9.7 (standard deviation 0.6, 95% CI 9.4, 9.9) for quick instructions. Overall, participants felt that either instructional guide was easy to use. Fifteen (20%) participants had difficulties with video file transmission, requiring additional support. CONCLUSIONS Parents can successfully use one of two different instructional guides for filming their infant's movements for GMA; however, support should be provided for safe and easy file transmission.

Background: Perfluorooctanoic Acid (PFOA) is one of the Perfluoroalkyl acids family that can affect human health. It can act as an endocrine disruptors which interfered the hypothalamus–pituitary–thyroid (HPT) axis and targeted the biosynthesis and secretion of thyroid hormones, which can caused thyroid diseases. To determine the causal relationship between PFOA and thyroid diseases, it is necessary to look for some evidence regarding this relationship. The search for evidence is also complemented by a seven-step occupational disease assessment to establish occupational diseases.Methods: The literature searching using the electronic database “PubMed”, “Cochrane”, and “Scopus” search engine. The keyword is “PFOA” “perfluoroalkyl substances” “perfluorooctanoic acid” “perfluorooctanoate” AND “thyroid disease” “thyroid function” “thyroid parameters” combined with MeSH and Title/Abstract terms. The inclusion criteria are research on humans, English language, free full article and the exclusion is duplicate articles.Result: From the five literature obtained, there are differences in results. Four articles stated that there are association between PFOA and thyroid diseases but one articles stated PFOA concentrations measured in this study were not associated with thyroid hormones.Conclusion: Althought most articles stated there are associations between PFOA and thyroid disease but it does not mean that PFOA can caused thyroid disease so it is still not clear the causal relationship between PFOA and thyroid disease especially in occupational setting.

Objective To compare, describe and assess the level of validation of all instruments measuring quality of induction and recovery from anesthesia in dogs. Databases used A search was performed using the electronic database PubMed to find articles containing an induction quality scale, a recovery quality scale or both in dogs. Articles not directly accessible through PubMed were obtained through the Auburn University Library website and Google Scholar. The phrases ‘induction scoring systems dogs’, ‘recovery scoring systems dogs’, ‘anesthetic induction score dogs’, and ‘anesthetic recovery score dogs’ were used for searches using the ‘best match search’ function. The time frame searched was from 1980 to May 2020. The search was conducted from March 2020 to May 2020. Conclusions A thoroughly tested and validated scale for measuring the quality of induction and recovery does not exist in the current veterinary literature. A large disagreement exists between studies on the use of induction and recovery scales, and many have reported inconsistent results with current instruments. It is recommended that an induction and recovery scale intended for wide-scale use be constructed and tested extensively for psychometric validation and reliability.

Introduction: This paper examines the correlates of needle and syringe sharing among People Who Inject Drugs in Dhaka city, Bangladesh, which is currently experiencing a steep increase in HIV prevalence despite the ongoing presence of Needle Exchange Programs. Methodology: This was a retrospective chart review with cross-sectional design that extracted data from 783 male People Who Inject Drugs enrolled into five Opioid Substitution Treatment clinics in Dhaka city between April 2010 and January 2016. Data were retrieved from the program’s electronic database. Needle and syringe sharing constituted the borrowing or lending of needles and syringes from others within the past month preceding data collection. Results: Buprenorphine was the preferred injection drug and 44.6% shared needles and syringes within the past month. Multivariate analysis indicated that People Who Inject Drugs who were homeless (OR = 8.1, 95% CI = 1.4-44.9, p < 0.05), living with friends (OR = 6.8, 95% CI = 2.5-18.2, p < 0.001), injecting 2-3 times/day (OR = 4.8, 95% CI = 1.2-19.7, p < 0.05), injecting more than three times/day (OR = 4.8, 95% CI = 1.1-20.0, p < 0.05), not using condom with non-commercial female sex partners (OR = 3.3, 95% CI = 1.8-6.0, p < 0.05), bought sex from female sex workers (OR = 2.9, 95% CI = 1.0-8.3, p < 0.05), and did non-suicidal self-injury (OR = 1.8, 95% CI = 1.0-3.0, p < 0.05) were more likely to share needles and syringes. Conclusions: This study demonstrates that operating a standalone harm reduction approach that just provides sterile needles and syringes may not adequately curb needle and syringe sharing among People Who Inject Drugs.

OBJECTIVE To analyse the mission profiles of helicopter emergency medical service (HEMS) winch operations involving LifeFlight Retrieval Medicine physicians in Queensland, Australia, specifically focusing on patients' clinical characteristics, extrication methods and scene times. METHODS A retrospective analysis was performed to identify all helicopter winch missions involving physicians during 2019. Demographic, clinical and non-clinical data were accessed from an electronic database used to log cases and findings presented using descriptive statistics. RESULTS Out of 4356 HEMS missions involving physicians, 100 (2.3%) were winch operations. Of these, 31 (31%) occurred overwater and 12 (12%) at night. In total, 106 patients were attended, and eight patient deaths occurred. Most patients were traumatically injured (66%), male (66%) and had a median (interquartile range) age of 43.5 (28-59) years. Thirteen missions (13%) involved drowning victims. This group had a higher burden of injury and comprised half of the patients treated with endotracheal intubation. Median scene time was 30 min (20-40), and the winch stretcher was the predominant patient extrication method. Physician winching occurred in 63 (63%) missions and was associated with increased scene time and increased use of the winch stretcher. CONCLUSIONS Winch operations involving physicians occur infrequently in Queensland HEMS, although almost a third of missions occur overwater. Drowning victims are encountered more frequently than reported elsewhere in Australian HEMS and comprised half of the patients who underwent endotracheal intubation. Patients' severity of illness and injury may contribute to the associations between winching of physicians, increased scene times and increased use of the winch stretcher.

Introdução: Em dezembro de 2019 surgiu o primeiro caso de COVID-19, a qual nos meses seguintes se tornou uma doença de caráter pandêmico. Dentre os principais sintomas associados a tal, febre, tosse e vômito são os mais recorrentes. Por esta razão, na busca por reduzir a contaminação em ambientes públicos, diversos estabelecimentos passaram a realizar triagens por aferição de temperatura nas entradas e/ou saídas, visando identificar possíveis indivíduos contaminados. Esta revisão visa avaliar a eficácia deste método de triagem para diagnóstico de COVID-19. Metodologia/Resultados: Esta revisão foi desenvolvida a partir da busca de artigos na base eletrônica de dados Pubmed, utilizando os descritores “Fever”, “Body Temperature”, “Mass screening”, “Diagnosis” e “COVID-19”. A seleção dos artigos foi realizada em pares às cegas e resultou na coleta de 8 artigos. A exposição e discussão dos resultados se diz respeito à transmissão na fase oligossintomática, uso dos termômetros e impacto epidemiológico. Discussão e Conclusão: A atual literatura não apresenta evidência suficiente favorável ao uso da triagem por temperatura e diversos estudos são contrários ao seu uso, dado baixa especificidade e sensibilidade. Em contrapartida, há ganhos secundários positivos, tais como a conscientização sobre a pandemia e o alerta sobre os cuidados necessários neste momento.

Introduction: Poor human immunodeficiency virus (HIV) testing practices and underreporting of HIV-related data in TB information systems remain barriers to effective care for TB-HIV co-infected patients. HIV testing and recording practices in national TB program have not been formally evaluated in Armenia. This study aimed to assess the recording completeness of HIV testing and HIV status in the national TB program electronic database, and to determine trend in HIV testing and the association between HIV testing and treatment outcomes for all TB patients registered in Armenia (2015-2019). Methodology: A cohort study of TB patients using routine programmatic data from the national TB program of Armenia. Results: From 2015 to 2019, the electronic database was completed for HIV testing and HIV status by 48.1% and 97.5%, respectively. Of all registered TB patients 93.6% were tested for HIV. Of a total 4,674 patients, 1,085 (23.2%) had unsuccessful outcomes. Patients with HIV status “not tested” and “not recorded” compared to HIV “negatives” had 1.76 (95%CI 1.42-2.11) and 1.6 (95%CI 1.20-2.06) times higher risk of unsuccessful outcomes, respectively. Lost to follow-up was the most frequent unsuccessful outcome in HIV status “not tested” group. Conclusions: An analysis of nationwide data revealed incompleteness of the national TB electronic database for HIV data. Patients with HIV status “not tested” and “not recorded” had higher risk of unsuccessful TB treatment outcomes. Upgrade of the electronic database with information on key indicators of TB-HIV services will facilitate improved monitoring and reporting.

Background: Saliva is a mixture of organic and inorganic components that comes in constant contact with the hard and soft tissues of the oral cavity. One of the most frequent disorders is dental caries, which is a multifactorial microbial disease of the tooth. Of which saliva plays a significant role in the process of dental caries. Aim: To systematically identify and evaluate the ability of salivary biomarkers in detection of dental caries. Methods: A comprehensive search was done using electronic data bases such as PubMed Central, Cochrane Database of Systematic Reviews, Google Scholar and direct web search. The title scan was used to find relevant articles, which were then read and appraised for inclusion. This review analyses all research that investigated the use of salivary protein biomarkers to detect dental caries. Results: Electronic database search identified 16 articles. After evaluating the title, abstract, and full text of these articles, only 4 were selected for the present systematic review. A final of 4 studies were included based on the inclusion criteria to meet the research question. All the studies analyzed the salivary biomarkers in dental caries detection. Conclusion: Salivary biomarkers are a significant indicator in detection of dental caries and can be used in determining the further treatment planning.

This review aimed to determine the implementation of inclusive education in regular schools. The implementation of education in regular schools has many obstacles, including teachers’ lack of the ability to manage inclusive schools. Teachers in this case are an important part of schools to run programs smoothly because teachers communicate directly with students in need. Students, knowledge, skills and experience of teachers determine how well inclusive programs are run in schools, especially in the classroom. To achieve that, teachers need to have several trainings to help them prepare and carry out their plans properly. An e-literature search was conducted to identify articles published from 2015 to 2021 on the steps needed to optimize teacher skills to achieve a good inclusive environment. The electronic database used is Google Scholar. This study used review. Based on the articles reviewed, it was found that the implementation of inclusive education in regular schools was done by improving the skills of teachers through co-teaching training. Apart from teachers, schools and parents were provided with sufficient information about inclusive programs and how to do them. The seven articles' findings were reviewed by the researchers, and indicate that several things must be done in the implementation of inclusive education in public schools. The teacher is the main concern in inclusive learning because the teacher is a school device that interacts directly with students and at the same time provides teaching to students in the classroom.

Introduction Availability and accessibility of a safe COVID-19 vaccine do not necessarily guarantee an effective means to mitigate the pandemic. However, the fragile hero’s or health care worker's attitude toward the vaccine is of paramount importance to promote its acceptance. So, the current review aims to provide the latest assessment of healthcare workers’ attitudes toward the COVID-19 vaccination and its contributing factor worldwide. Methods Peer-reviewed surveys in English indexed via an electronic database in Google Scholar, Science Direct and PubMed were systematically searched. The review was carried out per the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-2009) and registered on PROSPERO (CRD42021265534). Results Originally 8039 articles were searched from three databases PubMed, Science direct, and Google scholar. Finally, 24 studies met the inclusion criteria and made the root for the estimates of the attitude of COVID -19 vaccinations. In about two-thirds of the studies, respondents showed a positive attitude (≥50%) toward COVID-19 vaccination. However, in about one-quarter of the studies, a negative attitude (

Background: Good oral health during pregnancy can not only improve the health of the pregnant mother, but also potentially the health of her child. There is inconclusive and contrasting nature of evidence regarding the effect of pregnancy on oral health. So the purpose of this study was to systematically review the dental considerations during Pregnancy for further investigation. Methods: For the identification of the studies included in this review, we devised the search strategy for each database. The search strategy used a union of controlled vocabulary and free text terms. The main electronic database used to access the studies were PubMed, PubMed Central, Cochrane Review, Embase and Google Scholar. Results: A total of 28 articles fulfilled the criteria and were selected for the review. Some prenatal oral health conditions have adverse effects on the child. Periodontitis is associated with preterm birth, low birth weight infants and high level of cariogenic bacteria in pregnant mother can lead to increased risk of dental caries in the infant. Oral lesions such as gingivitis and pregnancy tumours are benign in nature and require only reassurance and monitoring. Conclusion: It has been suggested that some oral conditions may have adverse consequences on their children awareness related to oral health during pregnancy. Oral health care services should be routinely integrated with prenatal care services for all the pregnant women and specific preventive oral health care program should be made an integral part of antenatal care.

Strychnos nux-vomicais a homoeopathic remedy that has long been considered a panacea. This review collected the clinical trials and/or experimental studies on the pharmacological effects ofNux vomica. An electronic database search was run on Google Scholar and PubMed from 1980 to 2018. Data from homoeopathic texts available on paper and electronically were also included. Conventionally,Nux vomicais a medicine for alcoholism, anger effects of, colic, constipation, dyspepsia, gastrodynia, haemorrhoids, tea and tobacco habit, insomnia, nightmares, lumbago and many more diseases. Various pharmacological studies have proved its anti-alcoholic effect. Studies also showed its effect on sleep quality, anxiety-related behavioural patterns and epilepsy survival time. It also inhibitedHelicobacter pylori-induced gene expression.Nux vomicawas found to be beneficial in treating baker’s yeast-induced acute high-grade fever, pock-like lesions and Reiter’s disease. However, further research studies are required to explore its traditional uses for other diseases.

Purpose To evaluate and compare the implant survival rates, marginal bone loss, and mechanical complications of prostheses supported by splinted and nonsplinted short implants (≤ 8.5 mm). Material and methods Electronic database (MEDLINE, CENTRAL, Web of Science, and EMBASE) and manual searches up to May 2021 were conducted to identify studies comparing splinted and nonsplinted short implants (≤ 8.5 mm). The primary outcome was implant survival rate. Secondary outcomes were marginal bone loss and mechanical complications. The quality of included studies and risk-of-bias were assessed according to the Newcastle-Ottawa Scale. A random-effects model was used to analyze the data. Results Twelve studies fulfilled the inclusion criteria and featured 1506 short implants (596 nonsplinted and 910 splinted) with a follow-up time ranging from 1-16 years. Quantitative analysis found no statistically significant differences between splinted and nonsplinted short implants (≤ 8.5 mm) for survival rate (RR = 0.98; 95% CI 0.96, 1.01; p = 0.26)) and marginal bone loss (SMD = -0.08; 95% CI -0.23, 0.07; p = 0.28). Veneer chipping, abutment screw breakage, screw loosening, and loss of retention were reported in the selected studies as common complications. However, no statistically significant difference was found between splinted and nonsplinted short implants (RR = 0.56; 95% CI 0.20, 1.54; p = 0.26). Conclusions Within the limitations of the present meta-analysis, it might be concluded that splinted short implants (≤ 8.5 mm) do not present superior performance in survival rate, marginal bone maintenance and prevention of mechanical complications compared with single-unit prostheses. This article is protected by copyright. All rights reserved.

Today it is widely practiced to exhibit autographs, inscriptions at exhibitions in museums, institutions of science, education and culture. This is due to the increased interest in the history of scientific research, personal and official relation-ships of people, and testifies to the urgency of the problem, that requires the attention of specialists.According to Brockhaus and Efron, «the autographs of famous scientists, writers and poets constitute the true treasure of libraries ...» (Encyclopedic Dictionary of Brockhaus and Efron, St. Petersburg, 1890. T. 1, p. 123). Autographs, inscriptions on books can serve as an additional source of information about any author’s life, era, scientific or cultural phenomenon. In the libraries of the Academy of Sciences, one can find literature with autographs, donation inscriptions of scientists, various notes.The purpose of the article is to bring to the readers some autographs, inscripts, their content, handwriting of prominent Russian scientists on books from the library stock of the Central Scientific Library of the Irkutsk Scientific Center SB RAS (СSL ISC SB RAS) (previously – the library of the East-Siberian Branch of the USSR Academy of Sciences), to tell about these books and their authors destinies. Responses to the article will help to determine the authorship of unidentified inscriptions.In the course of the work, there were exposed and identified de visu books with autographs, donations (inscriptions) to the library from authors, to scientists from colleagues and owner’s inscriptions; the analysis of library materials was carried out, an attempt was made to systematize written sources with autographs and donations. At the second stage of the work, an electronic database was being compiled - the Catalog of Rare Books in EC IRBIS, which can be found on the library website.

Purpose: In adults, correction of such a jaw base relation is done by bilateral sagittal split osteotomy and mandibular advancement which often causes change in the cervicomental angle that might not be within the acceptable and aesthetic range. The objective of this systematic review was to evaluate the changes observed in cervicomental angle after mandibular advancement surgery. Data Sources: Based on the available data, we conducted an electronic database PubMed search, based on the search of published data from 1994 to 2017, six strategies were designed using two keywords, and four articles were shortlisted for systematic review. Study Eligibility Criteria: Studies that provide information on cervicomental angle changes after mandibular advancement surgery, published from 1994 to 2017. Results: The search yielded 168 articles, of which four were included based on the selection criteria. These articles described that the cervicomental angle observed after mandibular advancement surgery falls between 95° and 125°. Conclusion: Cervicomental angle decreases as the mandible is advanced to correct the jaw base Class II relation to Class I. Acceptable range is found to be between 95° and 125°. Implications: An esthetic look is the desire of every patient that reports to the clinics for an orthodontic correction. Surgical correction is an integral part of the treatment. While advancing the mandible, change is observed in the cervicomental angle. Knowing the acceptable range of this angle will help the orthodontist and the oral surgeon to plan the advancement accordingly.

Purpose This paper aims to systematically review the available evidence that explores adverse childhood experiences (ACEs) in people with intellectual disabilities (PwID). It is important to systematically review this literature as, to date, there is little known about the number of studies in this area, despite the World Health Organization declaring ACE prevention and support as a global public health priority. Design/methodology/approach Published studies were identified from electronic database searches. Key journals and reference lists were also hand searched. Findings Two studies met the inclusion criteria and the prevalence and frequency of ACEs experienced by participants of these studies analysed. Overall, due to the small number of studies meeting the inclusion criteria, it is difficult to establish any meaningful conclusions. Originality/value This appears to be the first systematic review to try and identify a research base looking at the prevalence of ACEs within a PwID population. Findings suggest that this is a highly neglected area of research, and the authors hope to have identified that further evidence is required to draw clearer conclusions about the impact of ACEs on PwID.

O objetivo desta revisão é descrever as alterações mais comumente observadas no periodonto causadas pelo tratamento ortodôntico, a fim de facilitar a colaboração e comunicação dos especialistas. Uma busca em banco de dados eletrônico foi realizada usando o banco de dados de resumos e citações do PubMed e material bibliográfico foi usado para encontrar outras fontes apropriadas. As alterações dos tecidos periodontais moles e duros durante o tratamento ortodôntico e a manutenção dos pacientes são discutidas a fim de fornecer um quadro exaustivo das possíveis interações entre essas duas disciplinas entrelaçadas.

Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Materials & methods: We searched the electronic database for articles on the relationship of PEAR1 SNPs and ischemic events in patients with coronary artery disease (CAD) up to October 2020. Results: A total of 9914 patients with CAD from six studies focusing on 12 SNPs of PEAR1 were included in this study. The A allele of rs12041331 were associated with ischemic events (odds ratio: 1.40; 95% CI: 1.04–1.88; p = 0.03). The AA homozygotes of rs2768759 was related to a higher risk of ischemic events than carriers of the C allele (odds ratio: 2.08; 95% CI: 1.09–3.97; p = 0.03). Conclusion: PEAR1 rs12041331 and rs2768759 are significantly associated with ischemic events in patients with CAD.

The challenge of multicriterion selection of lower-limb prosthesis components is discussed. The issue of developing software for a global electronic database of prosthetic modules for modular prostheses for the disabled is considered. The database is intended for remote use by specialists. Successfully solving this challenge should accelerate the development of personalized prosthetics and improve the quality of the medical rehabilitation of the disabled.

Background Data supporting the use of Chinese herbal medicine compound (CHMC) on breast hyperplasia (BH) based on the data from previous studies. However, the results are still contradictory. Thus, this study aims to compare the results obtained for effect on case-controlled study (CCS) of CHMC on BH. Methods This study will include CCS assessing the effect of CHMC on BH. A literature search will be carried out in Cochrane Library, MEDLINE, EMBASE, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure from inception to the present. We will not apply language limitation to any electronic database. Study quality will be evaluated using Newcastle-Ottawa Scale, and statistical analysis will be performed using RevMan 5.3 software. Results This study will summarize the up-to-date evidence to assess the effect of CHMC on BH. Conclusion The results of this study may exert helpful evidence to determine whether CHMC is effective on BH. OSF REGISTRATION NUMBER:: osf.io/3k8ch.

Background: Since COVID-19 spreads from one person to others, it is necessary to stay away from others or reduce contact. This habit or practice is called social distancing. It encourages people to stay at their homes and to avoid crowded and/or public places. Objective: To evaluate and discuss changes and shifts in the pharmaceutical marketing strategies due to COVID-19. Methods: This is a narrative review articles and we use triangulation method to collect the related information from multiple electronic database. The results and findings of the selected articles were summarized and synthesized. Results: As the number of COVID-19 infected people grows and the uncertainty of finding a cure continues, the people are becoming more apprehensive. Pharmaceutical companies made changes to their marketing strategies. From being too invested with in-person marketing, most companies are now exploring options that do not require as much physical interaction. Pharmaceutical companies have been reliant on telemarketing, digital marketing, and miscellaneous offers. This change is primarily driven by fear of being infected by the virus and self-preservation. Conclusions: Based on the studies collected and reviewed in this paper, the changes appear to be successful especially with regard to digital marketing. This review provides an insight to marketing managers in the pharmaceutical industryto continue adjusting and modifying theirmarketing strategies due to COVID-19.Because this study focused on a specific sector (i.e., pharmaceutical)the results cannot be generalized and extended to other sectors.Future studies are needed to investigate the trends of changes and shifts of the pharmaceutical marketing strategies due to COVID-19.

Introduction: Diabetic macular oedema (DMO) is a major cause of visual loss in the diabetic population. There are several treatment options for DMO, including intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections, which have been shown to improve visual outcomes. Good compliance to treatment regimens is associated with greater visual benefit. Purpose: To estimate dropout rates and the associated reasons among DMO patients on three different anti-VEGF treatments. Study design: A retrospective review of patients with DMO who were on bevacizumab, ranibizumab and aflibercept therapy from January 2014 to December 2016. Materials and methods: Patients with DMO on anti-VEGF treatment in a private ophthalmology center were identified via an electronic database. Data on Malaysian residents aged 18 years or older were included. Foreign residents, the deceased, and those whose care had been transferred to another center were excluded from further analysis. Telephone interviews were then conducted with these patients based on a standard questionnaire to identify reasons for non-compliance. Results: This study included 134 patients. The overall lost to follow-up rate was 56.0% (75/134). After excluding the deceased, those who opted for treatment at an alternative center, and uncontactable patients, 47 (35.1%) were then identified as drop-outs. Financial constraint was the most common reason cited by 38.3% patients (18/47) and was highest in the bevacizumab group (88.9%, 16/18). The second most common reason was lack of perceivable change in vision (25.5%). In addition, 19.1% opted to stop treatment due to logistical difficulties and 12.8% of patients were satisfied with their stable visual acuity. Lastly, 4.3% were unable to continue with treatment due to poor general health. Conclusion: The dropout rate of 35.1% is higher than in previous publications from other countries. This study clarifies the challenges face by some Malaysian patients in seeking treatment for what is often a chronic disease. These results have implications on designing ways to assist patients’ cooperation with the standard of care.

A tuberculose é uma doença infectocontagiosa que acontece no Brasil desde a época da colonização e que continua sendo um grave problema de saúde pública. Os medicamentos utilizados no tratamento da tuberculose são seguros e eficazes, porém ainda se evidencia elevado abandono ao tratamento medicamentoso. Diante disso, o presente trabalho teve o objetivo de realizar uma revisão sistemática de literatura sobre o tratamento da tuberculose pulmonar e multirresistente e averiguar os fatores que impossibilitam a continuação da terapêutica medicamentosa. Trata-se de um estudo de caráter descritivo, que aborda sobre o tratamento da tuberculose e os fatores relacionados ao abandono da terapia medicamentosa. Para tanto, foi realizado um levantamento bibliográfico na base de dados eletrônica SCIELO, sendo utilizados os seguintes descritores: abandono, tratamento e tuberculose. Nesta busca foram encontrados 100 estudos, publicados entre 2000 a 2017, sendo que após a leitura do título e resumo foram selecionados 12 artigos por apresentarem maior relevância e afinidade com o tema abordado. Os trabalhos analisados sugerem que o tratamento diretamente observado realizado por um profissional de saúde no ato da dispensação dos medicamentos contribui significativamente para o seguimento e comprometimento do tratamento em busca do favorecimento da cura nos pacientes acometidos por esta doença.

OBJECTIVE. Knowledge of normal testicular 18F-FDG PET/CT (FDG PET/CT) SUVs is crucial for accurate examination interpretation. The objective of this study was to establish normal testicular SUV ranges among adult men receiving health care in North America. MATERIALS AND METHODS. A retrospective review of an institutional electronic database identified adult men undergoing pretreatment clinical FDG PET/CT examinations from March 15, 2013, through March 15, 2018. An FDG PET/CT image review of 700 testicles in 350 male patients was performed. Data collected included testicular SUVmax, SUVmean, and visual PET pattern of uptake. RESULTS. Testicular SUVmean and SUVmax values (mean ± SD) by age group were as follows: 3.1 ± 0.7 and 3.8 ± 0.9 for the age group of 18-30 years; 3.2 ± 0.6 and 4.0 ± 0.8, 31-40 years; 3.1 ± 0.4 and 3.8 ± 0.5, 41-50 years; 3.0 ± 0.5 and 3.7 ± 0.7, 51-60 years; 2.9 ± 0.5 and 3.5 ± 0.7, 61-70 years; 2.8 ± 0.5 and 3.5 ± 0.7, 71-80 years; and 2.6 ± 0.5 and 3.3 ± 0.6, more than 80 years. A statistically significant difference exists between age groups for testicular SUVmean (p ≤ .001) and SUVmax (p < .001), with SUVs peaking in the 4th decade of life and subsequently declining with age. A small but significant negative correlation exists between blood glucose level and testicular SUVmean (r = -0.12). CONCLUSION. This study reports the largest currently known cohort of SUVs in normal testicles and may guide clinical interpretation of testicular FDG activity. Discrepancies in normal SUVs may exist because of differences in patient demographics and PET technology.

Background Effective communication between anaesthetists is an important way of ensuring adequate management plans are made for patients with known difficult airways. The Difficult Airway Society developed an electronic database to facilitate this. Previous studies have surveyed attitudes and behaviours of anaesthetists and primary care physicians but not patients. Aim We sought opinions of patients who received a difficult airway database alert card (signifying their pre-consented registration) on a variety of topics. Methods We asked 10 questions regarding i) Quality of information received, ii) Views on the relevance of the alert card, iii) patient’s overall experience, iv) their opinion regarding paying a fee. Results All 402 patients on the database were contacted once (follow-up curtailed by COVID-19). We received 221 replies (55%). Ninety-seven percent (205/211) reported the card useful, 90% (191/211) recalling the information given. All those (49/203, 24%) having a further anaesthetic had presented their card to the anaesthetist/preoperative team. 6% (13/203) felt anxious having the card and almost one fifth (12/67) of the respondents suggested improved communication between anaesthetists, patients and primary care physicians (GPs). Half of responders were willing to pay for the service, while 17% (36/211) were not. Conclusion Difficult airway alert cards are well received by the patients and are re-presented when future anaesthetics are required. Improved transfer of information between anaesthetists, primary care physicians and patients was a popular theme in the feedback. The issuing of an airway alert card may prove to be a vehicle for this in the future.

The authors substantiate the need for and the relevance of studying self-realization based on the records requested from the electronic database SciVal. The data categorized into thematic clusters, as well as by the countries and universities of the world and by journals from the list of the Scopus scientific database have been analyzed. A review of domestic and international scientific publications on the problem of social self-realization of volunteers is performed to discover and describe the motives of their participation in non-profit associations and their personal characteristics.Sixty adolescents (30 girls and 30 boys), participating in socially significant projects carried out on the territory of the Rostov region, composed the study sample. The average age of the respondents was 15.5 years. The experience in volunteering ranged from 2 to 5 years. Methodological toolkit included: multidimensional questionnaire of self-realization by S. I. Kudinov and the authors-developed questionnaire “Meaningful motives of self-realization”.The study revealed the following regularities: female volunteers have statistically significantly higher levels of social self-realization than the male volunteers. Regardless of gender, social self-realization of adolescent volunteers is moderately structured. As adolescents – participants in socially significant projects – grow up, the components of their social self-realization undergo changes, depending on their gender: female volunteers become more conservative, and male volunteers reduce personal barriers. For male volunteers, the predominant motive for social self-realization is the utilitarian-pragmatic one, whereas for female volunteers, it is the communicative motive.This knowledge about the discovered patterns in social self-realization of volunteers can be used to organize effective psychological and pedagogical help for adolescents as a part of an integral system of support for initiative and talented youth and to further encourage involvement of young people in social practices.

Background Preformed metal crowns (PMCs) have been the restoration of choice for paediatric dentistry; however, PMCs have a non-aesthetic appearance, which has become a point of concern. Recently, prefabricated zirconia crowns (PZCs) have been increasingly used as an aesthetic restorative material for primary teeth, as they have pleasing properties. Aim This systematic review summarises the clinical results for PZCs in the primary dentition, including wear on the opposing dentition, retention, fracture resistance, parental satisfaction, gingival health, and cementation materials. Materials and methods Electronic database searches were conducted using PubMed, Google Scholar, Web of Science, and the Cochrane Library. Clinical trials, observational studies, and case reports/series were included. The quality of the studies was analysed using the Cochrane tool and the domain-based evaluation for non-randomised studies of interventions. Results The search retrieved 166 references, of which 14 studies were included for qualitative analyses. The risk of bias varied from low to unclear. The included studies indicated that prefabricated zirconia crowns are retentive and are not associated with accelerated wear on the opposing dentition. They also exhibit a high fracture resistance, satisfy the parents and are compatible with gingival health. There is, however, inconclusive evidence with regard to cementation materials. Conclusion Prefabricated Zirconia Crowns appear to be a good alternative to preformed metal crowns in term of esthetics, retention, resistance to fracture, parent satisfaction, and gingival health.

The formation of databases of digitized vegetation relevés and the publication of content about them promote cooperation between researchers in solving problems of biodiversity analysis, the exchange of the used data, and, thus, the increase in research representativeness. The article is devoted to the review of the origin and use of the database of relevés of forest vegetation and considers the tasks in which it is used. The current stage of work is characterized as follows: improvement of the database structure, features of the stored information, replenishment of the database, issues of administration, and cooperation organization. Based on the analysis of current trends in the vegetation science and taking into account the features of information stored in the database, the relevant scientific problems, for the solution of which the use of the database is promising, and technical tasks that need to be solved to ensure its continued use were formulated.

Accounting for children with cancer is characterized by low reliability of statistics. In addition, the available data do not have significant scientific value., Since they represent only an approximate number of patients identified annually and some general information (incidence, prevalence, etc.). Moreover, subsequent analysis of the accumulated information is of particular importance. An electronic database of children with cancer has been developed that meets these requirements and has been introduced into the clinical practice of pilot medical organizations.Purpose of the study. Our aim was to study the opinions of pediatric oncologists on the issues of registration of children with oncological diseases.Materials and methods. In order to assess the results of the implementation of the electronic database, a "Questionnaire for a survey of a pediatric oncologist to assess the effectiveness of the implementation of an electronic database" was developed, which contained 15 questions. For objectivity, the questionnaires were filled in anonymously by the respondents.Results. The medico- social study involved 187 pediatric oncologists. The majority of respondents (71.3 ± 3.3%) noted that currently there is no register of children with cancer in the Russian Federation, 15.4 ± 2.6% noted the regional register, 9.1 ± 2.1% – independent in individual medical organizations, 1.7 ± 0.9% is a single register for the Russian Federation and 2.5 ± 1.1% are not aware of this. Among respondents, 81.9 ± 2.8% noted that the electronic database is an effective tool for recording children with cancer, while as an advantage, 15.1 ± 2.6% noted an increase in the reliability of statistical data, 9.2 ± 2.1% – reduction of time for searching patient information, 4.4 ± 1.5% – optimization of working time, 71.3 ± 3.3% – a combination of the above options.Conclusion. A medical and social study showed the feasibility of introducing an electronic database of children with cancer into the clinical practice of pediatric oncologists.

Background: Gentiana lutea (GL), commonly known as yellow gentian, bitter root, and bitterwort, belongs to family Gentianaceae. GL belongs to genus Gentiana, which is a rich natural source of iridoids, secoiridoids, xantones, flavonoids, triterpenoids, and carbohydrates. Medicinal plants from Gentiana species have anti-oxidant, anti-inflammatory, anti-mitogenic, anti-proliferative, and lipidlowering effects, as well as a cardioprotective, hypotensive, vasodilator and anti-platelet activities. Objective: We reviewed the recent literature related to the effects of Gentiana species, and their active components on vascular diseases. Methods: Data used for this review were obtained by searching the electronic database [PUBMED/ MEDLINE 1973 - February 2020]. The primary data search terms of interest were: Gentiana lutea, Gentienacea family, phytochemistry, vascular diseases, treatment of vascular diseases, antioxidant, anti-inflammatory, anti-atherogenic. Conclusion: Gentiana species and their constituents affect many different factors related to vascular disease development and progression. Therefore, Gentiana-based therapeutics represent potentially useful drugs for the management of vascular diseases.

Introduction: As humans get older, a degenerative aging process occurs which will have an impact on changes in humans. The changes that occur in the elderly can cause various kinds of disorders, one of which is sleep disturbance or insomnia. The aim of this systematic review is to gain a deeper understanding of complementary therapies to improve sleep quality in the elderly. Method: The design used by systematic review is that the reviewer looks for several articles through an electronic database, namely Scopus and ScienceDirect, the keywords used are "Therapy", "Sleep Quality" and "Elderly". Result: 16 selected articles, research conducted in Taiwan, Brazil, China, Singapore, Hong Kong, Korea, Japan and Iran found that the most widely used complementary therapy for improving the quality of sleep in the elderly is music therapy. Conclusion: The results of his study showed that the quality of sleep in the elderly improved with complementary therapy. For this reason, it is necessary to assess and provide complementary therapies such as music therapy regularly to improve sleep quality in the elderly.

Objectives: With an increasing number of patients undergoing ureteroscopic surgery worldwide for stone disease, and the concomitant pressures on health care resources, we aimed to review global patterns for ureteric stenting following ureteroscopy. With a centralized electronic database, a longitudinal cohort study was designed to help define the indications for stenting, type of drainage, and methods of stent removal. Methods: This multicenter study was conducted prospectively, with centralized data acquisition by uCARE (research arm of the Société Internationale d'Urologie), and registered at ClinicalTrials.gov (NCT03567421). Along with baseline demographic data, details were entered for stone imaging characteristics, intraoperative information, including urine culture, and exit strategy for stent removal. An independent audit was undertaken to sample the accuracy of data entered across the sites. Results: In total, 2544 patients were included from 50 centers in 15 countries. There were 1969 patients with ureteric stones, and 942 with renal stones. While 41% ureteric stones were distal (median length 10mm), 52% renal stones were in the lower pole (median diameter 11 mm). The majority of patients (68.8%) were given antibiotics at induction; 20.6% were “pre-stented” before the ureteroscopy, and a high percentage were stented following ureteroscopy (91%). The majority of the stents (85.1%) were polyurethane, mean duration of stent after surgery was 27 days, and 80% of stent removals were undertaken in the operating room. Conclusion: This is one of the largest prospective global cohort studies, reflecting widespread usage of stenting, despite emerging evidence to the contrary. Stent removals may also be modified with time, as the pressure on health care resources mounts.

Background The low‐dose dexamethasone suppression test (LDDT) is considered an accurate screening and valuable differentiation test in dogs with suspected hyperadrenocorticism (HAC). A recent study showed that the different response patterns not only provide complementary information about etiology, but also the probability of HAC in these patients. Objectives We aimed to determine the diagnostic test performance of LDDT response patterns in a population of dogs from an animal hospital. Methods The electronic database was retrospectively searched for dogs suspected of HAC that were given an LDDT. Dogs with acute non‐adrenal illnesses during the test were excluded. Response patterns were classified as complete suppression, lack of suppression, partial suppression, escape, inverse, and increasing patterns. Cortisol concentrations ≥ 27.59 nmol/L (≥1 µg/dL) 8 hours after dexamethasone administration were considered positive results irrespective of the patterns observed. Calculations included likelihood ratios (LRs) and predictive values (PVs). Results HAC and non‐adrenal illness were diagnosed in 115 (54%) and 62 (46%) dogs, respectively. The positive (+) LRs (95% CI) for the lack of suppression, partial suppression, escape, and an inverse pattern to diagnose HAC were infinite, 8.09 (2‐32.72), 3.23 (0.75‐14), and 0.2 (0.06‐0.73), respectively. Conclusions The study confirms that the “lack of suppression” pattern strongly supports a diagnosis of HAC. It shows that the “partial suppression” pattern moderately increases, and the “inverse” pattern decreases the likelihood of HAC. The fact that the study found no association between the “escape” pattern and a diagnosis of HAC, does not support its integration into decision making.

Background Deep brain stimulation (DBS) is an important treatment for patients with advanced Parkinson's disease (PD). Patients after DBS implantation need specialized programming to get optimal outcomes. However, access to timely and economical postoperative programming for many patients living in remote areas is limited. Teleprogramming, which refers to deliver real-time remote programming through Internet, can help to address this gap. Objective We aimed to evaluate the clinical application of remote programming for PD patients with DBS. Methods We retrospectively studied 90 patients with PD who received remote DBS programming after implantation at Yuquan Hospital (Beijing, China) between March 2016 and June 2018. Patients' medical records were reviewed in an electronic database. A self-designed questionnaire was performed on all patients by phone. Results Over a mean follow-up period of 27.0 months, 90 patients underwent a total of 386 remote programming visits, of which the average frequency within 6 months after DBS was 2.27 times/person. The average distance between the patients' residences and Yuquan Hospital was 1243.8 ± 746.5 km. The questionnaire survey showed that each remote programming visit saved ≥2000¥ for 76.7% of the patients and ≥12 hours for 90.0% of the patients, compared with the on-site programming visit. The acceptability of the remote programming platform was highly rated. Transient side effects related to programming were reported and were relieved after adjustments of parameters. Conclusions Remote programming may offer a feasible and acceptable approach to timely and economic management in patients with PD after DBS implantation.

Objectives: This study aims to determine the diagnostic test accuracy (DTA) of hypermethylated DNA biomarkers in saliva and oral swabs for oral squamous cell carcinoma (OSCC) detection from the prevalidation studies available. Materials and Methods: Electronic database searching of PubMed, EMBASE, Cochrane Library, Scopus, Web of Science, and LILACS was conducted to identify relevant articles that were published between January 1, 2000, and August 1, 2020. Results: Meta-analysis was conducted based on 11 of 20 studies selected for review. Included studies had high bias concerns on the QUADAS-2 study assessment tool. We found that salivary and oral swab hypermethylation markers had better specificity than sensitivity for oral cancer detection. Summary sensitivity and specificity (95% CI) of hypermethylation panels were 86.2% (60–96.2) and 90.6% (85.9–93.9) while for individual markers, summary sensitivity and specificity (95% CI) were 70% (56.9–80.5) and 91.9% (80.3–96.9), respectively. Respective positive and negative likelihood ratios for combined markers were 9.2 (5.89–14.36) and 0.15 (0.05–0.5), and 8.61 (3.39–21.87) and 0.33 (0.22–0.49) for single-application biomarkers. Conclusion: DNA hypermethylation biomarkers especially in combination have acceptable DTA that warrants further optimization with rigorous biomarker evaluation methods for conclusive determination of their efficacy.

Background Cardiopulmonary exercise-testing (CPET) and the (Portsmouth) Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity ((P)-POSSUM) are used as pre-operative risk stratification and audit tools in general surgery, however, both have been demonstrated to have limitations in major hepatopancreatobiliary (HPB) surgery. Materials and methods The aim of this review is to determine if CPET and (P)-POSSUM scoring systems accurately predict morbidity and mortality. Eligible articles were identified with an electronic database search. Analysis according to surgery type and tool used was performed. Results Twenty-five studies were included in the final review. POSSUM predicted morbidity demonstrated weighted O/E ratios of 0.75(95%CI0.57–0.97) in hepatic surgery and 0.85(95%CI0.8–0.9) in pancreatic surgery. P-POSSUM predicted mortality in pancreatic surgery demonstrated an O/E ratio of 0.75(95%CI0.27–2.13) and 0.94(95%CI0.57–1.55) in hepatic surgery. In both pancreatic and hepatic surgery an anaerobic threshold(AT) of between 9 0.5–11.5 ml/kg/min was predictive of post-operative complications, and in pancreatic surgery ventilatory equivalence of carbon dioxide(˙VE/˙VCO2) was predictive of 30-day mortality. Conclusion POSSUM demonstrates an overall lack of predictive fit for morbidity, whilst CPET variables provide some predictive power for post-operative outcomes. Development of a new HPB specific risk prediction tool would be beneficial; the combination of parameters from POSSUM and CPET, alongside HPB specific markers could overcome current limitations., Highlights • Current pre-operative scoring for pancreatic and liver surgery is inaccurate. • In pancreatic and liver surgery anaerobic threshold scores were predictive of complications. • In pancreatic surgery ventilatory equivalence of carbon dioxide was predictive of mortality. • P-POSSUM is inaccurate for predicting mortality and morbidity in pancreatic surgery.

This systematic review summarizes and analyzes the literature on sportsmanship interventions for individuals with autism. Electronic database searches (i.e., PsycNet, ERIC) and ancestral searches were conducted to find relevant articles. Twenty-eight studies were included in this study that used experimental designs that targeted sportsmanship behaviors. The results were summarized across participants, targeted behaviors, settings, interventions, and methodological rigor of the included studies. Although most studies reported positive outcomes on the targeted social-communication behaviors, methodological limitations should be considered when interpreting the results. Limitations of this review and implications for future research are discussed.

This article reviews the new lexical material related to the coronavirus pandemic. The empirical material was collected in the electronic database Integrum. The subject of the collected material are names of persons which were used in electronic mass media (newspapers, magazines, blogs, social networks). The volume of the lexical corpus is about 90 neolexemes. The collected corpus of innovations counts more than 600 words. The aim of the article is to describe the material from lexical and semantic, word-formation points of view, to demonstrate a language game.

BACKGROUND Hyaluronic acid filler reactions have been increasingly observed in recent years. Our study investigates whether the increased number of filler reactions observed since 2014 is associated with a specific histopathologic inflammatory pattern and type of filler. METHODS The institution's dermatopathology electronic database was retrospectively searched for histopathologic reactions to hyaluronic acid from January 2014 to December 2019. The age, sex, type of filler, procedure, location, and histopathologic patterns were recorded. RESULTS From 2014 to 2019, there were 15 cases of granulomatous reactions to hyaluronic acid filler. In 10 of these cases, there was a characteristic inflammatory pattern characterized by tightly cuffed palisades of histiocytes with varying numbers of eosinophils. Of the 11 cases in which the type of filler was known, all used Vycross technology, a novel manufacturing process in the production of hyaluronic acid filler. CONCLUSION A characteristic histopathologic pattern of discrete foci of tightly cuffed palisaded granulomas with eosinophils is associated with fillers manufactured using Vycross technology.

Background and objectives Candida species are one of the most common causes of healthcare-associated bloodstream infections. However, recurrent candidemia is rare, and the characteristics of late recurrent (LR) candidemia are partly unclear. Our aim was to evaluate the characteristics of LR candidemia in adult patients. Patients and methods A retrospective cohort study was performed in the hospital district of Helsinki and Uusimaa in Finland (2007-2016). All candidemia cases were searched in an electronic database during the study period. Patients with LR candidemia were compared with patients with a single candidemia episode to evaluate the characteristics of LR candidemia. LR candidemia was defined as having at least two episodes of candidemia more than 30 days apart. Results We identified 24 episodes of LR candidemia in 20 patients. Patients with LR candidemia represented 6% of all patients with candidemia during the study period, and most of the these cases were nosocomial. The median time between the first and the recurrent episode was 5.1 months. One-year mortality in LR candidemia was 45%. Underlying gastrointestinal disease (OR 7.21, 95% CI 2.52-20.61) and history of intra venous drug use (IVDU) (OR 3.62, 95% CI 1.03-12.69) were independent risk factors for LR candidemia in the multivariable analysis. Conclusion Our study indicates that the gastrointestinal tract may be a continuous source of infection in patients with chronic gastrointestinal diseases. Gastrointestinal diseases and IVDU should be regarded as risk factors for LR candidemia.

Purpose: This study aimed to compare the utilization of Alzheimer’s disease (AD) treatments, donepezil, galantamine, rivastigmine, and memantine, in Korea with Australia and other countries with universal health coverage. Methods: Reimbursement criteria and the patent status of four AD treatments in Korea and Australia were reviewed.The monthly spending and utilization of the treatments were extracted from the national electronic database in Korea and Australia. The defined daily dose per 1000 elderly population per day (DDD/1000e/day) were calculated from July 2008 to June 2019. Annual cost trends of Norway and England were compared with Korea and Australia. Results: With the highest share of the use of donepezil in both countries, the cost and utilization of AD treatments in Korea increased more rapidly and remained higher than Australia. The cost of AD treatments in Korea increased by 15.5% every year during the study period, while the spending of the same drugs in Australia decreased by 10.5%annually. The utilization in DDD/1000e/day of AD treatments in Korea increased by 18.3% annually compared with 1.4% in Australia. When compared with Norway and England, countries with similar universal health coverage (UHC) system and elderly polupation, the cost of AD treatments in Korea was still higher with the opposite trendfrom other countries. Conclusions: Despite the similar UHC systems, there were considerable differences in the post-market utilization of AD treatments in Korea from Australia and other countries. This results can be attributed to differences in re-assessment system, pricing and reimbursement policies, and prescribing culture. This study provides a baseline to explore more comprehensive crosscountry studies on rational use of medicines. Refereed/Peer-reviewed

Background: The prevalence of discharge against medical advice (DAMA) ranges from 1% to 2% in inpatient admissions and may reach up to 25.9% in some hospitals. The aim of this meta-analysis was to assess the prevalence, causes, and predictors of DAMA in the emergency departments. Methods: We conducted a systematic electronic database search for suitable studies from inception till 20th January 2020 in nine databases. Meta-analysis was used to pool the results. Results: Of the total 180 records screened, we included 14 studies. The overall prevalence rate of DAMA was 6.3% [95% confidence intervals (CI) = 3.41%-11.63%]. The most common cause of DAMA was not being content with the treatment or not agreeing with the diagnosis/treatment (19.93%; 95% CI = 11.02%-33.34%), followed by long waiting time (8.6%; 95% CI = 0.97%-47.45%) and financial problems (7.15%; 95% CI = 1.45-28.78). Regarding predictors, the reported significant unadjusted predictors were local emergency center [Odds ratios (OR) = 1.23%; 95% CI = 1.21-1.24%; p-value < 0.001], regional emergency center (OR = 0.83%; 95% CI = 0.82%- 0.84%; p-value < 0.001), and non-urgent triage (OR = 12.74%; 95% CI = 1.13%-143.97%; p-value = 0.040). In the same context, the significant adjusted predictors were ≤40 years (males) (OR = 3.94%; 95% CI = 1.31%-11.83%; p-value = 0.014), male gender (youth and middle-aged) (OR = 1.2%; 95% CI = 1.19%-1.21%; p-value < 0.001), and Male gender (aged group) (OR = 1.09%; 95% CI = 1.07%-1.11%; p-value < 0.001). Conclusion: DAMA prevalence in emergency departments is high. More attention should be devoted to those patients in relation to the possible DAMA causes for decreasing negative consequences resulted from committing DAMA.

Breast cancer is the most common oncologic disease among women worldwide. Survival rates vary significantly and depend on early diagnosis practice and access to treatment. Triple negative breast ca...