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2 results on '"Elder, Alison"'

1. How Geographies and Issues Matter in ESG–Agency Research

Author

Gerlak, Andrea K., Mills-novoa, Megan, Elder, Alison, Enechi, Okechukwu, Sharma, Pritee, Singh, Kanak, Betsill, Michele M., Benney, Tabitha M., Environmental Policy Analysis, Betsill, Michele M., Benney, Tabitha M., and Gerlak, Andrea K.

Subjects
Scholarship, SDG 17 - Partnerships for the Goals, Fresh water, Political science, Agency (sociology), Climate change, Public administration
Abstract

ESG-Agency scholarship most commonly focuses on the global arena as well as Asia and Europe, with critical geographic gaps in Africa and the Middle East.− Climate change is the dominant issue studied in ESG-Agency research, followed by forests and fresh water. − To address the geographic imbalance in ESG-Agency research, scholars need to develop research projects and collaborations in understudied regions while also recruiting and supporting scholars in those regions to engage with this research agenda.

Published
2020

2. Chick Chorioallantoic Membrane (CAM) Assay as an In Vivo Model to Study the Effect of Newly Identified Molecules on Ovarian Cancer Invasion and Metastasis

Author

Alison S. F. Elder, Noor A. Lokman, Carmela Ricciardelli, Martin K. Oehler, Lokman, Noor A, Elder, Alison SF, Ricciardelli, Carmela, and Oehler, Martin K

Subjects
Pathology, medicine.medical_specialty, endocrine system diseases, Angiogenesis, Cell, Apoptosis, Chick Embryo, Chorioallantoic Membrane, Article, ovarian cancer, invasion, metastasis, chick chorioallantoic membrane, Catalysis, Metastasis, Inorganic Chemistry, Mice, Cell Movement, In vivo, Cell Adhesion, Tumor Cells, Cultured, Animals, Humans, Medicine, Neoplasm Invasiveness, Neoplasm Metastasis, Physical and Theoretical Chemistry, Staphylococcal Protein A, Molecular Biology, Spectroscopy, Cell Proliferation, Ovarian Neoplasms, business.industry, Organic Chemistry, In vitro toxicology, General Medicine, Flow Cytometry, medicine.disease, Antibodies, Neutralizing, Computer Science Applications, Chorioallantoic membrane, medicine.anatomical_structure, Cancer cell, Cancer research, Biological Assay, Female, business, Ovarian cancer
Abstract

The majority of ovarian cancer patients present with advanced disease and despite aggressive treatment, prognosis remains poor. Significant improvement in ovarian cancer survival will require the development of more effective molecularly targeted therapeutics. Commonly, mouse models are used for the in vivo assessment of potential new therapeutic targets in ovarian cancer. However, animal models are costly and time consuming. Other models, such as the chick embryo chorioallantoic membrane (CAM) assay, are therefore an attractive alternative. CAM assays have been widely used to study angiogenesis and tumor invasion of colorectal, prostate and brain cancers. However, there have been limited studies that have used CAM assays to assess ovarian cancer invasion and metastasis. We have therefore developed a CAM assay protocol to monitor the metastatic properties of ovarian cancer cells (OVCAR-3, SKOV-3 and OV-90) and to study the effect of potential therapeutic molecules in vivo. The results from the CAM assay are consistent with cancer cell motility and invasion observed in in vitro assays. Our results demonstrate that the CAM assay is a robust and cost effective model to study ovarian cancer cell metastasis. It is therefore a very useful in vivo model for screening of potential novel therapeutics. Refereed/Peer-reviewed

Published
2012

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