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Background: Diffuse large B cell lymphoma (DLBCL) is considered the most common type of non-Hodgkin lymphoma. The global incidence of DLBCL has been doubled in the past decades, highlighting the need for more effective treatment regimens. The curability of DLBCL is heavily influenced by a number of factors, such as the age, the international prognostic index (IPI) score, the molecular cell of origin (COO) subtype, and presence/ absence of specific chromosomal rearrangements or protein expression. Recent gene profiling studies have classified DLBCL into two main categories, germinal center B-cell type (GCB) and activated B-cell type (ABC). Validation of these subtypes has become more applicable after the immunohistochemical algorithm suggested by Hans, which included three commercially available markers, CD10, BCL6, and MUM-1/IRF4. In addition to this classification, DLBCL prognostic models based on different sets of genes or immunohistochemical markers have been proposed. More recently, DLBCLs with translocations of MYC, along with a B-cell lymphoma 2 (BCL2) and/or B-cell lymphoma 6 (BCL6) rearrangement, are now called double-hit lymphoma (DHL) or triple-hit lymphoma (THL), respectively. Furthermore, the co-expre sion of MYC and BCL2 proteins without underlying rearrangements is considered a new adverse prognostic indicator termed double-expressor lymphoma (DEL). The present study is aiming to combine morphological, immunophenotypical, and genetic features of DLBCLs to reach a more reproducible subtyping. Aim: To identify the relation between clinicopathological features as patient age, sex, site of tumor, clinical presentation and tumor stage and the germinal center differentiation in DLBCL (germinal center B-cell (GCB) or activated B-cell (ABC)) and the double/triple genetic hits status.Material and Methods: The material of this study comprised 52 formalin-fixed paraffin- embedded blocks representative of diffuse large B cell lymphoma cases retrieved from the archival material available at the Pathology Department, Faculty of Medicine, Alexandria University. Subclassification of cases into (germinal center / and post-germinal center types) using a panel of immunohistochemical markers including CD10, BCL6 and MUM1 was done and scoring of double/triple hit expression using a panel of immunohistochemical markers including c-MYC, BCL6 and BCL2 was also done and correlation with their subtypes and clinical data was performed.Results: there was significant association between germinal center differentiation and tumor stage (MCp= 0.018).Conclusion: Germinal center differentiation status is a valid method to evaluate the prognosis of DLBCL.

To examine the effects of the nonlocal thermoelastic parameters in a nanoscale semiconductor material, a novel nonlocal model with variable thermal conductivity is provided in this study. The photothermal diffusion (PTD) processes in a chemical action are utilized in the framework of the governing equations. When elastic, thermal, and plasma waves interact, the nonlocal continuum theory is used to create this model. For the main formulations to get the analytical solutions of the thermal stress, displacement, carrier density, and temperature during the nanoscale thermo-photo-electric medium, the Laplace transformation approach in one dimension (1D) of a thin circular plate is utilized. To create the physical fields, mechanical forces and thermal loads are applied to the semiconductor’s free surface. To acquire the full solutions of the research areas in the time-space domains, the inverse of the Laplace transform is applied with several numerical approximation techniques. Under the impact of nonlocal factors, the principal physical fields are visually depicted and theoretically explained.

In this study, a novel model is introduced when the Hall effect associated with a strong magnetic field is taken into account when the electrons and holes interact in the processes of semiconductor material. The plasma-elastic-thermal waves are investigated in the context of diffusive processes during optical-generated transport processes. The variable of thermal conductivity is obtained during graduated temperature due to the thermal impact of fallen light. The governing equations of the novel model are investigated in a unidimensional (1D) way when the electronics and elastic deformations have occurred. The Laplace transforms are used to convert the main dimensionless physical fields according to the initial conditions into the Laplace domain. When certain thermal, mechanical, holes, and electronic conditions are used, the analytical solutions of the fundamental fields can be produced to the outer surface of the semiconductor medium. Mathematically, the Laplacian computational inversion algorithm with a numerical approximation is used to achieve the fundamental physical quantities numerically in the time domain. The influences of several parameters (thermal relaxation times, Hall impact, and thermal conductivity parameters) on thermal conditions, mechanical stress, holes charge carrier field, and carrier density are prescribed with the help of graphical diagrams that are discussed theoretically.

The present work is devoted to a study of the induced temperature and stress fields in an elastic infinite medium with a cylindrical cavity under the purview of hyperbolic two-temperature thermoelasticity. The medium is an isotropic homogeneous thermoelastic material. The bounding plane surface of the cavity is loaded thermally by a non-Gaussian laser beam with a pulse duration of two ps. An exact solution to the problem is obtained in the Laplace transform space and the inversions of the Laplace transform have been carried out numerically. The derived expressions are computed numerically for copper and the results are presented in graphical form. The two-temperature parameter has significant effects on all the studied functions and plays a vital role in the speed propagation of the thermomechanical waves.

Outlined here is an innovative method for characterizing a layer of microelongated semiconductor material under excitation. Fractional time derivatives of a heat equation with a rotational field are used to probe the model during photo-excitation processes. Micropolar-thermoelasticity theory, which the model implements, introduces the microelongation scalar function to characterize the processes occurring inside the microelements. When the microelongation parameters are considered following the photo-thermoelasticity theory, the model investigates the interaction scenario between optical-thermo-mechanical waves under the impact of rotation parameters. During electronic and thermoelastic deformation, the key governing equations have been reduced to dimensionless form. Laplace and Fourier's transformations are used to solve this mathematical problem. Isotropic, homogeneous, and linear microelongated semiconductor medium's general solutions to their respective fundamental fields are derived in two dimensions (2D). To get complete solutions, several measurements must be taken at the free surface of the medium. As an example of numerical modeling of the important fields, we will use the silicon (Si) material’s physicomechanical characteristics. Several comparisons were made using different values of relaxation time and rotation parameters, and the results were graphically shown.

This study simulates the start of coronavirus infection using a mathematical model based on ordinary differential equations (Covid-19). Additionally, provide the numerical treatment and simulation of this model using the finite element approach (FEM). The goal of this research is to stop and slow the spread of a sickness that is ravaging the globe. A susceptible person may also transfer immediately to the quarantined class after the exposed person has been quarantined or moved to one of the contaminated classes. This model was employed by the researchers to account for both asymptomatic and symptomatic infected people. The proposed model is reduced to a set of algebraic equations using the FEM. The resulting system is then created as an optimization problem with constraints, which is subsequently optimized to obtain the solution and the unknown coefficients. The obtained findings are compared to those produced using the fourth-order Runge-Kutta method (RK4). Finally, we calculate the residual error function of the approximation in order to validate the FEM, and it is presented in symmetric forms. MSC 2010: 34A12; 41A30; 47H10; 65N20.

Indroduction: The novel model of a non-local elastic semiconductor material that is microelongated is created. The process of photothermal transfer is responsible for the stimulation of the material. Photo-thermoelastic theories are used when the thermal conductivity is changed for the non-local medium. Under the influence of laser pulses, the effective framework describes the nanoscale microelongation instance as well as the interference between the photo-thermoelastic propagation waves in the non-local medium. It is possible to think of thermal conductivity as a linear function of temperature when electronic and thermoelastic deformation mechanisms are described. Two-dimensional deformation (2D) is used to extract the main fields, which obtained in non-dimension.Methods: Harmonic wave analysis, which is described by the normal mode, has been used to convert the basic equations into non-homogeneous higher-order ordinary differential equations. Applying a small subset of the possible non-local semiconductor surface conditions leads to exhaustive solutions.Result and Discussion: The outcomes of numerical simulations for silicon (Si) are graphically shown. There are comparisons made and explanations given for the investigated physical factors like their thermal conductivity, laser pulses and microelongation parameters.

In this study, the modified Green and Lindsay model is utilized to discuss the effects of heating caused by surface absorption of laser radiation in a two-dimensional thermoelastic half-space. The temporal profile of the pulsed laser is taken as a non-Gaussian and the spatial one is a Gaussian. The medium surface is taken to be traction free. The integral transform method is utilized to obtain the general solution by applying the two transformations Hankel and Laplace, in which the inverse of Laplace is performed numerically. The Silicon material is considered as an example to verify the consistency of the obtained results of the new model.

The key aim of this paper is to construct a modified version of the SEIQR essential disease dynamics model for the COVID-19 emergence. The modified SEIQR pandemic model takes a groundbreaking approach to evaluate and monitor the COVID-19 epidemic. The complex studies presented in this paper are based on real-world data from Saudi Arabia. A reproduction number and a systematic stability analysis are included in the new version of SEIQR model dynamics. Using the Jacobian linearization process, we can obtain the domain of the solution and the state of equilibrium based on the modified SEIQR model. The equilibrium and its importance have been identified, and the disease-free stability of the equilibrium has been investigated. The reproduction number was calculated using internal metrics, and the global stability of the current model's equilibrium was demonstrated using Lyapunov's stability theorem. To see how well the SEIQR proposed model went, it was compared to real COVID-19 spread data in Saudi Arabia. According to the results, the new SEIQR proposed model is a good match for researching the spread of epidemics like COVID-19. In the end, we presented an optimal protocol to prevent the dissemination of COVID-19. Staying at home and transporting sick people as far as possible to a safe region is the most effective strategy to prevent COVID-19 spread. It is critical to offer infected people safe and effective treatment, as well as antibiotics and nutrients to non-affected people. To detect confirmed infections, we must provide more effective and reliable diagnostic methods. Furthermore, increasing understanding of how to recognize the disease, its symptoms, and how to confirm the infection.

Reaching a sustainable industry is now possible through digitisation. The current era witnessed an increase in the impact of digital transformation on the economy; this encouraged various sectors to adopt Industry 4.0. Digital supply chain and Industry 4.0 are current buzzwords in all industries that can solve common drawbacks. The logistics sector in particular suffers from numerous weaknesses, one of which is cargo theft. Logistics companies started adopting technology in operations aiming to mitigate cargo thefts and reach a sustainable work environment through their digital supply chains. The Egyptian government intends to participate in the transition into a digital society. This case aims to demonstrate a best practice of digitisation in the logistics sector in the Egyptian market. Global Chains Company was one of the first logistics companies to apply a digital solution through ERP systems. Through the interviews conducted, cargo theft problems and consequences are demonstrated along with the results of applying digitisation to operations and the lessons learned.

The Penne’s bio-heat transfer equation can be used with normal mode technique to describe the characterizing of the temperature fluctuation in muscles. The analytical solutions of heating pattern is obtained in a closed-form when the propagation of ultrasonic waves in tissue system are taken into consideration. The impact of external electromagnetic field is used to investigate the influence of temporal and spatial distributions of temperature. The numerical simulations during the 2D and 3D graphs can be obtained for human tissue in simplified geometry in the context of the derived method. The normal mode analysis is used as a mathematical technique to solve the bioheat transfer equation analytically with some conditions to get the complete solution of the main variables in this model.

Electro-magnetic-thermal-microstretch elastic mathematical-physical model of semiconductor medium is investigated. The governing equations are studied in the context of photo-thermoelasticity theory during photothermal transport process. The semiconductor medium is exposed to an external magnetic field and a beam of laser. The coupled between electromagnetic field, thermal, elastic and plasma waves when the inertia-microstretch properties of elastic semiconductor material is taken into account. The main physical quantities are taken during two dimensions (2D) electronic-elastic deformation. The microinertia of microelement under the impact of external magnetic field is taken into consideration. The harmonic wave solutions in 2D with time variation is used to obtain the main physical fields. To obtain the complete solutions of the physical fields, some mechanical-thermal-elastic and plasma conditions for the semiconductor medium are taken at the boundary. The physical constants of the silicon (Si) material are used to make the numerical simulations and obtained the physical variables with the horizontal distance graphically. Many comparisons are made according to the thermal memories and the magnetic field influence.

Background: Obesity is a medical condition in which excess body fat has accumulated to extend that it may has an adverse effect on health. Leading to reduction of life expectancy or increasing health problems. Objective: To evaluate the improvement in plasma glucose level and lipid profile in type 2 diabetes mellitus obese patients after Laparoscopic Sleeve Gastrectomy (LSG). Patients and methods: This prospective study was conducted at Surgery Department, Al-Azhar University Hospitals during the period between December 2019 and August 2020. Study included 30 cases of type 2 diabetes mellitus morbidly obese patients (with BMI ≥35 Kg/m²) and all of them had failed in trials of conservative management including dietary control, and they were bulky eater but non sweet eater. Laparoscopic sleeve gastrectomy technique was done for all cases. Results: Our result showed that there was a significant improvement of the HbA1c measured at three and six months post-operatively. Five patients (17%) completely cured from T2DM, while 12 patients (40%) became pre-diabetic, and 13 patients (43%) remained diabetic with great improvement of their previous follow up of HbA1c. Conclusion: LSG was efficient in the remission and/or improvement of symptoms of T2DM and other obesity-related comorbidities, with a significant reduction in serum HbA1c and lipid profile.

A mathematical novel model for elastic semiconductor medium with microstretch properties is investigated. The generalized model is studied in the context of photo-thermoelasticity theory when the s...

In the present investigation, we constructed a novel mathematical model of a one-dimensional thermoelastic semiconducting solid sphere based on the L-S model to study the photothermal interaction. ...