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OBJETIVO: Analisar o perfil clínico de portadores de câncer colorretal (CCR). MÉTODOS: Estudo prospectivo com 390 pacientes submetidos a colonoscopia. 152 assintomáticos Grupo A (G-A) e 238 sintomáticos com CCR Grupo B (G-B). Analisamos história familiar (HF), sintomas, Índice de massa Corpórea (IMC), localização do tumor e histopatologia. P0,05. HF positiva em 79 (31%) com CCR, contra 34 (32%) sem câncer, P>0,05. IMC no G-A foi 25+/-4 contra 27+/-4 no G-B P>0,05. No G-A 9 (5,9%) tiveram CCR. Câncer superficial em 1 (11%) no G-A contra 21 (8,8%) no G-B, P>0,05. Câncer em cólon esquerdo em 6 (66%) no G-A contra 168 (69%) no G-B, P>0,05. Alteração do hábito intestinal com sangue, cólon esquerdo 56 (60%) contra 13 (31%) no direito P0,95. 79 patients (31%) of cancer had positive FH and positive FH was present in 34 patients without cancer (23%) P>0,05.BMI was 26+/-4 Group A and 27+/- for B P>0,05 9 patients (5,9%) from Group A was found to have cancer. Superficial in 1 (11%) Group A against 21 (8,8%) for Group B P>0,05. Change of bowel habits with bleeding was 56 (60%) on the left colon cancer against 13 (31%) on the right P

The objectives of this study were to determine both the prevalence of microsporidial intestinal infection and the clinical outcome of the disease in a cohort of 40 HIV-infected patients presenting with chronic diarrhea in Rio de Janeiro, Brazil. Each patient, after clinical evaluation, had stools and intestinal fragments examined for viral, bacterial and parasitic pathogens. Microsporidia were found in 11 patients (27.5%) either in stools or in duodenal or ileal biopsies. Microsporidial spores were found more frequently in stools than in biopsy fragments. Samples examined using transmission electron microscopy (n=3) or polymerase chain reaction (n=6) confirmed Enterocytozoon bieneusi as the causative agent. Microsporidia were the only potential enteric pathogens found in 5 of the 11 patients. Other pathogens were also detected in the intestinal tract of 21 patients, but diarrhea remained unexplained in 8. We concluded that microsporidial infection is frequently found in HIV infected persons in Rio de Janeiro, and it seems to be a marker of advanced stage of AIDS.