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Aim: When the respiratory system is unable to adequately absorb oxygen or excrete carbon dioxide, acute respiratory failure (ARF) develops. A current area of study is the survival analysis of patients with acute hypercapnic respiratory failure (AHRF) in the field of pulmonary diseases. In the follow-up period, several biochemical markers are repeatedly measured, such as respiration rate and Carrico Index; however, baseline or averaged values are mostly related to treatment failure. Although this approach is not inaccurate, it causes information loss, which leads to biased estimates. This prospective cohort study primarily looked at the relationship between changes in Carrico Indexand failure of treatmentin AHRFpatients. Methods: We included 86 patients from Ankara University School of Medicine Pulmonary Diseases Department. The association between the trajectory of the Carrico Index and failure in AHRF patients was examined using a joint modeling approach for longitudinal and survival data. Results: Results showed that averaged Carrico Index change was inversely and significantly associated with failure (HR: 0.97, 95% CI: -0.05 to 1.97). With hazard ratios of 1.43 and 1.4, chronic health evaluation II (Apache II), and COPD Assesment test (CAT) were positively correlated with failure risk. Conclusions: The present study demonstrate that applying the risk predictors' trajectory through an appropriate statistical method improved accuracy and avoid biased results.

Amac: Bu calisma spor yapan bireylerin besin destek urunu (BDU) kullanma oraninin tespiti ve BDU hakkinda bilgi duzeylerinin belirlenmesi amaciyla yapilmistir. Gerec ve Yontem: Arastirma Corum ilinde bulunan spor salonlarinda 55'i kadin 251'i erkek toplam 306 katilimci uzerinde yuz yuze anket yontemi kullanilarak yapilmistir. Istatistiksel degerlendirmelerde SPSS 21 kullanilmis ve elde edilen verilerin p anlamlilik degeri ve yuzde degerleri hesaplanmistir. Bulgular: Katilimcilarin %50,6'si 21-25 yas araliginda olup bunlarin %83,3 erkek, %16,7 kadin bireylerden olusmaktadir. Katilimcilarin %45,4'unun BDU kullandigi tespit edilmistir. BDU kullanan katilimcilarin cinsiyetleri ve spor yapma sureleri arasinda istatistiksel anlamli iliski bulunmustur. Kadinlarda BDU kullanma orani %7,8 iken erkeklerde bu oran %53,2 olarak tespit edilmistir. Katilimcilarin protein tozu, enerji icecekleri, vitamin ve mineral katkilari ve bu urunlerin yan etkileri konusunda bilgi eksikligi oldugu tespit edilmistir. Ayrica katilimcilarin %67’si BDU’nun spor yapanlar icin gerekli oldugunu, %74,8’i bu urunlerin performansi artirabilecegini belirtmistir. Sonuc: Spor yapan bireylerin sporcu beslenmesi ve BDU hakkinda yeterli bilgiye sahip olmadiklari belirlenmistir. Sporculara kolaylikla erisimin saglanabilecegi alanlarda (spor salonu, soyunma odasi, sosyal medya platformlari, kamu spotlari vb.) beslenmenin temel kurallarinin anlatilmasi gerekmektedir. Sporcular, spor beslenmesi uzmanlarina yonlendirilmelidir. Bu uzmanlar uluslararasi orgutler tarafindan belirlenen standartlar dogrultusunda BDU tavsiye etmeli ve sporculara dogru bilgileri vermelidir.

BACKGROUND: Due to the lack of precise research data related to the evaluation of the physical activity level (PAL) among obese individuals, the aims of the study were to evaluate declared and real volume of physical activity, and to assess the correlations between these methods. METHODS: The study consisted of 30 female (M-age =32.9 +/- 7.3 years) and 16 male (M-age=36.4 +/- 8.4 years) a total of 46 obese volunteer individuals were included (M-bmi:37.6 +/- 6.6 kg/m(2), M-bmi: 34.2 +/- 43 kg/m(2); body fat percentage: 42.1% and 35.2%, respectively). A cross-sectional study was conducted on the obese people. The inionnation form was prepared for obese individuals who applied the Health Institutions and body composition measurements were performed with Tanita BC-1000. PAL was assessed objectively by a Sense Wear Armband (SWA) for 7 consecutive days- and seven day later the participants fill out the International Physical Activity Questionnaire - Short Form (IPAQ-SF). For statistical analysis, the data were presented as mean values, Standard deviations (SD), frequency (f), and percentage (%). Spearman's Rho Correlation were used, and the significant level was P

WOS: 000527257800004 PubMed: 32297966 Objectives: The aim of this study was to test the utility and validity of the full cup test (FCT) to assess the severity of pain in subjects with painful diabetic peripheral neuropathy (PDPN). Methods: Subjects with diabetic PDPN were enrolled for this prospective, cross-sectional study. Other causes of PDPN and subjects with cognitive impairment were excluded. The diagnosis of neuropathic pain was made using the results of a physical examination and the Douleur Neuropathique 4 questionnaire. Pain severity was assessed with a FCT and a visual analog scale (VAS) administered before and after treatment. The correlation of FCT with VAS was evaluated to examine validity. Results: A total of 43 (33 female, 10 male) subjects were included. The mean age was 61.9 +/- 8.25 years and the mean disease duration was 13.02 +/- 7.6 years. Type I diabetes mellitus (DM) was present in 2 (4.7%) subjects and Type II DM in 41 (95.3%) subjects. The mean glycated hemoglobin level was 8.9 +/- 1.9 mmol/mol. When the mean VAS and FCT scores were analyzed, the results were 6.7 +/- 2.05 and 66.35 +/- 23.2, respectively, pretreatment and 4.6 +/- 2.2 and 41.36 +/- 23.5 posttreatment, which were both statistically significant (p

Buyuktortop Gokcinar, Nesrin/0000-0001-7795-5188 WOS: 000535250900001 PubMed: 32452640 Introduction Neuroimaging studies of patients with bipolar disorder (BD) have recently revealed neurodegenerative changes in the central nervous system. Optical coherence tomography (OCT) imaging of the retina, as an extension of brain, may be a biomarker in understanding the neurobiology of the disease. To assess OCT as a tool to detect neurodegeneration in BD we compared the retinal changes between patients with BD and healthy individuals. Methods We performed complete ophthalmological examinations and took OCT images for 70 eyes of 70 patients with BD, and for age and sex-matched individual controls. We compared retinal nerve fiber layers (RNFLs) and total retinal (TR) thickness in the peripapillary areas; and ganglion cell complexes (GCCs) and TR thickness in the maculas between the groups. Results The mean age of the patients was 40.41 +/- 13.22 years and that of the controls 40.20 +/- 13.03 years. The men/women ratios were 37/33 in both groups. BD was significantly associated with a decrease in the average peripapillary RNFL, with the average peripapillary TR, and with the average GCC thickness (P = .033, P = .008, and P = .009, respectively). The peripapillary RNFL and TR thinnings were prominent in the superior (P = .039, P = .033, respectively) and inferior quadrants (P = .031, P = .018, respectively). The BD effects on GCC thinning was prominent in the superior half (P = .001) and in the nasal sectors (except in the inner superonasal sector; all P < .05). BD was associated with a decrease in macular TR thickness only at the inner superior sector (P = .014). Disease duration was inversely correlated with the peripapillary RNFL, TR, and macular GCC thicknesses (P < .05). Discussion Our findings support the neurodegeneration hypothesis in the etiopathogenesis of BD. OCT, a non-invasive neuro-imaging method, may be useful for BD diagnosis and follow-ups. Kirikkale University Scientific Research Projects Coordination UnitKirikkale University [2018/087] Kirikkale University Scientific Research Projects Coordination Unit, Grant/Award Number: 2018/087

Objective: The Turkish Ministry of Health started a community-based screening program using Human Papilloma Virus (HPV) DNA in 2014. In our study, we aimed to investigate the results of this survey in Çorum province between the years of 2016-17 to determine the shortcomings and deficiencies in practice. Material and Method: All of the women between the ages of 30 and 65 years who had undergone High risk HPV DNA screening in Çorum province between 2016 and 2017 were included in the study. High risk HPV types were divided into three categories as type 16, 18 and others. The target group of patients to be screened were compared with the numbers reached in the survey. After colposcopic biopsy, the clinicopathological correlation of the patients who underwent colposcopic biopsy was determined via pathology reports. Results: HPV DNA was detected in 817 women (3.5%). HPV types 16, 18 and others were found to be positive in 216, 32 and 569 individuals, respectively. Cervical biopsy was performed with colposcopy in 212 (26%) women. As the result of colposcopy, LSIL and HSIL were detected in 63 and 56 patients, respectively. 34.5% of patients with the diagnosis of any kind of dysplasia received treatments. Conclusion: It was determined that 44% of HPV DNA-positive patients were not subjected to the appropriate processes according to the national guidelines. This shows that despite the screening, the desired therapeutic effect could not be achieved. WOS:000466572300003 2-s2.0-85065500907 PubMed: 30793760

WOS: 000460844400018 PubMed: 30538080 Clinical diagnosis of carpal tunnel syndrome (CTS) is confirmed by nerve conduction studies (NCS). In some cases, NCS may be normal. We aimed to demonstrate changes of distal motor latency (DML) and nerve conduction velocity (NCV) pathology of demyelination in entrapment neuropathy with cold application in case of clinical CTS with normal NCS. This prospective, cross-sectional, randomise, case-control involved 15 patients (25 hands) with clinically definite unilateral or bilateral CTS and normal nerve conduction studies (NCS), and 11 controls (22 hands). Ice pack was applied to median nerve trasse at wirst with monitoring skin temperature. NCS of median nerve were examinated again. Increases of DML, decrease of velocity of median nerve were observed in two groups after post-cooling. The change in NCV was greater than the change in DML. Cold effect was evident in DML and NCV in the patient group. This could be sign of the demyelination pathology. We think that cold application is influential to determine electrophysiologic abnormalities in clinic CTS with normal NCS. (C) 2018 Elsevier Ltd. All rights reserved.

Aims: Hyperechoic/echo-rich periportal cuffing (ErPC) is defined as an increase in echogenicity relative to the adjacent liver parenchyma. Thickening in the periportal area may occur with proliferation of bile ducts, hemorrhage, oedema, fibrosis, inflammatory changes or a combination of these. The aim of this study is to determine which intraabdominal inflammatory diseases arc associated with the presence of ErPC in the pediatric population and to calculate the sensitivity and specificity of this finding. Material and methods: In this prospective study 200 consecutive children who underwent abdominal ultrasonography (US) were included: group 1, the patient group (100 children with appendicitis, gastroenteritis, mesenteric lymphadenitis, intestinal infection, terminal ileitis and imagination as cause of intra-abdominal inflanunation) and group 2, the control group (100 children). Results: The ErPC was positive in 74 (74%) cases in the patient group and in 3 (3%) in the control group. According to final diagnoses, we found ErPC in most of patients with gastroenteritis (16/17), perforated appendicitis (10/11), mesenteric lymphadenitis (5/6) and acute appendicitis (27/37). The sensitivity of ErPC in indicating intra-abdominal inflammation was 0.80 and its specificity was 0.87. No significant correlation between ErPC and age, gender and CRP was found but a moderate and significant positive correlation between ErPC and WBC (p=0.010; r=0.255) was detected. Very good concordance between observers in terms of the presence of ErPC on abdominal US was found (concordance 97% and kappa 0.93). Conclusions: We consider that the presence of ErPC in pediatric patients, when evaluated alongside clinical and laboratory findings, has a high sensitivity and specificity for inflammatory intra-abdominal pathology. WOS:000484121500003 2-s2.0-85071759007 PubMed: 31476200

This study was conducted to investigate the prevalence of Blastocystis spp. and its subtypes (STs) in North Cyprus; and to evaluate the presence of this parasite and its STs with respect to demographic, socioeconomic, and epidemiological factors, as well as gastrointestinal symptoms. Stool samples were collected from 230 volunteers. Each participant also filled out a questionnaire. The samples were examined microscopically by native-Lugol and trichrome methods and further tested by polymerase chain reaction (PCR) and sequencing. Prevalence of Blastocystis spp. infection was found to be 10.5%, 10.5%, and 27.8%, by direct microscopy, trichrome method, and PCR, respectively. No other parasites were detected in the specimens except Giardia spp. (n = 2; 0.8%) and Entamoeba coli (n = 1; 0.4%). The most common Blastocystis STs were ST3 (20; 31.2%), ST2 (18; 28.2%), ST1 (8; 12.5%), and ST4 (7; 11%); whereas other STs were identified as ST6 (3; 4.7%), ST7 (2; 3.2%), and non-ST (6; 9.4%). Presence of Blastocystis spp. and its STs was not significantly related to any of the demographic, socioeconomic, and epidemiological factors. Furthermore, no significant association of Blastocystis spp. and its STs with gastrointestinal symptoms was found. This study is the first investigation of the epidemiology of Blastocystis spp. in North Cyprus. Distribution of Blastocystis spp. and its STs among demographic, socioeconomic, and epidemiological factors showed complete homogeneity. Presence of the parasite and its STs was not significantly related with the gastrointestinal symptoms among symptomatic and asymptomatic individuals. These findings suggest that Blastocystis spp. may be part of the intestinal flora in humans.

To define the role ofFifty-four (mean age: 55.5 ± 18.3 years, 20 female and 34 male) DLBCL patients who underwent pretreatmentBMBM uptake in pretreatment