1. Expression of matrix metalloproteinase 9 in pancreatic ductal carcinoma is associated with tumor metastasis formation
- Author
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Anna Pryczynicz, Guzinska-Ustymowicz, Katarzyna, Dymicka-Piekarska, Violetta, Czyzewska, Jolanta, and Kemona, Andrzej
- Subjects
Adult ,Male ,lcsh:Cytology ,Age Factors ,Middle Aged ,Prognosis ,Immunohistochemistry ,Pancreatic Neoplasms ,Matrix Metalloproteinase 9 ,Lymphatic Metastasis ,Humans ,Female ,Lymph Nodes ,lcsh:QH573-671 ,Aged ,Carcinoma, Pancreatic Ductal - Abstract
The objective of the current study was to assess the expression of matrix metalloproteinase 9 (MMP-9) in pancreatic ductal carcinoma and to examine its correlation with chosen clinico-anatomical parameters. The study group consisted of 36 patients with pancreatic ductal carcinoma. Tumors were stained using immunohistochemical method (NCL -MMP-9, Novocastra). No correlation was found between tumor MMP-9 expression and age, gender or grade of histological malignancy. However, statistical analysis revealed a relationship between tumor MMP-9 expression and histological type (adenocarcinoma mucinosum) of pancreatic carcinoma. The expression was strongly correlated with lymph node involvement and occurrence of distant metastases (p