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Conducting polymer coatings on metal electrodes are an efficient solution to improve neural signal recording and stimulation, due to their mixed electronic-ionic conduction and biocompatibility. To date, only a few studies have been reported on conducting polymer coatings on metallic wire electrodes for muscle signal recording. Chronic muscle signal recording of freely moving animals can be challenging to acquire with coated electrodes, due to muscle movement around the electrode that can increase instances of coating delamination and device failure. The poor adhesion of conducting polymers to some inorganic substrates and the possible degradation of their electrochemical properties after harsh treatments, such as sterilization, or during implantation limits their use for biomedical applications. Here, we demonstrate the mechanical and electrochemical stability of the conducting polymer, poly(3,4-ethylenedioxythiophene) (PEDOT) doped with LiClO4, deposited on stainless steel multistranded wire electrodes for invasive muscle signal recording in mice. The mechanical and electrochemical stability was achieved by tuning the electropolymerization conditions. PEDOT-coated and bare stainless steel electrodes were implanted in the neck muscle of five mice for electromyographic (EMG) activity recording over a period of 6 weeks. The PEDOT coating improved the electrochemical properties of the stainless steel electrodes, lowering the impedance, resulting in an enhanced signal-to-noise ratio during in vivo EMG recording compared to bare electrodes.