1. Folate attached, curcumin loaded Fe3O4 nanoparticles: A novel multifunctional drug delivery system for cancer treatment
- Author
-
Nguyen Xuan Phuc, Le Thi Thu Huong, Do Hai Doan, Ha Phuong Thu, P.H. Nam, Nguyen Hoai Nam, Bui Thuc Quang, Hoang Thi My Nhung, and Phan Quoc Thong
- Subjects
Thermogravimetric analysis ,Materials science ,Nanoparticle ,Nanotechnology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Cancer treatment ,chemistry.chemical_compound ,chemistry ,Folic acid ,Drug delivery ,Curcumin ,General Materials Science ,Fourier transform infrared spectroscopy ,0210 nano-technology ,Fe3o4 nanoparticles - Abstract
Study and development of drug delivery nanosystem for cancer treatment are attracting great attention in recent years. In this work, we studied the role of folic acid as a targeting factor on magnetic nanoparticle Fe 3 O 4 based curcumin loading nanosystem. Characteristics of the nanosystems were investigated by Fourier transform infrared spectroscopy (FTIR) and field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), thermal gravimetric analysis (TGA) and vibrating sample magnetometer (VSM), while targeting role of folic was accessed in vivo on tumor bearing mice. The results showed that folate attached Fe 3 O 4 based curcumin loading nanosystem has very small size and exhibits better targeting effect compared to the counterpart without folate. In addition, magnetic induction heating of this nanosystem evidenced its potential for cancer hyperthermia.
- Published
- 2016
- Full Text
- View/download PDF