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3. Heat acclimation reduces the effects of whole-body hyperthermia on knee-extensor relaxation rate, but does not affect voluntary torque production

Author

Ralph Joseph Frederick Hills Gordon, Jodie Natasha Moss, Federico Castelli, Thomas Reeve, Ceri Elen Diss, Christopher James Tyler, and Neale Anthony Tillin

Subjects
Physiology, Physiology (medical), Public Health, Environmental and Occupational Health, Orthopedics and Sports Medicine, General Medicine
Abstract

Purpose This study investigated the effects of acute hyperthermia and heat acclimation (HA) on maximal and rapid voluntary torque production, and their neuromuscular determinants. Methods Ten participants completed 10 days of isothermic HA (50 °C, 50% rh) and had their knee-extensor neuromuscular function assessed in normothermic and hyperthermic conditions, pre-, after 5 and after 10 days of HA. Electrically evoked twitch and octet (300 Hz) contractions were delivered at rest. Maximum voluntary torque (MVT), surface electromyography (EMG) normalised to maximal M-wave, and voluntary activation (VA) were assessed during brief maximal isometric voluntary contractions. Rate of torque development (RTD) and normalised EMG were measured during rapid voluntary contractions. Results Acute hyperthermia reduced neural drive (EMG at MVT and during rapid voluntary contractions; P P P P P Conclusion HA-induced favourable adaptations to the heat after 5 and 10 days of exposure, but there was no measurable benefit on voluntary neuromuscular function in normothermic or hyperthermic conditions. HA did reduce the hyperthermic-induced reduction in twitch half-relaxation time, which may benefit twitch force summation and thus help preserve voluntary torque in hot environmental conditions.

Published
2023

5. Wisconsin Forests 2019

Author

Cassandra M. Kurtz, Thomas A. Albright, Brian D. Anderson, Brett J. Butler, Collin Buntrock, Daniel Buckler, Susan J. Crocker, Andrea L. Diss-Torrance, Thomas C. Goff, Bryan Hemmer, Randall S. Morin, Mark D. Nelson, Ronald J. Piva, Scott A. Pugh, Rachel I. Riemann, Sjana Schanning, Brian F. Walters, and Christopher W. Woodall

Published
2023

8. Progressive hyperthermia elicits distinct responses in maximum and rapid torque production

Author

Neale A. Tillin, Ralph Gordon, Christopher J. Tyler, Ceri Diss, and Federico Castelli

Subjects
Adult, Male, Hyperthermia, medicine.medical_specialty, Hot Temperature, Physical Therapy, Sports Therapy and Rehabilitation, Isometric exercise, Electromyography, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Torque, Medicine, Orthopedics and Sports Medicine, Muscle Strength, 030212 general & internal medicine, Muscle, Skeletal, medicine.diagnostic_test, business.industry, Excitation–contraction coupling, Repeated measures design, Humidity, Rectal temperature, 030229 sport sciences, medicine.disease, Cardiology, medicine.symptom, business, Body Temperature Regulation, Muscle Contraction, Muscle contraction
Abstract

Objectives To investigate the effect of progressive whole-body hyperthermia on maximal, and rapid voluntary torque production, and their neuromuscular determinants. Design Repeated measures, randomised. Methods Nine participants performed sets of neuromuscular assessments in HOT conditions (∼50 °C, ∼35% relative humidity) at rectal temperatures (Tre) of 37, 38.5 and 39.5 °C and in CON conditions (∼22 °C, ∼35% relative humidity) at a Tre of ∼37 °C and pre-determined comparative time-points. Electrically evoked twitch (single impulse) and octet (8 impulses at 300 Hz) responses were measured at rest. Maximum voluntary torque (MVT), surface electromyography (EMG) normalised to maximal M-wave, and voluntary activation (VA) were measured during 3−5 s isometric maximal voluntary contractions. Rate of torque development (RTD) and normalised EMG were measured during rapid voluntary isometric contractions from rest. Results All neuromuscular variables were unaffected by time in CON. In HOT, MVT, normalised EMG at MVT and VA were lower at 39.5 °C compared to 37 °C (p 0.05), despite lower normalised EMG at Tre 39.5 °C (p Conclusions Hyperthermia reduced late-phase voluntary RTD, likely due to reduced neural drive and the reduction in MVT. In contrast, early- and middle-phase voluntary RTD were unaffected by hyperthermia, likely due to the conflicting effects of reduced neural drive but faster intrinsic contractile properties.

Published
2021

9. mutscan - a flexible R package for efficient end-to-end analysis of multiplexed assays of variant effect data

Author

Charlotte Soneson, Alexandra M Bendel, Guillaume Diss, and Michael B Stadler

Abstract

Multiplexed assays of variant effect (MAVE) experimentally measure the fitness of large numbers of sequence variants by selective enrichment of sequences with desirable properties followed by quantification by sequencing.mutscanis an R package for flexible analysis of such experiments, covering the entire workflow from raw reads up to statistical analysis and visualization. Core components are implemented in C++ for efficiency. Various experimental designs are supported, including single or paired reads with optional unique molecular identifiers. To find variants with changed relative abundance,mutscanemploys established statistical models provided in theedgeRandlimmapackages.mutscanis available fromhttps://github.com/fmicompbio/mutscan.

Published
2022

10. Majority properties of positional social preference correspondences

Author

Mostapha Diss and Michele Gori

Subjects
Property (philosophy), Relation (database), 05 social sciences, General Social Sciences, General Decision Sciences, Social preferences, Computer Science Applications, Arts and Humanities (miscellaneous), 0502 economics and business, Developmental and Educational Psychology, 050206 economic theory, 050207 economics, General Economics, Econometrics and Finance, Mathematical economics, Applied Psychology, Mathematics
Abstract

We characterize the positional social preference correspondences (spc) satisfying the qualified majority property for any given majority threshold. We also characterize the positional spcs satisfying the minimal majority property. We next evaluate the probability that the Borda, the plurality and the antiplurality spcs fulfil the two aforementioned properties under the Impartial and Anonymous Culture assumption in the presence of three and four alternatives for various sizes of the society. Our results show that the Borda spc is the positional spc which better behaves in relation with the qualified majority principle and the minimal majority principle.

Published
2021

11. The effects of combined action observation and motor imagery on corticospinal excitability and movement outcomes: Two meta-analyses

Author

Chye, Samantha, Chembila-Valappil, Ashika, Wright, David, Frank, Cornelia, Shearer, David, Tyler, Chris, Diss, Ceri, Mian, Omar, Tillin, Neale, and Bruton, Adam

Subjects
observation, AOMI, Cognitive Neuroscience, Movement, dual action simulation, Pyramidal Tracts, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, motor execution, Behavioral Neuroscience, Neuropsychology and Physiological Psychology, transcranial magnetic stimulation, Imagination, Humans, motor evoked potentials, motor imagery during action, Muscle, Skeletal
Abstract

Motor simulation interventions involving motor imagery (MI) and action observation (AO) have received considerable interest in the behavioral sciences. A growing body of research has focused on using AO and MI simultaneously, termed ‘combined action observation and motor imagery’ (AOMI). The current paper includes two meta-analyses that quantify changes in corticospinal excitability and motor skill performance for AOMI compared to AO, MI and control conditions. Specifically, the first meta-analysis collated and synthesized existing motor evoked potential (MEP) amplitude data from transcranial magnetic stimulation studies and the second meta-analysis collated and synthesized existing movement outcome data from behavioral studies. AOMI had a positive effect compared to control and AO but not MI conditions for both MEP amplitudes and movement outcomes. No methodological factors moderated the effects of AOMI, indicating a robust effect of AOMI across the two outcome variables. The results of the meta-analyses are discussed in relation to existing literature on motor simulation and skill acquisition, before providing viable directions for future research on this topic.HighlightsMotor imagery (MI) and action observation (AO) can be combined (AOMI)This paper synthesizes neurophysiological and behavioral evidence for AOMIAOMI had increased corticospinal excitability compared to AO and control but not MIAOMI led to improved movement outcomes compared to AO and control but not MIThe reported effects of AOMI were maintained across all moderators

Published
2022

12. Genetic correlations for reproductive and growth traits in rabbits

Author

Rafik Belabbas, Ali Berbar, Zoulikha Boudjella, María de la Luz García, María-José Argente, Nassima Boudahdir, Djamal Talaziza, Rym Ezzeroug, and Samir Diss

Subjects
0301 basic medicine, Litter (animal), 0402 animal and dairy science, 04 agricultural and veterinary sciences, Heritability, Biology, 040201 dairy & animal science, Genetic correlation, 03 medical and health sciences, 030104 developmental biology, Animal science, Food Animals, Weaning, Animal Science and Zoology, Weaning weight
Abstract

The objective of this study was to obtain heritability estimates for reproductive (litter size at birth, number born alive, litter size at weaning) and growth traits (individual weaning weight, individual weight at the end of the fattening period), then determine the genetic correlation between them in a synthetic rabbit line. A total of 805 females, 3242 parities, and 18 472 growth records were measured from 2006 to 2017. A pentavariate animal model was used with reproductive and growth traits. Heritability ranged from 0.025 to 0.126 for reproductive traits and from 0.033 to 0.059 for growth traits. These traits showed a large coefficient of variation (from 32% to 56% for reproductive traits and from 21% to 28% for growth traits). The repeatability of reproductive traits was low and the common litter effect for growth traits was the most important component of total variance. The genetic and phenotypic correlations between reproductive and growth traits were high and negative, especially with weight at weaning (−0.848, −0.922, and −0.854 for litter size at birth, number born alive, and litter size at weaning, respectively). In conclusion, because of the high negative correlation between reproductive and growth traits, both reproductive and growth traits should be selected in independent lines and the response to selection should be due mainly to the high coefficient of variation of the traits.

Published
2020

14. The Impact of Oral Health on Low-Income Pregnant Women living in the United States

Author

Ward, Olivia and Diss, Jill Jacobs

Abstract

Introduction: Oral health has a significant impact on pregnancy outcomes. Inter-professional collaboration can assist in bridging the gap between oral and systemic health and assist in optimizing the health of low-income pregnant women, infants, and children. Methods: A literature review was used to ascertain the impact of oral health on adverse pregnancy outcomes. Research sources used in this literature review were gathered from the U.S. National Library of Medicine at the National Institutes of Health, PubMed, The Centers for Disease Control and Prevention (CDC), Elsevier, Department of Medical Assistance Services (DMAS), the Office of the Surgeon General, and Google Scholars. Inclusion criteria were pregnant women. Results: Poor dental health during pregnancy can contribute to adverse pregnancy outcomes and contributes to early childhood caries. Conversely, many systemic diseases can present oral signs and symptoms. Low-income women are disproportionately affected due to limited or no access to oral health care through their health insurance, or due to poor quality health care. The socio-ecological model was used to identify factors that affect oral health at the individual, interpersonal, organizational, and public policy levels. Discussion: Studies have shown that inter-professional collaboration with health care professionals and other non-dental professionals can improve pregnant women’s oral health. Prenatal care that includes oral health screening, education, and referrals can mitigate the risk of oral diseases during pregnancy and the postpartum period. A systems change approach can be utilized to create a collaborative effort in addressing this public health issue.

Published
2022
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15. Highlights from the PHENIX experiment

Author

Abdulameer, N.J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N.N., Akiba, Y., Akimoto, R., Al-Ta'Ani, H., Alexander, J., Alfred, M., Andrieux, V., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Aschenauer, E.C., Atomssa, E.T., Awes, T.C., Ayuso, C., Azmoun, B., Babintsev, V., Bai, M., Bai, X., Bandara, N.S., Bannier, B., Barish, K.N., Bassalleck, B., Bathe, S., Baublis, V., Baumann, C., Baumgart, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Black, D., Blankenship, B., Blau, D.S., Boer, M., Bok, J.S., Borisov, V., Boyle, K., Brooks, M.L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Butler, C., Butsyk, S., Campbell, S., Canoa Roman, V., Castera, P., Cervantes, R., Chen, C.-H., Chiu, M., Chi, C.Y., Choi, I.J., Choi, J.B., Choi, S., Choudhury, R.K., Christiansen, P., Chujo, T., Chvala, O., Cianciolo, V., Citron, Z., Cole, B.A., Connors, M., Corliss, R., Corrales Morales, Y., Cronin, N., Crossette, N., Csanád, M., Csörgo, T., d'Orazio, L., Liu, L.D., Dairaku, S., Danley, T.W., Datta, A., Daugherity, M.S., David, G., Dean, C.T., Deblasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E.J., Dharmawardane, K.V., Dietzsch, O., Ding, L., Dion, A., Diss, P.B., Dixit, D., Donadelli, M., Doomra, V., Do, J.H., Drapier, O., Drees, A., Drees, K.A., Dumancic, M., Durham, J.M., Durum, A., Edwards, S., Efremenko, Y.V., Elder, T., En'Yo, H., Engelmore, T., Enokizono, A., Esha, R., Eyser, K.O., Fadem, B., Fan, W., Feege, N., Fields, D.E., Finger, M., Firak, D., Fitzgerald, D., Fleuret, F., Fokin, S.L., Frantz, J.E., Franz, A., Frawley, A.D., Fukao, Y., Fukuda, Y., Fusayasu, T., Gainey, K., Gallus, P., Gal, C., Garg, P., Garishvili, A., Garishvili, I., Ge, H., Giles, M., Giordano, F., Glenn, A., Gong, X., Gonin, M., Goto, Y., Granier de Cassagnac, R., Grau, N., Greene, S.V., Grosse Perdekamp, M., Gunji, T., Guo, L., Guragain, H., Gustafsson, H.-A., Gu, Y., Hachiya, T., Haggerty, J.S., Hahn, K.I., Hamagaki, H., Hamilton, H.F., Hanks, J., Han, S.Y., Harvey, M., Hasegawa, S., Haseler, T.O.S., Hashimoto, K., Haslum, E., Hayano, R., Hemmick, T.K., Hester, T., He, X., Hill, J.C., Hill, K., Hodges, A., Hollis, R.S., Homma, K., Hong, B., Horaguchi, T., Hori, Y., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Iinuma, H., Ikeda, Y., Imai, K., Imazu, Y., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Isinhue, A., Issah, M., Ito, Y., Ivanishchev, D., Jacak, B.V., Javani, M., Jeon, S.J., Jezghani, M., Jiang, X., Ji, Z., Johnson, B.M., Joo, E., Joo, K.S., Jorjadze, V., Jouan, D., Jumper, D.S., Kamin, J., Kanda, S., Kaneti, S., Kang, B.H., Kang, J.H., Kang, J.S., Kapukchyan, D., Kapustinsky, J., Karatsu, K., Karthas, S., Kasai, M., Kawall, D., Kazantsev, A.V., Kempel, T., Key, J.A., Khachatryan, V., Khandai, P.K., Khanzadeev, A., Khatiwada, A., Kihara, K., Kijima, K.M., Kimelman, B., Kim, B.I., Kim, C., Kim, D.H., Kim, D.J., Kim, E.-J., Kim, G.W., Kim, H.-J., Kim, H.J., Kim, K.-B., Kim, M., Kim, M.H., Kim, T., Kim, Y.-J., Kim, Y.K., Kincses, D., Kingan, A., Kinney, E., Kiss, A., Kistenev, E., Kitamura, R., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kofarago, M., Komatsu, Y., Komkov, B., Koster, J., Kotchetkov, D., Kotov, D., Kovacs, L., Krizek, F., Král, A., Kudo, S., Kunde, G.J., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G.S., Lai, Y.S., Lajoie, J.G., Lallow, E.O., Larionova, D., Lebedev, A., Lee, B., Lee, D.M., Lee, G.H., Lee, J., Lee, K.B., Lee, K.S., Lee, S., Lee, S.H., Lee, S.R., Leitch, M.J., Leite, M.A.L., Leitgab, M., Leung, Y.H., Lewis, B., Lewis, N.A., Lim, S.H., Linden Levy, L.A., Liu, M.X., Li, X., Loggins, V.-R., Loomis, D.A., Lovasz, K., Love, B., Lynch, D., Lökös, S., Maguire, C.F., Majoros, T., Makdisi, Y.I., Makek, M., Malaev, M., Manion, A., Manko, V.I., Mannel, E., Masuda, H., Masumoto, S., Mccumber, M., Mcgaughey, P.L., Mcglinchey, D., Mckinney, C., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A.C., Mihalik, D.E., Miller, A.J., Milov, A., Mishra, D.K., Mitchell, J.T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyachi, Y., Miyasaka, S., Mizuno, S., Mohanty, A.K., Mohapatra, S., Mondal, M.M., Montuenga, P., Moon, H.J., Moon, T., Morrison, D.P., Morrow, S.I., Moskowitz, M., Motschwiller, S., Moukhanova, T.V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagae, T., Nagai, K., Nagamiya, S., Nagashima, K., Nagashima, T., Nagle, J.L., Nagy, M.I., Nakagawa, I., Nakagomi, H., Nakamiya, Y., Nakamura, K.R., Nakamura, T., Nakano, K., Nattrass, C., Nederlof, A., Nelson, S., Netrakanti, P.K., Nihashi, M., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novotny, R., Novák, T., Nukazuka, G., Nyanin, A.S., O'Brien, E., Ogilvie, C.A., Oide, H., Okada, K., Orjuela Koop, J.D., Orosz, M., Osborn, J.D., Oskarsson, A., Ottino, G.J., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, B.H., Park, I.H., Park, J.S., Park, S., Park, S.K., Patel, L., Patel, M., Pate, S.F., Pei, H., Peng, J.-C., Peng, W., Pereira, H., Perepelitsa, D.V., Perera, G.D.N., Peressounko, D.Yu., Perezlara, C.E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pinson, R., Pisani, R.P., Potekhin, M., Proissl, M., Pun, A., Purschke, M.L., Qu, H., Radzevich, P.V., Rak, J., Ramasubramanian, N., Ramson, B.J., Ravinovich, I., Read, K.F., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Riveli, N., Roach, D., Roche, G., Rolnick, S.D., Rosati, M., Rowan, Z., Rubin, J.G., Runchey, J., Ryu, M.S., Safonov, A.S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sano, M., Sarsour, M., Sato, K., Sato, S., Sawada, S., Schaefer, B., Schmoll, B.K., Sedgwick, K., Seele, J., Seidl, R., Sekiguchi, Y., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shaver, A., Shein, I., Shibata, M., Shibata, T.-A., Shigaki, K., Shimomura, M., Shioya, T., Shi, Z., Shoji, K., Shukla, P., Sickles, A., Silva, C.L., Silvermyr, D., Sim, K.S., Singh, B.K., Singh, C.P., Singh, V., Skolnik, M., Slunečka, M., Smith, K.L., Snowball, M., Solano, S., Soltz, R.A., Sondheim, W.E., Sorensen, S.P., Sourikova, I.V., Stankus, P.W., Steinberg, P., Stenlund, E., Stepanov, M., Ster, A., Stoll, S.P., Stone, M.R., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Syed, S., Sziklai, J., Takagui, E.M., Takahama, R., Takahara, A., Takeda, A., Taketani, A., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M.J., Tarafdar, S., Taranenko, A., Tarnai, G., Tennant, E., Themann, H., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, L., Tomášek, M., Torii, H., Towell, C.L., Towell, M., Towell, R., Towell, R.S., Tserruya, I., Tsuchimoto, Y., Tsuji, T., Ueda, Y., Ujvari, B., Vale, C., van Hecke, H.W., Vargyas, M., Vazquez-Carson, S., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vossen, A., Vrba, V., Vukman, N., Vznuzdaev, E., Vértesi, R., Wang, X.R., Wang, Z., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y.S., Wei, F., Wei, R., Whitaker, S., White, A.S., White, S.N., Winter, D., Wolin, S., Wong, C.P., Woody, C.L., Wysocki, M., Xia, B., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y.L., Yamamoto, H., Yang, R., Yanovich, A., Ying, J., Yin, P., Yokkaichi, S., Yoon, I., Yoo, J.H., Younus, I., You, Z., Yushmanov, I.E., Yu, H., Zajc, W.A., Zelenski, A., Zhou, S., Zou, L., Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and PHENIX

Subjects
electron, charmonium, Nuclear Theory, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], direct photon, d+au, High Energy Physics::Lattice, energy loss, General Physics and Astronomy, FOS: Physical sciences, quarkonium: production, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], raa, bottom, Nuclear Theory (nucl-th), φ, correlations, jet, heavy quark, heavy flavor, structure, Nuclear Experiment (nucl-ex), Nuclear Experiment, J/Ψ, quark gluon: plasma, modification, qm22, High Energy Physics::Phenomenology, scaling, centrality, matter: effect, PHENIX, thermal photon, nuclear, statistics, small systems, flow, correlation, strange, High Energy Physics::Experiment, hadron, elliptic, π0, charm, p+au, 3he+au
Abstract

PHENIX has performed an extensive study on the evolution of medium effects from small to large systems. PHENIX has continued searching for Quark-Gluon Plasma (QGP) in small systems by measuring collectivity, modification of light hadron and quarkonia production, and jet substructure. In large systems, detailed studies on the property of the QGP have been done using direct photon, $\pi^{0}$-hadron correlation, heavy-flavor electron, and $J/\psi$ flow with a large statistics of data collected in 2014. This report covers new results from the PHENIX experiment in various collision systems., Comment: 9 pages, 8 figures, Quark Matter 2022 proceedings

Published
2022
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16. Study of $ϕ$-meson production in $p$$+$Al, $p$$+$Au, $d$$+$Au, and $^3$He$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Alfred, M., Andrieux, V., Apadula, N., Asano, H., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Cervantes, R., Chen, C. -H., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Corliss, R., Morales, Y. Corrales, Cronin, N., Csanád, M., Csörgő, T., Danley, T. W., Datta, A., Daugherity, M. S., David, G., Dean, C. T., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dion, A., Diss, P. B., Dixit, D., Do, J. H., Doomra, V., Drees, A., Drees, K. A., Durham, J. M., Durum, A., En'yo, H., Enokizono, A., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gallus, P., Gal, C., Garg, P., Ge, H., Giles, M., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Harvey, M., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Hemmick, T. K., He, X., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Imai, K., Inaba, M., Iordanova, A., Isenhower, D., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Jouan, D., Jumper, D. S., Kanda, S., Kang, J. H., Kapukchyan, D., Karthas, S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kimelman, B., Kim, C., Kim, D. J., Kim, E. -J., Kim, G. W., Kim, M., Kim, T., Kincses, D., Kingan, A., Kistenev, E., Kitamura, R., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Komkov, B., Kotov, D., Kovacs, L., Kudo, S., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lajoie, J. G., Larionova, D., Lebedev, A., Lee, S., Lee, S. H., Leitch, M. J., Leung, Y. H., Lewis, N. A., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Loomis, D. A., Lovasz, K., Lynch, D., Lökös, S., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mohamed, A., Mohanty, A. K., Mondal, M. M., Montuenga, P., Moon, T., Morrison, D. P., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagai, K., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Patel, M., Pate, S. F., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pinson, R., Pisani, R. P., Potekhin, M., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ramson, B. J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Safonov, A. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shi, Z., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takahama, R., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Towell, C. L., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Wang, X. R., Wang, Z., Watanabe, Y., Watanabe, Y. S., Wei, F., White, A. S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yoon, I., Yoo, J. H., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., Zhou, S., and Zou, L.

Subjects
High Energy Physics - Experiment (hep-ex), Nuclear Theory, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Small nuclear collisions are mainly sensitive to cold-nuclear-matter effects; however, the collective behavior observed in these collisions shows a hint of hot-nuclear-matter effects. The identified-particle spectra, especially the $ϕ$ mesons which contain strange and antistrange quarks and have a relatively small hadronic-interaction cross section, are a good tool to study these effects. The PHENIX experiment has measured $ϕ$ mesons in a specific set of small collision systems $p$$+$Al, $p$$+$Au, and $^3$He$+$Au, as well as $d$$+$Au [Phys. Rev. C {\bf 83}, 024909 (2011)], at $\sqrt{s_{_{NN}}}=200$ GeV. The transverse-momentum spectra and nuclear-modification factors are presented and compared to theoretical-model predictions. The comparisons with different calculations suggest that quark-gluon plasma may be formed in these small collision systems at $\sqrt{s_{_{NN}}}=200$ GeV. However, the volume and the lifetime of the produced medium may be insufficient for observing strangeness-enhancement and jet-quenching effects. Comparison with calculations suggests that the main production mechanisms of $ϕ$ mesons at midrapidity may be different in $p$$+$Al versus $p/d/$$^3$He$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. While thermal quark recombination seems to dominate in $p/d/$$^3$He$+$Au collisions, fragmentation seems to be the main production mechanism in $p$$+$Al collisions., 371 authors from 72 institutions, 13 pages, 7 figures, 7 tables, 2014 and 2015 data. v2 is version accepted for publication Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2022
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17. Measurements of second-harmonic Fourier coefficients from azimuthal anisotropies in $p$$+$$p$, $p$$+$Au, $d$$+$Au, and $^3$He$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV

Author

Abdulameer, N. J., Acharya, U., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Alfred, M., Andrieux, V., Aoki, K., Apadula, N., Asano, H., Ayuso, C., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Boer, M., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Butler, C., Campbell, S., Roman, V. Canoa, Cervantes, R., Chen, C. -H., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Corliss, R., Morales, Y. Corrales, Cronin, N., Csanád, M., Csörgő, T., Liu, L. D., Danley, T. W., Datta, A., Daugherity, M. S., David, G., Dean, C. T., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dion, A., Diss, P. B., Dixit, D., Doomra, V., Do, J. H., Drees, A., Drees, K. A., Dumancic, M., Durham, J. M., Durum, A., Elder, T., En'yo, H., Enokizono, A., Esha, R., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Firak, D., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gallus, P., Gal, C., Garg, P., Ge, H., Giles, M., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Harvey, M., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Hemmick, T. K., He, X., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Imai, K., Imrek, J., Inaba, M., Iordanova, A., Isenhower, D., Ito, Y., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Jorjadze, V., Jouan, D., Jumper, D. S., Kanda, S., Kang, J. H., Kapukchyan, D., Karthas, S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kimelman, B., Kim, C., Kim, D. J., Kim, E. -J., Kim, G. W., Kim, M., Kim, M. H., Kim, T., Kincses, D., Kingan, A., Kistenev, E., Kitamura, R., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Komkov, B., Kotov, D., Kovacs, L., Kudo, S., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lajoie, J. G., Lallow, E. O., Larionova, D., Lebedev, A., Lee, S., Lee, S. H., Leitch, M. J., Leung, Y. H., Lewis, N. A., Lim, S. H., Liu, M. X., Li, X., Loggins, V. -R., Loomis, D. A., Lovasz, K., Lynch, D., Lökös, S., Majoros, T., Makdisi, Y. I., Makek, M., Malaev, M., Manion, A., Manko, V. I., Mannel, E., Masuda, H., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Mignerey, A. C., Mihalik, D. E., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mohanty, A. K., Mondal, M. M., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I., Moukhanova, T. V., Muhammad, A., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagai, K., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novotny, R., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Oh, J., Koop, J. D. Orjuela, Orosz, M., Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Patel, M., Pate, S. F., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pinson, R., Pisani, R. P., Potekhin, M., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ramson, B. J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Safonov, A. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, K., Sato, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, M., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shi, Z., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Syed, S., Sziklai, J., Takahama, R., Takeda, A., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Towell, C. L., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Vazquez-Carson, S., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Wang, X. R., Wang, Z., Watanabe, Y., Watanabe, Y. S., Wei, F., White, A. S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yin, P., Yoon, I., Yoo, J. H., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., Zhou, S., and Zou, L.

Subjects
FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Recently, the PHENIX Collaboration has published second- and third-harmonic Fourier coefficients $v_2$ and $v_3$ for midrapidity ($|η, 393 authors from 72 institutions, 14 pages, 10 figures, 2014, 2015, and 2016 data. v2 is version accepted for publication in Physical Review C. HEPdata tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2022
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18. Charm- and Bottom-Quark Production in Au$+$Au Collisions at $\sqrt{s_{_{NN}}}$ = 200 GeV

Author

Acharya, U. A., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Alfred, M., Apadula, N., Asano, H., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Bichon, L., Blankenship, B., Blau, D. S., Bok, J. S., Borisov, V., Boyle, K., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Chen, C. -H., Chiu, M., Chi, C. Y., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Corliss, R., Morales, Y. Corrales, Csanád, M., Csörgő, T., Danley, T. W., Datta, A., Daugherity, M. S., David, G., Dean, C. T., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dion, A., Diss, P. B., Do, J. H., Doomra, V., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Enokizono, A., Esha, R., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, Jr., M., Finger, M., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Gallus, P., Gal, C., Garg, P., Ge, H., Giles, M., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Hanks, J., Han, S. Y., Harvey, M., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., Hemmick, T. K., He, X., Hill, J. C., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Imai, K., Inaba, M., Iordanova, A., Isenhower, D., Ivanishchev, D., Jacak, B. V., Jezghani, M., Jiang, X., Ji, Z., Johnson, B. M., Jouan, D., Jumper, D. S., Kanda, S., Kang, J. H., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kimelman, B., Kim, C., Kim, D. J., Kim, E. -J., Kim, G. W., Kim, M., Kim, T., Kincses, D., Kingan, A., Kistenev, E., Kitamura, R., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Komkov, B., Kotov, D., Kovacs, L., Kurita, K., Kurosawa, M., Kwon, Y., Lajoie, J. G., Larionova, D., Lebedev, A., Lee, S., Lee, S. H., Leitch, M. J., Lewis, N. A., Lim, S. H., Liu, M. X., Li, X., Loomis, D. A., Lynch, D., Lökös, S., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Mignerey, A. C., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankova, M., Mitrankov, Iu., Miyasaka, S., Mizuno, S., Mohanty, A. K., Mondal, M. M., Montuenga, P., Moon, T., Morrison, D. P., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagashima, K., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Niida, T., Nishimura, S., Nouicer, R., Novitzky, N., Novák, T., Nukazuka, G., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Patel, M., Pate, S. F., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Pinkenburg, C., Pinson, R., Pisani, R. P., Potekhin, M., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ramson, B. J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Slunečka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tieulent, R., Timilsina, A., Todoroki, T., Tomášek, M., Towell, C. L., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Velkovska, J., Virius, M., Vrba, V., Wang, X. R., Watanabe, Y., Watanabe, Y. S., Wei, F., White, A. S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yanovich, A., Yoon, I., Yoo, J. H., Yushmanov, I. E., Yu, H., Zajc, W. A., Zelenski, A., Zhou, S., and Zou, L.

Subjects
High Energy Physics::Lattice, Nuclear Theory, High Energy Physics::Phenomenology, FOS: Physical sciences, High Energy Physics::Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

The invariant yield of electrons from open-heavy-flavor decays for $1, Comment: 335 authors from 71 institutions, 16 pages, 17 figures, 2014 data. Submitted to Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2022
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19. Global mapping of the energetic and allosteric landscapes of protein binding domains

Author

Guillaume Diss, Jörn M. Schmiedel, Júlia Domingo, Ben Lehner, Andre J. Faure, and Cristina Hidalgo-Carcedo

Subjects
Chemistry, PDZ domain, Allosteric regulation, Mutagenesis (molecular biology technique), Plasma protein binding, Computational biology, Biological regulation, Protein secondary structure, Phenotype, SH3 domain
Abstract

Allosteric communication between distant sites in proteins is central to nearly all biological regulation but still poorly characterised for most proteins, limiting conceptual understanding, biological engineering and allosteric drug development. Typically only a few allosteric sites are known in model proteins, but theoretical, evolutionary and some experimental studies suggest they may be much more widely distributed. An important reason why allostery remains poorly characterised is the lack of methods to systematically quantify long-range communication in diverse proteins. Here we address this shortcoming by developing a method that uses deep mutational scanning to comprehensively map the allosteric landscapes of protein interaction domains. The key concept of the approach is the use of ‘multidimensional mutagenesis’: mutational effects are quantified for multiple molecular phenotypes—here binding and protein abundance—and in multiple genetic backgrounds. This is an efficient experimental design that allows the underlying causal biophysical effects of mutations to be accurately inferred en masse by fitting thermodynamic models using neural networks. We apply the approach to two of the most common human protein interaction domains, an SH3 domain and a PDZ domain, to produce the first global atlases of allosteric mutations for any proteins. Allosteric mutations are widely dispersed with extensive long-range tuning of binding affinity and a large mutational target space of network-altering ‘edgetic’ variants. Mutations are more likely to be allosteric closer to binding interfaces, at Glycines in secondary structure elements and at particular sites including a chain of residues connecting to an opposite surface in the PDZ domain. This general approach of quantifying mutational effects for multiple molecular phenotypes and in multiple genetic backgrounds should allow the energetic and allosteric landscapes of many proteins to be rapidly and comprehensively mapped.

Published
2021

20. Sport Psychology Consultants’ Perspectives on Facilitating Sport-Injury-Related Growth

Author

Kylie Roy-Davis, Karen Howells, Ceri Diss, Ross Wadey, Lynne Evans, and Jade Salim

Subjects
biology, Athletes, 05 social sciences, Applied psychology, Level of functioning, Professional practice, 030229 sport sciences, biology.organism_classification, Sport psychology, Experiential learning, 050105 experimental psychology, 03 medical and health sciences, 0302 clinical medicine, Mental stress, 0501 psychology and cognitive sciences, Generalizability theory, Psychology, Applied Psychology, Storytelling
Abstract

Despite recent conceptual, methodological, and theoretical advancements on sport injury-related 26 growth (SIRG), there is no research on sport psychology consultants’ (SPCs) experiential 27 knowledge of working with injured athletes to promote SIRG. Toward this end, this study examined 28 SPCs’ perspectives on facilitating SIRG to provide an evidence-base for professional practice. 29 Participants were purposefully sampled (4 females, 6 males; Mean of 19 years’ applied experience) 30 and interviewed. Transcripts were thematically analyzed. Methodological rigor and generalizability 31 were maximized through self-reflexivity and eliciting external reflections. Five themes were 32 identified: Hear the Story, Contextualize the Story, Reconstruct the Story, Live the Story, and Share 33 the Story. Findings offer practitioners a novel approach to working with injured athletes. Rather than 34 focusing on returning to preinjury level of functioning, the findings illustrate how SPCs can work 35 with injured athletes to help transform injury into an opportunity to bring about positive change.

Published
2019

21. Region specific differences in the effect of propofol on the murine colon result in dysmotility

Author

Bhavik Anil Patel, Mark Yeoman, Shannon Villeneuve, Kim R. Pearce, and Lucy B. Diss

Subjects
Male, Colon, Sedation, Motility, Pharmacology, Nitric Oxide, Nitric oxide, Tissue Culture Techniques, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Region specific, medicine, Animals, Proximal colon, Propofol, biology, Endocrine and Autonomic Systems, business.industry, digestive system diseases, Mice, Inbred C57BL, Nitric oxide synthase, chemistry, biology.protein, Neurology (clinical), Distal colon, medicine.symptom, Gastrointestinal Motility, business, Anesthetics, Intravenous, 030217 neurology & neurosurgery, medicine.drug
Abstract

Propofol is the most widely used intravenous anaesthetic agent for maintenance of anaesthesia and sedation. Studies in varying regions of the bowel have shown conflicting differences on the effects of propofol on motility. There the aim of this study was to understand the influence of propofol on colonic function and explore by which mechanism any changes occur. Functional studies were conducted using isolated colonic tissue from C57BL6 mice which were exposed to 5 μM propofol. Faecal pellet motility, colonic migratory motor complexes (CMMCs) and functional bioassays were utilised to monitor colonic function and nitric oxide production was monitored by amperometry. There was a signficant reduction in amplitude of CMMCs in the distal colon in the presence of 5 μM propofol, however no difference was observed in the proximal colon. A signficant increase in the 5-HT evoked contractions were observed in distal colon in the presence of 5 μM propofol. Additionally, a reduction in the NO production in the presence of 5 μM propofol was only observed in the distal colon. As a result, in the presence of 5 μM propofol, faecal pellet transit was increased, and velocity was reduced. At clinically relevant doses, propofol was shown to reduce colonic motility by inhibiting nitric oxide synthase in only the distal region of the colon. Our findings indicate that propofol has a considerable influence on colonic signalling mechanisms and impairs colonic motility, which may have implications in its clinical use especially for maintenance.

Published
2019

22. Resolution of a Complex Type IIb Endoleak with the Use of Translumbar Direct Injection of Precipitating Hydrophobic Injectable Liquid

Author

Zaid Aldin and James K Diss

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Resolution (electron density), Complex type, medicine.disease, Aortic aneurysm, Text mining, Blood vessel prosthesis, medicine, Intra arterial, Radiology, Nuclear Medicine and imaging, Radiology, Embolization, Cardiology and Cardiovascular Medicine, business, Abdominal surgery
Published
2019

23. PHENIX Collaboration

Author

A. Adare, S. Afanasiev, C. Aidala, N.N. Ajitanand, Y. Akiba, R. Akimoto, H. Al-Bataineh, J. Alexander, M. Alfred, A. Al-Jamel, H. Al-Ta'ani, K.R. Andrews, V. Andrieux, A. Angerami, K. Aoki, N. Apadula, L. Aphecetche, E. Appelt, Y. Aramaki, R. Armendariz, S.H. Aronson, J. Asai, H. Asano, E.C. Aschenauer, E.T. Atomssa, R. Averbeck, T.C. Awes, C. Ayuso, B. Azmoun, V. Babintsev, A. Bagoly, M. Bai, X. Bai, G. Baksay, L. Baksay, A. Baldisseri, N.S. Bandara, B. Bannier, K.N. Barish, P.D. Barnes, B. Bassalleck, A.T. Basye, S. Bathe, S. Batsouli, V. Baublis, F. Bauer, C. Baumann, S. Baumgart, A. Bazilevsky, M. Beaumier, S. Beckman, S. Belikov, R. Belmont, J. Ben-Benjamin, R. Bennett, A. Berdnikov, Y. Berdnikov, J.H. Bhom, A.A. Bickley, M.T. Bjorndal, D. Black, D.S. Blau, M. Boer, J.G. Boissevain, J.S. Bok, H. Borel, K. Boyle, M.L. Brooks, D.S. Brown, D. Broxmeyer, J. Bryslawskyj, D. Bucher, H. Buesching, V. Bumazhnov, G. Bunce, J.M. Burward-Hoy, C. Butler, S. Butsyk, C.M. Camacho, S. Campbell, V. Canoa Roman, A. Caringi, P. Castera, R. Cervantes, J.-S. Chai, B.S. Chang, W.C. Chang, J.-L. Charvet, C.-H. Chen, S. Chernichenko, C.Y. Chi, J. Chiba, M. Chiu, I.J. Choi, J.B. Choi, S. Choi, R.K. Choudhury, P. Christiansen, T. Chujo, P. Chung, A. Churyn, O. Chvala, V. Cianciolo, Z. Citron, C.R. Cleven, Y. Cobigo, B.A. Cole, M.P. Comets, Z. Conesa del Valle, M. Connors, P. Constantin, N. Cronin, N. Crossette, M. Csanád, T. Csörgő, T. Dahms, S. Dairaku, I. Danchev, T.W. Danley, K. Das, A. Datta, M.S. Daugherity, G. David, M.K. Dayananda, M.B. Deaton, K. DeBlasio, K. Dehmelt, H. Delagrange, A. Denisov, D. d'Enterria, A. Deshpande, E.J. Desmond, K.V. Dharmawardane, O. Dietzsch, L. Ding, A. Dion, P.B. Diss, D. Dixit, J.H. Do, M. Donadelli, L. D'Orazio, J.L. Drachenberg, O. Drapier, A. Drees, K.A. Drees, A.K. Dubey, M. Dumancic, J.M. Durham, A. Durum, D. Dutta, V. Dzhordzhadze, S. Edwards, Y.V. Efremenko, J. Egdemir, T. Elder, F. Ellinghaus, W.S. Emam, T. Engelmore, A. Enokizono, H. En'yo, B. Espagnon, S. Esumi, K.O. Eyser, B. Fadem, W. Fan, N. Feege, D.E. Fields, M. Finger, F. Fleuret, S.L. Fokin, B. Forestier, Z. Fraenkel, J.E. Frantz, A. Franz, A.D. Frawley, K. Fujiwara, Y. Fukao, Y. Fukuda, S.-Y. Fung, T. Fusayasu, S. Gadrat, K. Gainey, C. Gal, P. Gallus, P. Garg, A. Garishvili, I. Garishvili, F. Gastineau, H. Ge, M. Germain, F. Giordano, A. Glenn, H. Gong, X. Gong, M. Gonin, J. Gosset, Y. Goto, R. Granier de Cassagnac, N. Grau, S.V. Greene, G. Grim, M. Grosse Perdekamp, Y. Gu, T. Gunji, L. Guo, H. Guragain, H.-Å. Gustafsson, T. Hachiya, A. Hadj Henni, C. Haegemann, J.S. Haggerty, M.N. Hagiwara, K.I. Hahn, H. Hamagaki, J. Hamblen, H.F. Hamilton, R. Han, S.Y. Han, J. Hanks, H. Harada, C. Harper, E.P. Hartouni, K. Haruna, M. Harvey, S. Hasegawa, T.O.S. Haseler, K. Hashimoto, E. Haslum, K. Hasuko, R. Hayano, S. Hayashi, X. He, M. Heffner, T.K. Hemmick, T. Hester, J.M. Heuser, H. Hiejima, J.C. Hill, K. Hill, R. Hobbs, M. Hohlmann, R.S. Hollis, M. Holmes, W. Holzmann, K. Homma, B. Hong, T. Horaguchi, Y. Hori, D. Hornback, T. Hoshino, N. Hotvedt, J. Huang, S. Huang, M.G. Hur, T. Ichihara, R. Ichimiya, J. Ide, H. Iinuma, Y. Ikeda, K. Imai, Y. Imazu, J. Imrek, M. Inaba, Y. Inoue, A. Iordanova, D. Isenhower, L. Isenhower, M. Ishihara, A. Isinhue, T. Isobe, M. Issah, A. Isupov, Y. Ito, D. Ivanishchev, Y. Iwanaga, B.V. Jacak, M. Javani, S.J. Jeon, M. Jezghani, Z. Ji, J. Jia, X. Jiang, J. Jin, O. Jinnouchi, D. John, B.M. Johnson, T. Jones, E. Joo, K.S. Joo, V. Jorjadze, D. Jouan, D.S. Jumper, F. Kajihara, S. Kametani, N. Kamihara, J. Kamin, S. Kanda, M. Kaneta, S. Kaneti, B.H. Kang, J.H. Kang, J.S. Kang, H. Kanou, D. Kapukchyan, J. Kapustinsky, K. Karatsu, S. Karthas, M. Kasai, T. Kawagishi, D. Kawall, M. Kawashima, A.V. Kazantsev, S. Kelly, T. Kempel, J.A. Key, V. Khachatryan, P.K. Khandai, A. Khanzadeev, K. Kihara, K.M. Kijima, J. Kikuchi, A. Kim, B.I. Kim, C. Kim, D.H. Kim, D.J. Kim, E. Kim, E.-J. Kim, G.W. Kim, H.-J. Kim, H.J. Kim, K.-B. Kim, M. Kim, M.H. Kim, S.H. Kim, Y.-J. Kim, Y.K. Kim, Y.-S. Kim, B. Kimelman, D. Kincses, E. Kinney, K. Kiriluk, Á. Kiss, E. Kistenev, R. Kitamura, A. Kiyomichi, J. Klatsky, J. Klay, C. Klein-Boesing, D. Kleinjan, P. Kline, T. Koblesky, L. Kochenda, V. Kochetkov, M. Kofarago, Y. Komatsu, B. Komkov, M. Konno, J. Koster, D. Kotchetkov, D. Kotov, A. Kozlov, A. Král, A. Kravitz, F. Krizek, P.J. Kroon, J. Kubart, S. Kudo, G.J. Kunde, N. Kurihara, K. Kurita, M. Kurosawa, M.J. Kweon, Y. Kwon, G.S. Kyle, R. Lacey, Y.S. Lai, J.G. Lajoie, E.O. Lallow, D. Layton, A. Lebedev, Y. Le Bornec, S. Leckey, B. Lee, D.M. Lee, G.H. Lee, J. Lee, K. Lee, K.B. Lee, K.S. Lee, M.K. Lee, S. Lee, S.H. Lee, S.R. Lee, T. Lee, M.J. Leitch, M.A.L. Leite, M. Leitgab, E. Leitner, B. Lenzi, Y.H. Leung, B. Lewis, N.A. Lewis, X. Li, X.H. Li, P. Lichtenwalner, P. Liebing, H. Lim, S.H. Lim, L.A. Linden Levy, T. Liška, A. Litvinenko, H. Liu, L.D. Liu, M.X. Liu, V.-R. Loggins, S. Lokos, K. Lovasz, B. Love, R. Luechtenborg, D. Lynch, C.F. Maguire, T. Majoros, Y.I. Makdisi, M. Makek, M. Malaev, A. Malakhov, M.D. Malik, A. Manion, V.I. Manko, E. Mannel, Y. Mao, L. Mašek, H. Masuda, H. Masui, S. Masumoto, F. Matathias, M.C. McCain, M. McCumber, P.L. McGaughey, D. McGlinchey, C. McKinney, N. Means, A. Meles, M. Mendoza, B. Meredith, W.J. Metzger, Y. Miake, T. Mibe, J. Midori, A.C. Mignerey, D.E. Mihalik, P. Mikeš, K. Miki, A.J. Miller, T.E. Miller, A. Milov, S. Mioduszewski, D.K. Mishra, G.C. Mishra, M. Mishra, J.T. Mitchell, M. Mitrovski, G. Mitsuka, Y. Miyachi, S. Miyasaka, S. Mizuno, A.K. Mohanty, S. Mohapatra, P. Montuenga, H.J. Moon, T. Moon, Y. Morino, A. Morreale, D.P. Morrison, S.I.M. Morrow, M. Moskowitz, J.M. Moss, S. Motschwiller, T.V. Moukhanova, D. Mukhopadhyay, T. Murakami, J. Murata, A. Mwai, T. Nagae, K. Nagai, S. Nagamiya, K. Nagashima, T. Nagashima, Y. Nagata, J.L. Nagle, M. Naglis, M.I. Nagy, I. Nakagawa, H. Nakagomi, Y. Nakamiya, K.R. Nakamura, T. Nakamura, K. Nakano, S. Nam, C. Nattrass, A. Nederlof, P.K. Netrakanti, J. Newby, M. Nguyen, M. Nihashi, T. Niida, S. Nishimura, B.E. Norman, R. Nouicer, T. Novák, N. Novitzky, R. Novotny, A. Nukariya, A.S. Nyanin, J. Nystrand, C. Oakley, H. Obayashi, E. O'Brien, S.X. Oda, C.A. Ogilvie, H. Ohnishi, H. Oide, I.D. Ojha, M. Oka, K. Okada, O.O. Omiwade, Y. Onuki, J.D. Orjuela Koop, J.D. Osborn, A. Oskarsson, I. Otterlund, G.J. Ottino, M. Ouchida, K. Ozawa, R. Pak, D. Pal, A.P.T. Palounek, V. Pantuev, V. Papavassiliou, B.H. Park, I.H. Park, J. Park, J.S. Park, S. Park, S.K. Park, W.J. Park, S.F. Pate, L. Patel, M. Patel, H. Pei, J.-C. Peng, W. Peng, H. Pereira, D.V. Perepelitsa, G.D.N. Perera, V. Peresedov, D.Yu. Peressounko, C.E. PerezLara, J. Perry, R. Petti, M. Phipps, C. Pinkenburg, R. Pinson, R.P. Pisani, M. Proissl, A. Pun, M.L. Purschke, A.K. Purwar, H. Qu, P.V. Radzevich, J. Rak, A. Rakotozafindrabe, B.J. Ramson, I. Ravinovich, K.F. Read, S. Rembeczki, M. Reuter, K. Reygers, D. Reynolds, V. Riabov, Y. Riabov, E. Richardson, D. Richford, T. Rinn, N. Riveli, D. Roach, G. Roche, S.D. Rolnick, A. Romana, M. Rosati, C.A. Rosen, S.S.E. Rosendahl, P. Rosnet, Z. Rowan, J.G. Rubin, P. Rukoyatkin, J. Runchey, P. Ružička, V.L. Rykov, M.S. Ryu, S.S. Ryu, A.S. Safonov, B. Sahlmueller, N. Saito, T. Sakaguchi, S. Sakai, K. Sakashita, H. Sakata, H. Sako, V. Samsonov, M. Sano, S. Sano, M. Sarsour, H.D. Sato, K. Sato, S. Sato, T. Sato, M. Savastio, S. Sawada, B. Schaefer, B.K. Schmoll, K. Sedgwick, J. Seele, R. Seidl, Y. Sekiguchi, A.Yu. Semenov, V. Semenov, A. Sen, R. Seto, P. Sett, A. Sexton, D. Sharma, A. Shaver, T.K. Shea, I. Shein, A. Shevel, T.-A. Shibata, K. Shigaki, H.H. Shim, M. Shimomura, T. Shioya, T. Shohjoh, K. Shoji, P. Shukla, A. Sickles, C.L. Silva, D. Silvermyr, C. Silvestre, K.S. Sim, B.K. Singh, C.P. Singh, V. Singh, M.J. Skoby, M. Skolnik, S. Skutnik, M. Slunečka, K.L. Smith, W.C. Smith, M. Snowball, T. Sodre, S. Solano, A. Soldatov, R.A. Soltz, W.E. Sondheim, S.P. Sorensen, I.V. Sourikova, N.A. Sparks, F. Staley, P.W. Stankus, P. Steinberg, E. Stenlund, M. Stepanov, A. Ster, S.P. Stoll, M.R. Stone, T. Sugitate, C. Suire, A. Sukhanov, J.P. Sullivan, T. Sumita, J. Sun, S. Syed, J. Sziklai, T. Tabaru, S. Takagi, E.M. Takagui, A. Takahara, A. Takeda, A. Taketani, R. Tanabe, K.H. Tanaka, Y. Tanaka, S. Taneja, K. Tanida, M.J. Tannenbaum, S. Tarafdar, A. Taranenko, P. Tarján, G. Tarnai, E. Tennant, H. Themann, D. Thomas, T.L. Thomas, R. Tieulent, A. Timilsina, T. Todoroki, M. Togawa, A. Toia, J. Tojo, L. Tomášek, M. Tomášek, Y. Tomita, H. Torii, C.L. Towell, M. Towell, R. Towell, R.S. Towell, V.-N. Tram, I. Tserruya, Y. Tsuchimoto, T. Tsuji, S.K. Tuli, H. Tydesjö, N. Tyurin, Y. Ueda, B. Ujvari, K. Utsunomiya, C. Vale, H. Valle, H.W. van Hecke, M. Vargyas, S. Vazquez-Carson, E. Vazquez-Zambrano, A. Veicht, J. Velkovska, R. Vértesi, A.A. Vinogradov, M. Virius, B. Voas, A. Vossen, V. Vrba, N. Vukman, E. Vznuzdaev, M. Wagner, D. Walker, X.R. Wang, Z. Wang, D. Watanabe, K. Watanabe, Y. Watanabe, Y.S. Watanabe, F. Wei, R. Wei, J. Wessels, S. Whitaker, A.S. White, S.N. White, N. Willis, D. Winter, S. Wolin, C.P. Wong, J.P. Wood, C.L. Woody, R.M. Wright, M. Wysocki, B. Xia, W. Xie, C. Xu, Q. Xu, L. Xue, S. Yalcin, Y.L. Yamaguchi, H. Yamamoto, K. Yamaura, R. Yang, A. Yanovich, Z. Yasin, P. Yin, J. Ying, S. Yokkaichi, J.H. Yoo, J.S. Yoo, I. Yoon, Z. You, G.R. Young, I. Younus, H. Yu, I.E. Yushmanov, W.A. Zajc, O. Zaudtke, A. Zelenski, C. Zhang, S. Zharko, S. Zhou, J. Zimamyi, L. Zolin, and L. Zou

Subjects
Nuclear and High Energy Physics
Published
2019

24. Inoculative Releases and Natural Spread of the Fungal Pathogen Entomophaga maimaiga (Entomophthorales: Entomophthoraceae) into U.S. Populations of Gypsy Moth, Lymantria dispar (Lepidoptera: Erebidae)

Author

Andrea Diss-Torrance, Ann E. Hajek, Nathan W. Siegert, and Andrew M. Liebhold

Subjects
0106 biological sciences, Biological pest control, Zoology, Moths, 010603 evolutionary biology, 01 natural sciences, Lepidoptera genitalia, Lymantria dispar, medicine, Animals, Ecology, Evolution, Behavior and Systematics, Epizootic, Entomophaga maimaiga, Ecology, biology, fungi, Outbreak, biology.organism_classification, Gypsy moth, medicine.disease, Entomophthorales, 010602 entomology, Insect Science, Larva, Seasons
Abstract

While emphasis with entomopathogens has often been on inundative releases, we describe here historic widespread inoculative releases of a fungal entomopathogen. Several U.S. states and municipalities conducted inoculative releases of the gypsy moth, Lymantria dispar (L.) (Lepidoptera: Erebidae), pathogen Entomophaga maimaiga Humber, Shimazu et Soper (Entomophthorales: Entomophthoraceae) after 1993, as gypsy moth populations spread into the Midwest and North Carolina. This Japanese pathogen first caused epizootics in northeastern North America in 1989 and methods for its inoculative release were tested and proven to be effective from 1991 to 1993. After 1993, spores in soil or in late instar cadavers were collected during or after epizootics and were released inoculatively into newly established populations of this spreading invasive; the goal was that spores would overwinter and germinate the next spring to infect larvae, thus speeding pathogen spread and hastening the development of epizootics in newly established populations. The fungus was released in gypsy moth populations that were separated from areas where the fungus was already established. In particular, extensive releases by natural resource managers in Wisconsin and Michigan aided the spread of E. maimaiga throughout these states. Where it has become established, this acute pathogen has become the dominant natural enemy and has exerted considerable influence in reducing gypsy moth damage. While this pathogen most likely would have invaded these new regions eventually, releases accelerated the spread of E. maimaiga and helped to reduce impacts of initial outbreaks, while further outbreaks were reduced by the pathogen’s subsequent persistence and activity in those areas.

Published
2021

26. The Polymycovirus-Mediated Growth Enhancement of the Entomopathogenic Fungus Beauveria bassiana Is Dependent on Carbon and Nitrogen Metabolism

Author

Rebecca M Diss, Ioly Kotta-Loizou, Robert H.A. Coutts, John O Daudu, and Charalampos Filippou

Subjects
Microbiology (medical), Fungal growth, fungal sporulation, lcsh:QR1-502, chemistry.chemical_element, Beauveria bassiana, fungal growth, Microbiology, lcsh:Microbiology, 03 medical and health sciences, mycovirus, Botany, 0502 Environmental Science and Management, 0503 Soil Sciences, Nitrogen cycle, 030304 developmental biology, 0303 health sciences, biology, 030306 microbiology, Creative commons, Polymycoviridae, biology.organism_classification, chemistry, Entomopathogenic fungus, Mycovirus, Carbon, 0605 Microbiology
Abstract

Polymycoviridae is a growing family of mycoviruses whose members typically have non-conventional capsids and multi-segmented, double-stranded (ds) RNA genomes. Beauveria bassiana polymycovirus (BbPmV) 1 is known to enhance the growth and virulence of its fungal host, the entomopathogenic ascomycete and popular biological control agent B. bassiana. Here we report the complete sequence of BbPmV-3, which has six genomic dsRNA segments. Phylogenetic analysis of RNA-dependent RNA polymerase (RdRp) protein sequences revealed that BbPmV-3 is closely related to the partially sequenced BbPmV-2 but not BbPmV-1. Nevertheless, both BbPmV-3 and BbPmV-1 have similar effects on their respective host isolates ATHUM 4946 and EABb 92/11-Dm, affecting pigmentation, sporulation, and radial growth. Production of conidia and radial growth are significantly enhanced in virus-infected isolates as compared to virus-free isogenic lines on Czapek-Dox complete and minimal media that contain sucrose and sodium nitrate. However, this polymycovirus-mediated effect on growth is dependent on the carbon and nitrogen sources available to the host fungus. Both BbPmV-3 and BbPmV-1 increase growth of ATHUM 4946 and EABb 92/11-Dm when sucrose is replaced by lactose, trehalose, glucose, or glycerol, while the effect is reversed on maltose and fructose. Similarly, both BbPmV-3 and BbPmV-1 decrease growth of ATHUM 4946 and EABb 92/11-Dm when sodium nitrate is replaced by sodium nitrite, potassium nitrate, or ammonium nitrate. In conclusion, the effects of polymycoviruses on B. bassiana are at least partially mediated via its metabolic pathways.

Published
2021

27. Expression attenuation as a mechanism of robustness against gene duplication

Author

Christian R. Landry, Isabelle Gagnon-Arsenault, Diana Ascencio, Alexander DeLuna, Guillaume Diss, and Alexandre K. Dubé

Subjects
Proteasome Endopeptidase Complex, Evolution, Biology, 03 medical and health sciences, 0302 clinical medicine, Gene Expression Regulation, Fungal, Gene duplication, Gene expression, dosage balance hypothesis, Protein Interaction Maps, protein interaction, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Multidisciplinary, Genes, Essential, Mechanism (biology), gene duplication, Robustness (evolution), Biological Sciences, Phenotype, Protein Subunits, Proteasome, fitness effects, Saccharomycetales, gene expression, Fitness effects, Genetic Fitness, 030217 neurology & neurosurgery
Abstract

Significance Many studies have focused on the mechanisms of long-term retention of gene duplicates, such as the gain of functions or reciprocal losses. However, such changes are more likely to occur if the duplicates are maintained for a long period. This time span will be short if duplication is immediately deleterious. We measured the distribution of fitness effects of gene duplication for 899 genes in budding yeast. We find that gene duplication is more likely to be deleterious than beneficial. However, contrary to previous models, in general, gene duplication does not affect fitness by altering the organization of protein complexes. We show that expression attenuation may protect complexes from the effects of gene duplication., Gene duplication is ubiquitous and a major driver of phenotypic diversity across the tree of life, but its immediate consequences are not fully understood. Deleterious effects would decrease the probability of retention of duplicates and prevent their contribution to long-term evolution. One possible detrimental effect of duplication is the perturbation of the stoichiometry of protein complexes. Here, we measured the fitness effects of the duplication of 899 essential genes in the budding yeast using high-resolution competition assays. At least 10% of genes caused a fitness disadvantage when duplicated. Intriguingly, the duplication of most protein complex subunits had small to nondetectable effects on fitness, with few exceptions. We selected four complexes with subunits that had an impact on fitness when duplicated and measured the impact of individual gene duplications on their protein–protein interactions. We found that very few duplications affect both fitness and interactions. Furthermore, large complexes such as the 26S proteasome are protected from gene duplication by attenuation of protein abundance. Regulatory mechanisms that maintain the stoichiometric balance of protein complexes may protect from the immediate effects of gene duplication. Our results show that a better understanding of protein regulation and assembly in complexes is required for the refinement of current models of gene duplication.

Published
2021

28. Systematic study of nuclear effects in $p$$+$Al, $p$$+$Au, $d$$+$Au, and $^{3}$He$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV using $π^0$ production

Author

Acharya, U.A., Adare, A., Aidala, C., Ajitanand, N.N., Akiba, Y., Al-Bataineh, H., Alexander, J., Alfred, M., Andrieux, V., Angerami, A., Aoki, K., Apadula, N., Aramaki, Y., Asano, H., Atomssa, E.T., Averbeck, R., Awes, T.C., Azmoun, B., Babintsev, V., Bai, M., Baksay, G., Baksay, L., Bandara, N.S., Bannier, B., Barish, K.N., Bassalleck, B., Basye, A.T., Bathe, S., Baublis, V., Baumann, C., Bazilevsky, A., Beaumier, M., Beckman, S., Belikov, S., Belmont, R., Bennett, R., Berdnikov, A., Berdnikov, Y., Bhom, J.H., Bichon, L., Blankenship, B., Blau, D.S., Bok, J.S., Borisov, V., Boyle, K., Brooks, M.L., Bryslawskyj, J., Buesching, H., Bumazhnov, V., Bunce, G., Butsyk, S., Campbell, S., Canoa Roman, V., Caringi, A., Cervantes, R., Chen, C.-H., Chiu, M., Chi, C.Y., Choi, I.J., Choi, J.B., Choudhury, R.K., Christiansen, P., Chujo, T., Chung, P., Chvala, O., Cianciolo, V., Citron, Z., Cole, B.A., Conesa del Valle, Z., Connors, M., Corliss, R., Corrales Morales, Y., Cronin, N., Csörgő, T., Csanád, M., d'Orazio, L., Dahms, T., Dairaku, S., Danchev, I., Danley, T.W., Das, K., Datta, A., Daugherity, M.S., David, G., Dayananda, M.K., Dean, C.T., Deblasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E.J., Dharmawardane, K.V., Dietzsch, O., Dion, A., Diss, P.B., Dixit, D., Donadelli, M., Do, J.H., Doomra, V., Drapier, O., Drees, A., Drees, K.A., Durham, J.M., Durum, A., Dutta, D., Edwards, S., Efremenko, Y.V., Ellinghaus, F., En'Yo, H., Engelmore, T., Enokizono, A., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D.E., M.Finger, Jr., Finger, M., Fitzgerald, D., Fleuret, F., Fokin, S.L., Fraenkel, Z., Frantz, J.E., Franz, A., Frawley, A.D., Fujiwara, K., Fukao, Y., Fukuda, Y., Fusayasu, T., Gallus, P., Gal, C., Garg, P., Garishvili, I., Ge, H., Giles, M., Giordano, F., Glenn, A., Gong, H., Gonin, M., Goto, Y., Granier de Cassagnac, R., Grau, N., Greene, S.V., Grim, G., Grosse Perdekamp, M., Gunji, T., Guragain, H., Gustafsson, H.-Å., Hachiya, T., Haggerty, J.S., Hahn, K.I., Hamagaki, H., Hamblen, J., Hamilton, H.F., Hanks, J., Han, R., Han, S.Y., Harvey, M., Hasegawa, S., Haseler, T.O.S., Hashimoto, K., Haslum, E., Hayano, R., Heffner, M., Hemmick, T.K., Hester, T., He, X., Hill, J.C., Hill, K., Hodges, A., Hohlmann, M., Hollis, R.S., Holzmann, W., Homma, K., Hong, B., Horaguchi, T., Hornback, D., Hoshino, T., Hotvedt, N., Huang, J., Ichihara, T., Ichimiya, R., Ikeda, Y., Imai, K., Inaba, M., Iordanova, A., Isenhower, D., Ishihara, M., Issah, M., Ivanishchev, D., Iwanaga, Y., Jacak, B.V., Jezghani, M., Jiang, X., Jin, J., Ji, Z., Johnson, B.M., Jones, T., Joo, K.S., Jouan, D., Jumper, D.S., Kajihara, F., Kamin, J., Kanda, S., Kang, J.H., Kapukchyan, D., Kapustinsky, J., Karatsu, K., Karthas, S., Kasai, M., Kawall, D., Kawashima, M., Kazantsev, A.V., Kempel, T., Key, J.A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kijima, K.M., Kikuchi, J., Kimelman, B., Kim, A., Kim, B.I., Kim, C., Kim, D.J., Kim, E.-J., Kim, G.W., Kim, M., Kim, T., Kim, Y.-J., Kincses, D., Kingan, A., Kinney, E., Kiss, Á., Kistenev, E., Kitamura, R., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Kochenda, L., Komkov, B., Konno, M., Koster, J., Kotov, D., Král, A., Kravitz, A., Kudo, S., Kunde, G.J., Kurita, K., Kurosawa, M., Kwon, Y., Kyle, G.S., Lai, Y.S., Lajoie, J.G., Larionova, D., Lebedev, A., Lee, D.M., Lee, J., Lee, K.B., Lee, K.S., Lee, S., Lee, S.H., Leitch, M.J., Leite, M.A.L., Leung, Y.H., Lewis, N.A., Liška, T., Lichtenwalner, P., Liebing, P., Lim, S.H., Linden Levy, L.A., Liu, H., Liu, M.X., Li, X., Loggins, V.-R., Loomis, D.A., Lovasz, K., Love, B., Lynch, D., Lökös, S., Maguire, C.F., Majoros, T., Makdisi, Y.I., Makek, M., Malik, M.D., Manion, A., Manko, V.I., Mannel, E., Mao, Y., Masui, H., Matathias, F., Mccumber, M., Mcgaughey, P.L., Mcglinchey, D., Mckinney, C., Means, N., Meles, A., Mendoza, M., Meredith, B., Miake, Y., Mibe, T., Mignerey, A.C., Miki, K., Milov, A., Mishra, D.K., Mitchell, J.T., Mitrankova, M., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mohanty, A.K., Mondal, M.M., Montuenga, P., Moon, H.J., Moon, T., Morino, Y., Morreale, A., Morrison, D.P., Moukhanova, T.V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagai, K., Nagamiya, S., Nagashima, K., Nagashima, T., Nagle, J.L., Naglis, M., Nagy, M.I., Nakagawa, I., Nakagomi, H., Nakamiya, Y., Nakamura, K.R., Nakamura, T., Nakano, K., Nam, S., Nattrass, C., Nelson, S., Netrakanti, P.K., Newby, J., Nguyen, M., Nihashi, M., Niida, T., Nishimura, S., Nouicer, R., Novák, T., Novitzky, N., Nukazuka, G., Nyanin, A.S., O'Brien, E., Oakley, C., Oda, S.X., Ogilvie, C.A., Okada, K., Oka, M., Onuki, Y., Orjuela Koop, J.D., Osborn, J.D., Oskarsson, A., Ottino, G.J., Ouchida, M., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, I.H., Park, J.S., Park, S., Park, S.K., Park, W.J., Patel, M., Pate, S.F., Pei, H., Peng, J.-C., Peng, W., Pereira, H., Perepelitsa, D.V., Perera, G.D.N., Peressounko, D.Yu., Perezlara, C.E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pinson, R., Pisani, R.P., Potekhin, M., Proissl, M., Pun, A., Purschke, M.L., Qu, H., Radzevich, P.V., Rak, J., Ramasubramanian, N., Ramson, B.J., Ravinovich, I., Read, K.F., Rembeczki, S., Reygers, K., Reynolds, D., Riabov, V., Riabov, Y., Richardson, E., Richford, D., Rinn, T., Roach, D., Roche, G., Rolnick, S.D., Rosati, M., Rosendahl, S.S.E., Rosen, C.A., Rowan, Z., Ružička, P., Rubin, J.G., Runchey, J., Safonov, A.S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sakashita, K., Sako, H., Samsonov, V., Sano, S., Sarsour, M., Sato, S., Sato, T., Sawada, S., Schaefer, B., Schmoll, B.K., Sedgwick, K., Seele, J., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, M., Shibata, T.-A., Shigaki, K., Shimomura, M., Shioya, T., Shoji, K., Shukla, P., Sickles, A., Silva, C.L., Silvermyr, D., Silvestre, C., Sim, K.S., Singh, B.K., Singh, C.P., Singh, V., Slunečka, M., Smith, Krista Lizbeth, Snowball, M., Soltz, R.A., Sondheim, W.E., Sorensen, S.P., Sourikova, I.V., Stankus, P.W., Stenlund, E., Stepanov, M., Stoll, S.P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, Z., Sziklai, J., Takagui, E.M., Takahama, R., Taketani, A., Tanabe, R., Tanaka, Y., Taneja, S., Tanida, K., Tannenbaum, M.J., Tarafdar, S., Taranenko, A., Tarnai, G., Themann, H., Thomas, D., Thomas, T.L., Tieulent, R., Timilsina, A., Todoroki, T., Togawa, M., Toia, A., Tomášek, L., Tomášek, M., Torii, H., Towell, C.L., Towell, R., Towell, R.S., Tserruya, I., Tsuchimoto, Y., Ueda, Y., Ujvari, B., Vértesi, R., Vale, C., Valle, H., van Hecke, H.W., Vazquez-Zambrano, E., Veicht, A., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Vznuzdaev, E., Wang, X.R., Watanabe, D., Watanabe, K., Watanabe, Y., Watanabe, Y.S., Wei, F., Wei, R., Wessels, J., White, A.S., White, S.N., Winter, D., Wong, C.P., Woody, C.L., Wright, R.M., Wysocki, M., Xia, B., Xue, L., Xu, C., Xu, Q., Yalcin, S., Yamaguchi, Y.L., Yamamoto, H., Yamaura, K., Yang, R., Yanovich, A., Ying, J., Yokkaichi, S., Yoon, I., Yoo, J.H., Young, G.R., Younus, I., You, Z., Yushmanov, I.E., Yu, H., Zajc, W.A., Zelenski, A., Zharko, S., Zhou, S., Zou, L., Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and PHENIX

Subjects
deuteron nucleus: scattering, pi0: production, Cronin effect, FOS: Physical sciences, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], High Energy Physics - Experiment, hard scattering, High Energy Physics - Experiment (hep-ex), [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], multiplicity, Nuclear Experiment (nucl-ex), peripheral, initial state, impact parameter, Nuclear Experiment, p nucleus: scattering, enhancement, nuclear matter: effect, nucleus nucleus: scattering, suppression, PHENIX, correlation, 200 GeV-cms/nucleon, parton: energy loss, experimental results
Abstract

The PHENIX collaboration presents a systematic study of $π^0$ production from $p$$+$$p$, $p$$+$Al, $p$$+$Au, $d$$+$Au, and $^{3}$He$+$Au collisions at $\sqrt{s_{_{NN}}}=200$ GeV. Measurements were performed with different centrality selections as well as the total inelastic, 0%--100%, selection for all collision systems. For 0%--100% collisions, the nuclear modification factors, $R_{xA}$, are consistent with unity for $p_T$ above 8 GeV/$c$, but exhibit an enhancement in peripheral collisions and a suppression in central collisions. The enhancement and suppression characteristics are similar for all systems for the same centrality class. It is shown that for high-$p_T$-$π^0$ production, the nucleons in the $d$ and $^3$He interact mostly independently with the Au nucleus and that the counter intuitive centrality dependence is likely due to a physical correlation between multiplicity and the presence of a hard scattering process. These observations disfavor models where parton energy loss has a significant contribution to nuclear modifications in small systems. Nuclear modifications at lower $p_T$ resemble the Cronin effect -- an increase followed by a peak in central or inelastic collisions and a plateau in peripheral collisions. The peak height has a characteristic ordering by system size as $p$$+$Au $>$ $d$$+$Au $>$ $^{3}$He$+$Au $>$ $p$$+$Al. For collisions with Au ions, current calculations based on initial state cold nuclear matter effects result in the opposite order, suggesting the presence of other contributions to nuclear modifications, in particular at lower $p_T$., 554 authors from 81 institutions, 21 pages, 13 figures, and 3 tables. Data from 2008, 2014, and 2015. v2 is version accepted for publication in Physical Review C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2021
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29. Condorcet Efficiency of General Weighted Scoring Rules Under IAC: Indifference and Abstention

Author

Issofa Moyouwou, Mostapha Diss, Hatem Smaoui, Eric Kamwa, Centre de REcherches sur les Stratégies Economiques (EA 3190) (CRESE), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), MASS, Université de Yaoundé I, Centre d'Économie et de Management de l'Océan Indien (CEMOI), Université de La Réunion (UR), Laboratoire caribéen de sciences sociales (LC2S), Université des Antilles (UA)-Centre National de la Recherche Scientifique (CNRS), Springer, and Centre de REcherches sur les Stratégies Economiques (UR 3190) (CRESE)

Subjects
Class (set theory), media_common.quotation_subject, 05 social sciences, Conditional probability, Condorcet method, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 16. Peace & justice, Voting, 0502 economics and business, Probability distribution, JEL: D - Microeconomics/D.D7 - Analysis of Collective Decision-Making, 050206 economic theory, 050207 economics, Set (psychology), Mathematical economics, media_common, Mathematics
Abstract

International audience; In an election, individuals may sometimes abstain or report preferences that include ties among candidates. How abstention or ties within individual preferences impact the performances of voting rules is a natural question addressed in the literature. We reconsider this question with respect to one of the main characteristics of a voting rule: its Condorcet efficiency; that is the conditional probability that the rule selects a Condorcet winner assuming that one exists. We explore the impact of both ties and abstention on the Condorcet efficiency of the whole class of weighted scoring rules in three-candidate elections under the Impartial Anonymous Culture assumption. It appears in general that the possibility of indifference or abstention increases or decreases the Condorcet efficiency of weighted scoring rules depending of the rule in consideration or the probability distribution on the set of observable voting situations.

Published
2020

30. The Effect of Closeness on the Election of a Pairwise Majority Rule Winner

Author

Abdelmonaim Tlidi, Mostapha Diss, and Patrizia Pérez-Asurmendi

Subjects
Class (set theory), Majority rule, Voting, media_common.quotation_subject, Closeness, Conditional probability, Pairwise comparison, Condorcet method, Mathematical economics, Social choice theory, media_common, Mathematics
Abstract

Some studies (e.g., Lepelley et al. 2018; Miller 2017) recently examined the effect of closeness on the probability of observing the monotonicity paradox in three-candidate elections under Scoring Elimination Rules. It was shown that the frequency of such a paradox significantly increases as elections become more closely contested. In this chapter we consider the effect of closeness on one of the most studied notions in social choice theory: The election of the Condorcet winner, i.e., the candidate who defeats any other opponent in pairwise majority comparisons, when she exists. To be more concrete, we use the well-known concept of the Condorcet efficiency, that is, the conditional probability that a voting rule will elect the Condorcet winner, given that such a candidate exists. Our results, based on the Impartial Anonymous Culture (IAC) assumption, show that closeness has also a significant effect on the Condorcet efficiency of some voting rules in the class of Scoring Rules and Scoring Elimination Rules.

Published
2020

31. The Polymycovirus-Mediated Growth Enhancement of the Entomopathogenic Fungus

Author

Charalampos, Filippou, Rebecca M, Diss, John O, Daudu, Robert H A, Coutts, and Ioly, Kotta-Loizou

Subjects
fungal sporulation, mycovirus, fungal growth, Polymycoviridae, Microbiology, Beauveria bassiana, Original Research
Abstract

Polymycoviridae is a growing family of mycoviruses whose members typically have non-conventional capsids and multi-segmented, double-stranded (ds) RNA genomes. Beauveria bassiana polymycovirus (BbPmV) 1 is known to enhance the growth and virulence of its fungal host, the entomopathogenic ascomycete and popular biological control agent B. bassiana. Here we report the complete sequence of BbPmV-3, which has six genomic dsRNA segments. Phylogenetic analysis of RNA-dependent RNA polymerase (RdRp) protein sequences revealed that BbPmV-3 is closely related to the partially sequenced BbPmV-2 but not BbPmV-1. Nevertheless, both BbPmV-3 and BbPmV-1 have similar effects on their respective host isolates ATHUM 4946 and EABb 92/11-Dm, affecting pigmentation, sporulation, and radial growth. Production of conidia and radial growth are significantly enhanced in virus-infected isolates as compared to virus-free isogenic lines on Czapek-Dox complete and minimal media that contain sucrose and sodium nitrate. However, this polymycovirus-mediated effect on growth is dependent on the carbon and nitrogen sources available to the host fungus. Both BbPmV-3 and BbPmV-1 increase growth of ATHUM 4946 and EABb 92/11-Dm when sucrose is replaced by lactose, trehalose, glucose, or glycerol, while the effect is reversed on maltose and fructose. Similarly, both BbPmV-3 and BbPmV-1 decrease growth of ATHUM 4946 and EABb 92/11-Dm when sodium nitrate is replaced by sodium nitrite, potassium nitrate, or ammonium nitrate. In conclusion, the effects of polymycoviruses on B. bassiana are at least partially mediated via its metabolic pathways.

Published
2020

32. Expression attenuation as a mechanism of robustness to gene duplication in protein complexes

Author

Alexandre K. Dubé, Alexander DeLuna, Isabelle Gagnon-Arsenault, Guillaume Diss, Diana Ascencio, and Christian R. Landry

Subjects
Genetics, Individual gene, Proteasome, Gene duplication, Robustness (evolution), Fitness effects, Protein abundance, Biology, Gene, Phenotype
Abstract

Gene duplication is ubiquitous and is a major driver of phenotypic diversity across the tree of life, but its immediate consequences are not fully understood. Immediate deleterious effects would diminish the probability of retention of duplicates and thus prevent their contribution to long term evolution. One deleterious effect of duplication could be the perturbation of the stoichiometry of protein complexes. We measured the fitness effects of the duplication of 900 essential genes in the budding yeast using high-resolution competition assays. At least ten percent of genes caused a fitness disadvantage when duplicated. Intriguingly, the duplication of most protein complex subunits had small to non-detectable effects on fitness, with few exceptions. We selected four complexes with subunits that had an impact on fitness when duplicated and measured the impact of individual gene duplications on their protein-protein interactions. We found that very few duplications affect both fitness and interactions. Furthermore, we found that large complexes such as the 26S proteasome are protected from gene duplication by posttranslational attenuation of protein abundance. The presence of regulatory mechanisms that maintain the stoichiometric balance of protein complexes may, therefore, protect from the dosage effects of gene duplication. Our results show that a better understanding of protein regulation and assembly in complexes is required for the refinement of current models of gene duplication.

Published
2020

33. Measurement of J/ψ at forward and backward rapidity in p+p , p+Al , p+Au , and He3+Au collisions at sNN=200 GeV

Author

J. B. Choi, D. Fitzgerald, Dipak Kumar Mishra, S. Karthas, D. Kotov, C. L. Woody, A. Berdnikov, A. Sukhanov, K. Kurita, Y. H. Leung, T. V. Moukhanova, D. S. Jumper, L. Zou, N. S. Bandara, M. Stepanov, Vladimir Samsonov, Christine Nattrass, R. Pak, M. Csanad, S. P. Stoll, T. Todoroki, R. Kitamura, D. Jouan, Petr Gallus, Min-Hye Kim, Hari Guragain, S. H. Lee, C. Y. Scarlett, P. Sett, T. Nagashima, K. Ozawa, I. V. Sourikova, Minghui Liu, S. Hasegawa, H. Asano, Z. Rowan, Kenneth Francis Read, J. L. Nagle, S. Bathe, M. Chiu, C. A. Ogilvie, S. Nelson, T. K. Hemmick, A. Sen, B. J. Ramson, V. S. Pantuev, K. DeBlasio, R. Pinson, Keiji Nagai, M. Mendoza, N. Apadula, A. Drees, S. Suzuki, A. Deshpande, H. Yamamoto, N. Feege, E. A. Gamez, R. S. Towell, D. Lynch, A. Meles, Takafumi Niida, J. Huang, H. Ge, B. Azmoun, K. Nakano, A. Pun, B. Kimelman, B. M. Johnson, Dmitry Blau, V. Bumazhnov, A. V. Kazantsev, W. E. Sondheim, K. Hashimoto, Prakhar Garg, K. Boyle, D. V. Perepelitsa, Xingguo Li, B. Komkov, Alice Mignerey, B. Bannier, Y. Watanabe, D. E. Fields, E. J. Desmond, S. P. Sorensen, S. Miyasaka, H. En'yo, T. Shioya, Norio Saito, M. J. Leitch, H. Yu, Y. Fukuda, B. V. Jacak, A. Enokizono, D. Dixit, Motoi Inaba, Animesh Datta, T. Sumita, C. Y. Chi, Prashant Shukla, John Hill, B. Sahlmueller, B. Kurgyis, S. F. Pate, Toru Sugitate, G. David, Kiyoshi Tanida, Jan Rak, S. H. Lim, X. Sun, Agneta Oskarsson, Takao Sakaguchi, A. Taranenko, R. Lacey, Brajesh K. Singh, G. J. Ottino, M. Potekhin, J. G. Lajoie, M. Alfred, Y. Riabov, E. Kistenev, D. Kincses, John Matthew Durham, V. R. Loggins, J. T. Mitchell, J. Bryslawskyj, Kenta Shigaki, J. A. Key, N. Hotvedt, R. Seidl, Michael William Phipps, S. Lee, Jennifer E. Perry, M. S. Daugherity, R. Cervantes, A. Iordanova, Y. Berdnikov, S. Y. Han, Y. Akiba, S. Ishimaru, V. Babintsev, C. McKinney, C. P. Singh, Vladislav Manko, Viktor Riabov, Serpil Yalcin, A. Adare, Balazs Ujvari, Y. J. Kwon, A. D. Frawley, A. S. Nyanin, R. Nishitani, M. Slunečka, M. Snowball, H. Nakagomi, T. Hoshino, N. A. Lewis, Rachid Nouicer, A. N. Zelenski, Vaclav Vrba, K. Hill, R. J. Petti, D. Ivanishchev, J. Sun, I. E. Yushmanov, A. S. White, V. Papavassiliou, C. E. Perezlara, P. L. McGaughey, Z. Wang, Byung-Sik Hong, T. Murakami, Chong Kim, A. Bazilevsky, N. N. Ajitanand, D. E. Mihalik, S. Huang, J. Sziklai, C. P. Wong, D. Richford, A. S. Safonov, M. Connors, I. J. Choi, B. Xia, W. A. Zajc, Wesley James Metzger, D. McGlinchey, S. Beckman, Yoshifumi Ueda, J. H. Do, G. D. N. Perera, Qiao Xu, ShinIchi Esumi, D. Silvermyr, L. Xue, P. Kline, A. Dion, M. Kurosawa, Alexandre Lebedev, C. L. Towell, N. Vukman, N. Novitzky, A. Denisov, Yuki Watanabe, Y. Zhai, J. H. Yoo, A. Timilsina, R. Belmont, D. Kawall, Shunji Nishimura, S. I. Morrow, K. A. Drees, A. Durum, R. P. Pisani, H. F. Hamilton, Maya Hachiya Shimomura, R. S. Hollis, S. Mizuno, Y. I. Makdisi, A. Franz, J. Runchey, A. Yanovich, N. Ramasubramanian, H. W. Van Hecke, U. Acharya, M. McCumber, Sergey Fokin, X. Jiang, J. Murata, Zvi Hirsh Citron, Kensuke Homma, I. Shein, C. L. Silva, J. Klatsky, M. Beaumier, M. J. Tannenbaum, K. Sedgwick, T. Novák, Mihael Makek, J. Hanks, Hiroyuki Sako, B. K. Schmoll, T. Majoros, D. Sharma, Anne Marie Sickles, B. Schaefer, J. S. Bok, Martin Purschke, C. A. Aidala, M. J. Skoby, Pawan Kumar Netrakanti, V. Andrieux, V. Khachatryan, M. I. Nagy, D. Kapukchyan, G. Mitsuka, A. Taketani, K. Lovasz, J. H. Kang, M. Rosati, J. S. Haggerty, Tamás Csörgő, S. Kudo, Jiangyong Jia, Y. Goto, D. Kleinjan, S. Campbell, K. L. Smith, Senta Greene, M. Virius, Yanjun Wu, E. J. Mannel, T. Rinn, C. Gal, B. Fadem, E. O'Brien, Klaus Dehmelt, Julia Velkovska, A. Khatiwada, R. A. Soltz, M. Grosse Perdekamp, F. Giordano, J. D. Orjuela Koop, T. Hachiya, S. K. Park, C. H. Chen, C. Pinkenburg, A. Manion, I. Ravinovich, Z. Ji, D. Yu Peressounko, G. Tarnai, Z. Sun, M. Bai, S. Tarafdar, J. D. Osborn, Inseok Yoon, Kei Nagashima, M. Finger, V. Canoa Roman, G. W. Kim, Raphael Noel Tieulent, Susumu Sato, Jong-Min Park, Taku Gunji, B. Mulilo, M. Patel, N. Cronin, M. Tomášek, S. Kanda, W. Peng, P. W. Stankus, S. Zhou, R. Esha, P. Montuenga, S. D. Rolnick, N. Grau, Iu. Mitrankov, Ajit Kumar Mohanty, T. A. Shibata, Kenichi Imai, T. O. S. Haseler, D. Isenhower, T. Moon, P. B. Diss, Hideki Hamagaki, W. Fan, K. I. Hahn, Alexander Milov, I. Nakagawa, D. P. Morrison, M. Boer, Sándor Lökös, K. N. Barish, Tatsuya Chujo, I. Tserruya, M. Jezghani, V. Singh, A. Hodges, S. Zharko, T. Koblesky, M. Sarsour, F. Wei, A. Glenn, P. V. Radzevich, Eunja Kim, M. L. Brooks, Jen-Chieh Peng, J. G. Rubin, X. He, J. E. Frantz, D. Reynolds, Xiong Wang, Dong Jo Kim, M. Wysocki, A. Mwai, Y. L. Yamaguchi, C. Xu, A. Sexton, R. Seto, T. W. Danley, and Alexei Khanzadeev

Subjects
Physics, 010308 nuclear & particles physics, Projectile, Nuclear Theory, Observable, Nuclear matter, Collision, 7. Clean energy, 01 natural sciences, Nuclear physics, Yield (chemistry), 0103 physical sciences, Quark–gluon plasma, High Energy Physics::Experiment, Rapidity, Impact parameter, Nuclear Experiment, 010306 general physics
Abstract

Charmonium is a valuable probe in heavy-ion collisions to study the properties of the quark gluon plasma, and is also an interesting probe in small collision systems to study cold nuclear matter effects, which are also present in large collision systems. With the recent observations of collective behavior of produced particles in small system collisions, measurements of the modification of charmonium in small systems have become increasingly relevant. We present the results of J/ψ measurements at forward and backward rapidity in various small collision systems, p+p, p+Al, p+Au, and He3+Au, at sNN=200 GeV. The results are presented in the form of the observable RAB, the nuclear modification factor, a measure of the ratio of the J/ψ invariant yield compared to the scaled yield in p+p collisions. We examine the rapidity, transverse momentum, and collision centrality dependence of nuclear effects on J/ψ production with different projectile sizes p and He3, and different target sizes Al and Au. The modification is found to be strongly dependent on the target size, but to be very similar for p+Au and He3+Au. However, for 0%–20% central collisions at backward rapidity, the modification factor for He3+Au is found to be smaller than that for p+Au, with a mean fit to the ratio of 0.89±0.03(stat)±0.08(syst), possibly indicating final state effects due to the larger projectile size.

Published
2020

34. Examining the effects of combined gait retraining and video self-modeling on habitual runners experiencing knee pain: A pilot study

Author

Stephen D. Mellalieu, Ceri Diss, Adam M. Bruton, Simon Doyle, and Isabel S. Moore

Subjects
medicine.medical_specialty, Sports medicine, business.industry, Gait retraining, multidisciplinary intervention, Knee pain, Patellofemoral pain, Physical medicine and rehabilitation, medicine, Video self-modeling, medicine.symptom, Motor learning, business, motor learning, applied sport science, patellofemoral pain
Abstract

Article published as accepted manuscript in Translational Sports Medicine on 01 October 2018 available at https://doi.org/10.1002/tsm2.47

Published
2018

35. Cryopreservation of Pacific oyster ( Crassostrea gigas ) larvae: Revisiting the practical limitations and scaling up the procedure for application to hatchery

Author

Flore Rimond, Marc Suquet, Pierrick Haffray, Christian Mingant, Serean L. Adams, Catherine Labbé, H. Robin Tervit, Benjamin Quittet, Blandine Diss, Laboratoire de Physiologie et Génomique des Poissons (LPGP), Institut National de la Recherche Agronomique (INRA)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF), SATMAR, AgResearch, Cawthron Institute, CRECHE (Ofimer-FEP 136/08/C,30906-2009), CRYOAQUA (French CCRB/IBiSA 2009-2011), SCORE(FEP 2012-2014), and by the French PAI CRB Anim project«Investissements d'avenir», ANR-11-INBS-0003 (2012-2019)., and ANR-11-INBS-0003,CRB-Anim,Réseau de Centres de Ressources Biologiques pour les animaux domestiques(2011)

Subjects
0301 basic medicine, Oyster, animal structures, Cryoprotectant, [SDV]Life Sciences [q-bio], Aquatic Science, Hatchery, Cryopreservation, Cryobanking, 03 medical and health sciences, Human fertilization, Aquaculture, biology.animal, High throughput, 14. Life underwater, Ethylene glycol, biology, business.industry, D stage, fungi, 04 agricultural and veterinary sciences, Pacific oyster, biology.organism_classification, Horticulture, 030104 developmental biology, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Crassostrea, business
Abstract

International audience; Pacific oyster Crassostrea gigas is one major species for aquaculture, and the development of breeding programs and the need for preservation of wild stock genetic resources prompted the need for larvae cryopreservation. The objective of the present study was to choose the most reliable protocol from several existing publications, to test its biological and practical limitations, and to adapt it to hatchery conditions. The selected protocol was characterized by a very slow freezing rate without seeding, and by the use of ethylene glycol and sucrose as cryoprotectant. The best survivals after thawing and rearing up to 48 h post fertilization (hpf) were obtained with larvae that were frozen at late trochophore (20 hpf) and early-D (24 hpf) stages. Increasing the larvae concentration in the straws and using high throughput straw filling and freezing devices did not alter the cryopreservation outcome. The whole procedure was applied to cryopreservation in a commercial hatchery (Satmar, France), and the thawed larvae yielded 9.4 ± 4.5% survivals at 12 days post fertilization. The overall success was dampened by some variability in the larvae survival that is likely due to the physiological status of the larvae. In all, the proposed procedure is robust and reliable and can be used for cryobanking of oyster genetic resources.

Published
2018

36. Another perspective on Borda’s paradox

Author

Mostapha Diss, Abdelmonaim Tlidi, Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), École nationale des sciences appliquées de Marrakech (ENSA Marrakech), Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Dao, Taï, Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon)

Subjects
Plurality, JEL: D - Microeconomics/D.D7 - Analysis of Collective Decision-Making/D.D7.D72 - Political Processes: Rent-Seeking, Lobbying, Elections, Legislatures, and Voting Behavior, Borda's Paradox, Computer science, media_common.quotation_subject, Geometry, General Decision Sciences, Arts and Humanities (miscellaneous), Voting, 0502 economics and business, Developmental and Educational Psychology, Weighted Scoring Rules, 050207 economics, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, Applied Psychology, 050205 econometrics, Condorcet Pairwise Procedure, Mathematics, media_common, 05 social sciences, Perspective (graphical), General Social Sciences, JEL: D - Microeconomics/D.D7 - Analysis of Collective Decision-Making/D.D7.D71 - Social Choice • Clubs • Committees • Associations, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Computer Science Applications, Negative Plurality, Order (business), 050206 economic theory, Pairwise comparison, Borda, General Economics, Econometrics and Finance, Mathematical economics, Algorithm
Abstract

International audience; This paper presents the conditions required for a profile in order to never exhibit either the strong or the strict Borda paradoxes under all weighted scoring rules in three-candidate elections. The main particularity of our paper is that all the conclusions are extracted from the differences of votes between candidates in pairwise majority elections. This way allows us to answer new questions and provide an organized knowledge of the conditions under which a given profile never shows one of the two paradoxes. Abstract This paper presents the conditions required for a profile in order to never exhibit either the strong or the strict Borda paradoxes under all weighted scoring rules in three-candidate elections. The main particularity of our paper is that all the conclusions are extracted from the differences of votes between candidates in pairwise majority elections. This way allows us to answer new questions and provide an organized knowledge of the conditions under which a given profile never shows one of the two paradoxes.

Published
2017

37. Microstructure and mechanical behaviour of a Nextel™610/alumina weak matrix composite subjected to tensile and compressive loadings

Author

Y. Renollet, C. Ben Ramdane, A. Julian-Jankowiak, R. Valle, Michel Parlier, P. Diss, Eric Martin, ONERA - The French Aerospace Lab [Châtillon], ONERA-Université Paris Saclay (COmUE), Université de Bordeaux (UB), HERAKLES - SAFRAN, Laboratoire des Composites Thermostructuraux (LCTS), and Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut de Chimie du CNRS (INC)-Snecma-SAFRAN group-Centre National de la Recherche Scientifique (CNRS)

Subjects
FIBRE/MATRIX BOND, 010302 applied physics, Materials science, Scanning electron microscope, Delamination, Composite number, CERAMIC-MATRIX COMPOSITES, 02 engineering and technology, 021001 nanoscience & nanotechnology, Microstructure, Ceramic matrix composite, 01 natural sciences, [SPI.MAT]Engineering Sciences [physics]/Materials, 0103 physical sciences, Ultimate tensile strength, Volume fraction, Materials Chemistry, Ceramics and Composites, Composite material, 0210 nano-technology, Porosity, MECHANICAL PROPERTIES
Abstract

International audience; The present study was aimed at determining the mechanical behaviour of a weak matrix oxide/oxide CMC subjected to tensile and compressive loadings in the fibre direction and at identifying the damage mechanisms. The material consisted of Nextel™610 fibres (8 HSW) embedded in an alumina matrix, with a 49 % fibre volume fraction and 24 ± 2 % total porosity. The average ultimate tensile stress and strain of the material were, respectively, 260 ± 37 MPa and 0.3 ± 0.09 % under tensile loading and −261 ± 69 MPa and −0.19 ± 0.04 % under compressive loading. Three types of pores were differentiated within the material: nanopores (13 ± 1 %), micropores (6 ± 2 %) and macropores (5 ± 1 %). The latter appear to be the most detrimental for the material, enhancing delamination. The damage mechanisms of the material were assessed through SEM examination and in situ tensile tests.

Published
2017

38. Gene duplication can impart fragility, not robustness, in the yeast protein interaction network

Author

Caroline M. Berger, Anne-Marie Dion-Côté, Christian R. Landry, Guillaume Diss, Diana Ascencio, Hélène Vignaud, and Isabelle Gagnon-Arsenault

Subjects
0301 basic medicine, Genetics, Saccharomyces cerevisiae Proteins, Multidisciplinary, Yeast Proteins, Robustness (evolution), Saccharomyces cerevisiae, Biology, Yeast, Evolution, Molecular, 03 medical and health sciences, Duplicated genes, 030104 developmental biology, Fragility, Genes, Duplicate, Interaction network, Gene Duplication, Gene duplication, Protein Interaction Maps
Abstract

The maintenance of duplicated genes is thought to protect cells from genetic perturbations, but the molecular basis of this robustness is largely unknown. By measuring the interaction of yeast proteins with their partners in wild-type cells and in cells lacking a paralog, we found that 22 out of 56 paralog pairs compensate for the lost interactions. An equivalent number of pairs exhibit the opposite behavior and require each other's presence for maintaining their interactions. These dependent paralogs generally interact physically, regulate each other's abundance, and derive from ancestral self-interacting proteins. This reveals that gene duplication may actually increase mutational fragility instead of robustness in a large number of cases.

Published
2017

39. Towards attaining a quantitative and mechanistic model of a cell

Author

Guillaume Diss

Subjects
Multifactorial Inheritance, Genotype, Biochemical Phenomena, Systems biology, Quantitative Trait Loci, Cell, Computational biology, Quantitative trait locus, Biology, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, medicine, Molecular Biology, 030304 developmental biology, 0303 health sciences, Mutation, Models, Genetic, Systems Biology, Cell Biology, Phenotype, Molecular network, Order (biology), medicine.anatomical_structure, Thermodynamics, 030217 neurology & neurosurgery, Genome-Wide Association Study, Cell based
Abstract

Mutations cause phenotypic changes by perturbing the organization of molecular networks and the functions that emerge from these networks. A model of a cell based on molecular interactions will be required in order to understand the molecular mechanisms underlying complex traits. Mutations perturb molecular networks; thus, a model of molecular interactions will be required to fully understand complex phenotypes.

Published
2020

40. The effect of alterations in foot centre of pressure on lower body kinematics during the five-iron golf swing

Author

Ceri Diss, Lesley Faux, Alison Carlisle, and John Vickers

Subjects
Adult, Male, medicine.medical_specialty, Centre of pressure, Video Recording, 030209 endocrinology & metabolism, Physical Therapy, Sports Therapy and Rehabilitation, Kinematics, Athletic Performance, Sports Equipment, 03 medical and health sciences, 0302 clinical medicine, Lower body, Physical medicine and rehabilitation, Task Performance and Analysis, Pressure, Medicine, Humans, Orthopedics and Sports Medicine, business.industry, Foot, 030229 sport sciences, Swing, Middle Aged, Biomechanical Phenomena, Golf, business, Foot (unit)
Abstract

The research aimed to evaluate the effects of an intervention aimed at altering pressure towards the medial aspect of the foot relating to stability mechanisms associated with the golf swing. We hypothesised that by altering the position of the foot pressure, the lower body stabilisation would improve which in turn would enhance weight distribution and underpinning lower body joint kinematics. Eight professional golf association (PGA) golf coaches performed five golf swings, recorded using a nine-camera motion analysis system synchronised with two force platforms. Following verbal intervention, they performed further five swings. One participant returned following a one-year intervention programme and performed five additional golf swings to provide a longitudinal case study analysis. Golf performance was unchanged evidenced by the velocity and angle of the club at ball impact (BI), although the one-year intervention significantly changed the percentage of weight experienced at each foot in the final 9% of downswing, which provided an even weight distribution at BI. This is a highly relevant finding as it indicates that the foot centre of pressure was central to the base of support and in-line with the centre of mass (CoM), indicating significantly increased stability when the CoM is near maximal acceleration.

Published
2019

41. Multiparticle azimuthal correlations for extracting event-by-event elliptic and triangular flow in Au + Au collisions at sNN=200 GeV

Author

B. Azmoun, V. Bumazhnov, E. J. Desmond, Sándor Lökös, K. N. Barish, Z. Rowan, M. Mendoza, P. Kline, A. Dion, Serpil Yalcin, Min-Hye Kim, J. T. Mitchell, N. Hotvedt, R. Seidl, Vladislav Manko, Zvi Hirsh Citron, S. Zharko, Martin Purschke, C. A. Aidala, M. Beaumier, Barbara Jacak, D. K. Mishra, H. Ge, K. Nakano, J. G. Rubin, N. Apadula, L. Zou, R. Petti, S. Esumi, D. Sharma, Shunji Nishimura, Alice Mignerey, K. A. Drees, W. E. Sondheim, S. Miyasaka, C. P. Wong, K. Hashimoto, Jong-Min Park, Taku Gunji, W. A. Zajc, A. Iordanova, J. Murata, Haseler T.O.S., A. Timilsina, Pawan Kumar Netrakanti, K. Boyle, Aaron White, Dmitry Blau, S. Bathe, L. Xue, A. Denisov, Yuki Watanabe, N. S. Bandara, Takao Sakaguchi, A. Sen, N. Feege, Vladimir Samsonov, Minghui Liu, D. Richford, Xingguo Li, Kenneth Francis Read, M. L. Brooks, Christine Nattrass, Sergey Fokin, Agneta Oskarsson, A. D. Frawley, J. Hanks, Kensuke Homma, K. Dehmelt, J. Klatsky, M. E. Connors, J. D. Orjuela Koop, S. K. Park, D. Kincses, J. B. Choi, Qiao Xu, D. Silvermyr, Y. Berdnikov, S. H. Lee, C. McKinney, Brennan Schaefer, Anne Marie Sickles, C. L. Woody, A. Berdnikov, I. E. Yushmanov, J. Sun, H. F. Hamilton, J. S. Bok, Kim E.-J., S. P. Sorensen, A. Taranenko, S. Zhou, M. Virius, M. I. Nagy, J. L. Nagle, C. Xu, S. D. Rolnick, D. Reynolds, P. L. McGaughey, A. Manion, M. Alfred, I. Ravinovich, R. S. Hollis, Maya Hachiya Shimomura, Vardan Khachatryan, A. Yanovich, V. S. Pantuev, Vaclav Vrba, C. P. Singh, E. Mannel, Y. I. Makdisi, A. Sexton, Z. Sun, T. Niida, A. Lebedev, Alexei Khanzadeev, Petr Gallus, S. Huang, Kimberly Hill, D. Lynch, Z. Ji, Dennis Perepelitsa, S. Beckman, Viktor Riabov, B. M. Johnson, R. Seto, J. G. Lajoie, T. Murakami, Xiong Wang, M. Chiu, Ajit Kumar Mohanty, A. V. Kazantsev, T. W. Danley, A. Meles, D. Kawall, M. J. Tannenbaum, D. Kotov, B. K. Schmoll, I. V. Sourikova, Shibata T.-A., T. Hachiya, M. Bai, B. Fadem, K. Tanida, P. B. Diss, Jennifer E. Perry, M. J. Skoby, Y. L. Yamaguchi, Dong Jo Kim, R. Belmont, T. V. Moukhanova, Shih-Chang Lee, S. P. Stoll, Y. H. Leung, B. Sahlmueller, J. Bryslawskyj, X. He, J. Sziklai, S. Tarafdar, M. Finger, B. Kurgyis, H. Van Hecke, Senta Greene, R. Kitamura, Tamas Ferenc Csorgo, M. J. Leitch, S. I. Morrow, Y. Riabov, S. Mizuno, Toru Sugitate, A. Deshpande, H. Asano, J. D. Osborn, Inseok Yoon, Kenta Shigaki, D. Isenhower, Tamas Novak, T. Moon, Perera G.D.N., I. J. Choi, E. O'Brien, M. Kurosawa, A. S. Nyanin, J. H. Yoo, Hideki Hamagaki, W. Fan, A. Franz, D. E. Fields, Kyoichiro Ozawa, J. Runchey, Mate Csanad, G. David, T. Todoroki, B. Xia, T. Majoros, N. A. Lewis, M. Slunecka, Rachid Nouicer, A. N. Zelenski, Alexander Milov, K. I. Hahn, I. Nakagawa, A. Mwai, M. Grosse Perdekamp, G. Mitsuka, K. Imai, D. Jouan, R. S. Towell, Prashant Shukla, J. E. Frantz, S. F. Pate, D. Y.-U. Peressounko, Y. J. Kwon, Shoichi Hasegawa, H. Sako, Jan Rak, C. A. Ogilvie, R. Lacey, T. K. Hemmick, Bhawani Singh, B. J. Ramson, D. P. Morrison, S. Campbell, A. Enokizono, I. Shein, A. Adare, Kei Nagashima, J. A. Key, M. McCumber, K. DeBlasio, A. Taketani, Priyanka Sett, D. Ivanishchev, V. Canoa Roman, P. Montuenga, Peng J.-C., G. W. Kim, D. S. Jumper, C. Pinkenburg, Tatsuya Chujo, D. E. Mihalik, V. Papavassiliou, C. E. Perezlara, Raphael Noel Tieulent, R. Pinson, Don McGlinchey, I. Tserruya, M. Jezghani, F. Wei, N. Novitzky, J. Huang, V. Singh, A. Hodges, R. P. Pisani, K. Sedgwick, Prakhar Garg, M. Wysocki, T. Koblesky, B. Bannier, M. Sarsour, A. Drees, Animesh Datta, T. Sumita, E. Kistenev, C. Y. Chi, Yasutada Akiba, Mihael Makek, N. N. Ajitanand, M. Stepanov, Balazs Ujvari, A. Glenn, P. V. Radzevich, B. Komkov, J. H. Kang, J. S. Haggerty, A. Bagoly, Norio Saito, S. Kanda, W. Peng, P. W. Stankus, A. Durum, S. H. Lim, B. Kimelman, V. Babintsev, R. A. Soltz, M. Tomášek, H. Nakagomi, Byung-Sik Hong, T. Hoshino, C. L. Silva, A. Bazilevsky, Chen C.-H., Timothy Thomas Rinn, H. W. Yu, N. Grau, J. M. Durham, Yoshifumi Ueda, J. H. Do, C. L. Towell, Susumu Sato, Shuo Han, M. Patel, M. Boer, X. Jiang, Motoi Inaba, J. C. Hill, Y. Watanabe, M. S. Daugherity, Ferdinando Giordano, A. Sukhanov, K. Kurita, Matthew Snowball, C. O. Kim, R. Pak, C. Gal, Julia Velkovska, M. Rosati, Jiangyong Jia, Y. Goto, and D. Kleinjan

Subjects
Physics, 010308 nuclear & particles physics, Elliptic flow, 01 natural sciences, Charged particle, Nuclear physics, Momentum, Distribution (mathematics), Flow (mathematics), 0103 physical sciences, Quark–gluon plasma, Rapidity, 010306 general physics, Anisotropy
Abstract

We present measurements of elliptic and triangular azimuthal anisotropy of charged particles detected at forward rapidity 1

Published
2019

42. Multiparticle azimuthal correlations for extracting event-by-event elliptic and triangular flow in Au + Au collisions at sNN =200 GeV

Author

Adare, A, Aidala, C, Ajitanand, NN, Akiba, Y, Alfred, M, Apadula, N, Asano, H, Azmoun, B, Babintsev, V, Bagoly, A, Bai, M, Bandara, NS, Bannier, B, Barish, KN, Bathe, S, Bazilevsky, A, Beaumier, M, Beckman, S, Belmont, R, Berdnikov, A, Berdnikov, Y, Blau, DS, Boer, M, Bok, JS, Boyle, K, Brooks, ML, Bryslawskyj, J, Bumazhnov, V, Campbell, S, Roman, V Canoa, Chen, C-H, Chi, CY, Chiu, M, Choi, IJ, Choi, JB, Chujo, T, Citron, Z, Connors, M, Csanád, M, Csörgő, T, Danley, TW, Datta, A, Daugherity, MS, David, G, DeBlasio, K, Dehmelt, K, Denisov, A, Deshpande, A, Desmond, EJ, Dion, A, Diss, PB, H., J, Drees, A, Drees, KA, Durham, JM, Durum, A, Enokizono, A, Esumi, S, Fadem, B, Fan, W, Feege, N, Fields, DE, Finger, M, Fokin, SL, Frantz, JE, Franz, A, Frawley, AD, Gal, C, Gallus, P, Garg, P, Ge, H, Giordano, F, Glenn, A, Goto, Y, Grau, N, Greene, SV, Perdekamp, M Grosse, Gunji, T, Hachiya, T, Haggerty, JS, Hahn, KI, Hamagaki, H, Hamilton, HF, Han, SY, Hanks, J, Hasegawa, S, Haseler, TOS, Hashimoto, K, He, X, Hemmick, TK, Hill, JC, Hill, K, Hodges, A, Hollis, RS, Homma, K, Hong, B, Hoshino, T, Hotvedt, N, and Huang, J

Subjects
Particle and Plasma Physics, hep-ex, Molecular, Nuclear, nucl-ex, Atomic, Nuclear & Particles Physics
Abstract

We present measurements of elliptic and triangular azimuthal anisotropy of charged particles detected at forward rapidity 1

Published
2019

43. Measurement of $J/��$ at forward and backward rapidity in $p$+$p$, $p$$+A$l, $p$$+A$u, and $^3$He+Au collisions at $\sqrt{s_{_{NN}}}=200~{\rm GeV}$

Author

Acharya, U. A., Adare, A., Aidala, C., Ajitanand, N. N., Akiba, Y., Alfred, M., Andrieux, V., Apadula, N., Asano, H., Azmoun, B., Babintsev, V., Bai, M., Bandara, N. S., Bannier, B., Barish, K. N., Bathe, S., Bazilevsky, A., Beaumier, M., Beckman, S., Belmont, R., Berdnikov, A., Berdnikov, Y., Blau, D. S., Boer, M., Bok, J. S., Boyle, K., Brooks, M. L., Bryslawskyj, J., Bumazhnov, V., Campbell, S., Roman, V. Canoa, Cervantes, R., Chen, C. -H., Chi, C. Y., Chiu, M., Choi, I. J., Choi, J. B., Chujo, T., Citron, Z., Connors, M., Cronin, N., Csan��d, M., Cs��rg��, T., Danley, T. W., Datta, A., Daugherity, M. S., David, G., DeBlasio, K., Dehmelt, K., Denisov, A., Deshpande, A., Desmond, E. J., Dion, A., Diss, P. B., Dixit, D., Do, J. H., Drees, A., Drees, K. A., Durham, J. M., Durum, A., Enokizono, A., En'yo, H., Esha, R., Esumi, S., Fadem, B., Fan, W., Feege, N., Fields, D. E., Finger, M., Fitzgerald, D., Fokin, S. L., Frantz, J. E., Franz, A., Frawley, A. D., Fukuda, Y., Gal, C., Gallus, P., Gamez, E. A., Garg, P., Ge, H., Giordano, F., Glenn, A., Goto, Y., Grau, N., Greene, S. V., Perdekamp, M. Grosse, Gunji, T., Guragain, H., Hachiya, T., Haggerty, J. S., Hahn, K. I., Hamagaki, H., Hamilton, H. F., Han, S. Y., Hanks, J., Hasegawa, S., Haseler, T. O. S., Hashimoto, K., He, X., Hemmick, T. K., Hill, J. C., Hill, K., Hodges, A., Hollis, R. S., Homma, K., Hong, B., Hoshino, T., Hotvedt, N., Huang, J., Huang, S., Imai, K., Inaba, M., Iordanova, A., Isenhower, D., Ishimaru, S., Ivanishchev, D., Jacak, B. V., Jezghani, M., Ji, Z., Jia, J., Jiang, X., Johnson, B. M., Jouan, D., Jumper, D. S., Kanda, S., Kang, J. H., Kapukchyan, D., Karthas, S., Kawall, D., Kazantsev, A. V., Key, J. A., Khachatryan, V., Khanzadeev, A., Khatiwada, A., Kim, C., Kim, D. J., Kim, E. -J., Kim, G. W., Kim, M., Kimelman, B., Kincses, D., Kistenev, E., Kitamura, R., Klatsky, J., Kleinjan, D., Kline, P., Koblesky, T., Komkov, B., Kotov, D., Kudo, S., Kurgyis, B., Kurita, K., Kurosawa, M., Kwon, Y., Lacey, R., Lajoie, J. G., Lebedev, A., Lee, S., Lee, S. H., Leitch, M. J., Leung, Y. H., Lewis, N. A., Li, X., Lim, S. H., Liu, M. X., Loggins, V. -R., L��k��s, S., Lovasz, K., Lynch, D., Majoros, T., Makdisi, Y. I., Makek, M., Manion, A., Manko, V. I., Mannel, E., McCumber, M., McGaughey, P. L., McGlinchey, D., McKinney, C., Meles, A., Mendoza, M., Metzger, W. J., Mignerey, A. C., Mihalik, D. E., Milov, A., Mishra, D. K., Mitchell, J. T., Mitrankov, Iu., Mitsuka, G., Miyasaka, S., Mizuno, S., Mohanty, A. K., Montuenga, P., Moon, T., Morrison, D. P., Morrow, S. I., Moukhanova, T. V., Mulilo, B., Murakami, T., Murata, J., Mwai, A., Nagai, K., Nagashima, K., Nagashima, T., Nagle, J. L., Nagy, M. I., Nakagawa, I., Nakagomi, H., Nakano, K., Nattrass, C., Nelson, S., Netrakanti, P. K., Niida, T., Nishimura, S., Nishitani, R., Nouicer, R., Nov��k, T., Novitzky, N., Nyanin, A. S., O'Brien, E., Ogilvie, C. A., Koop, J. D. Orjuela, Osborn, J. D., Oskarsson, A., Ottino, G. J., Ozawa, K., Pak, R., Pantuev, V., Papavassiliou, V., Park, J. S., Park, S., Pate, S. F., Patel, M., Peng, J. -C., Peng, W., Perepelitsa, D. V., Perera, G. D. N., Peressounko, D. Yu., PerezLara, C. E., Perry, J., Petti, R., Phipps, M., Pinkenburg, C., Pinson, R., Pisani, R. P., Pun, A., Purschke, M. L., Radzevich, P. V., Rak, J., Ramasubramanian, N., Ramson, B. J., Ravinovich, I., Read, K. F., Reynolds, D., Riabov, V., Riabov, Y., Richford, D., Rinn, T., Rolnick, S. D., Rosati, M., Rowan, Z., Rubin, J. G., Runchey, J., Safonov, A. S., Sahlmueller, B., Saito, N., Sakaguchi, T., Sako, H., Samsonov, V., Sarsour, M., Sato, S., Scarlett, C. Y., Schaefer, B., Schmoll, B. K., Sedgwick, K., Seidl, R., Sen, A., Seto, R., Sett, P., Sexton, A., Sharma, D., Shein, I., Shibata, T. -A., Shigaki, K., Shimomura, M., Shioya, T., Shukla, P., Sickles, A., Silva, C. L., Silvermyr, D., Singh, B. K., Singh, C. P., Singh, V., Skoby, M. J., Slune��ka, M., Smith, K. L., Snowball, M., Soltz, R. A., Sondheim, W. E., Sorensen, S. P., Sourikova, I. V., Stankus, P. W., Stepanov, M., Stoll, S. P., Sugitate, T., Sukhanov, A., Sumita, T., Sun, J., Sun, X., Sun, Z., Suzuki, S., Sziklai, J., Taketani, A., Tanida, K., Tannenbaum, M. J., Tarafdar, S., Taranenko, A., Tarnai, G., Tieulent, R., Timilsina, A., Todoroki, T., Tom����ek, M., Towell, C. L., Towell, R., Towell, R. S., Tserruya, I., Ueda, Y., Ujvari, B., van Hecke, H. W., Velkovska, J., Virius, M., Vrba, V., Vukman, N., Wang, X. R., Wang, Z., Watanabe, Y., Watanabe, Y. S., Wei, F., White, A. S., Wong, C. P., Woody, C. L., Wysocki, M., Xia, B., Xu, C., Xu, Q., Xue, L., Yalcin, S., Yamaguchi, Y. L., Yamamoto, H., Yanovich, A., Yoo, J. H., Yoon, I., Yu, H., Yushmanov, I. E., Zajc, W. A., Zelenski, A., Zhai, Y., Zharko, S., Zhou, S., and Zou, L.

Subjects
High Energy Physics - Experiment (hep-ex), FOS: Physical sciences, Nuclear Experiment (nucl-ex), Nuclear Experiment
Abstract

Charmonium is a valuable probe in heavy-ion collisions to study the properties of the quark gluon plasma, and is also an interesting probe in small collision systems to study cold nuclear matter effects, which are also present in large collision systems. With the recent observations of collective behavior of produced particles in small system collisions, measurements of the modification of charmonium in small systems have become increasingly relevant. We present the results of $J/��$ measurements at forward and backward rapidity in various small collision systems, $p$$+$$p$, $p$$+$Al, $p$$+$Au and $^3$He$+$Au, at $\sqrt{s_{_{NN}}}$=200 GeV. The results are presented in the form of the observable $R_{AB}$, the nuclear modification factor, a measure of the ratio of the $J/��$ invariant yield compared to the scaled yield in $p$$+$$p$ collisions. We examine the rapidity, transverse momentum, and collision centrality dependence of nuclear effects on $J/��$ production with different projectile sizes $p$ and $^3$He, and different target sizes Al and Au. The modification is found to be strongly dependent on the target size, but to be very similar for $p$$+$Au and $^{3}$He$+$Au. However, for 0%--20% central collisions at backward rapidity, the modification for $^{3}$He$+$Au is found to be smaller than that for $p$$+$Au, with a mean fit to the ratio of $0.89\pm0.03$(stat)${\pm}0.08$(syst), possibly indicating final state effects due to the larger projectile size., 362 authors, 68 institutions, 23 pages, 28 figures, 3 tables, 2014 and 2015 data. v3 is version accepted for publication in Phys. Rev. C. Plain text data tables for the points plotted in figures for this and previous PHENIX publications are (or will be) publicly available at http://www.phenix.bnl.gov/papers.html

Published
2019
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44. Pseudorapidity Dependence of Particle Production and Elliptic Flow in Asymmetric Nuclear Collisions of p+Al , p+Au , d+Au , and He3+Au at sNN=200 GeV

Author

N. S. Bandara, C. H. Chen, G. Tarnai, Vladimir Samsonov, Y. Riabov, Kenichi Imai, Z. Sun, Christine Nattrass, R. Lacey, T. O. S. Haseler, S. Bathe, S. Hasegawa, Kenta Shigaki, R. Cervantes, M. Chiu, M. I. Nagy, I. Tserruya, P. B. Diss, M. Jezghani, V. Singh, A. Hodges, A. Adare, S. Tarafdar, R. Nishitani, P. L. McGaughey, M. Phipps, C. A. Ogilvie, A. S. Nyanin, X. He, R. A. Soltz, D. Kapukchyan, Rachid Nouicer, A. N. Zelenski, T. Koblesky, T. K. Hemmick, Maya Hachiya Shimomura, R. S. Hollis, F. Wei, D. E. Mihalik, S. Beckman, B. J. Ramson, Hideki Hamagaki, W. Fan, Serpil Yalcin, G. David, T. Todoroki, M. Grosse Perdekamp, E. O. Lallow, Shunji Nishimura, K. A. Drees, F. Giordano, J. Rak, K. I. Hahn, J. Klatsky, J. L. Nagle, A. Glenn, P. V. Radzevich, Y. I. Makdisi, Ajit Kumar Mohanty, T. A. Shibata, D. Sharma, K. DeBlasio, Eunja Kim, A. V. Kazantsev, T. Hachiya, S. K. Park, R. S. Towell, Y. J. Kwon, Prashant Shukla, C. L. Woody, S. F. Pate, A. Pun, B. Kimelman, R. Pinson, S. Vazquez-Carson, Z. Rowan, Anne Marie Sickles, M. Mendoza, A. Berdnikov, K. L. Smith, B. Schaefer, K. Hashimoto, C. P. Wong, L. D. Liu, A. Mwai, J. H. Kang, M. Boer, M. J. Tannenbaum, J. S. Haggerty, Xingguo Li, P. Montuenga, N. N. Ajitanand, C. L. Silva, David Olle Rickard Silvermyr, B. K. Schmoll, N. Grau, Z. Ji, Alexander Milov, I. Nakagawa, N. Novitzky, D. P. Morrison, J. A. Key, D. Isenhower, Tamas Novak, T. Moon, Jaehyeok Yoo, M. Connors, W. A. Zajc, L. Xue, S. Syed, J. S. Bok, D. Yu Peressounko, Sándor Lökös, K. N. Barish, S. Zharko, Petr Gallus, T. Nagashima, A. Denisov, Yuki Watanabe, G. D. N. Perera, N. Apadula, Y. Fukuda, V. Bumazhnov, D. Dixit, N. Feege, A. Drees, Sergey Fokin, Koji Sato, Iu. Mitrankov, Jong-Min Park, Taku Gunji, Moonhee Kim, Dennis Perepelitsa, M. Patel, Kyoichiro Ozawa, L. Zou, D. Ivanishchev, I. V. Sourikova, Keiji Nagai, V. Papavassiliou, M. L. Brooks, Alice Mignerey, H. Ge, C. E. Perezlara, Mikhail Malaev, T. Murakami, E. J. Mannel, T. Rinn, K. Nakano, Motoi Inaba, N. Saito, S. Miyasaka, A. Durum, Minghui Liu, B. Kurgyis, C. Gal, S. Zhou, S. Karthas, A. Takeda, Julia Velkovska, Takao Sakaguchi, A. Sen, C. Pinkenburg, S. D. Rolnick, K. Dehmelt, J. Bryslawskyj, Kenneth Francis Read, M. Sarsour, A. Iordanova, S. Y. Han, D. Kotov, M. Rosati, Agneta Oskarsson, W. E. Sondheim, D. Kincses, John Matthew Durham, A. D. Frawley, S. I. Morrow, M. Tomášek, T. Majoros, Senta Greene, S. Kanda, W. Peng, M. Virius, Tamás Csörgő, D. S. Jumper, Y. Berdnikov, A. S. White, S. Huang, C. Ayuso, A. Franz, J. Runchey, C. Butler, D. J. Kim, P. W. Stankus, A. Meles, M. Csanad, S. P. Stoll, C. McKinney, S. Kudo, Wesley James Metzger, A. Deshpande, C. Xu, E. Kistenev, T. Shioya, M. Snowball, A. Sukhanov, H. F. Hamilton, Kei Nagashima, K. Kurita, K. Aoki, P. Sett, B. Fadem, E. O'Brien, R. P. Pisani, V. Canoa Roman, M. McCumber, I. J. Choi, G. W. Kim, Vaclav Vrba, K. Hill, D. McGlinchey, H. En'yo, M. J. Leitch, Brajesh K. Singh, G. J. Ottino, D. E. Fields, B. Xia, B. V. Jacak, J. Imrek, A. Sexton, Raphael Noel Tieulent, R. Pak, Takafumi Niida, Susumu Sato, J. Huang, H. Asano, R. Kitamura, Y. Goto, J. Sun, S. P. Sorensen, R. Seto, T. W. Danley, D. Jouan, Y. L. Yamaguchi, J. Jia, M. Stepanov, Prakhar Garg, B. Bannier, Hari Guragain, D. Kleinjan, S. Campbell, J. G. Lajoie, J. D. Orjuela Koop, M. Alfred, S. Lee, Jennifer E. Perry, S. Mizuno, H. W. Van Hecke, Viktor Riabov, Martin Purschke, C. A. Aidala, John Hill, M. J. Skoby, Y. Ito, Pawan Kumar Netrakanti, V. Andrieux, Radek Novotny, V. Khachatryan, N. Cronin, A. Manion, Y. H. Leung, B. Azmoun, I. Ravinovich, Toru Sugitate, P. Kline, A. Dion, M. Beaumier, M. Bai, S. Esumi, Z. Wang, M. S. Daugherity, C. P. Singh, R. Petti, B. M. Johnson, N. A. Lewis, V. Jorjadze, T. Elder, Qiao Xu, J. Sziklai, D. Kawall, J. D. Osborn, S. H. Lim, K. Tanida, Inseok Yoon, A. Yanovich, Zvi Hirsh Citron, M. Finger, I. Shein, A. Taranenko, K. Sedgwick, Mihael Makek, H. Yamamoto, H. Yu, Animesh Datta, T. Sumita, C. Y. Chi, Yasutada Akiba, A. Enokizono, H. Masuda, Kensuke Homma, M. Kurosawa, D. Lynch, A. Taketani, Y. Watanabe, V. Pantuev, R. Belmont, B. Sahlmueller, K. Boyle, V. R. Loggins, J. T. Mitchell, N. Hotvedt, R. Seidl, Vladislav Manko, M. Slunečka, P. Yin, A. Timilsina, K. Lovasz, H. Nakagomi, T. Hoshino, D. Richford, A. S. Safonov, Yoshifumi Ueda, J. H. Do, C. L. Towell, N. Vukman, Dmitry Blau, Tatsuya Chujo, Jen-Chieh Peng, E. J. Desmond, J. G. Rubin, J. E. Frantz, D. Reynolds, Xiong Wang, Balazs Ujvari, M. Wysocki, I. E. Yushmanov, Alexei Khanzadeev, J. B. Choi, Dipak Kumar Mishra, T. V. Moukhanova, Min-Hye Kim, S. H. Lee, J. Murata, S. Suzuki, Mirta Dumancic, B. Komkov, V. Babintsev, Byung-Sik Hong, Chong Kim, A. Bazilevsky, Alexandre Lebedev, G. Mitsuka, X. Jiang, J. Hanks, and Hiroyuki Sako

Subjects
Physics, 010308 nuclear & particles physics, media_common.quotation_subject, Hadron, Quark model, Elliptic flow, General Physics and Astronomy, Collision, 01 natural sciences, Asymmetry, Nuclear physics, Pseudorapidity, 0103 physical sciences, High Energy Physics::Experiment, Rapidity, Multiplicity (chemistry), Nuclear Experiment, 010306 general physics, media_common
Abstract

Asymmetric nuclear collisions of p+Al, p+Au, d+Au, and ^{3}He+Au at sqrt[s_{NN}]=200 GeV provide an excellent laboratory for understanding particle production, as well as exploring interactions among these particles after their initial creation in the collision. We present measurements of charged hadron production dN_{ch}/dη in all such collision systems over a broad pseudorapidity range and as a function of collision multiplicity. A simple wounded quark model is remarkably successful at describing the full data set. We also measure the elliptic flow v_{2} over a similarly broad pseudorapidity range. These measurements provide key constraints on models of particle emission and their translation into flow.

Published
2018

45. Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signalling in the mouse

Author

Paul R. Gard, Mark Yeoman, Jon G. Mabley, Marcus Allen, Tina Ghela, Bhavik Anil Patel, Stephen Robinson, Talia Walter, Prabal K. Chatterjee, Jonathan Golding, Rachel Morris, Sara Fidalgo, Lucy B. Diss, Rosemary Tucker, Sarah Dyball, and Paul Young

Subjects
Paraquat, inorganic chemicals, 0301 basic medicine, Colon, Muscle Relaxation, Myenteric Plexus, Pharmacology, Nitric Oxide, medicine.disease_cause, Nitroarginine, Nitric oxide, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, Malondialdehyde, medicine, Animals, heterocyclic compounds, Migrating motor complex, Myoelectric Complex, Migrating, Gastrointestinal tract, biology, Endocrine and Autonomic Systems, Muscle, Smooth, NADH Dehydrogenase, Nitric oxide synthase, 030104 developmental biology, chemistry, Anesthesia, Toxicity, biology.protein, 030211 gastroenterology & hepatology, Neurology (clinical), Gastrointestinal Motility, Oxidative stress, Signal Transduction
Abstract

Paraquat, a common herbicide, is responsible for large numbers of deaths worldwide through both deliberate and accidental ingestion. Previous studies have eluded that the bioavailability of paraquat increases substantially with increasing dose and that these changes may in part be due to the effects that these high concentrations have on the gastrointestinal tract (GI tract). To date, the actions of acute, high concentrations (20mM for 60 min) of paraquat on the GI tract, particularly the colon which is a major site of paraquat absorption, are unknown. This study examined the effects of acute paraquat administration on colonic motility in the C57BL/6 mouse. Acute paraquat exposure decreased colonic motility and the amplitude of colonic migrating motor complexes (CMMCs), which are major motor patterns involved in faecal pellet propulsion. In isolated segments of distal colon, paraquat increased resting tension and markedly attenuated electrical field stimulation-evoked relaxations. Pharmacological dissection of paraquat's mechanism of action on both the CMMCs and field stimulated tissue using the nitric oxide synthase inhibitor NG-nitro-L-arginine and direct measurement of NO release from the myenteric plexus, demonstrated that paraquat selectively attenuates nitrergic signalling pathways. These changes did not appear to be due to alterations in colonic oxidative stress, inflammation or complex 1 activity, but were most likely caused by paraquat's ability to act as a redox couple. In summary, these data demonstrate that acute paraquat exposure attenuates colonic transit. These changes may facilitate the absorption of paraquat into the circulation and so facilitate its toxicity.

Published
2016

46. Xanthinurie héréditaire de type 1 : à propos de trois cas

Author

B. Ranchin, Pierre Cochat, F. Broly, M. Diss, and N. Pottier

Subjects
Genetics, Stone formation, Diagnostic methods, Xanthine Dehydrogenase Deficiency, Biology, medicine.disease, Genetic analysis, Enzyme assay, Pediatrics, Perinatology and Child Health, medicine, biology.protein, Missense mutation, Xanthinuria, Gene
Abstract

Type 1 xanthinuria is a rare cause of urolithiasis due to xanthine dehydrogenase deficiency. Pediatric cases are exceptional. Through the genetic analysis of two cases, we discovered three mutations responsible for a loss of enzyme activity. The first one had a C.3536T>C missense mutation in the XDH gene and the other one was heterozygous for two mutations c.700+1G>T and c.31778_82delTCAT. We review the diagnostic methods, possible complications, and preventive measures for stone formation.

Published
2015

47. Lessons from the Frontline: Exploring How Stakeholders May Respond to Emerald Ash Borer Management in Europe

Author

Mariella Marzano, Clare Hall, Norman Dandy, Cherie LeBlanc Fisher, Andrea Diss-Torrance, and Robert G. Haight

Subjects
0106 biological sciences, 010504 meteorology & atmospheric sciences, risk/benefit, Collateral, Fraxinus, 010603 evolutionary biology, 01 natural sciences, Emerald ash borer, medicine, Environmental planning, 0105 earth and related environmental sciences, biology, Hymenoscyphus fraxineus, Stakeholder, Forestry, trees, lcsh:QK900-989, Demise, biology.organism_classification, medicine.drug_formulation_ingredient, pest management, Geography, Harm, emerald ash borer, lcsh:Plant ecology, social acceptability, Twin cities
Abstract

The emerald ash borer (EAB) has caused extensive damage and high mortality to native ash trees (Fraxinus; sp.) in North America. As European countries battle with the deadly pathogen Hymenoscyphus fraxineus (ash dieback) affecting European ash (Fraxinus excelsior), there is concern that the arrival of EAB will signal the demise of this much-loved tree. While Europe prepares for EAB it is vital that we understand the social dimensions that will likely influence the social acceptability of potential management measures, and experiences from the USA can potentially guide this. We draw on differing sources including a literature review, documentary analysis, and consultation with key informants from Chicago and the Twin Cities of Minneapolis and St. Paul. In this paper, we focus on EAB management responses that involve chemical applications, tree felling and replanting, and biological control, and assess their likely social acceptability to stakeholders based on the perceived risks and benefits. Benefits involve protecting specific ash trees and slowing the spread of EAB across the landscape. Risks include collateral harm from insecticide use on human and environmental health, financial costs and liabilities, and the effectiveness of each approach. Biological control and replacing ash with other species are likely to be largely acceptable across contexts and stakeholder groups but pre-emptive felling and insecticide application could be more problematic if seeking widespread social acceptance. Based on our observations from the evidence collected we offer suggestions for approaching EAB management in Europe with a focus on improving prospects of social acceptability. Strong engagement will be necessary to establish the relevance and reason for using different management approaches and to build awareness and trust.

Published
2020

48. Lower limb tri-joint synchrony during running gait: A longitudinal age-based study

Author

Domenico Vicinanza, Genevieve K. R. Williams, Ceri Diss, and Lee Smith

Subjects
medicine.medical_specialty, business.industry, Biophysics, Experimental and Cognitive Psychology, 030229 sport sciences, General Medicine, Knee Joint, Sagittal plane, 03 medical and health sciences, Running gait, 0302 clinical medicine, medicine.anatomical_structure, Gait (human), Physical medicine and rehabilitation, medicine, Orthopedics and Sports Medicine, Ground reaction force, Ankle, business, Range of motion, Joint (geology), 030217 neurology & neurosurgery
Abstract

Biomechanical research exploring the age-based mechanics of running gait can provide valuable insight into the reported decline in master endurance running performance. However, few studies have shown consistent biomechanical differences in the gait of trained distance runners compared to their younger counterparts. It might be that differences occur in the interaction between joints. The aim was to explore the differences in tri-joint synchrony of the lower limb, quantified through cluster phase analysis, of runners at 50 years of age compared to seven years later. Cluster phase analysis was used to examine changes in synchrony between 3 joints of the lower limb during the stance phase of running. Ten male, endurance-trained athletes M50 (age = 53.54 ± 2.56 years, mass = 71.05 ± 7.92 kg) participated in the study and returned after seven years M57 (age = 60.49 ± 2.56 years, mass = 69.08 ± 8.23 kg). Lower limb kinematics (Vicon, 120 Hz) and ground reaction forces (Kistler, 1080 Hz) were collected as participants performed multiple trials at a horizontal running velocity = 3.83 ± 0.40 m·s−1 over the force plate. Significant increase (31%) in rate of force development in the absorption phase, and significantly reduced sagittal plane knee joint range of motion (30.50 v 23.68°) were found following the seven years of ageing. No further discrete single joint measures were significantly different between M50 and M57. Joint synchrony between the hip, knee and ankle was significantly higher at M57 compared to M50 during the absorption phase of stance. The force attenuation strategy is compromised after seven years of ageing, which is associated with more synchronous movements in the lower limb joints. Increased joint synchrony as a function of age could be a mechanism associated with this key injury provoking phase of running gait.

Published
2018

49. Measurements of mass-dependent azimuthal anisotropy in central p + Au, d + Au, and He3 + Au collisions at sNN=200 GeV

Author

Alexander Milov, I. Nakagawa, H. Sako, V. R. Loggins, J. T. Mitchell, N. Hotvedt, R. Seidl, Vladislav Manko, P. Yin, Agneta Oskarsson, D. Kincses, Kei Nagashima, V. Canoa Roman, D. P. Morrison, S. Campbell, Y. J. Kwon, A. Drees, Y. Berdnikov, S. H. Lee, C. Xu, Qiao Xu, D. Silvermyr, A. Meles, A. Takeda, C. L. Woody, A. Berdnikov, D. E. Fields, C. McKinney, Brennan Schaefer, G. W. Kim, M. McCumber, A. Timilsina, Tatsuya Chujo, J. Imrek, Raphael Noel Tieulent, Vaclav Vrba, A. Yanovich, Maya Hachiya Shimomura, A. Sexton, Hari Guragain, M. Rosati, Tamás Csörgő, S. Karthas, D. Kotov, S. Bathe, Vardan Khachatryan, Y. I. Makdisi, I. Tserruya, M. Jezghani, V. Singh, A. Hodges, Z. Rowan, M. Mendoza, A. Sukhanov, K. Kurita, S. Tarafdar, R. Seto, S. Kudo, Matthew Snowball, V. S. Pantuev, Petr Gallus, Moonhee Kim, Alexei Khanzadeev, H. Masuda, Kensuke Homma, V. Bumazhnov, Y. L. Yamaguchi, S. P. Stoll, M. Chiu, Ajit Kumar Mohanty, T. A. Shibata, J. H. Kang, T. Koblesky, M. Sarsour, Viktor Riabov, J. S. Haggerty, T. W. Danley, S. Huang, Zvi Hirsh Citron, H. Ge, K. Nakano, Jiangyong Jia, Y. Goto, H. Asano, C. O. Kim, R. Pak, W. E. Sondheim, M. J. Tannenbaum, M. I. Nagy, T. Nagashima, S. Mizuno, D. Richford, D. Isenhower, Tamas Novak, T. Moon, K. Boyle, B. Fadem, L. Zou, Kimberly Hill, B. K. Schmoll, D. Jouan, S. P. Sorensen, D. Lynch, Y. Akiba, I. V. Sourikova, A. Glenn, Shunji Nishimura, P. V. Radzevich, N. A. Lewis, X. He, Eunja Kim, Jong-Min Park, Taku Gunji, Y. H. Leung, D. Kleinjan, M. J. Skoby, Dhruv Utpalkumar Dixit, B. Sahlmueller, H. En'yo, M. J. Leitch, D. Kapukchyan, T. O. S. Haseler, Shoichi Hasegawa, P. B. Diss, Alexei Safonov, K. A. Drees, B. Kurgyis, Alice Mignerey, Toru Sugitate, K. Dehmelt, J. G. Lajoie, Jen-Chieh Peng, M. Patel, C. A. Ogilvie, S. Miyasaka, T. K. Hemmick, Bhawani Singh, B. J. Ramson, T. Hachiya, Michael William Phipps, S. Lee, Y. Riabov, Pawan Kumar Netrakanti, Jennifer E. Perry, J. Bryslawskyj, H. Van Hecke, Minghui Liu, Hideki Hamagaki, W. Fan, G. David, T. Todoroki, Kenta Shigaki, Aaron White, K. I. Hahn, T. V. Moukhanova, Anne Marie Sickles, D. Reynolds, R. Kitamura, Senta Greene, S. Zhou, Takao Sakaguchi, A. Sen, K. DeBlasio, Xiong Wang, J. S. Bok, R. Pinson, S. Vazquez-Carson, Serpil Yalcin, J. Klatsky, N. Feege, A. S. Nyanin, A. Deshpande, J. B. Choi, X. Jiang, S. D. Rolnick, Rachid Nouicer, A. N. Zelenski, Min-Hye Kim, Barbara Jacak, C. P. Wong, A. D. Frawley, Dong Jo Kim, Don McGlinchey, A. Taranenko, M. Virius, Kenneth Francis Read, E. O'Brien, J. Sun, E. J. Desmond, C. Pinkenburg, I. J. Choi, B. Xia, N. S. Bandara, W. A. Zajc, L. Xue, S. Kanda, A. Denisov, Yuki Watanabe, M. Grosse Perdekamp, Wesley James Metzger, Vladimir Samsonov, A. Mwai, G. J. Ottino, C. Gal, Julia Velkovska, A. Pun, Christine Nattrass, M. E. Connors, M. Stepanov, G. Tarnai, R. S. Hollis, H. F. Hamilton, J. D. Orjuela Koop, W. Peng, P. W. Stankus, S. K. Park, K. Hashimoto, Sergey Fokin, B. Kimelman, A. V. Kazantsev, Xingguo Li, A. Iordanova, J. Murata, T. Niida, A. Lebedev, C. H. Chen, Sándor Lökös, Dmitry Blau, P. Montuenga, K. N. Barish, T. Shioya, J. L. Nagle, S. Zharko, R. Belmont, Z. Ji, D. Yu Peressounko, Dennis Perepelitsa, J. Hanks, Koji Sato, A. Manion, M. Alfred, Jan Rak, Y. Fukuda, R. Lacey, G. Mitsuka, M. L. Brooks, I. E. Yushmanov, E. Kistenev, J. E. Frantz, A. Adare, Kyoichiro Ozawa, A. Enokizono, D. E. Mihalik, M. S. Daugherity, A. Taketani, M. Slunečka, Priyanka Sett, D. S. Jumper, P. L. McGaughey, K. Lovasz, S. Beckman, Ferdinando Giordano, I. Ravinovich, T. Majoros, M. Bai, K. Imai, J. D. Osborn, Inseok Yoon, Zirui Wang, M. Finger, B. Komkov, A. Bagoly, Norio Saito, E. Mannel, R. S. Towell, F. Wei, Timothy Thomas Rinn, S. H. Lim, Animesh Datta, T. Sumita, C. Y. Chi, V. Babintsev, Balazs Ujvari, M. Kurosawa, J. H. Yoo, M. Tomášek, Byung-Sik Hong, A. Bazilevsky, Prashant Shukla, S. F. Pate, C. P. Singh, H. W. Yu, B. M. Johnson, J. A. Key, V. Jorjadze, J. Sziklai, D. Ivanishchev, V. Papavassiliou, N. Novitzky, C. E. Perezlara, J. Huang, R. A. Soltz, H. Nakagomi, T. Hoshino, Prakhar Garg, C. L. Silva, M. Wysocki, B. Bannier, J. M. Durham, Yoshifumi Ueda, J. H. Do, T. Murakami, C. L. Towell, Susumu Sato, N. Vukman, S. I. Morrow, D. Kawall, A. Franz, J. Runchey, K. Tanida, I. Shein, N. N. Ajitanand, G. D. N. Perera, A. Durum, K. Sedgwick, Mihael Makek, H. Yamamoto, M. Boer, Mate Csanad, R. Cervantes, M. Beaumier, D. K. Mishra, Y. Watanabe, R. P. Pisani, J. G. Rubin, N. Apadula, R. Petti, K. Nagai, N. Grau, Shuo Han, Motoi Inaba, J. C. Hill, S. Esumi, D. Sharma, Martin Purschke, C. A. Aidala, V. Andrieux, N. Cronin, B. Azmoun, P. Kline, and A. Dion

Subjects
Physics, Large Hadron Collider, 010308 nuclear & particles physics, Nuclear Theory, Hadron, Elliptic flow, Constituent quark, Multiplicity (mathematics), Kinetic energy, 01 natural sciences, Nuclear physics, Pion, 0103 physical sciences, Nuclear Experiment, 010306 general physics, Anisotropy
Abstract

We present measurements of the transverse- momentum dependence of elliptic flow v2 for identified pions and (anti)protons at midrapidity (|η

Published
2018

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