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2 results on '"Dinardo, Giulio"'

1. An Overview on the Primary Factors That Contribute to Non-Allergic Asthma in Children

Author

Angela Klain, Giulio Dinardo, Alessandra Salvatori, Cristiana Indolfi, Marcella Contieri, Giulia Brindisi, Fabio Decimo, Anna Maria Zicari, Michele Miraglia del Giudice, Klain, Angela, Dinardo, Giulio, Salvatori, Alessandra, Indolfi, Cristiana, Contieri, Marcella, Brindisi, Giulia, Decimo, Fabio, Zicari, Anna Maria, and Miraglia Del Giudice, Michele

Subjects
exercise-induced asthma, children, non-allergic asthma, viral infections, pollution, premenstrual asthma, General Medicine
Abstract

The prevalence of non-allergic asthma in childhood is low, peaking in late adulthood. It is triggered by factors other than allergens, like cold and dry air, respiratory infections, hormonal changes, smoke and air pollution. In the literature, there are few studies that describe non-allergic asthma in pediatric age. Even though it is a less common disorder in kids, it is crucial to identify the causes in order to keep asthma under control, particularly in patients not responding to conventional treatments. In this review, we discuss non-IgE-mediated forms of asthma, collecting the latest research on etiopathogenesis and treatment.

Published
2022

2. Vitamin D status can affect COVID-19 outcomes also in pediatric population

Author

Michele Miraglia del Giudice, Cristiana Indolfi, Giulio Dinardo, Fabio Decimo, Alberto Decimo, Angela Klain, Miraglia Del Giudice, Michele, Indolfi, Cristiana, Dinardo, Giulio, Decimo, Fabio, Decimo, Alberto, and Klain, Angela

Subjects
RAS, renin-angiotensin system, ACE2, angiotensin-converting enzyme 2, PRRs, pattern recognition receptor, TNF-α, tumor necrosis factor-α, PAMPs, pathogen-associated molecular pattern, RCTs, randomized control trial, Pharmacology (medical), Vitamin D, Treg cells, CD, regulatory T cellcluster of differentiation, Children, RR, risk ratio, IgE, immunoglobulin E, DAMPs, damage-associated molecular pattern, TLRs, Toll-like receptor, Pharmacology, IFN-γ, reduce interferon-gamma, HR, Hazard Risk, SARS-CoV-2 infection, Immunity, COVID-19, MD, mean difference, ICU, intensive care unit, IL, interleukin, VDRs, vitamin D receptor, CI, confidence interval, OR, odds ratio, DCs, dendritic cell, NK, natural killer, Food Science
Abstract

Background: vitamin D influences the immune system and the inflammatory response. It is known that vitamin D supplementation reduces the risk of acute respiratory tract infection. In the last two years, many researchers have investigated vitamin D's role in the pathophysiology of COVID-19 disease. Results: the findings obtained from clinical trials and systematic reviews highlight that most patients with COVID19 have decreased vitamin D levels and low levels of vitamin D increase the risk of severe disease. This evidence seems to be also confirmed in the pediatric population. Conclusions: further studies (systematic review and meta-analysis) conducted on children are needed to confirm that vitamin D affects COVID-19 outcomes and to determine the effectiveness of supplementation and the appropriate dose, duration and mode of administration.

Published
2022
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