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2 results on '"Di Martino, Angela"'

1. Tracking the progressive spread of the SARS-CoV-2 Omicron variant in Italy, December 2021 to January 2022

Author

Stefanelli, Paola, Trentini, Filippo, Petrone, Daniele, Mammone, Alessia, Ambrosio, Luigina, Manica, Mattia, Guzzetta, Giorgio, D'Andrea, Valeria, Marziano, Valentina, Zardini, Agnese, Molina Grane', Carla, Ajelli, Marco, Di Martino, Angela, Riccardo, Flavia, Bella, Antonino, Sane Schepisi, Monica, Maraglino, Francesco, Poletti, Piero, Palamara, Anna Teresa, Brusaferro, Silvio, Rezza, Giovanni, Pezzotti, Patrizio, Merler, Stefano, Mencacci, A, Camilloni, B, and Stefanelli P, Trentini F, Petrone D, Mammone A, Ambrosio L, Manica M, Guzzetta G, d'Andrea V, Marziano V, Zardini A, Molina Grane' C, Ajelli M, Di Martino A, Riccardo F, Bella A, Sane Schepisi M, Maraglino F, Poletti P, Palamara AT, Brusaferro S, Rezza G, Pezzotti P, Merler S, Tramuto F

Subjects
Base Sequence, SARS-CoV-2, Epidemiology, COVID–19, SARS–COV–2, DOUBLING TIME, GENOMIC SURVEY, OMICRON, PREVALENCE, prevalence, Vaccination, Public Health, Environmental and Occupational Health, COVID-19, doubling time, omicron, Settore MED/42 - Igiene Generale E Applicata, genomic survey, Virology, SARS–CoV–2, COVID–19, Humans
Abstract

Background The SARS-CoV-2 variant of concern Omicron was first detected in Italy in November 2021. Aim To comprehensively describe Omicron spread in Italy in the 2 subsequent months and its impact on the overall SARS-CoV-2 circulation at population level. Methods We analyse data from four genomic surveys conducted across the country between December 2021 and January 2022. Combining genomic sequencing results with epidemiological records collated by the National Integrated Surveillance System, the Omicron reproductive number and exponential growth rate are estimated, as well as SARS-CoV-2 transmissibility. Results Omicron became dominant in Italy less than 1 month after its first detection, representing on 3 January 76.9–80.2% of notified SARS-CoV-2 infections, with a doubling time of 2.7–3.3 days. As of 17 January 2022, Delta variant represented Conclusion Estimates suggest a marked growth advantage of Omicron compared with Delta variant, but lower disease severity at population level possibly due to residual immunity against severe outcomes acquired from vaccination and prior infection.

Published
2022

2. Evaluation of humoral and cellular response to four vaccines against COVID-19 in different age groups: A longitudinal study

Author

Giorgio Fedele, Filippo Trentini, Ilaria Schiavoni, Sergio Abrignani, Guido Antonelli, Vincenzo Baldo, Tatjana Baldovin, Alessandra Bandera, Filippa Bonura, Pierangelo Clerici, Massimo De Paschale, Francesca Fortunato, Andrea Gori, Renata Grifantini, Giancarlo Icardi, Tiziana Lazzarotto, Vittorio Lodi, Claudio Maria Mastroianni, Andrea Orsi, Rosa Prato, Vincenzo Restivo, Rita Carsetti, Eva Piano Mortari, Pasqualina Leone, Eleonora Olivetta, Stefano Fiore, Angela Di Martino, Silvio Brusaferro, Stefano Merler, Anna Teresa Palamara, Paola Stefanelli, Fedele G, Trentini F, Schiavoni I, Abrignani S, Antonelli G, Baldo V, Baldovin T, Bandera A, Bonura F, Clerici P, De Paschale M, Fortunato F, Gori A, Grifantini R, Icardi G, Lazzarotto T, Lodi V, Mastroianni CM, Orsi A, Prato R, Restivo V, Carsetti R, Piano Mortari E, Leone P, Olivetta E, Fiore S, Di Martino A, Brusaferro S, Merler S, Palamara AT, Stefanelli P., Fedele, Giorgio, Trentini, Filippo, Schiavoni, Ilaria, Abrignani, Sergio, Antonelli, Guido, Baldo, Vincenzo, Baldovin, Tatjana, Bandera, Alessandra, Bonura, Filippa, Clerici, Pierangelo, De Paschale, Massimo, Fortunato, Francesca, Gori, Andrea, Grifantini, Renata, Icardi, Giancarlo, Lazzarotto, Tiziana, Lodi, Vittorio, Mastroianni, Claudio Maria, Orsi, Andrea, Prato, Rosa, Restivo, Vincenzo, Carsetti, Rita, Piano Mortari, Eva, Leone, Pasqualina, Olivetta, Eleonora, Fiore, Stefano, Di Martino, Angela, Brusaferro, Silvio, Merler, Stefano, Palamara, Anna Teresa, and Stefanelli, Paola

Subjects
COVID-19 Vaccines, Ad26COVS1, vaccines, SARS-CoV-2, Immunology, COVID-19, serology, Viral Vaccines, Humans, B-cell memory, cell-mediated immunity, Immunology and Allergy, B-CELL MEMORY, COVID-19, CELL-MEDIATED IMMUNITY, SEROLOGY, VACCINES, Longitudinal Studies, Aged
Abstract

To date there has been limited head-to-head evaluation of immune responses to different types of COVID-19 vaccines. A real-world population-based longitudinal study was designed with the aim to define the magnitude and duration of immunity induced by each of four different COVID-19 vaccines available in Italy at the time of this study. Overall, 2497 individuals were enrolled at time of their first vaccination (T0). Vaccine-specific antibody responses induced over time by Comirnaty, Spikevax, Vaxzevria, Janssen Ad26.COV2.S and heterologous vaccination were compared up to six months after immunization. On a subset of Comirnaty vaccinees, serology data were correlated with the ability to neutralize a reference SARS-CoV-2 B strain, as well as Delta AY.4 and Omicron BA.1. The frequency of SARS-CoV-2-specific CD4+ T cells, CD8+ T cells, and memory B cells induced by the four different vaccines was assessed six months after the immunization. We found that mRNA vaccines are stronger inducer of anti-Spike IgG and B-memory cell responses. Humoral immune responses are lower in frail elderly subjects. Neutralization of the Delta AY.4 and Omicron BA.1 variants is severely impaired, especially in older individuals. Most vaccinees display a vaccine-specific T-cell memory six months after the vaccination. By describing the immunological response during the first phase of COVID-19 vaccination campaign in different cohorts and considering several aspects of the immunological response, this study allowed to collect key information that could facilitate the implementation of effective prevention and control measures against SARS-CoV-2.

Published
2022

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