1. Gout, Hyperuricemia, and Crystal-Associated Disease Network Consensus Statement Regarding Labels and Definitions for Disease Elements in Gout
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Peter T. Chapman, Naomi Schlesinger, Tony R. Merriman, Eliseo Pascual, Masanari Kuwabara, Leslie R. Harrold, Mariano Andrés, Nicola Dalbeth, Fernando Perez-Ruiz, Anthony M. Reginato, Worawit Louthrenoo, Geraldo da Rocha Castelar-Pinheiro, Carlo Alberto Scirè, Marwin Gutierrez, Robert T. Keenan, Rebecca Grainger, Anne Kathrin Tausche, Ole Slot, T.L.Th.A. Jansen, Hang-Korng Ea, Ana Beatriz Vargas-Santos, N. Lawrence Edwards, Mark Fisher, Lisa K. Stamp, Matthijs Janssen, Michael S. Hershfield, Sara K. Tedeschi, Hyon K. Choi, William J. Taylor, Janitzia Vázquez-Mellado, Nitin Kumar, Edward Roddy, George Nuki, Carlos Pineda, Kenneth G. Saag, T. Uhlig, Thomas Bardin, Mats Dehlin, Rubén Burgos-Vargas, David Bursill, Frédéric Lioté, Tristan Pascart, Geraldine M. McCarthy, Pascal Richette, Ann K. Rosenthal, Lennart T H Jacobsson, Christine Czegley, Philip Robinson, Francisca Sivera, Seoyoung C. Kim, Sung Jae Choi, Edyta Biernat-Kaluza, Jasvinder A. Singh, Daniel H. Solomon, Ching Tsai Lin, Robert Terkeltaub, Bursill, D, Taylor, W, Terkeltaub, R, Kuwabara, M, Merriman, T, Grainger, R, Pineda, C, Louthrenoo, W, Edwards, N, Andres, M, Vargas-Santos, A, Roddy, E, Pascart, T, Lin, C, Perez-Ruiz, F, Tedeschi, S, Kim, S, Harrold, L, Mccarthy, G, Kumar, N, Chapman, P, Tausche, A, Vazquez-Mellado, J, Gutierrez, M, da Rocha Castelar-Pinheiro, G, Richette, P, Pascual, E, Fisher, M, Burgos-Vargas, R, Robinson, P, Singh, J, Jansen, T, Saag, K, Slot, O, Uhlig, T, Solomon, D, Keenan, R, Scire, C, Biernat-Kaluza, E, Dehlin, M, Nuki, G, Schlesinger, N, Janssen, M, Stamp, L, Sivera, F, Reginato, A, Jacobsson, L, Liote, F, H. -K., E, Rosenthal, A, Bardin, T, Choi, H, Hershfield, M, Czegley, C, Choi, S, and Dalbeth, N
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musculoskeletal diseases ,medicine.medical_specialty ,congenital, hereditary, and neonatal diseases and abnormalities ,Consensus ,Crystal Arthropathies ,Delphi Technique ,MEDLINE ,Delphi method ,Hyperuricemia ,Disease ,Article ,NO ,03 medical and health sciences ,gout ,0302 clinical medicine ,Podagra ,Rheumatology ,RC925 ,medicine ,Humans ,030203 arthritis & rheumatology ,biology ,business.industry ,Tophus ,nutritional and metabolic diseases ,medicine.disease ,biology.organism_classification ,Uric Acid ,Gout ,Family medicine ,business ,RA ,Medical literature - Abstract
OBJECTIVE: The language currently used to describe gout lacks standardisation. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout. METHODS: Experts in gout (n=130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labelling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting. RESULTS: There were 51 respondents to the Delphi exercise and 30 attendees at the face-to-face meeting. Consensus agreement (≥80%) was achieved for the labels of eight disease elements through the Delphi exercise; the remaining three labels reached consensus agreement through the face-to-face consensus meeting. The agreed labels were: monosodium urate crystals, urate, hyperuric(a)emia, tophus, subcutaneous tophus, gout flare, intercritical gout, chronic gouty arthritis, imaging evidence of monosodium urate crystal deposition, gouty bone erosion and podagra. The face-to-face meeting achieved consensus agreement for the definitions of all 11 elements and a recommendation that the label 'chronic gout' should not be used. CONCLUSION: Consensus agreement was achieved for the labels and definitions of 11 elements representing the fundamental components of gout aetiology, pathophysiology and clinical presentation. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) recommends the use of these labels when describing the basic disease elements of gout. This article is protected by copyright. All rights reserved.
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- 2019