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Unified theories such as string theory and loop quantum gravity allow the Lorentz Invariance Violation (LIV) at the Planck Scale ($M_P \sim 10^{19}$ GeV). Using an effective field theory, this effect can be observed at low energies in terms of new interactions with a strength of $\sim 1/M_P$. These new interactions contain operators with LIV coefficients which can be CPT-violating or CPT-conserving. In this work, we study in detail how these LIV parameters modify the transition probabilities in the next-generation long-baseline experiments, DUNE and T2HK. We evaluate the sensitivities of these experiments in isolation and combination to constrain the off-diagonal CPT-violating ($a_{e\mu}$, $a_{e\tau}$, $a_{\mu\tau}$) and CPT-conserving ($c_{e\mu}$, $c_{e\tau}$, $c_{\mu\tau}$) LIV parameters. We derive approximate compact analytical expressions of $\nu_{\mu}\to\nu_e$ and $\nu_{\mu}\to\nu_\mu$ probabilities in the presence of these LIV parameters to explain our numerical results. We explore the possible correlations and degeneracies between these LIV parameters & 3$\nu$ parameters $\theta_{23}$ & $\delta_{\rm CP}$. We find that for non-maximal values of $\theta_{23}$, there exist degenerate solutions in its opposite octant for standalone DUNE and T2HK. These degeneracies disappear when we combine the data from DUNE and T2HK. In case of no-show, we place the expected bounds on these CPT-violating and CPT-conserving LIV parameters at 95% C.L. using the standalone DUNE, T2HK, and their combination. We observe that due to its access to a longer baseline and high-energy neutrinos, DUNE has a better reach in probing all these LIV parameters as compared to T2HK. Since the terms containing the CPT-conserving LIV parameters are proportional to neutrino energy in oscillation probabilities, T2HK is almost insensitive to the CPT-conserving LIV parameters because it mostly deals with sub-GeV neutrinos., Comment: 34 pages, 10 figures, 5 tables

The demand for various unconventional foods to reduce the complications in both communicable and non-communicable diseases is increasing day by day. The aim of this review was to observe the efficacy of Aloe vera in hyperglycemia and in hyperlipidemia in vivo (both animals and humans). The studies of different authors were searched by using many scientific search engines such as Pub Med, Google Scholar, Science Direct, the database of Open Access Journals. There are 25 animal studies and 10 human studies included in this review. By analyzing data, data were extracted from selected articles that showed the effects of a different form of Aloe vera on diabetes and hyperlipidemia after consumption. The result of this review covers different doses and forms of Aloe vera, which were provided to target animals and humans for a different duration to achieve an outcome in those articles. Most of the studies showed a significant result that means Aloe vera has a positive effect on diabetes and hyperlipidemia. Further studies are needed to elucidate the pathophysiological mechanisms of action of Aloe vera as well as its efficacy and safety in the treatment of various diseases.

Our knowledge about 3$nu$ mixing angles and the CP-phase are becoming more accurate day-by-day. In this high-precision era of neutrino oscillation, it is inevitable to investigate the unitarity of the 3$nu$ mixing matrix. In this work, we study the impact of possible non-unitary neutrino mixing (NUNM) in the context of next-generation long-baseline experiments DUNE and T2HKK having one detector in Japan and a second detector in Korea. We estimate the sensitivities of these setups to place direct, model-independent, and competitive constraints on various NUNM parameters. Also, we study the correlation of these NUNM parameters with $theta_{23}$ and $delta_{CP}$. Our results using only far detector data, reveal that T2HKK has better sensitivities to the NUNM parameters $|alpha_{21}|$ and $alpha_{22}$ compared to DUNE as the former has larger statistics in the appearance channel and less systematic uncertainties in the disappearance channel. For $|alpha_{31}|$, $|alpha_{32}|$, and $alpha_{33}$, DUNE can establish better limits compared to T2HKK due to its larger matter effects. We also show how the presence of near detectors in these setups would modify the limits on these NUNM parameters. Finally, we observe that the $nu_{tau}$ appearance sample in DUNE can improve the constraints on $|alpha_{32}|$ and $alpha_{33}$. &nbsp

We explore the role of matter effect in the evolution of neutrino oscillation parameters in the presence of all possible lepton-flavour-conserving and lepton-flavour-violating non-standard interactions (NSIs) of the neutrino. We derive simple approximate analytical expressions for the mass-mixing parameters in matter in presence of NSIs. We observe that only the NSIs in 2-3 block($\varepsilon_{\mu\mu}, \varepsilon_{\tau\tau}$,and $\varepsilon_{\mu\tau}$) affect the running of $\theta_{23}$. Though all the NSIs influence the evolution of $\theta_{13}$, but, $\varepsilon_{e\mu}$ and $\varepsilon_{e\tau}$ have prominent impact at the energies relevant for DUNE. We demonstrate the utility of our approach in addressing several important features related to neutrino oscillation such as: a) estimating the resonance energy in presence of NSIs when $\theta_{13}$ in matter becomes maximal, b) figuring out the required baseline length and neutrino energies to have maximal matter effect in $\nu_{\mu}$ to $\nu_{e}$ transition, and c) unraveling interesting degeneracies between $\theta_{23}$ and NSI parameters.

Additional file 4: Table S1. Details of plant samples used in the study. Table S2. Primers (RAPD, ITS, and SSR) used in the study. Table S3. Calculation of cost per preparation for rHTTP method.

Orosomucoid like 3 (ORMDL3), a gene localized to chromosome 17q21, has been linked in epidemiologic studies to childhood asthma and rhinovirus (RV) infections. As the single nucleotide polymorphisms linking ORMDL3 to asthma are associated with increased expression of ORMDL3, we have used hORMDL3zp3-Cre mice (which have universal increased expression of human ORMDL3) to determine whether infection of these transgenic mice with RV influences levels of airway inflammation or RV viral load. RV infection of hORMDL3zp3-Cre mice resulted in reduced RV viral load assessed by quantitative real-time PCR (lung and airway epithelium), as well as reduced airway inflammation (total bronchoalveolar lavage cells, neutrophils, macrophages, and lymphocytes) compared with RV-infected wild-type mice. Levels of the antiviral pathways including IFNs (IFN-α, IFN-β, IFN-λ) and RNAse L were significantly increased in the lungs of RV-infected hORMDL3zp3-Cre mice. Levels of the antiviral mouse oligoadenylate synthetase (mOas)1g pathway and RNAse L were upregulated in the lungs of unchallenged hORMDL3zp3-Cre mice. In addition, levels of mOas2, but not mOas1 (mOas1a, mOas1b, mOas1g), or mOas3 pathways were significantly more upregulated by IFNs (IFN-α, IFN-β, IFN-λ) in epithelial cells from hORMDL3zp3-Cre mice compared with RV-infected wild-type mouse epithelial cells. RNAse L-deficient mice infected with RV had increased RV viral load. Overall, these studies suggest that increased levels of ORMDL3 contribute to antiviral defense to RV infection in mice through pathways that may include IFNs (IFN-α, IFN-β, IFN-λ), OAS, and RNAse L.

Chronic asthma is associated with airway remodeling and decline in lung function. In this article, we show that follistatin-like 1 (Fstl1), a mediator not previously associated with asthma, is highly expressed by macrophages in the lungs of humans with severe asthma. Chronic allergen-challenged Lys-Cre(tg) /Fstl1(Δ/Δ) mice in whom Fstl1 is inactivated in macrophages/myeloid cells had significantly reduced airway remodeling and reduced levels of oncostatin M (OSM), a cytokine previously not known to be regulated by Fstl1. The importance of the Fstl1 induction of OSM to airway remodeling was demonstrated in murine studies in which administration of Fstl1 induced airway remodeling and increased OSM, whereas administration of an anti-OSM Ab blocked the effect of Fstl1 on inducing airway remodeling, eosinophilic airway inflammation, and airway hyperresponsiveness, all cardinal features of asthma. Overall, these studies demonstrate that the Fstl1/OSM pathway may be a novel pathway to inhibit airway remodeling in severe human asthma.

Presence of higher derivative terms in the Horava model of gravity can generate an instability in the Minkowski ground state. This in turn leads to a space dependent vacuum metric with a length scale determined by the higher derivative coupling coefficient. The translation invariance is spontaneously broken in the process. The phenomenon is interpreted as a form of Landau liquid-solid phase translation. The (metric) condensate acts as a source that modifies the Newtonian potential below the length scale but keeps it unchanged for sufficiently large distance., Comment: 14 pages Latex

It is well known that in a firm real time system with a renewal arrival process, exponential service times and independent and identically distributed deadlines till the end of service of a job, the earliest deadline first (EDF) scheduling policy has smaller loss ratio (expected fraction of jobs, not completed) than any other service time independent scheduling policy, including the first come first served (FCFS). Various modifications to the EDF and FCFS policies have been proposed in the literature, with a view to improving performance. In this article, we compare the loss ratios of these two policies along with some of the said modifications, as well as their counterparts with deterministic deadlines. The results include some formal inequalities and some counter-examples to establish non-existence of an order. A few relations involving loss ratios are posed as conjectures, and simulation results in support of these are reported. These results lead to a complete picture of dominance and non-dominance relations between pairs of scheduling policies, in terms of loss ratios., Comment: 8 pages, 10 figures

A formalism is proposed to generate (the first step of) a discrete spacetime: spacetime with an inbuilt length scale. We follow the celebrated Landau theory of liquid - solid phase transition induced by Spontaneous Symmetry Breaking by a condensate whose Fourier transform has support at a {\it{non-zero}} momentum. The latter requirement is essential for breaking the translation symmetry. This, in turn, compels us to generalize Einstein action to higher derivative terms., Comment: 7 pages, Latex, Comments are welcome

The present thesis is a collection of papers which deals with analytic models that can drive the present accelerated expansion of the universe, starting from a decelerated expansion in the early matter dominated regime. Both minimally and non minimally coupled scalar fields are employed for the purpose. Interaction between nonminimally coupled scalar field, such as the Brans-Dicke field, with dark matter and dark energy are considered. This interactions are shown to solve some fine tuning problems. Curvature driven acceleration is also considered in this thesis, which shows that a smooth transition from a deceleration to an acceleration is possible in this scenario., Comment: 146 pages; thesis accepted for PhD. degree of Jadavpur University, Kolkata, India