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Introduction: Defective apical seals were identified as the main cause of failures in endodontic treatment, and several studies have emphasized the importance of adequate coronal sealing between sessions for successful endodontic therapy. Sodium hypochlorite is an irrigant solution widely used in chemotherapeutic treatment for a long time with great effectiveness. Gluconate chlorhexidine is a newer product but with excellent properties but there is still considerable controversy over which is the best product for the treatment of the canal. Objective: The objective of the present study was to perform a systematic review on the importance of the clinical use and outcomes of Chlorhexidine gluconate, Sodium hypochlorite and Coltosol® in endodontic treatment of canals. Methods: The words were included Treatment dental root. Chlorhexidine gluconate, Sodium hypochlorite and Coltosol®. For further specification, the root canal irrigation description for refinement was added during searches. The literature search was conducted through online databases: Pubmed, Periodicos.com and Google Scholar. It was stipulated deadline, and the related search covering all available literature on virtual libraries. A total of 55 articles were found involving temporomandibular dysfunction. Initially, it was held the exclusion existing title and duplications in accordance with the interest described this work. After this process, the summaries were evaluated and a new exclusion was held. A total of 41 articles were evaluated in full, and 30 were included and discussed in this study. Conclusion: Chlorhexidine gluconate, sodium hypochlorite and Coltosol® have great fundamental properties for endodontic treatment and neither product can be disregarded. It is only necessary to analyze in detail when hypochlorite should be used and when chlorhexidine gluconate can be used that can be used alternately in the preparation of the endodontic canal and should not be used simultaneously, since the interaction between the two products provides a high toxicity. Already Coltosol® prey expansion can cause significant strains in the remaining coronary structure.&nbsp