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5. Role of perfusion CT in the evaluation of metastatic nodal tumor response after radiochemotherapy in head and neck cancer: preliminary findings

Author

S, Ursino, L, Faggioni, F, Fiorica, D, Delishaj, V, Seccia, F, Pasqualetti, I, Desideri, C, Colosimo, R, Morganti, F, Paiar, and D, Caramella

Subjects
Head and Neck Neoplasms, Lymphatic Metastasis, Perfusion Imaging, Positron Emission Tomography Computed Tomography, Hemodynamics, Humans, Chemoradiotherapy
Abstract

To assess changes of CT perfusion parameters (ΔPCTp) of cervical lymph node metastases from head and neck cancer (HNC) before and after radiochemotherapy (RT-CT) and their association with nodal tumor persistence.Eligibility criteria included HNC (Stage III-IV) candidates for RT-CT. Patients underwent perfusion CT (PCT) at baseline 3 weeks and 3 months after RT-CT. Blood volume (BV), blood flow (BF), mean transit time (MTT) and permeability surface (PS) were calculated. PET/CT examination was also performed at baseline and 3 months after treatment for metabolic assessment.Between July 2012 and May 2016, 27 patients were evaluated. Overall, only 3 patients (11%) experienced tumor persistence in the largest metastatic lymph node. A significant reduction of all PCTp values (p0.0001), except MTT (from 6.3 to 5.7 s; p=0.089), was observed at 3 weeks post-RT-CT compared to baseline. All PCTp values including MTT were significantly lower at 3-month follow-up compared to baseline (p0.05). Moreover, a statistically significant association was observed between nodal tumor persistence and high BF values (p=0.045) at 3 months after treatment that did not occur for the other parameters.Our preliminary findings show that all PCTp except MTT are significantly reduced after RT-CT. High BF values at 3 months post-RT-CT are predictive of nodal tumor persistence.

Published
2017

6. The role of clinicopathologic and molecular prognostic factors in the post-mastectomy radiotherapy (PMRT): a retrospective analysis of 912 patients

Author

S, Ursino, F, Fiorica, V, Mazzotti, D, Delishaj, A, Cristaudo, S, Spagnesi, C, Laliscia, F, Pasqualetti, A, Fontana, M, Ghilli, R, Morganti, A, Falcone, M, Roncella, and F, Paiar

Subjects
Adult, Humans, Breast Neoplasms, Female, Radiotherapy, Adjuvant, Middle Aged, Neoplasm Recurrence, Local, Prognosis, Combined Modality Therapy, Mastectomy, Aged, Retrospective Studies
Abstract

To assess the association of clinicopathologic and molecular features with loco-regional recurrence (LRR) in post-mastectomy breast cancer patients with or without adjuvant radiotherapy (PMRT).We retrospectively reviewed data of patients undergone to mastectomy followed or not by PMRT between January 2004 and June 2013. The patients were divided according to clinicopathologic and molecular sub-classification features. LRR and Cancer Specific Survival (CSS) were calculated using the Kaplan-Meier method; the prognostic factors were compared using long-rank tests and Cox regression model.A total of 912 patients underwent to mastectomy of whom 269 (29.5%) followed by PMRT and 643 (70.5%) not; among the PMRT group, 77 underwent to the chest wall (CW) and 202 to the chest wall and lymphatic drainage (CWLD) irradiation. The median follow-up was 54 months (range, 3-118). No significant difference in terms of LRR and CSS was found between non-PMRT and PMRT group (p=0.175; and p=0.628). The multivariate analysis of LRR for patients who did not undergo PMRT showed a significant correlation with the presence of extracapsular extension (ECE) (p=0.049), Ki-6730% (p=0.048) and triple negative status (p=0.001). In the PMRT group, triple negative status resulted as the only variable significantly correlated to LRR (p=0.006) at the multivariate analysis and T-stage also showed a trend to significance (p=0.073). Finally, no difference in LRR control was shown between CW and CWLD-PMRT (p=0.078).After mastectomy ECE, a cut off of Ki-6730% and triple negative status were strictly correlated with LRR regardless of clinicopathologic stage. PMRT has a positive impact in decreasing LRR in patients with this molecular profile. Besides, CW might represent a valid option for patients with one to three positive nodes.

Published
2017

7. PO-1088: Pattern of late dysphagia after IMRT of head and neck cancers: a prospective study

Author

Riccardo Morganti, Francesco Pasqualetti, A. Nacci, P. Coccuzza, S. Montrone, A. Gonnelli, S. Santopadre, A. Molinari, Stefano Ursino, Fabiola Paiar, B. Fattori, F. Orlandi, P. Giusti, A. Cristaudo, D. Delishaj, Veronica Seccia, and D. Baldaccini

Subjects
medicine.medical_specialty, Oncology, business.industry, medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, medicine.symptom, business, Head and neck, Prospective cohort study, Dysphagia
Published
2018

8. EP-2092: Impact of treatment volumes in loco-regional failure of oral cancer in patients treated with IMRT

Author

D. Delishaj, E. Lombardo, S. Montrone, L. Fatigante, M. Cantarella, F. Matteucci, Maria Grazia Fabrini, G. Coraggio, and Stefano Ursino

Subjects
Oncology, medicine.medical_specialty, business.industry, Cancer, Hematology, medicine.disease, urologic and male genital diseases, female genital diseases and pregnancy complications, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, In patient, business
Published
2016
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9. PO-0630: The role of mc4r gene polymorphisms in gbm patients treated with concomitant radio-chemotherapy

Author

Guido Bocci, S. Montrone, G. Coraggio, Fabiola Paiar, Paola Orlandi, Francesco Pasqualetti, S. Guarini, Vittorio Simeon, Anna Fioravanti, A. Gonnelli, T. Di Desiderio, D. Giuliani, Romano Danesi, Maria Grazia Fabrini, M. Cantarella, E. Lombardo, and D. Delishaj

Subjects
Oncology, business.industry, Concomitant, Cancer research, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, business, Gene, Radio chemotherapy
Published
2017

11. The treatment of acute and late vaginal toxicity after adjuvant high dose rate [HDR] vaginal brachytherapy in patients with intermediate risk endometrial cancer: Is local therapy with hyaluronic acid of clinical benefit?

Author

Francesco Perrone, Fabiola Paiar, C. Laliscia, B. Manfredi, R. Morganti, D. Delishaj, Angiolo Gadducci, Maria Grazia Fabrini, A. Gonnelli, A. Molinari, and F. Orlandi

Subjects
Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, Endometrial cancer, Urology, medicine.disease, Surgery, chemistry.chemical_compound, Oncology, chemistry, Toxicity, Hyaluronic acid, Vaginal brachytherapy, Medicine, In patient, business, Intermediate risk, Dose rate, Adjuvant
Published
2017

12. EP-1129: Perfusion CT in the evaluation of Nodal response after RCT in H&N cancers: a prospective study

Author

A. Cristaudo, D. Baldaccini, Davide Caramella, E. Calistri, M. Cantarella, A. Gonnelli, F. Matteucci, L. Faggioni, P. Ferrazza, E. Lombardo, Fabiola Paiar, R. Mattioli, A. Molinari, Riccardo Morganti, D. Delishaj, S. Montrone, Stefano Ursino, F. Orlandi, and Francesco Pasqualetti

Subjects
Oncology, Randomized controlled trial, law, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, NODAL, Nuclear medicine, business, Prospective cohort study, Perfusion, law.invention
Published
2018

13. EP-2288: Role of circulating DNA in Glioblatoma IDH1 wild type patients suitable for radiotherapy

Author

A. Molinari, Giuliana Restante, Eleonora Rofi, D. Delishaj, M. Del Re, M. Cantarella, Fabiola Paiar, S. Montrone, A. Gonnelli, and Francesco Pasqualetti

Subjects
Radiation therapy, IDH1, Oncology, business.industry, medicine.medical_treatment, Cancer research, Wild type, Medicine, Circulating DNA, Radiology, Nuclear Medicine and imaging, Hematology, business
Published
2018

15. PO-0756: Choline PET/CT and Stereotactic Body Radiotherapy in oligometastatic prostate cancer patients

Author

D. Delishaj, M. Cantarella, S. Montrone, Carlo Greco, L. Derosa, A. Cristaudo, P. Erba, P. Cocuzza, P. Ferrazza, G. Coraggio, M. Panichi, Francesco Pasqualetti, F. Matteucci, Aldo Sainato, and Maria Grazia Fabrini

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, business.industry, Hematology, Choline pet ct, medicine.disease, 03 medical and health sciences, Prostate cancer, 030104 developmental biology, 0302 clinical medicine, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, business, Nuclear medicine, Stereotactic body radiotherapy
Published
2016
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16. PO-0665: The role of post-mastectomy radiotherapy (PMRT) and prognostic factors of locoregional recurrence

Author

F. Orlandi, Riccardo Morganti, L. Fatigante, B. Manfredi, V. Mazzotti, D. Delishaj, Davide Caramella, S. Spagnesi, F. Matteucci, M. Pnichi, Maria Grazia Fabrini, A. Gonnelli, Stefano Ursino, Fabiola Paiar, Francesco Pasqualetti, A. Cristaudo, Aldo Sainato, A. Molinari, M. Roncella, Concetta Laliscia, Alfredo Falcone, D. Baldaccini, M. Cantarella, and E. Lombardo

Subjects
medicine.medical_specialty, Oncology, business.industry, Medicine, Radiology, Nuclear Medicine and imaging, Hematology, Radiology, business, Post mastectomy radiotherapy
Published
2017

18. OC-0274: Analysis of set-up errors in head and neck cancer treated with IMRT technique assessed by CBCT

Author

F. Matteucci, C. La Liscia, E. Lombardo, Maria Grazia Fabrini, Stefano Ursino, Aldo Sainato, S. Spagnesi, Francesco Pasqualetti, M. Panichi, D. Delishaj, L. Fatigante, and B. Manfredi

Subjects
business.industry, Head and neck cancer, Hematology, medicine.disease, 030218 nuclear medicine & medical imaging, Set (abstract data type), 03 medical and health sciences, 0302 clinical medicine, Oncology, Radiology Nuclear Medicine and imaging, 030220 oncology & carcinogenesis, Medicine, Radiology, Nuclear Medicine and imaging, business, Nuclear medicine
Published
2016

19. 2042 Preoperative short course radiotherapy in elderly patients (^75 years) affected by locally advanced rectal cancer

Author

Francesco Pasqualetti, E. Lombardo, Piero Buccianti, G. Coraggio, D. Delishaj, B. Manfredi, S. Montrone, Aldo Sainato, Riccardo Balestri, M. Cantarella, and C. Laliscia

Subjects
Cancer Research, medicine.medical_specialty, Oncology, business.industry, Colorectal cancer, Locally advanced, Medicine, Radiology, business, medicine.disease, Short course radiotherapy
Published
2015

20. 2918 Preliminary experiences of second surgery combined with postoperative systemic therapy in patients with recurrent Glioblastoma

Author

A. Cristaudo, D. Caramella, L. Fatigante, Maria Grazia Fabrini, A. Gonnelli, F. Matteucci, S. Ursino, M. Cosottini, A. Weiss, Francesco Pasqualetti, R. Vannozzi, M. Cantarella, P. Perrini, and D. Delishaj

Subjects
Cancer Research, medicine.medical_specialty, Oncology, business.industry, Recurrent glioblastoma, medicine, In patient, business, Systemic therapy, Surgery
Published
2015

22. 2253 Interferon-based adjuvant chemoradiation in patients with resected pancreatic adenocarcinoma: Long-term outcomes

Author

Alfredo Falcone, G. Coraggio, V. Menghini, Francesco Pasqualetti, E. Lombardo, Ugo Boggi, M. Coppola, Aldo Sainato, D. Delishaj, S. Montrone, Enrico Vasile, and N.L.V. Cernusco

Subjects
Oncology, Cancer Research, medicine.medical_specialty, business.industry, medicine.medical_treatment, medicine.disease, Interferon, Internal medicine, medicine, Long term outcomes, Adenocarcinoma, In patient, business, Adjuvant, medicine.drug
Published
2015

23. 3316 Non-melanoma skin cancer treated with HDR Brachytherapy and Valencia applicator in elderly patients

Author

G. Coraggio, Francesco Pasqualetti, Francesco Perrone, E. Lombardo, Maria Grazia Fabrini, S. Ursino, S. Montrone, M. Cantarella, P. Cocuzza, D. Delishaj, C. Laliscia, and B. Manfredi

Subjects
Cancer Research, medicine.medical_specialty, Oncology, business.industry, medicine.medical_treatment, Brachytherapy, Medicine, Skin cancer, business, medicine.disease, Surgery, Non melanoma
Published
2015

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