1. Effect of early hyperoxemia on the outcome in servere blunt chest trauma: A propensity score-based analysis of a single-center retrospective cohort
- Author
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Duclos, Gary, Rivory, Adrien, Rességuier, Noémie, Hammad, Emmanuelle, Vigne, Coralie, Meresse, Zoé, Pastène, Bruno, d'Journo, Xavier-Benoit, Jaber, Samir, Zieleskiewicz, Laurent, Leone, Marc, Maille, Baptiste, Wilkin, Marie, Million, Matthieu, Franceschi, Frédéric, Koutbi-Franceschi, Linda, Hourdain, Jérôme, Martinez, Elisa, Zabern, Maxime, Gardella, Christophe, Tissot-Dupont, Hervé, Singh, Jagmeet, Deharo, Jean-Claude, Fiorina, Laurent, Assistance Publique - Hôpitaux de Marseille (APHM), Support Unit for Clinical Research and Economic Evaluation, Assistance Publique-Hôpitaux de Marseille, Marseille 13385, Centre d'études et de recherche sur les services de santé et la qualité de vie (CEReSS), Aix Marseille Université (AMU), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Microbes évolution phylogénie et infections (MEPHI), and Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Pediatrics ,medicine.medical_specialty ,Thoracic Injuries ,[SDV]Life Sciences [q-bio] ,macromolecular substances ,Hyperoxia ,Wounds, Nonpenetrating ,Critical Care and Intensive Care Medicine ,Single Center ,03 medical and health sciences ,Mechanical ventilation ,0302 clinical medicine ,Blunt ,medicine ,Humans ,Propensity Score ,Retrospective Studies ,Blunt chest trauma ,business.industry ,Incidence (epidemiology) ,Trauma center ,Hyperoxemia ,030208 emergency & critical care medicine ,Retrospective cohort study ,Pneumonia ,3. Good health ,Critical care ,030228 respiratory system ,Cohort ,Propensity score matching ,ARDS ,business - Abstract
International audience; Purpose Our study aimed to explore the association between early hyperoxemia of the first 24 h on outcomes in patients with severe blunt chest trauma.Materials and methods In a level I trauma center, we conducted a retrospective study of 426 consecutive patients. Hyperoxemic groups were classified in severe (average PaO2 ≥ 200 mmHg), moderate (≥150 and < 200 mmHg) or mild (≥ 100 and < 200 mmHg) and compared to control group (≥60 and < 100 mmHg) using a propensity score based analysis. The first endpoint was the incidence of a composite outcome including death and hospital-acquired pneumonia occurring from admission to day 28. The secondary endpoints were the incidence of death, the number of hospital-acquired pneumonia, mechanical ventilation-free days and intensive care unit-free day at day 28.Results The incidence of the composite endpoint was lower in the severe hyperoxemia group(OR, 0.25; 95%CI, 0.09–0.73; P < 0.001) compared with control. The 28-day mortality incidence was lower in severe (OR, 0.23; 95%CI, 0.08–0.68; P < 0.001) hyperoxemia group (OR, 0.41; 95%CI, 0.17–0.97; P = 0.04). Significant association was found between hyperoxemia and secondary outcomes.Conclusion In our cohort early hyperoxemia during the first 24 h of admission after severe blunt chest trauma was not associated with worse outcome.
- Published
- 2021