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Your search keyword '"Crudu, Valeriu"' showing total 7 results
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7 results on '"Crudu, Valeriu"'

1. Evaluation of the antifungal and antibacterial action of a new unsaturated 1,2,4-triazole derivative (Nitrotriazon)

Author

Valica Vladimir, Uncu Livia, Crudu Valeriu, Drumea Maria, Macaev Fliur, and Stingaci Eugenia

Subjects
Chemistry, medicine.drug_class, Chloramphenicol, Ampicillin, Bifonazole, medicine, Ketoconazole, Pharmacophore, Antibacterial activity, Antimycobacterial, Antimicrobial, Combinatorial chemistry, medicine.drug
Abstract

The growing clinical importance of drug-resistant fungal and bacterial pathogens has given additional urgency to microbiological research and the development of new antimicrobial compounds. 1,2,4-Triazoles act as important pharmacophores by interacting with high affinity biological receptors due to their dipole character, hydrogen binding capacity, stiffness and solubility. Following the evaluation of the antifungal activity, Nitrotriazon has MIC/MFC values: from 0.07 to 0.19 mM compared to the reference drugs: Ketoconazole, Bifonazole. Nitrotriazone also showed good antibacterial activity with MIC / MBC values from 0.0006 to 0.0013 mM, compared to the reference drugs Ampicillin and Chloramphenicol. The antimycobacterial activity of Nitrotriazone against M. tuberculosis, the reference strain (H37Rw) and the extended resistance of M. tuberculosis (M/XDR) were also studied.

Published
2021

2. MOESM1 of A retrospective genomic analysis of drug-resistant strains of M. tuberculosis in a high-burden setting, with an emphasis on comparative diagnostics and reactivation and reinfection status

Author

Wollenberg, Kurt, Harris, Michael, Gabrielian, Andrei, Ciobanu, Nelly, Chesov, Dumitru, Long, Alyssa, Taaffe, Jessica, Hurt, Darrell, Rosenthal, Alex, Tartakovsky, Michael, and Crudu, Valeriu

Abstract

Additional file 1: Table S1. File containing data about paired samples analyzed in this article. These data include the SRA identifiers, TB Portal anonymized patient identifier, octal spoligotype, spoligotype and SNP barcode numerical lineage, pairwise distance (number of SNPs) between samples, days between sample collection, maximum drug resistance test result, case definition, case outcome, patient age at onset, and patient gender. A key to abbreviations used in the table are included in the header.

Published
2020
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3. Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage (vol 47, pg 242, 2015)

Author

Merker, Matthias, Blin, Camille, Mona, Stefano, Duforet-Frebourg, Nicolas, Lecher, Sophie, Willery, Eve, Blum, Michael, Ruesch-Gerdes, Sabine, Mokrousov, Igor, Aleksic, Eman, Allix-Beguec, Caroline, Antierens, Annick, Augustynowicz-Kopec, Ewa, Ballif, Marie, Barletta, Francesca, Beck, Hans Peter, Clifton E Barry, Bonnet, Maryline, Borroni, Emanuele, Campos-Herrero, Isolina, Cirillo, Daniela, Cox, Helen, Crowe, Suzanne, Crudu, Valeriu, Diel, Roland, Drobniewski, Francis, Fauville-Dufaux, Maryse, Gagneux, Sebastien, Ghebremichael, Solomon, Hanekom, Madeleine, Hoffner, Sven, Jiao, Wei-Wei, Kalon, Stobdan, Kohl, Thomas A., Kontsevaya, Irina, Lillebeak, Troels, Maeda, Shinji, Nikolayevskyy, Vladyslav, Rasmussen, Michael, Rastogi, Nalin, Samper, Sofia, Sanchez-Padilla, Elisabeth, Savic, Ranislava, Shamputa, Isdore Chola, Shen, Adong, Sng, Li-Hwei, Stakenas, Petras, Toit, Kadri, Varaine, Francis, Vukovic, Dragana, Wahl, Celine, Warren, Robin, Supply, Philip, Niemann, Stefan, and Wirth, Thierry

4. Additional file 1: Table S1. of Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis

Author

Georghiou, Sophia, Seifert, Marva, Shou-Yean Lin, Catanzaro, Donald, Garfein, Richard, Jackson, Roberta, Crudu, Valeriu, Rodrigues, Camilla, Victor, Thomas, Catanzaro, Antonino, and Rodwell, Timothy

Subjects
3. Good health
Abstract

Pyrosequencing (PSQ) Success of Each Gene Target by Smear- and Culture-Status. Table S2. Proportion of Successful Pyrosequencing (PSQ) Reactions by Smear- and Culture-Status. (DOCX 18 kb)

5. Additional file 1: of Cost analysis of rapid diagnostics for drug-resistant tuberculosis

Author

Groessl, Erik, Ganiats, Theodore, Hillery, Naomi, Trollip, Andre, Jackson, Roberta, Catanzaro, Donald, Rodwell, Timothy, Garfein, Richard, Rodrigues, Camilla, Crudu, Valeriu, Victor, Thomas, and Catanzaro, Antonino

Subjects
polycyclic compounds, heterocyclic compounds, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, 3. Good health
Abstract

Table S1 Clinical and Laboratory Characteristics of the Patients. Table S2 Agreement between three rapid tests and MGIT for detection of resistance for isoniazid (INH), rifampin (RIF), amikacin (AMK), capreomycin (CAP), kanamycin (KAN), moxifloxacin (MOX), and ofloxacin (OFX). Table S3 Proportion of total assay runs that produced interpretable results from three diagnostic platforms (LPA, PSQ and MODS) with the ability to detect resistance to isoniazid (INH), rifampin (RIF), amikacin (AMK), capreomycin (CAP), kanamycin (KAN), moxifloxacin (MOX), and ofloxacin (OFX). (DOCX 35 kb)

6. Additional file 1: Table S1. of Shedding light on the performance of a pyrosequencing assay for drug-resistant tuberculosis diagnosis

Author

Georghiou, Sophia, Seifert, Marva, Shou-Yean Lin, Catanzaro, Donald, Garfein, Richard, Jackson, Roberta, Crudu, Valeriu, Rodrigues, Camilla, Victor, Thomas, Catanzaro, Antonino, and Rodwell, Timothy

Subjects
3. Good health
Abstract

Pyrosequencing (PSQ) Success of Each Gene Target by Smear- and Culture-Status. Table S2. Proportion of Successful Pyrosequencing (PSQ) Reactions by Smear- and Culture-Status. (DOCX 18 kb)

7. Additional file 1: of Cost analysis of rapid diagnostics for drug-resistant tuberculosis

Author

Groessl, Erik, Ganiats, Theodore, Hillery, Naomi, Trollip, Andre, Jackson, Roberta, Catanzaro, Donald, Rodwell, Timothy, Garfein, Richard, Rodrigues, Camilla, Crudu, Valeriu, Victor, Thomas, and Catanzaro, Antonino

Subjects
polycyclic compounds, heterocyclic compounds, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, 3. Good health
Abstract

Table S1 Clinical and Laboratory Characteristics of the Patients. Table S2 Agreement between three rapid tests and MGIT for detection of resistance for isoniazid (INH), rifampin (RIF), amikacin (AMK), capreomycin (CAP), kanamycin (KAN), moxifloxacin (MOX), and ofloxacin (OFX). Table S3 Proportion of total assay runs that produced interpretable results from three diagnostic platforms (LPA, PSQ and MODS) with the ability to detect resistance to isoniazid (INH), rifampin (RIF), amikacin (AMK), capreomycin (CAP), kanamycin (KAN), moxifloxacin (MOX), and ofloxacin (OFX). (DOCX 35 kb)

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