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Additional file 1. Assumptions and hierarchical regression analysis statistics.

Discrete Mathematical Equations Governing HPA axis. Details the derivation of discrete equations employed for the simulation of HPA axis. (PDF 132 kb)

Asynchronous Simulation. Asynchronous update of the network contains two complex cyclic attractors. Since under asynchronous update each state might have more than two successors several state nodes in the graph present with multiple out-bound edges. (PDF 52 kb)

Priority Memory Update. Simulations in priority class with memory. CORT is placed in a second priority class update and the rest of the parameters in the model have a higher priority and frequency of update. (PDF 24 kb)

Stress Response Parameterization. Parameterization of stress response. (PDF 332 kb)

Interactive Parameter Tuning Algorithm. Describes the parameter identification algorithm and pseudo-code. (PDF 300 kb)

Synchronous Simulation. Simulations with synchronous update where each node has only one successor state. It is well known that synchronous update can result in spurious cycles [12]. (PDF 36 kb)