35 results on '"Cordier, J."'
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2. Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity
- Author
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Cottin, V., Nunes, H., Brillet, P.-Y., Delaval, P., Devouassaoux, G., Tillie-Leblond, I., Israel-Biet, D., Court-Fortune, I., Valeyre, D., Cordier, J.-F., Carré, P., Chabot, F., Chatté, G., Coëtmeur, D., Crestani, B., Dalphin, J.C., Dietemann, A., Gentil, B., Humbert, M., Lacronique, J., Mairesse, M., Marchand, Eric, Reynaud-Gaubert, M., Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL), Centre Hospitalier Universitaire de Lyon, Service de Pneumologie, Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Pontchaillou [Rennes], Centre Hospitalier Universitaire de Lille (CHU de Lille), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Hospices Civils de Lyon (HCL), UCL - MD/MINT - Département de médecine interne, and UCL - (MGD) Service de pneumologie
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Hypertension, Pulmonary ,[SDV]Life Sciences [q-bio] ,Interstitial lung disease ,EMPHYSEMA ,030204 cardiovascular system & hematology ,Pulmonary arterial hypertension ,Pulmonary fibrosis ,Pulmonary function testing ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,PULMONARY ARTERIAL HYPERTENSION ,Aged ,Retrospective Studies ,Aged, 80 and over ,Emphysema ,INTERSTITIAL LUNG DISEASE ,Lung ,medicine.diagnostic_test ,business.industry ,Smoking ,Middle Aged ,respiratory system ,medicine.disease ,Survival Analysis ,Pulmonary hypertension ,Combined pulmonary fibrosis and emphysema ,Respiratory Function Tests ,respiratory tract diseases ,3. Good health ,Surgery ,PULMONARY FIBROSIS ,medicine.anatomical_structure ,Pulmonary Emphysema ,030228 respiratory system ,Cardiology ,Female ,Tomography, X-Ray Computed ,business - Abstract
The syndrome resulting from combined pulmonary fibrosis and emphysema has not been comprehensively described. The current authors conducted a retrospective study of 61 patients with both emphysema of the upper zones and diffuse parenchymal lung disease with fibrosis of the lower zones of the lungs on chest computed tomography. Patients (all smokers) included 60 males and one female, with a mean age of 65 yrs. Dyspnoea on exertion was present in all patients. Basal crackles were found in 87% and finger clubbing in 43%. Pulmonary function tests were as follows (mean ± SD): total lung capacity 88% ± 17, forced vital capacity (FVC) 88% ± 18, forced expiratory volume in one second (FEV1) 80% ± 21 (% predicted), FEV1/FVC 69% ± 13, carbon monoxide diffusion capacity of the lung 37% ± 16 (% predicted), carbon monoxide transfer coefficient 46% ± 19. Pulmonary hypertension was present in 47% of patients at diagnosis, and 55% during follow-up. Patients were followed for a mean of 2.1 ± 2.8 yrs from diagnosis. Survival was 87.5% at 2 yrs and 54.6% at 5 yrs, with a median of 6.1 yrs. The presence of pulmonary hypertension at diagnosis was a critical determinant of prognosis. The authors hereby individualise the computer tomography-defined syndrome of combined pulmonary fibrosis and emphysema characterised by subnormal spirometry, severe impairment of gas exchange, high prevalence of pulmonary hypertension, and poor survival. Copyright©ERS Journals Ltd 2005.
- Published
- 2005
3. The rapid atmospheric monitoring system of the Pierre Auger Observatory
- Author
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Abreu, P., Aglietta, M, Ahlers, M., Ahn, M., Albuquerque, E. J., Allard, I. F. M., Allekotte, D., Allen, I., Allison, J., Almela, P., Castillo, A., Alvarez Muniz, J. A., Batista, J., Ambrosio, R. A., Aminaei, M., Anchordoqui, A., Andringa, L., Antici'C, S., Aramo, T., Arganda, C., Arqueros, E., Asorey, F., Assis, H., Aublin, P., Ave, J., Avenier, M., Avila, M., Badescu, G., Balzer, A. M., Barber, M., Barbosa, K. B., Bardenet, A. F., Barroso, R., Baughman, S. L. C., Bauml, B., Baus, J., Beatty, C., Becker, J. J., Belletoile, K. H., Bellido, A., Benzvi, J. A., Berat, S., Bertou, C., Biermann, X., Billoir, P. L., Blanco, P., Blanco, F., Bleve, M., Blumer, C., Bohacova, H., Boncioli, M., Bonifazi, D., Bonino, C., Borodai, R., Brack, N., Brancus, J., Brogueira, I., Brown, P., Bruijn, W. C., Buchholz, R., Bueno, P., Buroker, A., Burton, L., Caballero Mora, R. E., Caccianiga, K. S., Caramete, B., Caruso, L., Castellina, R., Catalano, A., Cataldi, O., Cazon, G., Cester, L., Chauvin, R., Cheng, J., Chiavassa, S. H., Chinellato, A., Diaz, J. A., Chudoba, J. C., Cilmo, J., Clay, M., Cocciolo, R. W., Collica, G., Coluccia, L., Conceicao, M. R., Contreras, R., Cook, F., Cooper, H., Coppens, M. J., Cordier, J., Coutu, A., Covault, S., Creusot, C. E., Criss, A., Cronin, A., Curutiu, J., Dagoret Campagne, A., Dallier, S., Daniel, R., Dasso, B., Daumiller, S., Dawson, K., de Almeida, B. R., De Domenico, R. M., De Donato, M., de Jong, C., De la Vega, S. J., de Mello, G., Neto, W. J. M., Mitri, Jrtd, de Souza, I., de Vries, V., del Peral, K. D., del Rio, L., Deligny, M., Dembinski, O., Dhital, H., Di Giulio, N., Castro, C., Diep, M. L. D., Diogo, P. N., Dobrigkeit, F., Docters, C., D'Olivo, W., Dong, J. C., Dorofeev, P. N., dos Anjos, A., Dova, J. C., D'Urso, M. T., Dutan, D., Ebr, I., Engel, J., Erdmann, R., Escobar, M., Espadanal, C. O., Etchegoyen, J., Luis, A., Falcke, P. F. S., Fang, H., Farrar, K., Fauth, G., Fazzini, A. C., Ferguson, N., Fick, A. P., Figueira, B., Filevich, J. M., Filipcic, A., Fliescher, A., Fracchiolla, S., Fraenkel, C. E., Fratu, E. D., Frohlich, O., Fuchs, U., Gaior, B., Gamarra, R., Gambetta, R. F., Garcia, S., Roca, B., Garcia Gamez, S. T. G., Garcia Pinto, D., Garilli, D., Bravo, G., Gemmeke, A. G., Ghia, H., Giller, P. L., Gitto, M., Glass, J., Gold, H., Golup, M. S., Albarracin, G., Berisso, F. G., Vitale, M. G., Goncalves, P. F. G., Gonzalez, P., Gookin, G., Gorgi, B., Gouffon, A., Grashorn, P., Grebe, E., Griffith, S., Grillo, N., Guardincerri, A. F., Guarino, Y., Guedes, F., Hansen, G. P., Harari, P., Harrison, D., Harton, T. A., Haungs, J. L., Hebbeker, A., Heck, T., Herve, D., Hojvat, A. E., Hollon, C., Holmes, N., Homola, V. C., Horandel, P., Horvath, J. R., Hrabovsky, P., Huber, M., Huege, D., Insolia, T., Ionita, A., Italiano, F., Jansen, A., Jarne, S., Jiraskova, C., Josebachuili, S., Kadija, M., Kampert, K., Karhan, K. H., Kasper, P., Katkov, P., Kegl, I., Keilhauer, B., Keivani, B., Kelley, A., Kemp, J. L., Kieckhafer, E., Klages, R. M., Kleifges, H. O., Kleinfeller, M., Knapp, J., Koang, J., Kotera, D. H., Krohm, K., Kromer, N., Kruppke Hansen, O., Kuempel, D., Kulbartz, D., Kunka, J. K., La Rosa, N., Lachaud, G., Lahurd, C., Latronico, D., Lauer, L., Lautridou, R., Le Coz, P., Leao, S., Lebrun, Msab and, Lebrun, D., de Oliveira, P., Letessier Selvon, M. A. L., Lhenry Yvon, A., Link, I., Lopez, K., Aguera, R., Louedec, A. L., Bahilo, K., J. L., Lu, Lucero, L., Ludwig, A., Lyberis, M., Maccarone, H., Macolino, M. C., Maldera, C., Maller, S., Mandat, J., Mantsch, D., Mariazzi, P., Marin, A. G., Marin, J., Maris, V., Falcon, I. C., Marsella, H. R. M., Martello, G., Martin, D., Martinez, L., Bravo, H., Martraire, O. M., Meza, D., Mathes, J. J. M., Matthews, H. J., Matthews, J., Matthiae, A. J., Maurel, G., Maurizio, D., Mazur, D., Medina Tanco, P. O., Melissas, G., Melo, M., Menichetti, D., Menshikov, E., Mertsch, A., Meurer, P., Meyhandan, C., Mi'Canovi'C, R., Micheletti, S., Minaya, M. I., Miramonti, I. A., Molina Bueno, L., Mollerach, L., Monasor, S., Ragaigne, M., Montanet, D. M., Morales, F., Morello, B., Moreno, C., Moreno, E., Mostafa, J. C., Moura, M., Muller, C. A., Muller, M. A., Munchmeyer, G., Mussa, M., Navarra, R., Navarro, G., Navas, J. L., Necesal, S., Nellen, P., Nelles, L., Neuser, A., Nhung, J., Niechciol, P. T., Niemietz, M., Nierstenhoefer, L., Nitz, N., Nosek, D., Nozka, D., Oehlschlager, L., Olinto, J., Ortiz, A., Pacheco, M., Selmi Dei, N., Palatka, D. P., Pallotta, M., Palmieri, J., Parente, N., Parizot, G., Parra, E., Pastor, A., Paul, S., Pech, T., Pekala, M., Pelayo, J., Pepe, R., Perrone, I. M., Pesce, L., Petermann, R., Petrera, E., Petrolini, Alessandro, Petrov, A., Pfendner, Y., Piegaia, C., Pierog, R., Pieroni, T., Pimenta, P., Pirronello, M., Platino, V., Plum, M., Ponce, M., Pontz, V. H., Porcelli, M., Privitera, A., Prouza, P., Quel, M., Querchfeld, E. J., Rautenberg, S., Ravel, J., Ravignani, O., Revenu, D., Ridky, B., Riggi, J., Risse, S., Ristori, M., Rivera, P., Rizi, H., Roberts, V., de Carvalho, J., Rodriguez, W. R., Cabo, G., Martino, I. R., Rojo, J. R., Rodriguez Frias, J. R., Ros, M. D., Rosado, G., Rossler, J., Roth, T., Rouille d'Orfeuil, M., Roulet, B., Rovero, E., Ruhle, A. C., Saftoiu, C., Salamida, A., Salazar, F., Greus, H., Salina, F. S., Sanchez, G., Santo, F., Santos, C. E., Santos, E., Sarazin, E. M., Sarkar, F., Sarkar, B., Sato, S., Scharf, R., Scherini, N., Schieler, V., Schiffer, H., Schmidt, P., Scholten, A., Schoorlemmer, O., Schovancova, H., Schovanek, J., Schroder, P., Schulte, F., Schuster, S., Sciutto, D., Scuderi, S. J., Segreto, M., Settimo, A., Shadkam, M., Shellard, A., Sidelnik, R. C., Sigl, I., Lopez, G., Sima, H. H. S., Smialkowski, O., Smida, A., Snow, R., Sommers, G. R., Sorokin, P., Spinka, J., Squartini, H., Srivastava, R., Stanic, Y. N., Stapleton, S., Stasielak, J., Stephan, J., Stutz, M., Suarez, A., Suomijarvi, F., Supanitsky, T., Susa, A. D., Sutherland, T., Swain, M. S., Szadkowski, J., Szuba, Z., Tapia, M., Tartare, A., Tascau, M., Tcaciuc, O., Thao, R., Thomas, N. T., Tiffenberg, D., Timmermans, J., Tkaczyk, C., Peixoto, W., Toma, C. J. T., Tomankova, G., Tome, L., Tonachini, B., Travnicek, A., Tridapalli, P., Tristram, D. B., Trovato, G., Tueros, E., Ulrich, M., Unger, R., Urban, M., Galicia, M., Valino, J. F. V., Valore, I., Van Aar, L., van den Berg, G., van Vliet, A. M., Varela, A., Cardenas, E., Vazquez, B. V., Vazquez, J. R., Veberic, R. A., Verzi, D., Vicha, V., Videla, J., Villasenor, M., Wahlberg, L., Wahrlich, H., Wainberg, P., Walz, O., Watson, D., Weber, A. A., Weidenhaupt, M., Weindl, K., Werner, A., Westerhoff, F., Whelan, S., Widom, B. J., Wieczorek, A., Wiencke, G., Wilczynska, L., Wilczynski, B., Will, H., Williams, M., Winchen, C., Wommer, T., Wundheiler, M., Yamamoto, B., Yapici, T., Younk, T., Yuan, P., Yushkov, G., Garcia, A., Zas, B. Z., Zavrtanik, E., Zavrtanik, D., Zaw, M., Zepeda, I., Zhou, A., Zhu, J., Silva, Y., Ziolkowski, M. Z., Pierre Auger, M., APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire d'Orsay (IPNO), PIERRE AUGER, P., Abreu, M., Aglietta, M., Ahler, E. J., Ahn, I. F. M., Albuquerque, D., Allard, I., Allekotte, J., Allen, P., Allison, A., Almela, J., Alvarez Castillo, J., Alvarez Muñiz, R., Alves Batista, M., Ambrosio, A., Aminaei, L., Anchordoqui, S., Andringa, T., Antičić, C., Aramo, E., Arganda, F., Arquero, H., Asorey, P., Assi, J., Aublin, M., Ave, M., Avenier, G., Avila, A. M., Badescu, M., Balzer, K. B., Barber, A. F., Barbosa, R., Bardenet, S. L. C., Barroso, B., Baughman f, J., Bäuml, C., Bau, J. J., Beatty, K. H., Becker, A., Bellétoile, J. A., Bellido, S., Benzvi, C., Berat, X., Bertou, P. L., Biermann, P., Billoir, F., Blanco, M., Blanco, C., Bleve, H., Blümer, M., Boháčová, D., Boncioli, C., Bonifazi, R., Bonino, N., Borodai, J., Brack, I., Brancu, P., Brogueira, W. C., Brown, R., Bruijn i, P., Buchholz, A., Bueno, L., Buroker, R. E., Burton, K. S., Caballero Mora, B., Caccianiga, L., Caramete, R., Caruso, A., Castellina, O., Catalano, G., Cataldi, L., Cazon, R., Cester, J., Chauvin, S. H., Cheng, A., Chiavassa, J. A., Chinellato, J., Chirinos Diaz, J., Chudoba, M., Cilmo, R. W., Clay, Cocciolo, Giuseppe, L., Collica, Coluccia, MARIA RITA, R., Conceição, F., Contrera, H., Cook, M. J., Cooper, J., Coppen, A., Cordier, S., Coutu, C. E., Covault, A., Creusot, A., Cri, J., Cronin, A., Curutiu, S., Dagoret Campagne, R., Dallier, B., Daniel, S., Dasso, K., Daumiller, B. R., Dawson, R. M., de Almeida, M., De Domenico, C., De Donato, S. J., de Jong, G., De La Vega, W. J. M., de Mello Junior, J. R. T., de Mello Neto, DE MITRI, Ivan, V., de Souza, K. D., de Vrie, L., del Peral, M., del Río, O., Deligny, H., Dembinski, N., Dhital, C., Di Giulio, M. L., Díaz Castro, P. N., Diep, F., Diogo, C., Dobrigkeit, W., Docter, J. C., D'Olivo, P. N., Dong, A., Dorofeev, J. C., dos Anjo, M. T., Dova, D., D'Urso, I., Dutan, J., Ebr, R., Engel, M., Erdmann, C. O., Escobar, J., Espadanal, A., Etchegoyen, P., Facal San Lui, H., Falcke, K., Fang, G., Farrar, A. C., Fauth, N., Fazzini, A. P., Ferguson, B., Fick, J. M., Figueira, A., Filevich, A., Filipčič, S., Fliescher, C. E., Fracchiolla, E. D., Fraenkel!, O., Fratu, U., Fröhlich, B., Fuch, R., Gaior, R. F., Gamarra, S., Gambetta, B., García, S. T., Garcia Roca, D., Garcia Gamez, D., Garcia Pinto, G., Garilli, A., Gascon Bravo, H., Gemmeke, P. L., Ghia, M., Giller, J., Gitto, H., Gla, M. S., Gold, G., Golup, F., Gomez Albarracin, M., Gómez Berisso, P. F., Gómez Vitale, P., Gonçalve, J. G., Gonzalez, B., Gookin, A., Gorgi, P., Gouffon, E., Grashorn, S., Grebe, N., Griffith, A. F., Grillo, Y., Guardincerri, F., Guarino, G. P., Guede, P., Hansen, D., Harari, T. A., Harrison, J. L., Harton, A., Haung, T., Hebbeker, D., Heck, A. E., Herve, C., Hojvat, N., Hollon, V. C., Holme, P., Homola, J. R., Hörandel, P., Horvath, M., Hrabovský, D., Huber, T., Huege, A., Insolia, F., Ionita, A., Italiano, S., Jansen, C., Jarne, S., Jiraskova, M., Josebachuili, K., Kadija, K. H., Kampert, P., Karhan, P., Kasper, I., Katkov, B., Kégl, B., Keilhauer, A., Keivani, J. L., Kelley, E., Kemp, R. M., Kieckhafer, H. O., Klage, M., Kleifge, J., Kleinfeller, J., Knapp, D. H., Koang, K., Kotera, N., Krohm, O., Krömer, D., Kruppke Hansen, D., Kuempel, J. K., Kulbartz, N., Kunka, G., La Rosa, C., Lachaud, D., Lahurd, L., Latronico, R., Lauer, P., Lautridou, S., Le Coz, M. S. A. B., Leão, D., Lebrun, P., Lebrun, M. A., Leigui de Oliveira, A., Letessier Selvon, I., Lhenry Yvon, K., Link, R., López, A., Lopez Agüera, K., Louedec, J., Lozano Bahilo, L., Lu, A., Lucero, M., Ludwig, H., Lyberi, M. C., Maccarone, C., Macolino, S., Maldera, J., Maller, D., Mandat, P., Mantsch, A. G., Mariazzi, J., Marin, V., Marin, I. C., Mari, H. R., Marquez Falcon, Marsella, Giovanni, Martello, Daniele, L., Martin, H., Martinez, O., Martínez Bravo, D., Martraire, J. J., Masías Meza, H. J., Mathe, J., Matthew, J. A. J., Matthew, G., Matthiae, D., Maurel, D., Maurizio, P. O., Mazur, G., Medina Tanco, M., Melissa, D., Melo, E., Menichetti, A., Menshikov, P., Mertsch, C., Meurer, R., Meyhandan, S., Mićanović, M. I., Micheletti, I. A., Minaya, L., Miramonti, L., Molina Bueno, S., Mollerach, M., Monasor, D., Monnier Ragaigne, F., Montanet, B., Morale, C., Morello, E., Moreno, J. C., Moreno, M., Mostafá, C. A., Moura, M. A., Muller, G., Müller, M., Münchmeyer, R., Mussa, G., Navarra ‡, J. L., Navarro, S., Nava, P., Necesal, L., Nellen, A., Nelle, J., Neuser, P. T., Nhung, M., Niechciol, L., Niemietz, N., Nierstenhoefer, D., Nitz, D., Nosek, L., Nožka, J., Oehlschläger, A., Olinto, M., Ortiz, N., Pacheco, D., Pakk Selmi Dei, M., Palatka, J., Pallotta, N., Palmieri, G., Parente, E., Parizot, A., Parra, S., Pastor, T., Paul, M., Pech, J., Pękala, R., Pelayo, I. M., Pepe, Perrone, Lorenzo, R., Pesce, E., Petermann, S., Petrera, A., Petrolini, Y., Petrov, C., Pfendner, R., Piegaia, T., Pierog, P., Pieroni, M., Pimenta, V., Pirronello, M., Platino, M., Plum, V. H., Ponce, M., Pontz, A., Porcelli, P., Privitera, M., Prouza, E. J., Quel, S., Querchfeld, J., Rautenberg, O., Ravel, D., Ravignani, B., Revenu, J., Ridky, S., Riggi, M., Risse, P., Ristori, H., Rivera, V., Rizi, J., Robert, W., Rodrigues de Carvalho, G., Rodriguez, I., Rodriguez Cabo, J., Rodriguez Martino, J., Rodriguez Rojo, M. D., Rodríguez Fría, G., Ro, J., Rosado, T., Rossler, M., Roth, B., Rouillé d'Orfeuil, E., Roulet, A. C., Rovero, C., Rühle, A., Saftoiu, F., Salamida, H., Salazar, F., Salesa Greu, G., Salina, F., SÃ! ¡nchez, C. E., Santo, E., Santo, E. M., Santo, F., Sarazin, B., Sarkar, S., Sarkar, R., Sato, N., Scharf, V., Scherini, H., Schieler, P., Schiffer, A., Schmidt, O., Scholten, H., Schoorlemmer, J., Schovancova, P., Schovánek, F., Schröder, S., Schulte, D., Schuster, S. J., Sciutto, M., Scuderi, A., Segreto, M., Settimo, A., Shadkam, R. C., Shellard, I., Sidelnik, G., Sigl, H. H., Silva Lopez, O., Sima, A., Śmiałkowski, R., Šmída, G. R., Snow, P., Sommer, J., Sorokin, H., Spinka, R., Squartini, Y. N., Srivastava, S., Stanic, J., Stapleton, J., Stasielak, M., Stephan, A., Stutz, F., Suarez, T., Suomijärvi, A. D., Supanitsky, T., Šuša, M. S., Sutherland, J., Swain, Z., Szadkowski, M., Szuba, A., Tapia, M., Tartare, O., Taşcău, R., Tcaciuc, N. T., Thao, D., Thoma, J., Tiffenberg, C., Timmerman, W., Tkaczyk, C. J., Todero Peixoto, G., Toma, L., Tomankova, B., Tomé, A., Tonachini, P., Travnicek, D. B., Tridapalli, G., Tristram, E., Trovato, M., Tuero, R., Ulrich, M., Unger, M., Urban, J. F., Valdés Galicia, I., Valiño, L., Valore, G., van Aar, A. M., van den Berg, A., van Vliet, E., Varela, B., Vargas Cárdena, J. R., Vázquez, R. A., Vázquez, D., Veberič, V., Verzi, J., Vicha, M., Videla, L., Villaseñor, H., Wahlberg, P., Wahrlich, O., Wainberg, D., Walz, A. A., Watson, M., Weber, K., Weidenhaupt, A., Weindl, F., Werner, S., Westerhoff, B. J., Whelan, A., Widom, G., Wieczorek, L., Wiencke, B., Wilczyńska, H., Wilczyński, M., Will, C., William, T., Winchen, M., Wommer, B., Wundheiler, T., Yamamoto a, T., Yapici, P., Younk, G., Yuan, A., Yushkov, B., Zamorano Garcia, E., Za, D., Zavrtanik, M., Zavrtanik, I., Zaw h, A., Zepeda b, J., Zhou, Y., Zhu, M., Zimbres Silva, M. Ziolkowski, ., P. Abreu, M. Aglietta, M. Ahler, E.J. Ahn, I.F.M. Albuquerque, D. Allard, I. Allekotte, J. Allen, P. Allison, A. Almela, J. Alvarez Castillo, J. Alvarez-Muñiz, R. Alves Batista, M. Ambrosio, A. Aminaei, L. Anchordoqui, S. Andringa, T. Antičić, C. Aramo, E. Arganda, F. Arquero, H. Asorey, P. Assi, J. Aublin, M. Ave, M. Avenier, G. Avila, A.M. Badescu, M. Balzer, K.B. Barber, A.F. Barbosa, R. Bardenet, S.L.C. Barroso, B. Baughman f, J. Bäuml, C. Bau, J.J. Beatty, K.H. Becker, A. Bellétoile, J.A. Bellido, S. BenZvi, C. Berat, X. Bertou, P.L. Biermann, P. Billoir, F. Blanco, M. Blanco, C. Bleve, H. Blümer, M. Boháčová, D. Boncioli, C. Bonifazi, R. Bonino, N. Borodai, J. Brack, I. Brancu, P. Brogueira, W.C. Brown, R. Bruijn i, P. Buchholz, A. Bueno, L. Buroker, R.E. Burton, K.S. Caballero-Mora, B. Caccianiga, L. Caramete, R. Caruso, A. Castellina, O. Catalano, G. Cataldi, L. Cazon, R. Cester, J. Chauvin, S.H. Cheng, A. Chiavassa, J.A. Chinellato, J. Chirinos Diaz, J. Chudoba, M. Cilmo, R.W. Clay, G. Cocciolo, L. Collica, M.R. Coluccia, R. Conceição, F. Contrera, H. Cook, M.J. Cooper, J. Coppen, A. Cordier, S. Coutu, C.E. Covault, A. Creusot, A. Cri, J. Cronin, A. Curutiu, S. Dagoret-Campagne, R. Dallier, B. Daniel, S. Dasso, K. Daumiller, B.R. Dawson, R.M. de Almeida, M. De Domenico, C. De Donato, S.J. de Jong, G. De La Vega, W.J.M. de Mello Junior, J.R.T. de Mello Neto, I. De Mitri, V. de Souza, K.D. de Vrie, L. del Peral, M. del Río, O. Deligny, H. Dembinski, N. Dhital, C. Di Giulio, M.L. Díaz Castro, P.N. Diep, F. Diogo, C. Dobrigkeit, W. Docter, J.C. D'Olivo, P.N. Dong, A. Dorofeev, J.C. dos Anjo, M.T. Dova, D. D'Urso, I. Dutan, J. Ebr, R. Engel, M. Erdmann, C.O. Escobar, J. Espadanal, A. Etchegoyen, P. Facal San Lui, H. Falcke, K. Fang, G. Farrar, A.C. Fauth, N. Fazzini, A.P. Ferguson, B. Fick, J.M. Figueira, A. Filevich, A. Filipčič, S. Fliescher, C.E. Fracchiolla, E.D. Fraenkel!, O. Fratu, U. Fröhlich, B. Fuch, R. Gaior, R.F. Gamarra, S. Gambetta, B. García, S.T. Garcia Roca, D. Garcia-Gamez, D. Garcia-Pinto, G. Garilli, A. Gascon Bravo, H. Gemmeke, P.L. Ghia, M. Giller, J. Gitto, H. Gla, M.S. Gold, G. Golup, F. Gomez Albarracin, M. Gómez Berisso, P.F. Gómez Vitale, P. Gonçalve, J.G. Gonzalez, B. Gookin, A. Gorgi, P. Gouffon, E. Grashorn, S. Grebe, N. Griffith, A.F. Grillo, Y. Guardincerri, F. Guarino, G.P. Guede, P. Hansen, D. Harari, T.A. Harrison, J.L. Harton, A. Haung, T. Hebbeker, D. Heck, A.E. Herve, C. Hojvat, N. Hollon, V.C. Holme, P. Homola, J.R. Hörandel, P. Horvath, M. Hrabovský, D. Huber, T. Huege, A. Insolia, F. Ionita, A. Italiano, S. Jansen, C. Jarne, S. Jiraskova, M. Josebachuili, K. Kadija, K.H. Kampert, P. Karhan, P. Kasper, I. Katkov, B. Kégl, B. Keilhauer, A. Keivani, J.L. Kelley, E. Kemp, R.M. Kieckhafer, H.O. Klage, M. Kleifge, J. Kleinfeller, J. Knapp, D.-H. Koang, K. Kotera, N. Krohm, O. Krömer, D. Kruppke-Hansen, D. Kuempel, J.K. Kulbartz, N. Kunka, G. La Rosa, C. Lachaud, D. LaHurd, L. Latronico, R. Lauer, P. Lautridou, S. Le Coz, M.S.A.B. Leão, D. Lebrun, P. Lebrun, M.A. Leigui de Oliveira, A. Letessier-Selvon, I. Lhenry-Yvon, K. Link, R. López, A. Lopez Agüera, K. Louedec, J. Lozano Bahilo, L. Lu, A. Lucero, M. Ludwig, H. Lyberi, M.C. Maccarone, C. Macolino, S. Maldera, J. Maller, D. Mandat, P. Mantsch, A.G. Mariazzi, J. Marin, V. Marin, I.C. Mari, H.R. Marquez Falcon, G. Marsella, D. Martello, L. Martin, H. Martinez, O. Martínez Bravo, D. Martraire, J.J. Masías Meza, H.J. Mathe, J. Matthew, J.A.J. Matthew, G. Matthiae, D. Maurel, D. Maurizio, P.O. Mazur, G. Medina-Tanco, M. Melissa, D. Melo, E. Menichetti, A. Menshikov, P. Mertsch, C. Meurer, R. Meyhandan, S. Mićanović, M.I. Micheletti, I.A. Minaya, L. Miramonti, L. Molina-Bueno, S. Mollerach, M. Monasor, D. Monnier Ragaigne, F. Montanet, B. Morale, C. Morello, E. Moreno, J.C. Moreno, M. Mostafá, C.A. Moura, M.A. Muller, G. Müller, M. Münchmeyer, R. Mussa, G. Navarra ‡, J.L. Navarro, S. Nava, P. Necesal, L. Nellen, A. Nelle, J. Neuser, P.T. Nhung, M. Niechciol, L. Niemietz, N. Nierstenhoefer, D. Nitz, D. Nosek, L. Nožka, J. Oehlschläger, A. Olinto, M. Ortiz, N. Pacheco, D. Pakk Selmi-Dei, M. Palatka, J. Pallotta, N. Palmieri, G. Parente, E. Parizot, A. Parra, S. Pastor, T. Paul, M. Pech, J. Pękala, R. Pelayo, I.M. Pepe, L. Perrone, R. Pesce, E. Petermann, S. Petrera, A. Petrolini, Y. Petrov, C. Pfendner, R. Piegaia, T. Pierog, P. Pieroni, M. Pimenta, V. Pirronello, M. Platino, M. Plum, V.H. Ponce, M. Pontz, A. Porcelli, P. Privitera, M. Prouza, E.J. Quel, S. Querchfeld, J. Rautenberg, O. Ravel, D. Ravignani, B. Revenu, J. Ridky, S. Riggi, M. Risse, P. Ristori, H. Rivera, V. Rizi, J. Robert, W. Rodrigues de Carvalho, G. Rodriguez, I. Rodriguez Cabo, J. Rodriguez Martino, J. Rodriguez Rojo, M.D. Rodríguez-Fría, G. Ro, J. Rosado, T. Rossler, M. Roth, B. Rouillé-d'Orfeuil, E. Roulet, A.C. Rovero, C. Rühle, A. Saftoiu, F. Salamida, H. Salazar, F. Salesa Greu, G. Salina, F. SÃ! ¡nchez, C.E. Santo, E. Santo, E.M. Santo, F. Sarazin, B. Sarkar, S. Sarkar, R. Sato, N. Scharf, V. Scherini, H. Schieler, P. Schiffer, A. Schmidt, O. Scholten, H. Schoorlemmer, J. Schovancova, P. Schovánek, F. Schröder, S. Schulte, D. Schuster, S.J. Sciutto, M. Scuderi, A. Segreto, M. Settimo, A. Shadkam, R.C. Shellard, I. Sidelnik, G. Sigl, H.H. Silva Lopez, O. Sima, A. Śmiałkowski, R. Šmída, G.R. Snow, P. Sommer, J. Sorokin, H. Spinka, R. Squartini, Y.N. Srivastava, S. Stanic, J. Stapleton, J. Stasielak, M. Stephan, A. Stutz, F. Suarez, T. Suomijärvi, A.D. Supanitsky, T. Šuša, M.S. Sutherland, J. Swain, Z. Szadkowski, M. Szuba, A. Tapia, M. Tartare, O. Taşcău, R. Tcaciuc, N.T. Thao, D. Thoma, J. Tiffenberg, C. Timmerman, W. Tkaczyk, C.J. Todero Peixoto, G. Toma, L. Tomankova, B. Tomé, A. Tonachini, P. Travnicek, D.B. Tridapalli, G. Tristram, E. Trovato, M. Tuero, R. Ulrich, M. Unger, M. Urban, J.F. Valdés Galicia, I. Valiño, L. Valore, G. van Aar, A.M. van den Berg, A. van Vliet, E. Varela, B. Vargas Cárdena, J.R. Vázquez, R.A. Vázquez, D. Veberič, V. Verzi, J. Vicha, M. Videla, L. Villaseñor, H. Wahlberg, P. Wahrlich, O. Wainberg, D. Walz, A.A. Watson, M. Weber, K. Weidenhaupt, A. Weindl, F. Werner, S. Westerhoff, B.J. Whelan, A. Widom, G. Wieczorek, L. Wiencke, B. Wilczyńska, H. Wilczyński, M. Will, C. William, T. Winchen, M. Wommer, B. Wundheiler, T. Yamamoto a, T. Yapici, P. Younk, G. Yuan, A. Yushkov, B. Zamorano Garcia, E. Za, D. Zavrtanik, M. Zavrtanik, I. Zaw h, A. Zepeda b, J. Zhou, Y. Zhu, M. Zimbres Silva, M. Ziolkowski ., Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Aramo, Carla, D'Urso, Domenico, Guarino, Fausto, Valore, Laura, The Pierre Auger, Collaboration, KVI - Center for Advanced Radiation Technology, Research unit Astroparticle Physics, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)
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[PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,Astronomy ,FOS: Physical sciences ,Cosmic ray ,Real-time monitoring ,01 natural sciences ,Large detector systems for particle and astroparticle physics, Real-time monitoring, Control and monitor systems online ,Optical telescope ,Observatory ,0103 physical sciences ,SHOWERS ,Large detector systems for particle and astroparticle physics ,Control and monitor systems online ,FLUORESCENCE ,010303 astronomy & astrophysics ,Instrumentation ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,DETECTOR ,Mathematical Physics ,Remote sensing ,Event reconstruction ,Pierre Auger Observatory ,High Energy Astrophysical Phenomena (astro-ph.HE) ,010308 nuclear & particles physics ,[SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE] ,Física ,ENERGY-SPECTRUM ,Monitoring program ,Aerosol ,ATMOSFERA (MONITORAMENTO) ,Air shower ,Experimental High Energy Physics ,Física nuclear ,Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Pierre Auger Observatory is a facility built to detect air showers produced by cosmic rays above 1017 eV. During clear nights with a low illuminated moon fraction, the UV fluorescence light produced by air showers is recorded by optical telescopes at the Observatory. To correct the observations for variations in atmospheric conditions, atmospheric monitoring is performed at regular intervals ranging from several minutes (for cloud identification) to several hours (for aerosol conditions) to several days (for vertical profiles of temperature, pressure, and humidity). In 2009, the monitoring program was upgraded to allow for additional targeted measurements of atmospheric conditions shortly after the detection of air showers of special interest, e. g., showers produced by very high-energy cosmic rays or showers with atypical longitudinal profiles. The former events are of particular importance for the determination of the energy scale of the Observatory, and the latter are characteristic of unusual air shower physics or exotic primary particle types. The purpose of targeted (or "rapid") monitoring is to improve the resolution of the atmospheric measurements for such events. In this paper, we report on the implementation of the rapid monitoring program and its current status. The rapid monitoring data have been analyzed and applied to the reconstruction of air showers of high interest, and indicate that the air fluorescence measurements affected by clouds and aerosols are effectively corrected using measurements from the regular atmospheric monitoring program. We find that the rapid monitoring program has potential for supporting dedicated physics analyses beyond the standard event reconstruction.
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- 2012
4. Pulmonary hypertension in patients with combined pulmonary fibrosis and emphysema syndrome
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Cottin, V., Le Pavec, J., Prévot, G., Mal, H., Humbert, M., Simonneau, G., Cordier, J.-F., Berezné, A., Coëtmeur, D., Danner-Boucher, I., Funke, D., Israel-Biet, D., Marchand, Eric, Mouthon, L., Rétrovirus et Pathologie Comparée (RPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Ecole Nationale Vétérinaire de Lyon (ENVL), Hôpital Louis Pradel, Service de Pneumologie, Centre de Référence National des Maladies Pulmonaires Rares, Hospices Civils de Lyon (HCL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Service de Pneumologie et Réanimation, Centre de reference de l'hypertension artérielle pulmonaire, Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Sud (Paris 11), Hôpital Larrey, Service de Pneumologie, Centre Hospitalier Universitaire de Toulouse, Hôpital Bichat - Claude Bernard, Assistance Publique - Hôpitaux de Paris (AP-HP), Groupe de recherches sur les Maladies Orphelines Pulmonaires (GERMOP), European Respiratory Society [ERS TF 2008-08], UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (MGD) Service de pneumologie, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL)
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Male ,emphysème pulmonaire ,Pulmonary Fibrosis ,Cardiac index ,030204 cardiovascular system & hematology ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Pulmonary function testing ,0302 clinical medicine ,Pulmonary fibrosis ,pulmonary hypertension ,disproportionate ,Aged, 80 and over ,Chronic obstructive pulmonary disease ,Respiratory disease ,Syndrome ,Middle Aged ,Combined pulmonary fibrosis and emphysema ,Tobacco smoking ,3. Good health ,Survival Rate ,medicine.anatomical_structure ,emphysema ,Pulmonary Emphysema ,Cardiology ,Female ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,fibrose pulmonaire ,Hypertension, Pulmonary ,Pulmonary hypertension ,chronic obstructive pulmonary disease ,03 medical and health sciences ,Internal medicine ,medicine.artery ,medicine ,hypertension pulmonaire ,Humans ,tabagisme ,tobacco smoking ,Aged ,Retrospective Studies ,Emphysema ,Disproportionate ,business.industry ,Hemodynamics ,medicine.disease ,Surgery ,030228 respiratory system ,Pulmonary artery ,Vascular resistance ,business ,taux de survie - Abstract
This study aims to describe the haemodynamic and survival characteristics of patients with pulmonary hypertension in the recently individualised syndrome of combined pulmonary fibrosis and emphysema. A retrospective multicentre study was conducted in 40 patients (38 males; age 68±9 yrs; 39 smokers) with combined pulmonary fibrosis and emphysema, and pulmonary hypertension at right heart catheterisation. Dyspnoea was functional class II in 15%, III in 55% and IV in 30%. 6-min walk distance was 244±126 m. Forced vital capacity was 86±18%, forced expiratory volume in 1 s 78±19%, and carbon monoxide diffusion transfer coefficient 28±16% of predicted. Room air arterial oxygen tension was 7.5±1.6 kPa (56±12 mmHg). Mean pulmonary artery pressure was 40±9 mmHg, cardiac index 2.5±0.7 L·min -1·m -2 and pulmonary vascular resistance 521±205 dyn·s·cm -5. 1-yr survival was 60%. Higher pulmonary vascular resistance, higher heart rate, lower cardiac index and lower carbon monoxide diffusion transfer were associated with shorter survival. Patients with combined pulmonary fibrosis and emphysema syndrome and pulmonary hypertension confirmed by right heart catheterisation have a dismal prognosis despite moderately altered lung volumes and flows and moderately severe haemodynamic parameters. Copyright©ERS Journals Ltd 2010.
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- 2009
5. Effect of interferon gamma-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): a multicentre, randomised, placebo-controlled trial
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King TE Jr, Albera, C, Bradford, Wz, Costabel, U, Hormel, P, Lancaster, L, Noble, Pw, Sahn, Sa, Szwarcberg, J, Thomeer, M, Valeyre, D, du Bois RM, INSPIRE Study Group, Agostini, Carlo, Allen, J, Anzueto, A, Behr, J, Bonnet, R, Buhl, R, Burge, S, Chan, A, Chan, C, Chanez, P, Chapman, J, Cordier, J, Covelli, H, Crimi, N, de Andrade, J, Delaval, P, Dromer, C, Egan, J, Enelow, R, Ettinger, N, Flaherty, K, Floreani, A, Frankel, S, Frost, A, Gibson, K, Glassberg, M, Gottfried, M, Harari, S, Helmersen, D, Hollingsworth, H, Horton, M, Jennings, J, Kallay, M, Lasky, J, Lee, A, Leonard, C, Lorch, D, Lynch, J, Mageto, Y, Mette, S, Millar, A, Morell Brotad, F, Müller Quernheim, J, Nathan, S, Noth, I, Padilla, M, Poletti, V, Raghu, G, Richeldi, L, Robbins, M, Rolf, J, Roman, J, Rosen, G, Rottoli, P, Saltini, C, Schaberg, T, Schaumberg, T, Scholand, M, Schönfeld, N, Sharma, S, Simonelli, P, Steele, M, Sussman, R, Tino, G, Vogelmeier, C, Wallaert, B, Wells, A, Wencel, M, Wesselius, L, Whelan, T, Wilcox, P, Wolters, P, Xaubet, A, and Zisman, D.
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Male ,medicine.medical_specialty ,Settore MED/10 - Malattie dell'Apparato Respiratorio ,Injections, Subcutaneous ,Vital Capacity ,Placebo-controlled study ,Kaplan-Meier Estimate ,Placebo ,Severity of Illness Index ,Drug Administration Schedule ,Pulmonary function testing ,Injections ,Idiopathic pulmonary fibrosis ,Interferon-gamma ,Double-Blind Method ,Internal medicine ,Pulmonary fibrosis ,medicine ,Humans ,Aged ,Analysis of Variance ,Disease Progression ,Europe ,Exercise Test ,Female ,Idiopathic Pulmonary Fibrosis ,North America ,Proportional Hazards Models ,Pulmonary Diffusing Capacity ,Recombinant Proteins ,Survival Rate ,Treatment Failure ,Medicine (all) ,Survival rate ,business.industry ,Subcutaneous ,Hazard ratio ,General Medicine ,Interim analysis ,medicine.disease ,Surgery ,business - Abstract
Summary Background Idiopathic pulmonary fibrosis is a fatal disease for which no effective treatment exists. We assessed whether treatment with interferon gamma-1b improved survival compared with placebo in patients with idiopathic pulmonary fibrosis and mild-to-moderate impairment of pulmonary function. Methods 826 patients with idiopathic pulmonary fibrosis were enrolled from 81 centres in seven European countries, the USA, and Canada. Patients were randomly assigned (double-blind) in a 2:1 ratio to receive 200 μg interferon gamma-1b (n=551) or equivalent placebo (n=275) subcutaneously, three times per week. Eligible patients were aged 40–79 years, had been diagnosed in the past 48 months, had a forced vital capacity of 55–90% of the predicted value, and a haemoglobin-corrected carbon monoxide diffusing capacity of 35–90% of the predicted value. The primary endpoint was overall survival time from randomisation measured at the second interim analysis, when the proportion of deaths had reached 75% of those expected by the study conclusion. This study is registered with ClinicalTrials.gov, number NCT00075998. Findings At the second interim analysis, the hazard ratio for mortality in patients on interferon gamma-1b showed absence of minimum benefit compared with placebo (1·15, 95% CI 0·77–1·71, p=0·497), and indicated that the study should be stopped. After a median duration of 64 weeks (IQR 41–84) on treatment, 80 (15%) patients on interferon gamma-1b and 35 (13%) on placebo had died. Almost all patients reported at least one adverse event, and more patients on interferon gamma-1b group had constitutional signs and symptoms (influenza-like illness, fatigue, fever, and chills) than did those on placebo. Occurrence of serious adverse events (eg, pneumonia, respiratory failure) was similar for both treatment groups. Treatment adherence was good and few patients discontinued treatment prematurely in either group. Interpretation We cannot recommend treatment with interferon gamma-1b since the drug did not improve survival for patients with idiopathic pulmonary fibrosis, which refutes previous findings from subgroup analyses of survival in studies of patients with mild-to-moderate physiological impairment of pulmonary function. Funding InterMune.
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- 2009
6. Characterisation of severe obliterative bronchiolitis in rheumatoid arthritis
- Author
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Devouassoux, G., Cottin, V., Lioté, H., Marchand, Eric, Frachon, I., Schuller, A., Béjui-Thivolet, F., Cordier, J-F., Groupe d'Etudes et de Recherche sur les Maladies \\'Orphelines\\' Pulmonaires (GERM\\'O\\'P), UCL - MD/MINT - Département de médecine interne, UCL - (MGD) Service de pneumologie, Service de pneumologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Centre de référence des maladies rares de l'adulte (CRMRA), Hospices Civils de Lyon (HCL), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Cliniques Universitaires UCL (UCL), Cliniques Universitaires UCL de Mont-Godinne, Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO)
- Subjects
AIRFLOW OBSTRUCTION ,rheumatoid arthritis ,Male ,Vital capacity ,BRONCHIECTASIS ,MESH: Chi-Square Distribution ,bronchiectasis ,[SDV]Life Sciences [q-bio] ,Biopsy ,Vital Capacity ,EMPHYSEMA ,Gastroenterology ,Bronchoalveolar Lavage ,Severity of Illness Index ,OBLITERATIVE BRONCHIOLITIS ,Pulmonary function testing ,Arthritis, Rheumatoid ,MESH: Biopsy ,0302 clinical medicine ,Forced Expiratory Volume ,MESH: Thoracoscopy ,Bronchiolitis Obliterans ,MESH: Aged ,MESH: Arthritis, Rheumatoid ,MESH: Middle Aged ,MESH: Bronchoalveolar Lavage ,small airways disease ,Respiratory disease ,respiratory system ,Middle Aged ,3. Good health ,emphysema ,Echocardiography ,Female ,Radiography, Thoracic ,medicine.symptom ,MESH: Tomography, X-Ray Computed ,Pulmonary and Respiratory Medicine ,Adult ,medicine.medical_specialty ,obliterative bronchiolitis ,MESH: Forced Expiratory Volume ,Bronchorrhea ,03 medical and health sciences ,FEV1/FVC ratio ,MESH: Bronchiolitis Obliterans ,Internal medicine ,MESH: Severity of Illness Index ,medicine ,Airflow obstruction ,Humans ,RHEUMATOID ARTHRITIS ,Aged ,Retrospective Studies ,030203 arthritis & rheumatology ,Bronchiectasis ,MESH: Humans ,Chi-Square Distribution ,business.industry ,SMALL AIRWAYS DISEASE ,Thoracoscopy ,Total Lung Capacity ,MESH: Adult ,MESH: Retrospective Studies ,MESH: Radiography, Thoracic ,MESH: Vital Capacity ,medicine.disease ,MESH: Male ,Surgery ,respiratory tract diseases ,030228 respiratory system ,Respiratory failure ,Bronchiolitis ,MESH: Echocardiography ,business ,Tomography, X-Ray Computed ,MESH: Female ,MESH: Total Lung Capacity - Abstract
International audience; The characteristics of patients with rheumatoid arthritis (RA) who develop obliterative bronchiolitis characterised by severe airflow obstruction have been hitherto poorly investigated. A retrospective study of 25 patients with RA and functional evidence of obliterative bronchiolitis (forced expiratory volume in one second (FEV(1))/forced vital capacity (FVC) 140% predicted) was conducted. Patients (mean+/-SD age 64+/-11 yrs) included 17 never-smokers and eight ex-smokers (10.5+/-5.4 pack-yrs). The diagnosis of RA preceded respiratory symptoms in 88% of cases. Dyspnoea on exertion was present in all patients and bronchorrhea in 44%. High-resolution computed tomography findings included: bronchial wall thickening (96%), bronchiectasis (40%), mosaic pattern (40%), centrilobular emphysema (56%), and reticular and/or ground-glass opacities (32%). Pulmonary function tests showed: FEV(1) 41+/-12% pred, FEV(1)/FVC 49+/-14%, FVC 70+/-20% pred, RV 148+/-68% pred and RV/TLC 142+/-34% pred. Lung biopsy, available in nine patients, demonstrated constrictive, follicular and mixed bronchiolitis. Patients were followed for 48.2+/-49 months. Treatment was poorly effective. Chronic respiratory failure occurred in 40% of patients, and four patients died. Obliterative bronchiolitis associated with rheumatoid arthritis is a severe and under-recognised condition leading to respiratory failure and death in a high proportion of patients.
- Published
- 2009
7. Statement on sarcoidosis
- Author
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Hunninghake, G. W., Costabel, U., Ando, M., Baughman, R., Cordier, J. F., Du Bois, R., Eklund, A., Kitaichi, M., Lynch, J., Rizzato, G., Rose, C., Selroos, O., Gianpietro Semenzato, and Sharma, O. P.
8. ATS/ERS/WASOG statement on sarcoidosis
- Author
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Hunninghake, G. W., Costabel, U., Ando, M., Baughman, R., Cordier, J. F., Du Bois, R., Eklund, A., Kitaichi, M., Lynch, J., Rizzato, G., Rose, C., Selroos, O., Gianpietro Semenzato, and Sharma, O. P.
9. Rational Management of Stochasticity in Operating Theatres
- Author
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Tancrez, J.-S., Roland, B., and Cordier, J. P.
10. TORE SUPRA TEAM MEMBERS 1988-2008
- Author
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Abgrall, R., Achard, M. H., Adam, J., Agarici, G., Agostini, E., Airaj, M., Albajar-Vinas, F., Allegretti, L., Allibert, J. P., Alliez, J. C., Allouche, A., Andreoletti, J., Ane, J. M., Angelino, P., Aniel, T., Antar, G., Arcis, N., Argouarch, A., Arnas, C., Arnoux, G., Arslanbekov, R., Artaud, J. F., Asp, E., Assas, S., Atttuel, G., Aymar, R., Azeroual, A., Balme, S., Barana, O., Bareyt, B., Basiuk, V., Basko, M., Bayetti, P., Baylor, L., Beaumont, B., Becherer, R., Becoulet, A., Becoulet, M., Begrambekov, L., Benkadda, S., Benoit, F., Bergeaud, V., Berger-By, G., Berio, S., Bernascolle, P., Bernier, N., Berroukeche, M., Bertrand, B., Bessette, D., Beyer, P., Bibet, P., Bizzaro, J., Blanchard, P., Blum, J., Boddeker, S., Boilson, D., Mardion, G. Bon, Bonnel, P., Bonnin, X., Boscary, J., Bosia, G., Bottereau, J. M., Bottiglioni, F., Bottollier-Curtet, H., Bouchand, C., Bouligand, G., Bouquey, F., Bourdelle, C., Bregeon, R., Bremond, F., Bremond, S., Breton, C., Breton, M., Brosset, C., Brugnetti, R., Bruneau, J. L., Bucalossi, J., Budny, R. V., Buravand, Y., Bush, C., Bussac, M. N., Cambe, A., Capes, H., Capitain, J. J., Cara, P., Carbonnier, J. L., Carpentier, S., Carrasco, J., Casati, A., Chaibi, O., Chamouard, C., Chantant, M., Chappuis, P., Chatain, D., Chatelier, E., Chatelier, M., Chatenet, J. H., Chen, X. P., Cherigier, L., Chevet, G., Chiarazzo, L., Ciazynski, D., Ciraolo, G., Cismondi, F., Clairet, F., Clary, J., Clement, C., Colas, L., Commaux, N., Corbel, E., Cordier, J. J., Corre, Y., Costanzo, L., Cote, A., Coulon, J. P., Courtois, L., Courtois, X., Couturier, B., Crenn, J. P., Cristofani, P., Crouseilles, N., Czarny, O., Rosa, P. Da Silva, Darbos, C., Darmet, G., Davi, M., Daviot, R., Esch, H., Gentile, B., Haas, J. C., La Cal, E., Michelis, C., Deck, C., Decker, J., Decool, P., Degond, P., Renaud Dejarnac, Delchambre, E., Delmas, E., Delpech, L., Demarthe, H., Dentan, M., Depret, G., Deschamps, P., Desgranges, C., Devynck, P., Doceul, L., Dolgetta, N., Doloc, C., Dong, Y., Dore, P., Douai, D., Dougnac, H., Drawin, H. W., Druaux, J., Druetta, M., Dubois, F., Dubois, M., Dubuit, N., Duchateau, J. L., Wit, T. Dudok, Dufour, E., Dumont, R., Dunand, G., Dupas, L., Duran, Y., Durocher, A., Edery, D., Ekedahl, A., Elbeze, D., Eriksson, L. G., Escande, D., Escarguel, A., Escourbiac, F., Evans, T., Faisse, F., Falchetto, G., Fall, T., Farge, M., Farjon, J. L., Faudot, E., Fazilleau, P., Fedorczak, N., Fenzi-Bonizec, C., Ferron, J. R., Fidone, I., Figarella, C., Fleurence, E., Fleury, I., Fois, M., Forrest, C., Foster, C. A., Fouquet, S., Fourment, C., Fraboulet, D., Francois, P., Franel, B., Frigione, D., Froissard, P., Fubiani, G., Fuchs, V., Fumelli, M., Gagey, B., Galindo, V., Gambier, D., Garampon, L., Garbet, X., Garbil, R., Garcia, J., Gardarein, J. L., Gargiulo, L., Garibaldi, P., Garin, P., Gauthier, E., Geraud, A., Gerbaud, T., Gervais, F., Geynet, M., Ghendrih, P., Gianakon, T., Giannella, R., Gil, C., Girard, J. P., Giruzzi, G., Godbert-Mouret, L., Gomez, P., Goniche, M., Gordeev, A., Granata, G., Grandgirard, V., Gravier, R., Gravil, B., Gregoire, M., Gregoire, S., Grelot, P., Gresillon, D., Grisolia, C., Gros, G., Grosman, A., Grua, P., Guerin, O., Guigon, R., Guilhem, D., Guillerminet, B., Guirlet, R., Guiziou, L., Gunn, J., Hacquin, S., Harris, J., Haste, G., Hatchressian, J. C., Hemsworth, R., Hennequin, P., Hennion, F., Hennion, V., Henry, D., Hernandez, C., Hertout, P., Hess, W., Hesse, M., Heuraux, S., Hillairet, J., Hoang, G. T., Hogan, J., Hong, S. H., Honore, C., Horton, L., Horton, W. W., Houlberg, W. A., Hourtoule, J., Houry, M., Houy, P., How, J., Hron, M., Hutter, T., Huynh, P., Huysmans, G., Idmtal, J., Imbeaux, F., Isler, R., Jaben, C., Jacquinot, J., Jacquot, C., Jager, B., Jaunet, M., Javon, C., Jelea, A., Jequier, F., Jie, Y. X., Jimenez, R., Joffrin, E., Johner, J., Jourd Heuil, L., Journeaux, J. Y., Joyer, P., Ju, M., Jullien, F., Junique, F., Kaye, S. M., Kazarian, F., Khodja, H., Klepper, C., Kocan, M., Koski, J., Krivenski, V., Krylov, A., Kupfer, K., Kuus, H., Labit, B., Laborde, L., Lacroix, B., Ladurelle, L., Lafon, D., Lamaison, V., Laporte, P., Lasalle, J., Latu, G., Laugier, F., Laurent, L., Lausenaz, Y., Laviron, C., Layet, J. M., Le Bris, A., Le Coz, F., Le Niliot, C., Lebris, A., Leclert, G., Lecoustey, P., Ledyankinc, A., Leloup, C., Lennholm, M., Leroux, F., Li, Y. Y., Libeyre, P., Linez, F., Lipa, M., Lippmann, S., Litaudon, X., Liu, W. D., Loarer, T., Lott, F., Lotte, P., Lowry, C., Luciani, J. F., Luetjens, H., Luty, J., Lutz, T., Lyraud, C., Maas, A., Macor, A., Madeleine, S., Magaud, P., Maget, P., Magne, R., Mahdavi, A., Mahe, F., Mailloux, J., Mandl, W., Manenc, L., Marandet, Y., Marbach, G., Marechal, J. L., Martin, C., Martin, G., Martin, V., Martinez, A., Martins, J. P., Maschke, E., Masse, L., Masset, R., Massmann, P., Mattioli, M., Mayaux, G., Mayoral, M. L., Mazon, D., Mcgrath, R., Mercier, C., Meslin, B., Meunier, L., Meyer, O., Michelot, Y., Million, L., Millot, P., Minguella, G., Minot, F., Mioduszewski, P., Misguich, J. H., Miskane, F., Missirlian, M., Mitteau, R., Moerel, F., Mollard, P., Monakhov, I., Moncada, V., Moncel, L., Monier-Garbet, P., Moreau, D., Moreau, F., Moreau, P., Morera, J. P., Moret, J. M., Moulin, B., Moulin, D., Mourgues, F., Moustier, M., Nakach, R., Nannini, M., Nanobashvili, I., Nardon, E., Navarra, P., Nehme, H., Nguyen, C., Nguyen, F., Nicollet, S., Nygren, R., Ogorodnikova, O., Olivain, J., Orlandelli, P., Ottaviani, M., Ouvrier-Buffet, P., Ouyang, Z., Owen, L., Pacella, D., Pain, M., Pamela, J., Pamela, S., Panek, R., Panzarella, A., Paris, R., Parisot, T., Park, S. H., Parlange, F., Parrat, H., Pastor, G., Pastor, P., Pastor, T., Patris, R., Paume, M., Payan, J., Pecquet, A. L., Pegourie, B., Petrov, Y., Petrzilka, V., Peysson, Y., Piat, D., Picchiottino, J. M., Pierre, J., Platz, P., Portafaix, C., Prou, M., Pugno, R., Putchy, L., Qin, C. M., Quallis, L., Quemeneur, A., Quet, P., Rabaglino, E., Raharijaona, J. J., Ramette, J., Ravenel, N., Rax, J. M., Reichle, R., Renard, B., Renner, H., Reuss, J. D., Reux, C., Reverdin, C., Rey, G., Reynaud, P., Riband, P. H., Richou, M., Rigollet, F., Rimini, F., Riquet, D., Rochard, F., Rodriguez, L., Romanelli, M., Romannikov, A., Rosanvallon, S., Roth, J., Rothan, B., Roubin, J. P., Roubin, P., Roupillard, G., Roussel, P., Ruggieri, R., Sabathier, F., Sabbagh, S. A., Sabot, R., Saha, S. K., Saint-Laurent, F., Salasca, S., Salmon, T., Salvador, J., Samaille, F., Samain, A., Santagiustina, A., Saoutic, B., Sarazin, Y., Schild, T., Schlosser, J., Schneider, M., Schneider, K., Schunke, B., Schwander, F., Schwob, J. L., Sebelin, E., Segui, J. L., Seigneur, A., Shepard, T., Shigin, P., Signoret, J., Simoncini, J., Simonet, F., Simonin, A., Sirinelli, A., Sledziewski, Z., Smits, F., Soler, K., Sonato, P. G., Song, S. D., Sonnendrucker, E., Sourd, F., Spitz, P., Spuig, P., Stamm, R., Stephan, Y., Stirling, W., Stockel, J., Stott, P., Sthal, K. Strom, Surle, F., Svensson, L., Tachon, J., Talvard, M., Tamain, P., Tavian, L., Tena, M., Theis, J. M., Thomas, C. E., Thomas, P., Thonnat, M., Tobin, S., Tokar, M., Tonon, G., Torossian, A., Torre, A., Trainham, R. C., Travere, J. M., Tresset, G., Trier, E., Truc, A., Tsitrone, E., Turck, B., Turco, F., Turlur, S., Uckan, T., Udintsev, V., Urguijo, G., Utzel, N., Vallet, J. C., Valter, J., Houtte, D., Rompuy, T., Vatry, A., Verga, A., Vermare, L., Vezard, D., Viallet, H., Villecroze, F., Villedieu, E., Villegas, D., Vincent, E., Voitsekovitch, I., Hellermann, M., Voslamber, D., Voyer, D., Vulliez, K., Wachter, C., Wagner, T., Waller, V., Wang, G., Wang, Z., Watkins, J., Weisse, J., White, R., Wijnands, T., Witrant, E., Worms, J., Xiao, W., Yu, D., Zabeo, L., Zabiego, M., Zani, L., Zhuang, G., Zou, X. L., Zucchi, E., Zunino, K., Zwingmann, W., and Tore Supra, Team
11. Lower Hybrid Current Drive in Tore Supra and Jet
- Author
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Moreau, D., Gormezano, C., Agarici, G., Agostini, E., Ane, J. M., Auge, N., Balme, S., Basiuk, V., Bareyt, B., Bayetti, P., Beaumont, B., Becherer, R., Becoulet, A., Benkadda, M., Bergerby, G., Bessette, D., Bibet, P., Bizarro, J. P., Bonmardion, G., Bonnel, P., Bottereau, J. M., Bottiglioni, F., Brugnetti, R., Bruneau, J. L., Buravand, Y., Capes, H., Capitain, J. J., Chappuis, P., Chatain, D., Chatelier, A., Chatelier, M., Ciazynski, D., Cordier, J. J., Coston, J. F., Coulon, J. P., Couturier, B., Crenn, J. P., Deck, C., Degentile, B., Demarthe, H., Demichelis, C., Deschamps, P., Devynck, P., Doceul, L., Dougnac, M., Drawin, H. W., Dubois, M., Duchateau, J. L., Dupas, L., Edery, D., Elbeze, D., Evans, T., Fall, T., Farjon, J. L., Fidone, I., Fois, M., Foster, C. A., Fumelli, M., Gagey, B., Garbet, X., Gauthier, E., Geraud, A., Gervais, F., Gendrih, P., Gil, C., Giruzzi, G., Goniche, M., Gravier, R., Gravil, B., Gregoire, M., Gresillon, D., Grisolia, C., Grosman, A., Guilhem, D., Guillerminet, B., Hennequin, P., Hennion, F., Hertout, P., Hess, W. R., Hesse, M., Hoang, G. T., Horton, L., Hubbard, A., Hutter, T., Idmtal, J., Jacquot, C., Jager, B., Javon, C., Jequier, F., Joffrin, E., Johner, J., Journeaux, J. Y., Joyer, P., Kuus, H., Lafon, D., Lasalle, J., Laurent, L., Laviron, C., Leclert, G., Lecoustey, P., Leloup, C., Libeyre, P., Lipa, M., Litaudon, X., Loarer, T., Lotte, P., Magaud, P., Magne, R., Martin, G., Martinez, A., Maschke, E. K., Mattioli, M., Mayaux, G., Mioduszewski, P., Misguich, J., Moniergarbet, P., Morera, J. P., Moret, J. M., Moulin, B., Moulin, D., Mourguesmillot, F., Moustier, M., Nguyen, F., Olivain, J., Ouvrierbuffet, P., Pamela, J., Panzarella, A., Parlange, F., Pastor, G., Patris, R., Paume, M., Pecquet, A. L., Pegourie, B., Peysson, Y., Piat, D., Picchiottino, J. M., Pierre, J., Platz, P., Portafaix, C., Poutchy, F., Prou, M., Quemeneur, A., Rax, J. M., Rey, G., Riband, P., Rigaud, D., Rodriguez, L., Rothan, B., Roubin, J. P., Roussel, P., Saha, S. K., Samaille, F., Samain, A., Saoutic, B., Schlosser, J., Seigneur, A., Segui, J. L., Shepard, T., Soler, K., Stirling, W., Tachon, J., Talvard, M., Tonon, G., Torossian, A., Truc, A., Turck, B., Uckan, T., Vallet, J. C., Vanhoutte, D., Weisse, J., and Zou, X. L.
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JET - Abstract
Recent Lower Hybrid Current Drive (LHCD) experiments in TORE SUPRA and JET are reported. Large multijunction launchers have allowed the coupling of 5 MW to the plasma for several seconds with a maximum of 3.8 kw/cm2. Measurements of the scattering matrices of the antennae show good agreement with theory. The current drive efficiency in TORE SUPRA is about 0.2 x 10(20) Am-2/W with LH power alone and reaches 0.4 x 10(20) Am-2/W in JET thanks to a high volume-averaged electron temperature (1.9 keV) and also to a synergy between Lower Hybrid and Fast Magnetosonic Waves. At N(e)BAR = 1.5 x 10(19) m-3 in TORE SUPRA, sawteeth are suppressed and m = 1 MHD oscillations the frequency of which clearly depends on the amount of LH power are observed on soft x-rays, and also on non-thermal ECE. In JET ICRH produced sawtooth-free periods are extended by the application of LHCD (2.9 s. with 4 MW ICRH) and current profile broadening has been clearly observed consistent with off-axis fast electron populations. LH power modulation experiments performed in TORE SUPRA at N(e)BAR = 4 x 10(19) m-3 show a delayed central electron heating despite the off-axis creation of suprathermal electrons, thus ruling out the possibility of a direct heating through central wave absorption. A possible explanation in terms of anomlous fast electron transport and classical slowing down would yield a diffusion coefficient of the order of 10 m2/s for the fast electrons. Other interpretations such as an anomalous heat pinch or a central confinement enhancement cannot be excluded. Finally, successful pellet fuelling of a partially LH driven plasma was obtained in TORE SUPRA, 28 successive pellets allowing the density to rise to N(e)BAR = 4 x 10(19) m-3. This could be achieved by switching the LH power off for 90 ms before each pellet injection, i.e. without modifying significantly the current density profile.
12. American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias
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Travis, W. D., King Jr, T. E., Bateman, E. D., Lynch, D. A., Capron, F., Center, D., Colby, T. V., Cordier, J. -F, Dubois, R. M., Galvin, J., Grenier, P., Hansell, D. M., Hunninghake, G. W., Kitaichi, M., Müller, N. L., Myers, J. L., Nagai, S., Nicholson, A., Raghu, G., Wallaert, B., Brambilla, C. G., Brown, K. K., Cherniaev, A. L., Costabel, U., Coultas, D. B., Davis, G. S., Demedts, M. G., Douglas, W. W., Egan, J., Eklund, A. G., Fabbri, L. M., Henke, C. A., Hubbard, R. B., Inoue, Y., Izumi, T., Jansen, H. M., Johnston, I., Kim, D. S., Khalil, N., Lake, F. R., Lungarella, G., Lynch Iii, J. P., Mapel, D. W., Martinez, F., Matthay, R., Newman, L. S., Noble, P. W., Ohta, K., Olivieri, D., Ortiz, L. A., Poletti, V., Rodriguez-Roisin, R., Rom, W. N., Jay Ryu, Saldiva, P., Sansores, R. H., Schwarz, M. L., Selman, M., Smith, C. M., Tong, Z., Udwadia, Z., Valeyre, D., Wells, A., Wise, R. A., Xaubet, A., Alvarez Fernandez, E., Brambilla, E., Capelozzi, V., Cherniaev, A., Dalquen, P., Dekan, G., Hasleton, P. S., Hogg, J. C., Jambhekar, N. A., Katzenstein, A. -L, Koss, M. N., Matsubara, O., Müller, K. -M, Thunnissen, F. B. J. M., Waldron, J. A., Li, W. -H, Friedman, P. J., Remy-Jardin, M., and Mcloud, T. C.
13. Alveolar haemorrhage in ANCA-associated vasculitides: 80 patients' features and prognostic factors
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Kostianovsky, A., Hauser, T., Pagnoux, C., Cohen, P., Eric DAUGAS, Mouthon, L., Miossec, P., Cordier, J. -F, Guillevin, L., Bachmeyer, C., Barbier, S., Belmatoug, N., Bielefeld, P., Bouredji, D., Bourgarit, A., Bruet, A., Cadranel, J., Chazerain, P., Chinet, T., Coëtmeur, D., Cottin, V., Demolombe-Rague, S., Dhôte, R., Girault, A., Fauchais, A. -L, Gobert, P., Godeau, B., Hillion, D., Janin-Magnificat, L., Kaloustian, E., Kouyoumdjian, L., Kyndt, X., Israël-Biet, D., Lassence, A., Leclerc, P., Le Jeunne, C., Le Noach, J., Lhote, F., Lifermann, F., Lobbedez, T., Longuet, O., Pastural, M., Plaisier, E., Ponge, T., Rogé, C., Rince, M., Rondeau, E., Rossert, J., Roux, M., Stern, M., Tanter, Y., Tirot, P., Valeyre, D., Vanhille, P., Vidal, E., Vrtovsnik, F., and Zoulim, A.
14. Guidelines of the ATS/ERS/WASOG on sarcoidosis | Linee guida ATS/ERS/WASOG sulla sarcoidosi
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Hunninghake, G. W., Costabel, U., Ando, M., Baughman, R., Cordier, J. F., Du Bois, R., Eklund, A., Kitaichi, M., Lynch, J., Rizzato, G., Rose, C., Selroos, O., Gianpietro Semenzato, and Sharma, O. P.
15. Pulmonary alveolar proteinosis,Lipoprotéinose alvéolaire pulmonaire
- Author
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Briens, E., Delaval, Ph, Mairesse, M. -P, Valeyre, D., Wallaert, B., Lazor, R., Cordier, J. -F, André, N., Belleguic, Ch, Desrues, B., Benzaquen, H., Bonnet, D., dominique Valeyre, Dussopt, Ch, Pacheco, Y., Lauque, D., Lebas, F. X., Leduc, D., Mornex, J. F., Nouvet, G., Rapin, J. P., Silvani, J. A., Sohier, L., Vandevenne, A., Delaunois, L., and Marchand, E.
16. Assessing the Impact of Stochasticity for Operating Theater Sizing
- Author
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Tancrez, J.-S., Roland, B., Cordier, J.-P., and Riane, F.
- Subjects
Healthcare management ,Markov process ,Emergencies ,Stochastic modeling ,Sizing ,Operating theater - Abstract
Over the last few decades, rational health care management and, in particular, operating theater planning, has attracted increased attention from practitioners and from the scientific community. However, although the operating theater environment is clearly stochastic, the impact of this randomness has often been ignored. In practice, simple rules based largely on past experience (such as keeping a safety margin), are most frequently used when making plans for the operating theater. In this paper, we propose an approach to help rationalize, at a strategic decision-making level, the way in which stochasticity can be taken into account in operating theater management, to help in the sizing and in the allocation of capacity. The three main sources of randomness are considered: durations of operations, unexpected emergencies and blocking because of a full recovery unit. Based on the Markov theory, our tool enables several performance measures to be estimated. An operating theater manager can use our approach to make informed decisions and assess, for example, the disruption of the planning by emergencies, the waiting times for emergency patients, the impact of the recovery unit, or the distribution of the working time. In particular, our approach helps determine the number of operations that should be planned in order to keep expected overtime limited. The tool is described in detail, discussed, and applied to the illustrative case of a Belgian hospital. (C) 2012 Elsevier B.V. All rights reserved.
17. Lower-hybrid current drive experiments in TORE SUPRA
- Author
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Moreau, D., Agarici, G., Agostini, E., Ané, J. M., Augé, N., Balme, S., Basiuk, V., Bareyt, B., Bayetti, P., Beaumont, B., Becherer, R., Bécoulet, A., Benkadda, M., Berger-By, G., Bessette, D., Bibet, P., João P. S. Bizarro, Bon-Mardion, G., Bonnel, P., Bottereau, J. M., Bottiglioni, F., Brugnetti, R., Bruneau, J. L., Buravand, Y., Capes, H., Capitain, J. J., Carrasco, J., Chappuis, P., Chatain, D., Chatelier, E., Chatelier, M., Ciazynski, D., Cordier, J. J., Coston, J. F., Coulon, J. P., Couturier, B., Crenn, J. P., Deck, C., Gentile, B., Demarthe, H., Michelis, C., Deschamps, P., Devynck, P., Doceul, L., Dougnac, M., Drawin, H. W., Dubois, M., Duchâteau, J. L., Dupas, L., Edery, D., Elbèze, D., Evans, T., Fall, T., Farjon, J. L., Fidone, I., Fois, M., Foster, C. A., Fumelli, M., Gagey, B., Garbet, X., Gauthier, E., Géraud, A., Gervais, F., Ghendrih, P., Gil, C., Giruzzi, G., Goniche, M., Gravier, R., Gravil, B., Grégoire, M., Grésillon, D., Grisolia, C., Grosman, A., Guilhem, D., Guillerminet, B., Hennequin, P., Hennion, F., Hertout, P., Hess, W. R., Hesse, M., Hoang, G. T., Horton, L., Hubbard, A., Hutter, T., Idmtal, J., Jacquot, C., Jager, B., Javon, C., Jequier, F., Joffrin, E., Johner, J., Journeaux, J. Y., Joyer, P., Kupfer, K., Kuus, H., Lafon, D., Lasalle, J., Laurent, L., Laviron, C., Leclert, G., Lecoustey, P., Leloup, C., Libeyre, P., Lipa, M., Litaudon, X., Loarer, T., Lotte, P., Magaud, P., Magne, R., Martin, G., Martinez, A., Maschke, E. K., Mattioli, M., Mayaux, G., Mioduszewski, P., Misguich, J., Monier-Garbet, P., Morera, J. P., Moret, J. M., Moulin, B., Moulin, D., Mourgues-Millot, F., Moustier, M., Nakach, R., Nguyen, F., Olivain, J., POuvrier-Buffet, Pamela, J., Panzarella, A., Parlange, F., Pastor, G., Patris, R., Paume, M., Pecquet, A. L., Pégourié, B., Peysson, Y., Piat, D., Picchiottino, J. M., Pierre, J., Platz, P., Portafaix, C., Poutchy, F., Prou, M., Quemeneur, A., Rax, J. M., Rey, G., Riband, P., Rigaud, D., Rodriguez, L., Rothan, B., Roubin, J. P., Roussel, P., Saha, S. K., Samaille, F., Samain, A., Saoutic, B., Schlosser, J., Seigneur, A., Segui, J. L., Shepard, T., Soler, K., Stirling, W., Tachon, J., Talvard, M., Tonon, G., Torossian, A., Truc, A., Turck, B., Uckan, T., Vallet, J. C., Houtte, D., Weisse, J., and Zou, X. L.
18. European Respiratory Society guidelines for the diagnosis and management of lymphangioleiomyomatosis
- Author
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Johnson, S R, Cordier, J F, Lazor, R, Cottin, V, Costabel, U, Harari, S, Reynaud-Gaubert, M, Boehler, A, Brauner, M, Popper, H, Bonetti, F, and Kingswood, C
- Subjects
3. Good health
19. Smoking-related interstitial lung disease
- Author
-
Fabrizio Luppi, Stefania Cerri, Luca Richeldi, Paolo Spagnolo, Cordier, J-F, Cerri, S, Spagnolo, P, Luppi, F, and Richeldi, L
- Subjects
interstitial lung disease ,medicine.medical_specialty ,Lung ,business.industry ,Interstitial lung disease ,Cigarette smoke ,respiratory system ,medicine.disease ,Desquamative interstitial pneumonia ,Combined pulmonary fibrosis and emphysema ,Pulmonary hypertension ,smoking ,lung ,respiratory tract diseases ,Lung Disorder ,Histiocytosis ,emphysema ,medicine.anatomical_structure ,Internal medicine ,Epidemiology ,medicine ,interstitial fibrosi ,business - Abstract
Cigarette smoking has a clear epidemiological association with lung diseases, characterised by chronic inflammation of both the bronchiolar and the interstitial lung compartments. There are several different smoking-related interstitial lung diseases, mainly desquamative interstitial pneumonia, respiratory bronchiolitis-associated interstitial lung disease and pulmonary Langerhans' cell histiocytosis. The epidemiology of such diseases is largely unknown, although the prevalence of cigarette smoking, particularly in low-income developing countries, indicates that smoking-induced interstitial lung disorders represent a high burden of disease worldwide. The role of chest high-resolution computed tomography has become increasingly important in differential diagnosis and follow-up. A new entity, the syndrome of combined pulmonary fibrosis and emphysema, emerged as another important smoking-related lung disorder with a poor prognosis, associated with the high prevalence of pulmonary hypertension. At the moment the role of anti-inflammatory and immunosuppressive treatment remains unclear, although in clinical practice most of these patients will receive at least one course of corticosteroid therapy. It is vital to stress the importance of identifying these patients and helping them quit smoking.
- Published
- 2011
20. [Ocular manifestations in Ehlers-Danlos disease].
- Author
-
THOMAS C, NEIMANN N, CORDIER J, and ALGAN B
- Subjects
- Humans, Ehlers-Danlos Syndrome, Eye, Head, Muscles
- Published
- 1953
21. [Angioid striae of the retina and epilepsy].
- Author
-
CORDIER J, VITTE G, and DUREUX J
- Subjects
- Humans, Disease, Epilepsy, Retina, Retinal Diseases
- Published
- 1953
22. [Studies on chronic poliomyelitis. I. Pure degenerative form or spinal atrophy of Duchenne (of Boulogne); two personal cases].
- Author
-
CORDIER J
- Subjects
- Humans, Atrophy, Muscular Atrophy, Spinal, Poliomyelitis
- Published
- 1951
23. [Visual disorders in lung surgery].
- Author
-
THOMAS C, CORDIER J, ALGAN B, and FIEL J
- Subjects
- Humans, Eye, Tuberculosis, Tuberculosis, Pulmonary surgery, Vision Disorders, Vision, Ocular
- Published
- 1954
24. [Proliferating conjunctivitis with pre-auricular tumefaction].
- Author
-
CORDIER J and ALGAN B
- Subjects
- Humans, Conjunctivitis
- Published
- 1953
25. [Benign ocular lymphoreticulosis].
- Author
-
THOMAS C, CORDIER J, and ALGAN B
- Subjects
- Humans, Conjunctiva, Eye, Lymphoma, Neoplasms
- Published
- 1952
- Full Text
- View/download PDF
26. [Comments on a case of encysted abscess of the cerebellum].
- Author
-
BRIHAYE J and CORDIER J
- Subjects
- Humans, Abscess, Brain Abscess, Cerebellum
- Published
- 1952
27. [Studies on chronic poliomyelitis. II. Chronic poliomyelitis after a former infantile paralysis (new anatomo-clinical observations)].
- Author
-
CORDIER J
- Subjects
- Poliomyelitis
- Published
- 1951
28. [Tuberculous retinal periarteritis].
- Author
-
CORDIER J, ALGAN B, and VITTE G
- Subjects
- Niacin, Nicotinic Acids therapeutic use, Retina blood supply, Streptomycin therapeutic use, Tuberculosis, Tuberculosis, Ocular
- Published
- 1953
29. [Proliferating conjunctivitis with pre-auricular tumefaction].
- Author
-
CORDIER J and ALGAN B
- Subjects
- Humans, Conjunctivitis
- Published
- 1954
30. [New etiological factor in syndrome of spontaneous dislocation of the cristalline lense; Ehlers-Danlos disease].
- Author
-
THOMAS C, CORDIER J, and ALGAN B
- Subjects
- Humans, Ehlers-Danlos Syndrome complications, Lens, Crystalline
- Published
- 1952
31. [V. A congenital hereditary form of generalized muscular sclerosis: the Duc family].
- Author
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CORDIER J, LOWENTHAL A, RADERMECKER MA, and VAN BOGAERT L
- Subjects
- Humans, Disease, Muscles, Muscular Diseases, Sclerosis
- Published
- 1952
32. [Oculoglandular tularemia].
- Author
-
THOMAS C, CORDIER J, and ALGAN B
- Subjects
- Humans, Eye Diseases, Tularemia
- Published
- 1952
33. [Parkinson's syndrome with amyotrophia resembling lateral amyotrophic sclerosis and of post-traumatic origin].
- Author
-
CORDIER J
- Subjects
- Humans, Amyotrophic Lateral Sclerosis, Muscular Atrophy, Parkinson Disease, Parkinsonian Disorders, Sclerosis
- Published
- 1951
34. [Two new antibiotics: bacitracin and terramycin].
- Author
-
CORDIER J
- Subjects
- Humans, Anti-Bacterial Agents, Antibiotics, Antitubercular, Bacitracin, Oxytetracycline
- Published
- 1951
35. [Diffuse ossification of the spinal arachnoid; case report].
- Author
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CARBONE F, HASAERTS R, and CORDIER J
- Subjects
- Humans, Arachnoid, Disease, Ossification, Heterotopic, Osteogenesis
- Published
- 1954
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