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Poverty is one of the major drivers of adverse pregnancy outcomes. These outcomes could be mitigated through adequate social protection policies. Despite promising evidence related to maternity protection there is paucity of data on the impact of pregnancy income support interventions in sub-Saharan Africa. Aims and objectives This scoping review aims to explore maternity protection programmes during the first 1000 days of the child's life in low- and middle- income countries and to highlight promising examples of effective existing programs on which future programs can be designed. Methods and analysis This scoping review will follow the five steps of a scoping review as described by Arksey & O’Malley, (2005), of identifying the research questions, identifying relevant studies, selecting studies, charting the data, and collating, summarising, and reporting results. The target population includes pregnant females and mothers living in low- and or middle- income countries, as defined by the World Bank. Studies that consider maternity protection and/or related outcomes within the first 1000 days of among pregnant females, mothers, or for children, are included in this study. Relevant articles shall be searched through databases and grey literature and contacting experts in the field. Covidence, a systematic review support tool, will be used to screen the titles and abstracts of the relevant studies from the literature search. The most relevant studies identified will be included into the data extraction process. A standardized data extraction sheet will be developed and piloted by two reviewers to ensure the consistency with the research questions and inclusion criteria. Data will be analysed using thematic content analysis described by Braun and Clarke (2006) as it may offer a theoretically flexible approach to analysing qualitative data. Ethics and dissemination This research will be carried out in accordance with ethical practice We will disseminate results through journal publications and conferences and academic meetings.

This paper describes the final prototype of an assistive robot used for increasing engagement of older adults in the context of SHAPES project. It then highlights lessons learned from hands-on training during the first phases of the pilots at Clinica Humana and Can Granada residence in Mallorca (Spain)., Comment: in TRAITS Workshop Proceedings (arXiv:2206.08270) held in conjuntion with Companion of the 2022 ACM/IEEE International Conference on Human-Robot Interaction, March 2022, Pages Pages 1284-1286

Additional file 2: TIDIER Checklist. A summary description of the final StAR2D intervention that was experimentally tested.

Additional file 1: Interview guide. Interview guide used for the in-depth individual interviews and focus groups with patient participants in Phase 1.

Additional file 2: Figure S1. (A) Schematic detailing the screening workflow. (B) A heatmap of the sgRNA count per million, z-scored by row for the most variable 500 sgRNAs across all of our CRISPRa screen replicates in the PANC-1 cell line. (C-F) Boxplots describing the replicate, non-replicate, and scrambled null permutation Spearman correlations for knockout screens in Panc-1 (C) and BxPC3 (E) and activation screens in Panc-1 (D) and BxPC3 (F). Figure S2. Irinotecan resistance following overexpression of ABCG2 compared to controls in two cell lines. A) BxPC-3 cells over expressing ABCG2 show resistance to irinotecan (p = 0.037, t-test comparing IC50 values for ABCG2 v. NTC2). B) MiaPaca-2 cells over expressing ABCG2 show resistance to irinotecan (p = 0.026, t-test comparing IC50 values for ABCG2 v. NTC2). Figure S3. The percentile rank for genes known to be involved in chromatin remodeling. HDAC1 is among the genes in this pathway. Figure S4. ChIP-seq analysis of HDAC1-overexpressing (red) MiaPaca-2 cells compared to non-targeting controls (blue). HDAC1 overexpressing cells show increased HDAC1 peak height at (A) the IGF2BP2 promoter, (B) the WNK1 promoter, and (C) the B4GALT6 promoter.

Supplemental material, Supplementary_Figures_12-11-19 for Inhibition of the Wnt/β-catenin pathway enhances antitumor immunity in ovarian cancer by David W. Doo, Selene Meza-Perez, Angelina I. Londoño, Whitney N. Goldsberry, Ashwini A. Katre, Jonathan D. Boone, Dylana J. Moore, Cindy T. Hudson, Ilaria Betella, Tyler R. McCaw, Abhishek Gangrade, Riyue Bao, Jason J. Luke, Eddy S. Yang, Michael J. Birrer, Dmytro Starenki, Sara J. Cooper, Donald J. Buchsbaum, Lyse A. Norian, Troy D. Randall and Rebecca C. Arend in Therapeutic Advances in Medical Oncology

Design features for improving use of CPGs. This file reports features that were suggested by participants to improve implementability and use of the available clinical practice guidelines. (DOCX 12 kb)

Training: Advantages and disadvantages of training delivered in-facility or off-site. This file reports on perceptions and suggestions of primary care healthcare providers to meet guideline training needs. (DOCX 14 kb)

Supplemental figures S1â S7. (PDF 524 kb)

Supplemental text with detailed methods. (DOCX 134 kb)

ROC curve and waterfall plot for the top hypermethylated CpG model in the TCGA validation cohort (a-b) and BPH cohort (c-d). (PDF 842Â kb)

Background The Ugandan government recognizes mental health as a serious public health and development concern, and has of recent implemented a number of reforms aimed at strengthening the country's mental health system. The aim of this study was to provide a profile of the current mental health policy, legislation and services in Uganda. Methods A survey was conducted of public sector mental health policy and legislation, and service resources and utilisation in Uganda, in the year 2005, using the World Health Organization's Assessment Instrument for Mental Health Systems (WHO-AIMS) Version 2.2. Results Uganda's draft mental health policy encompasses many positive reforms, including decentralization and integration of mental health services into Primary Health Care (PHC). The mental health legislation is however outdated and offensive. Services are still significantly underfunded (with only 1% of the health expenditure going to mental health), and skewed towards urban areas. Per 100,000 population, there were 1.83 beds in mental hospitals, 1.4 beds in community based psychiatric inpatient units, and 0.42 beds in forensic facilities. The total personnel working in mental health facilities were 310 (1.13 per 100,000 population). Only 0.8% of the medical doctors and 4% of the nurses had specialized in psychiatry. Conclusion Although there have been important developments in Uganda's mental health policy and services, there remains a number of shortcomings, especially in terms of resources and service delivery. There is an urgent need for more research on the current burden of mental disorders and the functioning of mental health programs and services in Uganda.

ROC curve and waterfall plots for diagnostic model applied to a) lung b) pancreatic and c) breast cancer TCGA datasets. (PDF 1091Â kb)

Boxplots of CpGs in the top diagnostic model from hypermethylated CpGs. Normal data is from benign-adjacent tissues and Tumor data is from patient cancer tissues. (PDF 129Â kb)

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Boxplots of CpGs in the top diagnostic model from hypermethylated CpGs. Normal data is from benign-adjacent tissues and Tumor data is from patient cancer tissues. (PDF 129Â kb)

ROC curve and waterfall plots for diagnostic model applied to a) lung b) pancreatic and c) breast cancer TCGA datasets. (PDF 1091Â kb)

All supplemental figures with captions. (PDF 23001 kb)

Gene expression of genes in close proximity to the top diagnostic model. (PDF 118Â kb)

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All supplemental figures with captions. (PDF 23001 kb)

Gene expression of genes in close proximity to the top diagnostic model. (PDF 118Â kb)

IntroductionDespite the unparalleled success of immunisation in the control of vaccine preventable diseases, immunisation coverage in South Africa remains suboptimal. While many evidence-based interventions have successfully improved vaccination coverage in other countries, they are not necessarily appropriate to the immunisation needs, barriers and facilitators of South Africa. The aim of this research is to investigate barriers and facilitators to optimal vaccination uptake, and develop contextualised strategies and implementation plans to increase childhood and adolescent vaccination coverage in South Africa.MethodsThe study will employ a mixed-methods research design. It will be conducted over three iterative phases and use the Adopt, Contextualise or Adapt (ACA) model as an overarching conceptual framework. Phase 1 will identify, and develop a sampling frame of, immunisation stakeholders involved in the design, planning and implementation of childhood and human papillomavirus immunisation programmes in South Africa. Phase 2 will identify the main barriers and facilitators to, and solutions for, increasing vaccination coverage. This phase will comprise exploratory qualitative research with stakeholders and a review of existing systematic reviews on interventions for improving vaccination coverage. Using the findings from Phase 2 and the ACA model, Phase 3 will develop a set of proposed interventions and implementation action plans for improving immunisation coverage in South Africa. These plans will be discussed, revised and finalised through a series of participatory stakeholder workshops and an online questionnaire, conducted as part of Phase 3.EthicsEthical approval was obtained from the South African Medical Research Council (EC018-11/2018). No risks to participants are expected. Various steps will be taken to ensure the anonymity and confidentiality of participants.DisseminationThe study findings will be shared at stakeholder workshops, the website of Cochrane South Africa and academic publications and conferences.