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48 results on '"Consolini R."'

1. Development and External Validation of a Model Predicting New-Onset Chronic Uveitis at Different Disease Durations in Juvenile Idiopathic Arthritis

Author: van Straalen JW, Kearsley-Fleet L, Klotsche J, de Roock S, Minden K, Heiligenhaus A, Hyrich KL, de Boer JH, Lamot L, Olivieri AN, Gallizzi R, Smolewska E, Faugier E, Pastore S, Hashkes PJ, Herrera CN, Emminger W, Consolini R, Wulffraat NM, Ruperto N, Swart JF, Paediatric Rheumatology International Trials Organisation (PRINTO), UK CAPS study, and German ICON study., van Straalen, Jw, Kearsley-Fleet, L, Klotsche, J, de Roock, S, Minden, K, Heiligenhaus, A, Hyrich, Kl, de Boer, Jh, Lamot, L, Olivieri, An, Gallizzi, R, Smolewska, E, Faugier, E, Pastore, S, Hashkes, Pj, Herrera, Cn, Emminger, W, Consolini, R, Wulffraat, Nm, Ruperto, N, Swart, Jf, Paediatric Rheumatology International Trials Organisation, (PRINTO), UK CAPS, Study, and and German ICON, Study.
Published: 2022

2. Therapeutic aspects of Sydenham's Chorea: an update

Author: Depietri, G., Carli, N., Sica, A., Oliviero, D., Costagliola, G., Striano, P., Bonuccelli, A., Frisone, F., Peroni, D., Consolini, R., Foiadelli, T., and Orsini, A.
Subjects: Acute Rheumatic Fever, Beta-Hemolytic Streptococcal Pharyngitis, Hyperkinetic Movement Disorder, Sydenham’s Chorea, Humans, Knowledge, Uncertainty, Writing, Chorea, Rheumatic Fever, Acute Rheumatic Fever, Beta-Hemolytic Streptococcal Pharyngitis, Hyperkinetic Movement Disorder, Sydenham’s Chorea
Abstract: Sydenham's Chorea (SC) is a hyperkinetic movement disorder associated with neuropsychiatric manifestations. It is believed to be caused by the autoimmune response following a group A beta-hemolytic streptococcal (GABHS) pharyngitis, and it is one of the major diagnostic criteria for Acute Rheumatic Fever (ARF) diagnosis. Despite having been known and studied for centuries, there are still no standardized therapies or official guidelines for SC treatment, so that it is necessarily left to physicians' clinical experience. Antibiotic treatment, symptomatic therapies, and immunomodulatory treatment are the three pillars upon which SC patients' management is currently based, but they still lack a solid scientific basis. The aim of this writing is precisely to review the state of the art of SC's treatment, with an overview of the advances made in the last 5 years. However, since the therapeutic uncertainties are a mere reflection of the severe gap of knowledge that concerns SC's pathogenesis and manifestations, the importance of high-quality research studies based on homogenized methodologies, instruments, and measured outcomes will also be stressed.
Published: 2021

3. The decrease of Kawasaki syndrome during the second COVID-19 wave: a potential, unexpected effect of social distancing

Author: Mastrolia, Mv, Agostiniani, R, Azzari, C, Bernardini, R, Bottone, U, Calabri, Gb, Civitelli, F, Consolini, R, Danieli, R, Di Silvio, R, Falorni, S, Gagliardi, L, Grosso, S, Indolfi, G, L'Erario, M, Martini, M, Memmini, G, Peroni, D, Pezzati, M, Suriano, G, Tafi, L, Trapani, S, Vaccaro, A, Vasarri, Pl, and Gabriele, S
Subjects: Rheumatology, SARS-CoV-2, Immunology, Physical Distancing, Immunology and Allergy, COVID-19, Humans, Mucocutaneous Lymph Node Syndrome
Published: 2021

4. Behçet's Disease in Children: Diagnostic and Management Challenges

Author: Costagliola, G., Cappelli, S., and Consolini, R.
Subjects: Behçet’s disease, differential diagnosis, autoimmunity, aphtosis, Review, autoinflammatory diseases, biologic drugs, Aphtosis, Autoimmunity, Autoinflammatory diseases, Biologic drugs, Differential diagnosis
Abstract: Behçet’s Disease (BD) is an inflammatory disease of unknown etiology with multisystemic involvement, being the main clinical manifestations represented by recurrent oral and genital ulcerations and uveitis. The disease has typically a chronic-relapsing course and may cause significant morbidity and mortality due to eye, vascular and neurological involvement. Although BD is more frequently diagnosed in adulthood, the disease onset can also be in pediatric age. Pediatric-onset BD is commonly featured by an incomplete clinical picture, and therefore the diagnosis represents a considerable clinical challenge for the physicians. The first classification criteria for pediatric BD, based on a scoring system, have been proposed few years ago. This work focuses on the main difficulties concerning both the diagnostic approach and the treatment of BD in pediatric age. The recommendation for the treatment of pediatric BD has been recently updated and allowed a considerable improvement of the therapeutic strategies. In particular, the use of anti-TNFα drugs as a second-line option for refractory BD, and as a first-line treatment in severe ocular and neurological involvement, has demonstrated to be effective in improving the outcome of BD patients. The knowledge about the molecular pathogenesis is progressively increasing, showing that BD shares common features with autoimmune and autoinflammatory disorders, and thus leading to the use of new biologic agents targeting the main mediators involved in the determination of BD. Anti-IL-17, anti-IL-23, anti-IL-1 and anti-IL-6 agents have shown promising results for the treatment of refractory BD in clinical trials and will represent an important alternative for the therapeutic approach to the disease.
Published: 2020

5. Time to Switch to Second-line Antiretroviral Therapy in Children With Human Immunodeficiency Virus in Europe and Thailand

Author: Goetghebuer T, Hainaut M, Van der Kelen E, Delforge M, Warszawski J, Le Chenadec J, Ramos E, Dialla O, Wack T, Laurent C, Selmi L, Leymarie I, Benali F, Brossard M, Boufassa L, Floch-Tudal C, Firtion G, Hau I, Chace A, Bolot P, Blanche S, Granier M, Labrune P, Lachassine E, Dollfus C, Levine M, Fourcade C, Heller-Roussin B, Runel-Belliard C, Tricoire J, Monpoux F, Chirouze C, Reliquet V, Brouard J, Kebaili K, Fialaire P, Lalande M, Mazingue F, Partisani M, Koenigs C, Schultze-Strasser S, Baumann U, Niehues T, Neubert J, Kobbe R, Feiterna-Sperling C, Buchholz B, Notheis G, Spoulou V, Tovo P, Galli L, Chiappini E, Patrizia O, Larovere D, Ruggeri M, Faldella G, Baldi F, Badolato R, Montagnani C, Venturini E, Lisi C, Di Biagio A, Taramasso L, Giacomet V, Erba P, Esposito S, Lipreri R, Salvini F, Tagliabue C, Cellini M, Bruzzese E, Lo Vecchio A, Rampon O, Dona D, Romano A, Dodi I, Maccabruni A, Consolini R, Bernardi S, Genovese O, Olmeo P, Cristiano L, Mazza A, Garazzino S, Pellegatta A, Pajkrt D, Scherpbier H, Weijsenfeld A, van der Plas A, Jurriaans S, Back N, Zaaijer H, Berkhout B, Cornelissen M, Schinkel C, Wolthers K, Fraaij P, van Rossum A, van der Knaap L, Visser E, Boucher C, Koopmans M, van Kampen J, Pas S, Henriet S, de Flier M, van Aerde K, Strik-Albers R, Rahamat-Langendoen J, Stelma F, Scholvinck E, de Groot-de Jonge H, Niesters H, van Leer-Buter C, Knoester M, Bont L, Geelen S, Wolfs T, Nauta N, Ang C, van Houdt R, Pettersson A, Vandenbroucke-Grauls C, Reiss P, Bezemer D, van Sighem A, Smit C, Wit F, Boender T, Zaheri S, Hillebregt M, de Jong A, Bergsma D, Grivell S, Jansen A, Raethke M, Meijering R, de Groot L, van den Akker M, Bakker Y, Claessen E, El Berkaoui A, Koops J, Kruijne E, Lodewijk C, Munjishvili L, Peeck B, Ree C, Regtop R, Ruijs Y, Rutkens T, Schoorl M, Timmerman A, Tuijn E, Veenenberg L, van der Vliet S, Wisse A, Woudstra T, Tuk B, Marczynska M, Oldakowska A, Popielska J, Coupland U, Doroba M, Marques L, Teixeira C, Fernandes A, Prata F, Ene L, Gingaras C, Radoi R, Okhonskaia L, Voronin E, Miloenko M, Labutina S, Soler-Palacin P, Antoinette Frick M, Perez-Hoyos S, Mur A, Lopez N, Mendez M, Mayol L, Vallmanya T, Calavia O, Garcia L, Coll M, Pineda V, Rius N, Rovira N, Duenas J, Fortuny C, Noguera-Julian A, Jose Mellado M, Escosa L, Garcia Hortelano M, Sainz T, Isabel Gonzalez-Tome M, Rojo P, Blazquez D, Tomas Ramos J, Prieto L, Guillen S, Luisa Navarro M, Saavedra J, Santos M, Angeles Munoz M, Ruiz B, Fernandez Mc Phee C, Jimenez de Ory S, Alvarez S, Angel Roa M, Beceiro J, Martinez J, Badillo K, Apilanez M, Pocheville I, Garrote E, Colino E, Gomez Sirvent J, Garzon M, Roman V, Montesdeoca A, Mateo M, Jose Munoz M, Angulo R, Neth O, Falcon L, Terol P, Luis Santos J, Moreno D, Lendinez F, Grande A, Jose Romero F, Perez C, Lillo M, Losada B, Herranz M, Bustillo M, Guerrero C, Collado P, Antonio Couceiro J, Perez A, Isabel Piqueras A, Breton R, Segarra I, Gavilan C, Jareno E, Montesinos E, Dapena M, Alvarez C, Gloria Andres A, Marugan V, Ochoa C, Alfayate S, Isabel Menasalvas A, de Miguel E, Naver L, Soeria-Atmadja S, Hagas V, Aebi-Popp K, Asner S, Aubert V, Battegay M, Baumann M, Bernasconi E, Boni J, Brazzola P, Bucher H, Calmy A, Cavassini M, Ciuffi A, Duppenthaler A, Dollenmaier G, Egger M, Elzi L, Fehr J, Fellay J, Francini K, Furrer H, Fux C, Grawe C, Gunthard H, Haerry D, Hasse B, Hirsch H, Hoffmann M, Hosli I, Kahlert C, Kaiser L, Keiser O, Klimkait T, Kovari H, Kouyos R, Ledergerber B, Martinetti G, de Tejada M, Metzner K, Muller, Nicca D, Paioni P, Pantaleo G, Polli C, Posfay-Barbe K, Rauch A, Rudin C, Schmid P, Scherrer A, Speck R, Tarr P, Lecompte T, Trkola A, Vernazza P, Wagner N, Wandeler G, Weber R, Wyler C, Yerly S, Techakunakorn P, Prachanukroh C, Hansudewechakul R, Wanchaitanawong V, Theansavettrakul S, Nanta S, Ngampiyaskul C, Phanomcheong S, Hongsiriwon S, Karnchanamayul W, Chacheongsao B, Kwanchaipanich R, Kanjanavanit S, Prapinklao S, Kamonpakorn N, Nantarukchaikul M, Adulyadej B, Layangool P, Mekmullica J, Lucksanapisitkul P, Watanayothin S, Lertpienthum N, Warachit B, Hanpinitsak S, Potchalongsin S, Thanasiri P, Krikajornkitti S, Attavinijtrakarn P, Srirojana S, Bunjongpak S, Puangsombat A, Na-Rajsima S, Ananpatharachai P, Akarathum N, Phuket V, Lawtongkum W, Kheunjan P, Suriyaboon T, Saipanya A, Than-in-at K, Jaisieng N, Suaysod R, Chailoet S, Naratee N, Kawilapat S, Kaleeva T, Baryshnikova Y, Soloha S, Bashkatova N, Raus I, Glutshenko O, Ruban Z, Prymak N, Kiseleva G, Bailey H, Lyall H, Butler K, Doerholt K, Foster C, Klein N, Menson E, Riordan A, Shingadia D, Tudor-Williams G, Tookey P, Welch S, Collins I, Cook C, Dobson D, Fairbrother K, Gibb D, Judd A, Harper L, Parrott F, Tostevin A, Van Looy N, Walsh A, Scott S, Vaughan Y, Laycock N, Bernatoniene J, Finn A, Hutchison L, Sharpe G, Williams A, Lyall E, Seery P, Lewis P, Miles K, Subramaniam B, Hutchinson L, Ward P, Sloper K, Gopal G, Doherty C, Hague R, Price V, Bamford A, Bundy H, Clapson M, Flynn J, Novelli V, Ainsley-Walker P, Tovey P, Gurtin D, Garside J, Fall A, Porter D, Segal S, Ball C, Hawkins S, Chetcuti P, Dowie M, Bandi S, McCabe A, Eisenhut M, Handforth J, Roy P, Flood T, Pickering A, Liebeschuetz S, Kavanagh C, Murphy C, Rowson K, Tan T, Daniels J, Lees Y, Kerr E, Thompson F, Le Provost M, Cliffe L, Smyth A, Stafford S, Freeman A, Reddy T, Fidler K, Christie S, Gordon A, Rogahn D, Harris S, Collinson A, Jones L, Offerman B, Van Someren V, Benson C, Riddell A, O'Connor R, Brown N, Ibberson L, Shackley F, Faust S, Hancock J, Donaghy S, Prime K, Sharland M, Storey S, Gorman S, Monrose C, Walters S, Cross R, Broomhall J, Scott D, Stroobant J, Bridgwood A, McMaster P, Evans J, Gardiner T, Jones R, Gardiner K, European Pregnancy Paediat HIV Coh, Stichting HIV Monitoring, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Department of Sciences for Woman and Child's Health, Florence University, Dipartimento di Pediatria, Azienda Ospedaliera di Padova, Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Pediatrics, and Virology
Subjects: Male, 0301 basic medicine, Time Factors, HIV, antiretroviral therapy, children, second-line, switch, [SDV]Life Sciences [q-bio], medicine.medical_treatment, Drug Resistance, INFANTS, HIV Infections, Cohort Studies, chemistry.chemical_compound, 0302 clinical medicine, Interquartile range, Antiretroviral Therapy, Highly Active, ADOLESCENTS, Cumulative incidence, Viral, Treatment Failure, 030212 general & internal medicine, Child, ComputingMilieux_MISCELLANEOUS, Antiretroviral therapy, Children, Second-line, Switch, Age Factors, Anti-HIV Agents, Child, Preschool, Drug Resistance, Viral, Drug Substitution, Europe, Female, Humans, Infant, Reverse Transcriptase Inhibitors, Thailand, Viral Load, Reverse-transcriptase inhibitor, Immunosuppression, OPEN-LABEL, VIROLOGICAL FAILURE, 3. Good health, Infectious Diseases, Viral load, medicine.drug, Microbiology (medical), medicine.medical_specialty, Efavirenz, Nevirapine, SCALE-UP, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Internal medicine, medicine, Highly Active, Preschool, business.industry, HIV-1 DRUG-RESISTANCE, ADULTS, 030112 virology, RANDOMIZED-TRIAL, Regimen, INFECTED CHILDREN, VIRAL LOAD, chemistry, business
Abstract: Background. Data on durability of first-line antiretroviral therapy (ART) in children with human immunodeficiency virus (HIV) are limited. We assessed time to switch to second-line therapy in 16 European countries and Thailand.Methods. Children aged = 2 nucleoside reverse transcriptase inhibitors p[NRTIs] plus nonnucleoside reverse transcriptase inhibitor p[NNRTI] or boosted protease inhibitor p[PI]) were included. Switch to second-line was defined as (i) change across drug class (PI to NNRTI or vice versa) or within PI class plus change of >= 1 NRTI; (ii) change from single to dual PI; or (iii) addition of a new drug class. Cumulative incidence of switch was calculated with death and loss to follow-up as competing risks.Results. Of 3668 children included, median age at ART initiation was 6.1 (interquartile range (IQR), 1.7-10.5) years. Initial regimens were 32% PI based, 34% nevirapine (NVP) based, and 33% efavirenz based. Median duration of follow-up was 5.4 (IQR, 2.9-8.3) years. Cumulative incidence of switch at 5 years was 21% (95% confidence interval, 20%-23%), with significant regional variations. Median time to switch was 30 (IQR, 16-58) months; two-thirds of switches were related to treatment failure. In multivariable analysis, older age, severe immunosuppression and higher viral load (VL) at ART start, and NVP-based initial regimens were associated with increased risk of switch.Conclusions. One in 5 children switched to a second-line regimen by 5 years of ART, with two-thirds failure related. Advanced HIV, older age, and NVP-based regimens were associated with increased risk of switch.
Published: 2017
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6. Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children

Author: Chiappini, E, Galli, L, Tovo, PA, Gabiano, C, de Martino, M, Osimani, P, Cordiali, R, De Mattia, D, Manzioma, M, DI BARI, DANIELA COLOMBA, Ruggeri, M, Masi, M, Miniaci, A, Specchia, F, Ciccia, M, Lanari, M, Baldi, F, Battisti, L, Schumacher, R, Duse, M, Fiorino, C, Dessi, C, Pintor, C, Dedoni, M, Fenu, ML, CAVALLINI, RAFFAELLA, D'ANASTASIO, ELISABETTA, Merolla, F, Sticca, M, Pomero, G, Bezzi, T, Fiumana, E, Paganelli, S, Vierucci, A, Vitucci, P, CECCHI, MARIA TERESA, Cosso, D, Timitilli, A, Stronati, M, Plebani, A, PINZANI, ROBERTO, VIGANO', ALDO, Giacomet, V, Bianchi, R, SALVINI, FRANCESCO, Zuccotti, GV, Giovannini, M, Ferraris, G, Lipreri, R, Moretti, C, Cellini, M, Cano, MC, Palazzi, G, Guarino, A, Bruzzese, E, DE MARCO, GIUSEPPINA, Tarallo, L, TANCREDI, FERNANDO ANTONIO, Giaquinto, C, D'Elia, R, Rampon, O, Nogare, EDR, SANFILIPPO, ALESSIA, Romano, A, Saitta, M, Dodi, I, Barone, A, Maccabruni, A, Consolini, R, Legitimo, A, Magnani, C, Falconieri, P, Fundaro, C, Genovese, O, Salvucci, S, Casadei, AM, Gattinara, GC, Bernardi, S, PALMA, PASQUALE, Anzidei, G, Anzidei, M, Cerilli, S, Catania, S, Ajassa, C, Ganau, A, Cristiano, L, Mazza, A, Di Palma, A, Garetto, S, Riva, C, Scolfaro, C, Portelli, V, Rabusin, M, Pellegatta, A, Molesini, M, Chiappini, E, Galli, L, Tovo, PA, Gabiano, C, de Martino, M, Osimani, P, Cordiali, R, De Mattia, D, Manzioma, M, Di Bari, C, Ruggeri, M, Masi, M, Miniaci, A, Specchia, F, Ciccia, M, Lanari, M, Baldi, F, Battisti, L, Schumacher, R, Duse, M, Fiorino, C, Dessi, C, Pintor, C, Dedoni, M, Fenu, ML, Cavallini, R, Anastasio, E, Merolla, F, Sticca, M, Pomero, G, Bezzi, T, Fiumana, E, Paganelli, S, Vierucci, A, Vitucci, P, Cecchi, MT, Cosso, D, Timitilli, A, Stronati, M, Plebani, A, Pinzani, R, Vigano, A, Giacomet, V, Bianchi, R, Salvini, F, Zuccotti, GV, Giovannini, M, Ferraris, G, Lipreri, R, Moretti, C, Cellini, M, Cano, MC, Palazzi, G, Guarino, A, Bruzzese, E, De Marco, G, Tarallo, L, Tancredi, F, Giaquinto, C, D'Elia, R, Rampon, O, Nogare, EDR, Sanfilippo, A, Romano, A, Saitta, M, Dodi, I, Barone, A, Maccabruni, A, Consolini, R, Legitimo, A, Magnani, C, Falconieri, P, Fundaro, C, Genovese, O, Salvucci, S, Casadei, AM, Gattinara, GC, Bernardi, S, Palma, P, Anzidei, G, Anzidei, M, Cerilli, S, Catania, S, Ajassa, C, Ganau, A, Cristiano, L, Mazza, A, Di Palma, A, Garetto, S, Riva, C, Scolfaro, C, Portelli, V, Rabusin, M, Pellegatta, A, and Molesini, M
Subjects: Adult, medicine.medical_specialty, Adolescent, immunogiobulins, Immunology, immunoglobulins, combined antiretroviral therapy, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Gastroenterology, children, Hypergammaglobulinemia, Internal medicine, medicine, Humans, Immunology and Allergy, Child, Therapeutic regimen, biology, business.industry, Immunoglobulins, Intravenous, Infant, Normal population, hiv-1 infection, Settore MED/38, Antiretroviral therapy, HIV Reverse Transcriptase, Infectious Diseases, Child, Preschool, Intravenous IG, HIV-1, biology.protein, HIV-1 infection, Drug Evaluation, Reverse Transcriptase Inhibitors, Drug Therapy, Combination, Antibody, business, Viral load
Abstract: Objective: To evaluate the effect of combined antiretroviral therapy on serum immunoglobulin (Ig) levels in HIV-1 perinatally infected children.Methods: Data from 1250 children recorded by the Italian Register for HIV Infection in Children from 1985 to 2002 were analysed. Since Ig levels physiologically vary with age, differences at different age periods were evaluated as differences in z-scores calculated using means and standard deviations of normal population for each age period. Combined antiretroviral therapy has become widespread in Italy since 1996, thus differences in Ig z-scores between the periods 1985-1995 and 1996-2002 were analysed. Data according to type of therapeutic regimen were also analysed.Results: Between the two periods 1985-1995 and 1996-2002, significant (P < 0.0001) decreases in IgG (6.29 +/- 4.72 versus 4.44 +/- 4.33), IgM (9.25 +/- 13.32 versus 5.61 +/- 7.93), and IgA (10.25 +/- 15.68 versus 6.48 +/- 11.56) z-scores, together with a parallel significant (P < 0.0001) increase in CD4 T-lymphocyte percentages, were found. These decreases were confirmed regardless of whether the children were receiving intravenous Ig or not. Ig z-scores were significantly higher in children receiving mono-therapy than in those receiving double-combined therapy (IgG, P < 0.0001; IgM, P = 0.003; IgA, P = 0.031) and in the latter children than in those receiving three or more drugs (P < 0.0001 for all z-scores). Ig z-scores correlated inversely with CD4 T lymphocyte percentages and, directly, with viral loads.Conclusions: Our data show that in HIV-1 infected children combined antiretroviral therapy leads to reduction of hyperimmunoglobulinemia which parallels restoration of CD4 T-lymphocyte percentage and viral load decrease, which it turn probably reflects improved B-lymphocyte functions.(C) 2004 Lippincott Williams Wilkins.
Published: 2004
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7. Duration of ruptured membranes and vertical transmission of HIV-1: a meta-analysis from 15 prospective cohort studies

Author: Bulterys, M. B., Fowler, M. G., Hanson, I. C., Lemay, M., Mayaux, M. J., Mofenson, L., Newell, M. -L., Peavy, H., Peckham, C., Read, J. S., Rother, C., Simpson, B. J., Van Dyke, R. B., Harris, D. R., Peavy, H. H., Easley, K., Khammy, A., Nugent, R. P., Mitchell, R., Owen, W., Van Dyke, R., Widmayer, S., Bardeguez, A., Hanson, C., Wiznia, A., Luzuriaga, K., Viscarello, R., Ho, D., Koup, R., Chen, I., Krogstad, P., Mullins, J., Wolinsky, S., Korber, B., Walker, B., Ammann, A., Clapp, S., Mcdonald, D., Lapointe, N., Boucher, M., Fauvel, M., Hankins, C., Samson, J., Newell, M. L., Peckham, C. S., Thorne, C. N., Giaquinto, C., Ruga, E., De Rossi, A., Truscia, D., Grosch-Worner, I., Schafer, A., Mok, J., Johnstone, F., Jiminez, J., de Alba, C., Garcia Rodriguez, M. C., Bates, I., de Josee, I., Hawkins, F., Martinez Zapico, R., Pena, J. M., Gonzalez Garcia, J., Arribas Lopez, J. R., Asensi-Botet, F., Otero, M. C., Peerez-Tamarit, D., Moya, A., Galbis, M. J., Scherpbier, H., Boer, K., Bohlin, A. B., Lindgren, S., Anzen, B., Belfrage, E., Lidin-Jansson, G., Levy, J., Barlow, P., Hainaut, M., Peltier, A., Ferrazin, A., De Maria, A., Gotta, C., Mur, A., Vinolas, M., Paya, A., Loepez-Vilchez, M. A., Coll, O., Fortuny, C., Boguna, J., Casellas Caro, M., Canet, Y., Pardi, G., Ravizza, M., Semprini, E., Castagna, C., Fiore, S., Guerra, B., Lanari, M., Bianchi, S., Bovicelli, L., Prati, E., Zanelli, S., Duse, M., Soresina, A., Scaravelli, G., Stegagno, M., De Santis, M., Muggiasca, M. L., Vigano, A., Spinillo, A., Ravagni Probizer, F., Bucceri, A., Rancilio, L., Taylor, G. P., Lyall, H., Penn, Z., Blott, M., Valerius, N. H., Martinelli, P., Buffolano, W., Tibaldi, C., Ziarati, N., Semprini, A., Della Torre, M., Parazzini, F., Dallacasa, P., Bianchi, U., Pachi, A., Mancuso, S., Villa, P., Conti, M., Principi, N., Muggiasca, M., Marchisio, P., Zara, C., Ravagni, F., Vignali, M., Rossi, G., Selvaggi, L., Greco, P., Vimercati, A., Massi, G., Innocenti, T., Fiscella, A., Sansone, M., Benedetto, C., Tadrist, B., Thevenieau, D., Gondry, J., Paulard, B., Alisy, C., Brault, D., Tordjeman, N., Mamou, J., Rozan, M., Colombani, D., Pincemaille, O., Salvetti, A., Chabanier, C., Hernandorena, X., Leroy, J., Schaal, J., Balde, P., Faucher, P., Lachassinne, E., Benoit, S., Douard, D., Hocke, C., Barjot, P., Brouard, J., Delattre, P., Stien, L., Audibert, F., Labrune, P., Vial, M., Mazy, F., Sitbon, D., Crenn-Hebert, C., Floch-Tudal, C., Akakpo, R., Daveau, C., Leblanc, A., Cesbron, P., Duval-Arnould, M., Huraux-Rendu, C., Lemerle, S., Touboul, C., Guerin, M., Maingueneau, C., Reynaud, I., Rousseau, T., Ercoil, V., Lanza, M., Denavit, M., Garnier, J., Lahsinat, K., Pia, P., Allouche, C., Nardou, M., Grall, F., May, A., Dallot, M., Lhuillier, P., Cecile, W., Mezin, R., Bech, A., Lobut, J., Algava, G., Chalvon Dermesay, A., Busuttil, R., Jacquemot, M., Bader-Meunier, B., Fridman, S., Codaccioni, X., Maxingue, F., Thomas, D., Alain, J., De Lumley, L., Tabaste, J., Bailly Salin, P., Seaume, H., Guichard, A., Kebaill, K., Roussouly, C., Botto, C., De Lanete, A., Wipff, P., Cravello, L., De Boisse, P., Leclaire, M., Michel, G., Crumiere, C., Lefevre, V., Le Lorier, B., Pauly, I., Robichez, B., Seguy, D., Delhinger, M., Rideau, F., Talon, P., Benos, P., Huret, C., Nicolas, J., Heller-Roussin, B., Saint-Leger, S., Delaporte, M., Hubert, C., De Sarcus, B., Karoubi, P., Mechinaud, F., Bertcrottiere, D., Bongain, A., Monpoux, F., De Gennes, C., Devianne, F., Nisand, I., Rousset, M., Mouchnino, G., Muray, J., Munzer, M., Quereux, C., Brossard, V., Clavier, B., Allemon, M., Rotten, D., Stephan, J., Varlet, M., Guyot, B., Narcy, P., Bardinet, F., De Caunes, F., Jeny, R., Robin, M., Raison Boulley, A., Savey, L., Berrebi, A., Tricoire, J., Borderon, J., Fignon, A., Guillot, F., Maria, B., Broyard, A., Chitrit, Y., Firtion, G., Mandelbrot, L., Lafay Pillet, M., Parat, S., Boissinot, C., Garec, N., Levine, M., Ottenwalter, A., Schaller, F., Vilmer, E., Courpotin, C., Brunner, C., Ciraru-Vigneron, N., Hatem-Gantzer, G., Fritel, X., Wallet, A., Bouille, J., Milliez, J., Bensaid Mrejen, D., Dermer, E., Noseda, G., Bardou, D., Cressaty, J., Francoual, C., Carlus Moncomble, C., Cohen, H., Blanche, S., Bastion, H., Benifla, J., Benkhatar, F., Berkane, N., Hervee, F., Ronzier, M., Mayaux, Mj., de Martino, M., Tovo, P. -A., Galli, L., Gabiano, C., Ferraris, G., Garetto, S., Palomba, E., Riva, C., Vierucci, A., de Luca, M., Farina, S., Fundaro, C., Genovese, O., Mereu, G., Forni, G. L., Casadei, A., Zuccotti, G. V., Riva, E., Cellini, M., Baraldi, C., Consolini, R., Palla, G., Ruggeri, M., Ciccimarra, F., Guarino, A., Osimani, P., Benaglia, G., Romano, A., De Mattia, D., Caselli, D., Boni, S., Dell'Erba, G., Bassanetti, F., Sticca, M., Timpano, C., Magnani, C., Salvatore, C., Lipreri, R., Tornaghi, R., Pinzani, R., Cecchi, M. T., Bezzi, T., Battisti, L., Bresciani, E., Castelli Gattinara, G., Nasi, C., Pellegatta, A., Mazza, A., Baldi, F., Altobelli, R., Deiana, M., Colnaghi, C., Tarallo, L., Tondo, U., Anastasio, E., Chiriaco, P. G., Ruggeri, C., Scott, G., Hutto, C., O'Sullivan, M., Malmsberry, A., Willoughby, A., Burns, D., Goedert, J., Landesman, S., Minkoff, H., Mendez, H., Holman, S., Rubinstein, A., Durako, S., Muenz, L., Goodwin, S., Bryson, Y., Dillon, M., Nielsen, K., Boyer, P., Liao, D., Keller, M., Deveikis, A., Nesheim, S., Lindsay, M., Lee, F., Nahmias, A., Sawyer, M., Vink, P., Farley, J., Alger, L., Abrams, E., Bamji, M., Lambert, G., Schoenbaum, E., Thomas, P., Weedon, J., Palumbo, P., Denny, T., Oleske, J., Bulterys, M., Simonds, R., Ethier-Ives, J., Rogers, M., Schluchter, M., Kutner, M., Kaplan, S., Kattan, M., Lipshultz, S., Mellins, R., Shearer, W., Sopko, G., Sloand, E., Wu, M., Kind, C., Nadal, D., Rudin, C., Siegrist, C. -A., Wyler, C. -A., Cheseaux, J. -J., Aebi, C., Gnehm, H., Schubiger, G., Klingler, J., Hunziker, U., Kuchler, H., Gianinazzi, M., Buhlmann, U., Biedermann, K., Lauper, U., Irion, O., Brunelli, A., Spoletini, G., Schreyer, A., Hosli, I., Saurenmann, E., Drack, G., Isenschmid, M., Poorbeik, M., Schupbach, J., Perrin, L., Erb, P., Joller, H., Kovacs, A., Stek, A., Chan, L., Khoury, M., Diaz, C., Pacheco-Acosta, E., Tuomala, R., Cooper, E., Mesthene, D., Pitt, J., Higgins, A., Moroso, G., Rich, K., Turpin, D., Cooper, N., Davenny, K., Thompson, B., Andiman, W., Simpson, J., THE INTERNATIONAL PERINATAL HIV, Group, Martinelli, Pasquale, Bulterys M.B., Fowler M.G., Hanson I.C., Lemay M., Mayaux M.J., Mofenson L., Newell M.-L., Peavy H., Peckham C., Read J.S., Rother C., Simpson B.J., Van Dyke R.B., Harris D.R., Peavy H.H., Easley K., Khammy A., Nugent R.P., Mitchell R., Owen W., Van Dyke R., Widmayer S., Bardeguez A., Hanson C., Wiznia A., Luzuriaga K., Viscarello R., Ho D., Koup R., Chen I., Krogstad P., Mullins J., Wolinsky S., Korber B., Walker B., Ammann A., Clapp S., McDonald D., Lapointe N., Boucher M., Fauvel M., Hankins C., Samson J., Newell M.L., Peckham C.S., Thorne C.N., Giaquinto C., Ruga E., De Rossi A., Truscia D., Grosch-Worner I., Schafer A., Mok J., Johnstone F., Jiminez J., de Alba C., Garcia Rodriguez M.C., Bates I., de Josee I., Hawkins F., Martinez Zapico R., Pena J.M., Gonzalez Garcia J., Arribas Lopez J.R., Asensi-Botet F., Otero M.C., Peerez-Tamarit D., Moya A., Galbis M.J., Scherpbier H., Boer K., Bohlin A.B., Lindgren S., Anzen B., Belfrage E., Lidin-Jansson G., Levy J., Barlow P., Hainaut M., Peltier A., Ferrazin A., De Maria A., Gotta C., Mur A., Vinolas M., Paya A., Loepez-Vilchez M.A., Coll O., Fortuny C., Boguna J., Casellas Caro M., Canet Y., Pardi G., Ravizza M., Semprini E., Castagna C., Fiore S., Guerra B., Lanari M., Bianchi S., Bovicelli L., Prati E., Zanelli S., Duse M., Soresina A., Scaravelli G., Stegagno M., De Santis M., Muggiasca M.L., Vigano A., Spinillo A., Ravagni Probizer F., Bucceri A., Rancilio L., Taylor G.P., Lyall H., Penn Z., Blott M., Valerius N.H., Martinelli P., Buffolano W., Tibaldi C., Ziarati N., Semprini A., Della Torre M., Parazzini F., Dallacasa P., Bianchi U., Pachi A., Mancuso S., Villa P., Conti M., Principi N., Muggiasca M., Marchisio P., Zara C., Ravagni F., Vignali M., Rossi G., Selvaggi L., Greco P., Vimercati A., Massi G., Innocenti T., Fiscella A., Sansone M., Benedetto C., Tadrist B., Thevenieau D., Gondry J., Paulard B., Alisy C., Brault D., Tordjeman N., Mamou J., Rozan M., Colombani D., Pincemaille O., Salvetti A., Chabanier C., Hernandorena X., Leroy J., Schaal J., Balde P., Faucher P., Lachassinne E., Benoit S., Douard D., Hocke C., Barjot P., Brouard J., Delattre P., Stien L., Audibert F., Labrune P., Vial M., Mazy F., Sitbon D., Crenn-Hebert C., Floch-Tudal C., Akakpo R., Daveau C., Leblanc A., Cesbron P., Duval-Arnould M., Huraux-Rendu C., Lemerle S., Touboul C., Guerin M., Maingueneau C., Reynaud I., Rousseau T., Ercoil V., Lanza M., Denavit M., Garnier J., Lahsinat K., Pia P., Allouche C., Nardou M., Grall F., May A., Dallot M., Lhuillier P., Cecile W., Mezin R., Bech A., Lobut J., Algava G., Chalvon Dermesay A., Busuttil R., Jacquemot M., Bader-Meunier B., Fridman S., Codaccioni X., Maxingue F., Thomas D., Alain J., De Lumley L., Tabaste J., Bailly Salin P., Seaume H., Guichard A., Kebaill K., Roussouly C., Botto C., De Lanete A., Wipff P., Cravello L., De Boisse P., Leclaire M., Michel G., Crumiere C., Lefevre V., Le Lorier B., Pauly I., Robichez B., Seguy D., Delhinger M., Rideau F., Talon P., Benos P., Huret C., Nicolas J., Heller-Roussin B., Saint-Leger S., Delaporte M., Hubert C., De Sarcus B., Karoubi P., Mechinaud F., Bertcrottiere D., Bongain A., Monpoux F., De Gennes C., Devianne F., Nisand I., Rousset M., Mouchnino G., Muray J., Munzer M., Quereux C., Brossard V., Clavier B., Allemon M., Rotten D., Stephan J., Varlet M., Guyot B., Narcy P., Bardinet F., De Caunes F., Jeny R., Robin M., Raison Boulley A., Savey L., Berrebi A., Tricoire J., Borderon J., Fignon A., Guillot F., Maria B., Broyard A., Chitrit Y., Firtion G., Mandelbrot L., Lafay Pillet M., Parat S., Boissinot C., Garec N., Levine M., Ottenwalter A., Schaller F., Vilmer E., Courpotin C., Brunner C., Ciraru-Vigneron N., Hatem-Gantzer G., Fritel X., Wallet A., Bouille J., Milliez J., Bensaid Mrejen D., Dermer E., Noseda G., Bardou D., Cressaty J., Francoual C., Carlus Moncomble C., Cohen H., Blanche S., Bastion H., Benifla J., Benkhatar F., Berkane N., Hervee F., Ronzier M., Mayaux MJ., de Martino M., Tovo P.-A., Galli L., Gabiano C., Ferraris G., Garetto S., Palomba E., Riva C., Vierucci A., de Luca M., Farina S., Fundaro C., Genovese O., Mereu G., Forni G.L., Casadei A., Zuccotti G.V., Riva E., Cellini M., Baraldi C., Consolini R., Palla G., Ruggeri M., Ciccimarra F., Guarino A., Osimani P., Benaglia G., Romano A., De Mattia D., Caselli D., Boni S., Dell'Erba G., Bassanetti F., Sticca M., Timpano C., Magnani C., Salvatore C., Lipreri R., Tornaghi R., Pinzani R., Cecchi M.T., Bezzi T., Battisti L., Bresciani E., Castelli Gattinara G., Nasi C., Pellegatta A., Mazza A., Baldi F., Altobelli R., Deiana M., Colnaghi C., Tarallo L., Tondo U., Anastasio E., Chiriaco P.G., Ruggeri C., Scott G., Hutto C., O'Sullivan M., Malmsberry A., Willoughby A., Burns D., Goedert J., Landesman S., Minkoff H., Mendez H., Holman S., Rubinstein A., Durako S., Muenz L., Goodwin S., Bryson Y., Dillon M., Nielsen K., Boyer P., Liao D., Keller M., Deveikis A., Nesheim S., Lindsay M., Lee F., Nahmias A., Sawyer M., Vink P., Farley J., Alger L., Abrams E., Bamji M., Lambert G., Schoenbaum E., Thomas P., Weedon J., Palumbo P., Denny T., Oleske J., Bulterys M., Simonds R., Ethier-Ives J., Rogers M., Schluchter M., Kutner M., Kaplan S., Kattan M., Lipshultz S., Mellins R., Shearer W., Sopko G., Sloand E., Wu M., Kind C., Nadal D., Rudin C., Siegrist C.-A., Wyler C.-A., Cheseaux J.-J., Aebi C., Gnehm H., Schubiger G., Klingler J., Hunziker U., Kuchler H., Gianinazzi M., Buhlmann U., Biedermann K., Lauper U., Irion O., Brunelli A., Spoletini G., Schreyer A., Hosli I., Saurenmann E., Drack G., Isenschmid M., Poorbeik M., Schupbach J., Perrin L., Erb P., Joller H., Kovacs A., Stek A., Chan L., Khoury M., Diaz C., Pacheco-Acosta E., Tuomala R., Cooper E., Mesthene D., Pitt J., Higgins A., Moroso G., Rich K., Turpin D., Cooper N., Davenny K., Thompson B., Andiman W., and Simpson J.
Subjects: Time Factors, Epidemiology, Infectious Disease Transmission, Prevention of perinatal transmission, Extraembryonic Membranes, Human immunodeficiency virus (HIV), HIV Infections, medicine.disease_cause, Cohort Studies, Pregnancy, Risk Factors, INFECTION, Vertical, Immunology and Allergy, HIV Infection, MOTHER-TO-CHILD, Pregnancy Complications, Infectious, Prospective cohort study, prevention of perinatal transmission, vertical transmission, obstetrics/gynaecology, epidemiology, Obstetrics, Transmission (medicine), Infectious, HUMAN-IMMUNODEFICIENCY-VIRUS, MOTHER-TO-CHILD, ZIDOVUDINE PROPHYLAXIS, RISK-FACTORS, TYPE-1, PREGNANCY, INFECTION, TRIAL, PREVENTION, Breast Feeding, Infectious Diseases, Meta-analysis, HUMAN-IMMUNODEFICIENCY-VIRUS, Vertical transmission, Regression Analysis, TRIAL, Female, Delivery, Obstetrics gynaecology, Human, medicine.medical_specialty, Time Factor, Ruptured membranes, Immunology, Regression Analysi, NO, ZIDOVUDINE PROPHYLAXIS, Extraembryonic Membrane, medicine, Humans, TYPE-1, business.industry, Risk Factor, Infant, Newborn, Infant, Obstetric, Delivery, Obstetric, Newborn, PREVENTION, Infectious Disease Transmission, Vertical, Pregnancy Complications, Obstetrics/gynaecology, RISK-FACTORS, Cohort Studie, business
Abstract: Objective: To test the a priori hypothesis that longer duration of ruptured membranes is associated with increased risk of vertical transmission of HIV. Design: The relationship between duration of ruptured membranes and vertical transmission of HIV was evaluated in an individual patient data meta-analysis. Methods: Eligible studies were prospective cohort studies including at least 100 mother-child pairs, from regions where HIV-infected women are counselled not to breastfeed. Analyses were restricted to vaginal deliveries and non-elective Cesarean sections; elective Cesarean section deliveries (those performed before onset of labour and before rupture of membranes) were excluded. Results: The primary analysis included 4721 deliveries with duration of ruptured membranes ≤ 24 h. After adjusting for other factors known to be associated with vertical transmission using logistic regression analysis to assess the strength of the relationship, the risk of vertical HIV transmission increased approximately 2% with an increase of 1 h in the duration of ruptured membranes [adjusted odds ratio, 1.02; 95% confidence interval, 1.01-1.04; for each 1 h increment]. There were no significant interactions of duration of ruptured membranes with study cohort or with any of the covariates, except maternal AIDS. Among women diagnosed with AIDS, the estimated probability of transmission increased from 8% to 31% with duration of ruptured membranes of 2 h and 24 h respectively (P < 0.01). Conclusions: These results support the importance of duration of ruptured membranes as a risk factor for vertical transmission of HIV and suggest that a diagnosis of AIDS in the mother at the time of delivery may potentiate the effect of duration of ruptured membranes. © 2001 Lippincott Williams & Wilkins.
Published: 2001
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8. Corrigendum to: 'Vaccination in immunocompromised host: Recommendations of Italian Primary Immunodeficiency Network Centers (IPINET)' [Vaccine 36 (2018) Pages 3541–3542]

Author: Martire, Baldassarre, Azzari, Chiara, Badolato, Raffaele, Canessa, Clementina, Cirillo, Emilia, Gallo, Vera, Graziani, Simona, Lorenzini, Tiziana, Milito, Cinzia, Panza, Raffaella, Moschese, Viviana, Pignata, Claudio, Martire, B, Lassandro, G, Panza, R, Vacca, A, Marasco, C, Cardinale, F, Sisto, C, Pession, A, Ricci, G, Rondelli, R, Specchia, F, Plebani, A, Badolato, R, Lougaris, V, Soresina, A, Miniero, R, Anastasio, E, Paganelli, R, Dilizia, Sperli, D, Carpino, L, Cirillo, E, Gallo, V, Giardino, G, Spadaro, G, Pecoraro, A ), Putti, Mc, Agostini, C, Cinetto, F, Trizzino, A, Bertolini, P), Arlotta, A, Marseglia, Gl, Bossi, G, Consolini, R, and Et, Al.
Subjects: ANTIBODY-RESPONSES, Secondary immunodeficiency KeyWords Plus:CHRONIC GRANULOMATOUS-DISEASE, ADVISORY-COMMITTEE, ROTAVIRUS VACCINATION, IMMUNIZATION PRACTICES, Medicine, HUMORAL IMMUNITY, Author Keywords:Vaccination, Primary immunodeficiency, Syndromic immunodeficiency, ACUTE LYMPHOBLASTIC-LEUKEMIA, CALMETTE-GUERIN, POLYSACCHARIDE VACCINATION, MENDELIAN SUSCEPTIBILITY, General Veterinary, General Immunology and Microbiology, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Virology, Vaccination, Infectious Diseases, Molecular Medicine, business, Host (network)
Published: 2018
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9. Intravenus immunoglobulin therapy: a prospective multicentric study monitoring adverse reactions

Author: Soresina A, Rondelli R, Quinti I, Agostini C, Martino S, Pietrogrande MC, Putti C, Arico M, Moschese V, Consolini R, Plebani A, Pession A, Ugazio A., SPADARO, GIUSEPPE, Soresina, A, Rondelli, R, Quinti, I, Agostini, C, Spadaro, Giuseppe, Martino, S, Pietrogrande, Mc, Putti, C, Arico, M, Moschese, V, Consolini, R, Plebani, A, Pession, A, and Ugazio, A.
Published: 2008

10. The Mode of Delivery and the Risk of Vertical Transmission of Human Immunodeficiency Virus Type 1 — A Meta-Analysis of 15 Prospective Cohort Studies

Author: Andiman, W., Boucher, M., Burns, D., Bryson, Y., Farley, J., Fowler, H., Gabiano, C., Galli, L., Hutto, C., Kind, C., Korber, B., Kovacs, A., Krogstad, P., Landesman, S., Lapointe, N., Lemay, M., Lew, J., Mandelbrot, L., Mayaux, Mj, Mellins, R., Minkoff, H., Mofenson, L., Nielsen, K., Newell, Ml, Pardi, G., Peavy, H., Peckham, C., Read, J., Rother, C., Rudin, C., Scott, G., Semprini, A., Shearer, W., Simonds, R., Simpson, B., Stek, A., Tovo, Pa, Tuomala, R., Dyke, R., Weedon, J., Martino, M., Lindsay, M., Belair, S., Chan, L., Harris, D., Kalish, L., Muenz, L., Nugent, R., Schluchter, M., Durako, S., Goodwin, S., Mitchell, R., Nourjah, P., Owen, W., Widmayer, S., Bardeguez, A., Hanson, C., Wiznia, A., Luzuriaga, K., Viscarello, R., Ho, D., Koup, R., Chen, I., Mullins, J., Wolinsky, S., Walker, B., Ammann, A., Clapp, S., Mcdonald, D., Fauvel, M., Hankins, C., Samson, J., Bailey, A., Giaquinto, C., Ruga, E., Rossi, A., Truscia, D., Grosch-Worner, I., Schafer, A., Mok, J., Johnstone, F., Jiminez, J., Alba, C., Garcia-Rodriguez, M., Bates, I., Jose, I., Hawkins, F., Zapico, Rm, Asensi-Botet, F., Otero, M., Perez-Tamarit, D., Moya, A., Galbis, M., Scherpbier, H., Boer, K., Bohlin, A., Lindgren, S., Ehrnst, A., Anzen, B., Belfrage, E., Levy, J., Alimenti, A., Barlow, P., Ferrazin, A., Maria, A., Gotta, C., Maritati, V., Mur, A., Rovira, M., Paya, A., Coll, O., Fortuny, C., Boguna, J., Caro, Mc, Canet, Y., Ravizza, M., Castagna, C., Fiore, S., Guerra, B., Lanari, M., Bianchi, S., Bovicelli, L., Prati, E., Duse, M., Soresina, A., Scaravelli, G., Santis, M., Muggiasca, M., Vigano, A., Marchisio, P., Iasci, A., Spinillo, A., Bucceri, A., Grossi, E., Rancilio, L., Della Torre, M., Dallacasa, P., Pachi, A., Principi, N., Zara, C., Vignali, M., Rossi, G., Selvaggi, L., Greco, P., Vimercati, A., Massi, G., Innocenti, T., Fiscella, A., Sansone, M., Benedetto, C., Tibaldi, C., Ziarati, N., Tadrist, B., Thevenicau, D., Gondry, J., Paulard, B., Alisy, C., Brault, D., Tordjeman, P., Mamou, J., Rozan, M., Colombani, D., Pincemaille, O., Salvetti, A., Chabanier, C., Hernandorena, X., Leroy, J., Schaal, J., Balde, P., Faucher, P., Lachassinne, E., Benoit, S., Douard, D., Hocke, C., Barjot, P., Brouard, J., Delattre, P., Stien, L., Audibert, F., Labrune, P., Vial, M., Mazy, F., Sitbon, D., Crenn-Hebert, C., Floch-Tudal, C., Akakpo, R., Daveau, C., Leblanc, A., Cesbron, P., Duval-Arnould, H., Huraux-Rendu, C., Lemerle, S., Touboul, C., Guerin, M., Maingueneau, C., Reynaud, I., Rousseau, T., Ercoil, V., Lanza, M., Denavit, M., Garnier, J., Lahsinat, K., Pia, R., Allouche, C., Nardou, M., Grall, F., May, A., Dallot, M., Lhuillier, P., Cecile, W., Mezin, R., Bech, A., Lobut, J., Algava, G., Dermesay, Ac, Busuttil, R., Jacquemot, M., Bader-Meunier, B., Fridman, S., Codaccioni, X., Maxingue, F., Thomas, D., Alain, J., Lumley, L., Tabaste, J., Salin, Pb, Seaume, H., Guichard, A., Kebaili, K., Roussouly, C., Botto, C., Lanete, A., Wipff, P., Cravello, L., Boisse, P., Leclaire, M., Michel, G., Crumiere, C., Lefevre, V., Le Lorier, B., Pauly, I., Robichez, B., Seguy, D., Dehlinger, M., Rideau, F., Talon, P., Benos, P., Huret, C., Nicolas, J., Heller-Roussin, B., Saint-Leger, S., Delaporte, M., Hubert, C., Sarcus, B., Karoubi, P., Mechinaud, F., Bertcrottiere, D., Bongain, A., Monpoux, F., Gennes, C., Devianne, F., Nisand, I., Rousset, M., Mouchnino, G., Muray, J., Munzer, M., Quereux, C., Brossard, V., Clavier, B., Allemon, M., Rotten, D., Stephan, J., Varlet, M., Guyot, B., Narey, P., Bardinet, F., Caunes, F., Jeny, R., Robin, M., Bouley, Ar, Savey, L., Berrebi, A., Tricoire, J., Borderon, J., Fignon, A., Guillot, F., Maria, B., Broyard, A., Chitrit, Y., Firtion, G., Pillet, Ml, Parat, S., Boissinot, C., Garec, N., Levine, M., Ottenwalter, A., Schaller, F., Vilmer, B., Courpotin, C., Brunner, C., Ciraru-Vigneron, N., Hatem-Gantzer, G., Xavier FRITEL, Wallet, A., Bouille, J., Milliez, J., Mrejen, Db, Dermer, E., Noseda, G., Bardou, D., Cressaty, J., Francoual, C., Moncomble, Cc, Cohen, H., Blanche, S., Bastion, H., Benifla, J., Benkhatar, F., Berkane, N., Herve, F., Ronzier, M., Ferraris, G., Rancillo, L., Tulisso, S., Scolfaro, C., Riva, C., Vierucci, A., Luca, M., Farina, S., Fundaro, C., Genovese, O., Mercu, G., Forni, G., Stegagno, M., Falconieri, P., Zuccotti, G., Riva, E., Cellini, M., Baraldi, C., Consolini, R., Palla, G., Ruggeri, M., Pignata, C., Guarino, A., Osimani, P., Metri, A., Antonellini, A., Benaglia, G., Romano, A., Mattia, D., Caselli, D., Boni, S., Erba, G., Bassanetti, F., Sticca, M., Timpano, C., Magnani, C., Salvatore, C., Gambaretto, G., Lipreri, R., Tornaghi, R., Pinzani, R., Cecchi, M., Bezzi, T., Battisti, L., Bresciani, E., Gattinara, G., Berrino, R., Pellegatta, A., Mazza, A., Baldi, F., Micheletti, E., Altobelli, R., Deiana, M., Colnaghi, C., Tarallo, L., Tondo, U., Anastasio, E., Chiriaco, P., Contardi, I., Ruggeri, C., Ibba, P., O Sullivan, M., Malmsberry, A., Willoughby, A., Goedert, J., Mendez, H., Holman, S., Rubinstein, A., Nesheim, S., Clark, S., Lee, F., Nahmias, A., Sawyer, M., Vink, P., Alger, L., Abrams, E., Bamji, M., Lambert, G., Schoenbaum, E., Thea, D., Thomas, P., Palumbo, P., Denny, T., Oleske, J., Orloff, S., Ethier-Ives, J., Rogers, M., Kutner, M., Kaplan, S., Kattan, M., Lipshultz, S., Sopko, G., Sloand, E., Wu, M., Nadal, D., Siegrist, Ca, Wyler, Ca, Cheseaux, Jj, Aebi, C., Gnehm, H., Schubiger, G., Klingler, J., Hunziker, U., Kuchler, H., Gianinazzi, M., Buhlmann, U., Biedermann, K., Lauper, U., Irion, O., Brunelli, A., Spoletini, G., Schreyer, A., Hosli, I., Saurenmann, E., Drack, G., Isenschmid, M., Poorbeik, M., Schupbach, J., Perrin, L., Erb, P., Joller, H., Dillon, M., Nielsen, R., Boyer, P., Liao, D., Keller, M., Deveikis, A., Khoury, M., Diaz, C., Pacheco-Acosta, E., Cooper, E., Mesthene, D., Pitt, J., Higgins, A., Moroso, G., Rich, K., Turpin, D., Cooper, N., Fowler, M., Smeriglio, V., Mckinlay, S., and Ellis, S.
Subjects: Male, medicine.medical_specialty, Multivariate analysis, Anti-HIV Agents, Birth weight, HIV Infections, Cohort Studies, Pregnancy, Risk Factors, medicine, Birth Weight, Humans, Rupture of membranes, Pregnancy Complications, Infectious, Prospective cohort study, Cesarean Section, Obstetrics, business.industry, Infant, Newborn, General Medicine, Odds ratio, Delivery, Obstetric, medicine.disease, Infectious Disease Transmission, Vertical, Confidence interval, Logistic Models, Multivariate Analysis, Immunology, HIV-1, Female, business, Zidovudine, Cohort study
Abstract: Background To evaluate the relation between elective cesarean section and vertical transmission of human immunodeficiency virus type 1 (HIV-1), we performed a meta-analysis using data on individual patients from 15 prospective cohort studies. Methods North American and European studies of at least 100 mother-child pairs were included in the meta-analysis. Uniform definitions of modes of delivery were used. Elective cesarean sections were defined as those performed before onset of labor and rupture of membranes. Multivariate logistic-regression analysis was used to adjust for other factors known to be associated with vertical transmission. Results The primary analysis included data on 8533 mother-child pairs. After adjustment for receipt of antiretroviral therapy, maternal stage of disease, and infant birth weight, the likelihood of vertical transmission of HIV-1 was decreased by approximately 50 percent with elective cesarean section, as compared with other modes of delivery (adjusted odds ratio, 0.43; 95 percent confidence interval, 0.33 to 0.56). The results were similar when the study population was limited to those with rupture of membranes shortly before delivery. The likelihood of transmission was reduced by approximately 87 percent with both elective cesarean section and receipt of antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, as compared with other modes of delivery and the absence of therapy (adjusted odds ratio, 0.13; 95 percent confidence interval, 0.09 to 0.19). Among mother-child pairs receiving antiretroviral therapy during the prenatal, intrapartum, and neonatal periods, rates of vertical transmission were 2.0 percent among the 196 mothers who underwent elective cesarean section and 7.3 percent among the 1255 mothers with other modes of delivery. Conclusions The results of this meta-analysis suggest that elective cesarean section reduces the risk of transmission of HIV-1 from mother to child independently of the effects of treatment with zidovudine.
Published: 1999
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11. Colorectal carcinoma and folate

Author: Gagliardi, G., Biricotti, M., Failli, A., Orsini, G., Consolini, R., Migheli, F., Andrea Nicolini, Spinelli, C., and Spisni, R.
Subjects: Folate, Folic Acid, Colorectal cancer, Epigenetic, Humans, CpG Islands, Microsatellite Instability, DNA Methylation, Colorectal Neoplasms
Abstract: More than a million people a year worldwide develops colorectal cancer (CRC), with a mortality rate close to 33%. Most of the CRC cases are sporadic, only 25% of the patients have a family history of the disease, and major genes causing syndromes predisposing to CRC only account for 5-6% of the total cases. The following subtypes can be recognized: MIN (microsatellite instability), CIN (chromosomal instability), and CIMP (CpG island methylator phenotype). CRC arises from an accumulation of genetic and epigenetic alterations such as DNA methylation, which is able to modulate gene expression. Several studies in the literature show a possible correlation between an altered methylation in the promoter of tumor suppressor genes, proto-oncogenes, genes involved in DNA repair and the CRC risk; it has also been observed a global DNA hypomethylation, especially in the presence of a low folate uptake. Epigenetic changes are reversible, then could be interesting to evaluate on their relationship with dietary factors (as well as folates) and the genetic background of the individuals, for the development of novel strategies for cancer prevention.
Published: 2012

12. Prevalence of HIV-1 integrase mutations related to resistance to dolutegravir in raltegravir naïve and pretreated patients

Author: Saladini, F, Meini, G, Bianco, C, Monno, L, Punzi, G, Pecorari, M, Borghi, V, Di Pietro, M, Filice, G, Gismondo, Mr, Micheli, V, Penco, G, Carli, T, De Luca, A, Zazzi, M, Consolini, Rita, for the ARCA Collaborative Group, and Consolini, R.
Subjects: Microbiology (medical), Pyridones, Integrase inhibitor, HIV Infections, Drug resistance, HIV Integrase, Pharmacology, medicine.disease_cause, Piperazines, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Raltegravir Potassium, Drug Resistance, Viral, Oxazines, medicine, Humans, HIV Integrase Inhibitors, 030304 developmental biology, 0303 health sciences, Mutation, drug resistance, biology, human immunodeficiency virus, 030306 microbiology, General Medicine, Raltegravir, Virology, Pyrrolidinones, 3. Good health, Integrase, Regimen, Infectious Diseases, chemistry, Dolutegravir, biology.protein, HIV-1, Heterocyclic Compounds, 3-Ring, medicine.drug
Abstract: The prevalence of HIV-1 integrase mutations related to resistance to the next-generation integrase inhibitor (INI), dolutegravir (DTG), was assessed in 440 INI-naïve subjects and in 120 patients failing a raltegravir (RTG)-containing regimen. Of the mutations selected by DTG in vitro, S153FY was not detected in any isolate while L101I and T124A were highly prevalent in both groups and significantly associated with non-B subtype. RTG-selected double and triple mutants, mostly the G140S/Q148H variant, were detected in only 32 (26.7%) RTG-treated patients. As L101I and T124A do not appear to exert any major effect in vivo and double and triple mutants resistant to DTG are infrequently selected by RTG, DTG can be effectively used in INI-naïve patients and may retain activity in many patients failing RTG.
Published: 2012

13. Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection. Italian Register for HIV Infection in Children and the Italian National AIDS Registry

Author: de Martino M, Tovo PA, Balducci M, Galli L, Gabiano C, Rezza G, Pezzotti P, Osimani P, Di Bari C, Larovere D, Ruggeri m, Masi M, SpecchiaM, Battisti L, Duse M, Crispino P, Carrara P, Pintor C, Dedoni M, Dessì C, Loriano D, Anastasio E, Bezzi T, De Luca M, Farina S, Vierucci A, Bassetti D, Pontali E, Boni S, Marazzi M. G, Tasso L, Giovanettoni C, Salvini F, Pinzani R, Marchisio P, Viganò A, Tornaghi R, Zuccotti G. V, Riva E, Giovannini M, Lipreri R, Conio S, Ferraris G, Cellini M, Baraldi C, Tarallo L, Giaquinto C, Ruga E, Rampon O, Dalle Nogare E. R, Sanfilippo A, Romano A, Benaglia G, Dodi I, Caselli D, maccabruni A, Pacati I, Consolini R, Palla G, Cecchi M. T, Vecchi C, Anzidei G, Cerilli S, Chiodi R, Castelli Gattianra G, Krzysztofiak A, Bernardi S, Fundarò C, Genovese O, Colafati G. S, Catania A, Ajassa C, Mazza A, Garetto S, Riva C, Scolfaro C., GUARINO, ALFREDO, BERNI CANANI, ROBERTO, de Martino, M, Tovo, Pa, Balducci, M, Galli, L, Gabiano, C, Rezza, G, Pezzotti, P, Osimani, P, Di Bari, C, Larovere, D, Ruggeri, M, Masi, M, Specchiam, Battisti, L, Duse, M, Crispino, P, Carrara, P, Pintor, C, Dedoni, M, Dessì, C, Loriano, D, Anastasio, E, Bezzi, T, De Luca, M, Farina, S, Vierucci, A, Bassetti, D, Pontali, E, Boni, S, Marazzi, M. G., Tasso, L, Giovanettoni, C, Salvini, F, Pinzani, R, Marchisio, P, Viganò, A, Tornaghi, R, Zuccotti, G. V., Riva, E, Giovannini, M, Lipreri, R, Conio, S, Ferraris, G, Cellini, M, Baraldi, C, Guarino, Alfredo, BERNI CANANI, Roberto, Tarallo, L, Giaquinto, C, Ruga, E, Rampon, O, Dalle Nogare, E. R., Sanfilippo, A, Romano, A, Benaglia, G, Dodi, I, Caselli, D, Maccabruni, A, Pacati, I, Consolini, R, Palla, G, Cecchi, M. T., Vecchi, C, Anzidei, G, Cerilli, S, Chiodi, R, Castelli Gattianra, G, Krzysztofiak, A, Bernardi, S, Fundarò, C, Genovese, O, Colafati, G. S., Catania, A, Ajassa, C, Mazza, A, Garetto, S, Riva, C, and Scolfaro, C.
Abstract: CONTEXT: Since the introduction of combined antiretroviral therapy, mortality rates in adults with human immunodeficiency virus type 1 (HIV-1) infection have decreased. However, little information is available outside the setting of controlled trials on survival of perinatally HIV-infected children treated with antiretroviral therapy. OBJECTIVE: To assess effect of availability of antiretroviral therapy on decreasing mortality in perinatally HIV-infected children. DESIGN: Population-based, multicenter longitudinal study involving data collected by the Italian Register for HIV Infection in Children. SETTING: A network of 106 pediatric clinical centers. SUBJECTS: A total of 1142 children born between November 1980 and December 1997 with perinatally acquired HIV infection with a median follow-up of 5.9 years. MAIN OUTCOME MEASURE: Time to HIV-related death calculated for birth cohort and calendar period and grouped by distribution of predominant type of antiretroviral therapy administered over time. RESULTS: Survival was longer in the 1996-1997 birth cohort (crude relative hazard [RH] of death, 0.39; 95% confidence interval [CI], 0.15-0.96) and 1996-1998 calendar period (crude RH of death, 0.65; 95% CI, 0.45-0.95) than in birth cohort and calendar period 1980-1995, but not when adjusted for maternal antiretroviral treatment during pregnancy and clinical condition at time of delivery, gestational age, and birth weight (adjusted RH of death, 0.55; 95% CI, 0.20-1.50, for birth cohort; and adjusted RH of death, 0.71, 95% CI, 0.43-1.16, for calendar period). In a multivariate model with 1980-1995 as comparison, the 1996-1997 birth cohort had an RH of 0.57 (95% CI, 0.22-1.47; P=.27) but RH for calendar period 1996-1998 was 0.63 (95% CI, 0.47-0.85; P
Published: 2000

14. A novel methodology for large-scale phylogeny partition

Author: Prosperi, Mattia C. F., Ciccozzi, Massimo, Fanti, Iuri, Saladini, Francesco, Pecorari, Monica, Borghi, Vanni, Di Giambenedetto, Simona, Bruzzone, Bianca, Capetti, Amedeo, Vivarelli, Angela, Rusconi, Stefano, Maria Carla, Re, Gismondo, Maria Rita, Sighinolfi, Laura, Gray, Rebecca R., Salemi, Marco, Zazzi, Maurizio, De Luca, Andrea, Giacometti, A, Butini, L, Menzo, S, Tacconi, D, Corbelli, G, Zanussi, S, Monno, L, Punzi, G, Maggiolo, F, Callegaro, A, Calza, L, Re, Mc, Pristerà, R, Turconi, P, Mandas, A, Tini, S, Zoncada, A, Paolini, E, Amadio, G, Sighinolfi, L, Zuccati, G, Morfini, M, Manetti, R, Corsi, P, Galli, L, Di Pietro, M, Bartalesi, F, Colao, G, Tosti, A, Di Biagio, A, Setti, M, Bruzzone, B, Penco, G, Trezzi, M, Orani, A, Pardelli, R, De Gennaro, M, Chiodera, A, Scalzini, A, Palvarini, L, Almi, P, Todaro, G, Cicconi, P, Rusconi, S, Gismondo, Mr, Micheli, V, Biondi, Ml, Gianotti, N, Capetti, A, Meraviglia, P, Boeri, E, Mussini, C, Pecorari, M, Soria, A, Vecchi, L, Santirocchi, M, Brustia, D, Ravanini, P, Dal Bello, F, Romano, N, Mancuso, S, Calzetti, C, Maserati, R, Filice, G, Baldanti, F, Francisci, D, Parruti, G, Polilli, E, Sacchini, D, Martinelli, C, Consolini, R, Vatteroni, L, Vivarelli, A, Dionisio, D, Nerli, A, Lenzi, L, Magnani, G, Ortolani, P, Andreoni, M, Palamara, G, Fimiani, C, Palmisano, L, De Luca, A, Fadda, G, Vullo, Vincenzo, Turriziani, Ombretta, Montano, M, Cenderello, G, Gonnelli, A, Palumbo, M, Ghisetti, V, Bonora, S, Delle Foglie, P, Rossi, C, Grossi, P, Seminari, E, Poletti, F, Mondino, V, Malena, M, Lattuada, E., Prosperi MC, Ciccozzi M, Fanti I, Saladini F, Pecorari M, Borghi V, Di Giambenedetto S, Bruzzone B, Capetti A, Vivarelli A, Rusconi S, Re MC, Gismondo MR, Sighinolfi L, Gray RR, Salemi M, Zazzi M, De Luca A, ARCA collaborative group., Prosperi, M, Ciccozzi, M, Fanti, I, Saladini, F, Pecorari, M, Borghi, V, Di Giambenedetto, S, Bruzzone, B, Capetti, A, Vivarelli, A, Rusconi, S, Re, M, Gismondo, M, Sighinolfi, L, Gray, R, Salemi, M, Zazzi, M, De Luca, A, and Mancuso, S
Subjects: Genetics and Molecular Biology (all), Male, pol, Theoretical computer science, Inference, Gene Products, pol, General Physics and Astronomy, HIV Infections, Biology, Network topology, Settore MED/17 - MALATTIE INFETTIVE, Biochemistry, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Physics and Astronomy (all), 0302 clinical medicine, Search algorithm, phylogenetic analysis, virus transmission, Gene Products, Humans, HIV Infection, 030212 general & internal medicine, Phylogeny, 030304 developmental biology, Algorithms, Classification, Female, HIV-1, Biochemistry, Genetics and Molecular Biology (all), Chemistry (all), Genetics, 0303 health sciences, Multidisciplinary, Phylogenetic tree, Node (networking), HIV, General Chemistry, Partition (database), Algorithm, Identification (information), Transmission (telecommunications), METHODOLOGY, Human
Abstract: Understanding the determinants of virus transmission is a fundamental step for effective design of screening and intervention strategies to control viral epidemics. Phylogenetic analysis can be a valid approach for the identification of transmission chains, and very-large data sets can be analysed through parallel computation. Here we propose and validate a new methodology for the partition of large-scale phylogenies and the inference of transmission clusters. This approach, on the basis of a depth-first search algorithm, conjugates the evaluation of node reliability, tree topology and patristic distance analysis. The method has been applied to identify transmission clusters of a phylogeny of 11,541 human immunodeficiency virus-1 subtype B pol gene sequences from a large Italian cohort. Molecular transmission chains were characterized by means of different clinical/demographic factors, such as the interaction between male homosexuals and male heterosexuals. Our method takes an advantage of a flexible notion of transmission cluster and can become a general framework to analyse other epidemics. © 2011 Macmillan Publishers Limited. All rights reserved.
Published: 2011
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15. Detection of drug resistance mutations at low plasma HIV-1 RNA load in a European multicentre cohort study

Author: Prosperi, Mc1, Mackie, N, Di Giambenedetto, S, Zazzi, M, Camacho, R, Fanti, I, Torti, C, Sönnerborg, A, Kaiser, R, Codoñer, Fm, Van Laethem, K, Bansi, L, van de Vijver DA, Geretti, Am, De Luca, A, Giacometti A, SEHERE c. o. n. s. o. r. t. i. u. m., Butini, L, del Gobbo, R, Menzo, S, Tacconi, D, Corbelli, G, Zanussi, S, Monno, L, Punzi, G, Maggiolo, F, Callegaro, A, Calza, L, Carla Re, M, Pristerà, R, Turconi, P, Mandas, A, Tini, S, Zoncada, A, Paolini, E, Amadio, G, Sighinolfi, L, Zuccati, G, Morfini, M, Manetti, R, Corsi, P, Galli, L, Di Pietro, M, Bartalesi, F, Colao, G, Tosti, A, Di Biagio, A, Setti, M, Bruzzone, B, Penco, G, Trezzi, M, Orani, A, Pardelli, R, De Gennaro, M, Chiodera, A, Scalzini, A, Palvarini, L, Almi, P, Todaro, G, d'Arminio Monforte, A, Cicconi, P, Rusconi, S, Gismondo, Mr, Micheli, V, Biondi, Ml, Gianotti, N, Capetti, A, Meraviglia, P, Boeri, E, Mussini, C, Pecorari, M, Soria, A, Vecchi, L, Santirocchi, M, Brustia, D, Ravanini, P, Bello, Fd, Romano, N, Mancuso, S, Calzetti, C, Maserati, R, Filice, G, Baldanti, F, Francisci, D, Parruti, G, Polilli, E, Sacchini, D, Martinelli, C, Consolini, R, Vatteroni, L, Vivarelli, A, Dionisio, D, Nerli, A, Lenzi, L, Magnani, G, Ortolani, P, Andreoni, M, Palamara, G, Fimiani, C, Palmisano, L, Fadda, G, Vullo, Vincenzo, Turriziani, O, Montano, M, Cenderello, G, Gonnelli, A, Palumbo, M, Ghisetti, V, Bonora, S, Foglie, Pd, Rossi, C, Grossi, P, Seminari, E, Poletti, F, Mondino, V, Malena, M, Lattuada, E, Lengauer, T, Däumer, M, Hoffmann, D, Schülter, E, Müller, C, Oette, M, Reuter, S, Esser, S, Fätkenheuer, G, Rockstroh, J, Incardona, F, Rosen Zvi, M, Clotet, B, Thalme, A, Svedhem, V, Bratt, G, Gargiulo, F, Lapadula, G, Manca, N, Paraninfo, G, Quiros Roldan, E, Carosi, G, Castelnuovo, F, Vandamme, Am, Van Wijngaerden, E, Ainsworth, J, Anderson, J, Babiker, A, Dunn, D, Easterbrook, P, Fisher, M, Gazzard, B, Garrett, N, Gilson, R, Gompels, M, Hill, T, Johnson, M, Leen, C, Orkin, C, Phillips, A, Pillay, D, Porter, K, Post, F, Sabin, C, Sadiq, T, Schwenk, A, Walsh, J, Delpech, V, Palfreeman, A, Glabay, A, Lynch, J, Hand, J, de Souza, C, Perry, N, Tilbury, S, Churchill, D, Nelson, M, Waxman, M, Mandalia, S, Kall, M, Korat, H, Taylor, C, Ibrahim, F, Campbell, L, James, L, Brima, N, Williams, I, Youle, M, Lampe, F, Smith, C, Grabowska, H, Chaloner, C, Puradiredja, Di, Weber, J, Ramzan, F, Carder, M, Wilson, A, Dooley, D, Asboe, D, Pozniak, A, Cameron, S, Cane, P, Chadwick, D, Clark, D, Collins, S, Lazarus, L, Dolling, D, Fearnhill, E, Castro, H, Coughlin, K, Zuckerman, M, Booth, C, Goldberg, D, Hale, A, Kaye, S, Kellam, P, Leigh Brown, A, Smit, E, Templeton, K, Tilston, P, Tong, W, Zhang, H, Ushiro Lumb, I, Oliver, T, Bibby, D, Mitchell, S, Mbisa, T, Wildfire, A, Tandy, R, Shepherd, J, Maclean, A, Bennett, D, Hopkins, M, Garcia Diaz, A, Kirk, S, Sloot, P. M., Virology, Prosperi, M, Mackie, N, di Giambenedetto, S, Zazzi, M, Camacho, R, Fanti, I, Torti, C, Sönnerborg, A, Kaiser, R, Codoñer, F, van laethem, K, Bansi, L, van de Vijver, D, Geretti, A, de luca, A, and Mancuso, S
Subjects: Male, Drug Resistance, HIV Infections, Drug resistance, Cohort Studies, 0302 clinical medicine, Genotype, HIV Infection, Pharmacology (medical), 030212 general & internal medicine, Viral, 0303 health sciences, Proteolytic enzymes, Genotypic testing, HIV, Viral load, Adult, Anti-HIV Agents, CD4 Lymphocyte Count, Europe, Female, HIV-1, Humans, RNA, Viral, Viral Proteins, Drug Resistance, Viral, Mutation, Missense, Viral Load, Pharmacology, Infectious Diseases, 3. Good health, Cohort, Cohort study, Human, Microbiology (medical), Biology, Settore MED/17 - MALATTIE INFETTIVE, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Viral Protein, 030306 microbiology, Anti-HIV Agent, Virology, Reverse transcriptase, Regimen, genotypic testing, viral load, Immunology, Mutation, RNA, Missense, Cohort Studie
Abstract: Background and objectives: Guidelines indicate a plasma HIV-1 RNA load of 500-1000 copies/mL as the minimal threshold for antiretroviral drug resistance testing. Resistance testing at lower viral load levels may be useful to guide timely treatment switches, although data on the clinical utility of this remain limited. We report here the influence of viral load levels on the probability of detecting drug resistance mutations (DRMs) and other mutations by routine genotypic testing in a large multicentre European cohort, with a focus on tests performed at a viral load
Published: 2011

16. Rapid disease progression in HIV-1 perinatally infected children born to mothers receiving zidovudine monotherapy during pregnancy. The Italian register for HIV Infection in Children

Author: de Martino M, Galli L, Tovo P. A, Gabiano C, Osimani P, Zizzadoro P, de Mattia D, Ruggeri M, Lanari M, Dalla Vecchia S, Masi M, Miniaci A, Baldi F, Dell' Erba G, Battisti L, Duse M, Crispino P, Uberti E, Bresciani E, Chiriacò P. G, Pintor C, Dedoni M, Loriano D, Dessì C, Anastasio L, Sabatino G, Sticca M, Berrino R, Lodato A, Vierucci A, Farina S, de Luca M, de Maria A, Fioredda F, Boni S, Marazzi M. G, Pontali E, Forni GL, Gotta C, Tasso, L, Gambaretto G, Meo A, Plebani R, Pinzani R, Salvini F, Marchisio P, Massironi E, Tornaghi R, Zuccotti GV, Riva S, de Carlis S, Ferraris G, Bucceri A, Lipreri R, Cellini M, Tarallo L, Giaquinto C, Ruga E, Rampon O, Romano A, Benaglia G, Caselli D, Maccabruni A, Consolini R, Palla G, Antonellini A, Magnani C, Cecchi T, Castelli Gattinara G, Bernardi S, Cancrini C, Fundarò C, Genovese O, Rendeli C, Timpano C, Anzidei G, Catania S, Stegagno M, Mazza A, Salvatore C, Scolfaro C, Palomba E, Riva C, Pellegatta A., GUARINO, ALFREDO, PIGNATA, CLAUDIO, de Martino, M, Galli, L, Tovo, P. A., Gabiano, C, Osimani, P, Zizzadoro, P, de Mattia, D, Ruggeri, M, Lanari, M, Dalla Vecchia, S, Masi, M, Miniaci, A, Baldi, F, Dell' Erba, G, Battisti, L, Duse, M, Crispino, P, Uberti, E, Bresciani, E, Chiriacò, P. G., Pintor, C, Dedoni, M, Loriano, D, Dessì, C, Anastasio, L, Sabatino, G, Sticca, M, Berrino, R, Lodato, A, Vierucci, A, Farina, S, de Luca, M, de Maria, A, Fioredda, F, Boni, S, Marazzi, M. G., Pontali, E, Forni, Gl, Gotta, C, Tasso, L, Gambaretto, G, Meo, A, Plebani, R, Pinzani, R, Salvini, F, Marchisio, P, Massironi, E, Tornaghi, R, Zuccotti, Gv, Riva, S, de Carlis, S, Ferraris, G, Bucceri, A, Lipreri, R, Cellini, M, Guarino, Alfredo, Pignata, Claudio, Tarallo, L, Giaquinto, C, Ruga, E, Rampon, O, Romano, A, Benaglia, G, Caselli, D, Maccabruni, A, Consolini, R, Palla, G, Antonellini, A, Magnani, C, Cecchi, T, Castelli Gattinara, G, Bernardi, S, Cancrini, C, Fundarò, C, Genovese, O, Rendeli, C, Timpano, C, Anzidei, G, Catania, S, Stegagno, M, Mazza, A, Salvatore, C, Scolfaro, C, Palomba, E, Riva, C, and Pellegatta, A.
Abstract: OBJECTIVE: To investigate the outcome in children perinatally infected with HIV-1 whose mothers received zidovudine (ZDV) monotherapy in pregnancy. DESIGN: Observational retrospective study of a prospectively recruited cohort. SETTING: Italian Register for HIV Infection in Children. PATIENTS: A group of 216 children perinatally infected with HIV-1, born in 1992-1997 and derived prospectively from birth: 38 children had mothers receiving ZDV monotherapy and for 178 children the mothers received no antiretroviral treatment during pregnancy. MAIN OUTCOME MEASURES: The estimated probability of developing severe disease or severe immune suppression, survival probability [95% confidence interval (CI)] within 3 years, and the hazard ratio (95% CI), adjusted for year of birth, maternal clinical condition at delivery, birthweight and treatments (Pneumocystis carinii pneumonia chemoprophylaxis and/or antiretroviral therapy before the onset of severe disease, severe immune suppression or death) were compared. RESULTS: Comparison of HIV-1-infected children whose mothers were treated with ZDV with children whose mothers were not treated showed that the former group had a higher probability of developing severe disease [57.3% (95% CI 40.9-74.3) versus 37.2% (95% CI 30.0-45.4); log-rank test 7.83, P = 0.005; adjusted hazard ratio 1.8 (95% CI 1.1-3.1)] or severe immune suppression [53.9% (95% CI 36.3-73.5) versus 37.5% (95% CI 30.0-46.2); log-rank test 5.58, P = 0.018; adjusted hazard ratio 2.4, (95% CI: 1.3-4.3)] and a lower survival [72.2% (95% CI 50.4-85.7) versus 81.0% (95% CI 73.7-86.5); log-rank test 4.23, P = 0.039; adjusted hazard ratio of death 1.9 (95% CI 1.1-3.6)]. CONCLUSIONS: This epidemiological observation could stimulate virologic studies to elucidate whether this rapid progression depends on in utero infection or transmission of resistant virus. Findings may suggest a need to hasten HIV-1 diagnosis in infants of ZDV-treated mothers and undertake an aggressive antiretroviral therapy in those found to be infected
Published: 1999

17. Low rate of virological failure and maintenance of susceptibility to HIV-1 protease inhibitors with first-line lopinavir/ritonavir-based antiretroviral treatment in clinical practice

Author: Prosperi, Mc1, Zazzi, M, Punzi, G, Monno, L, Colao, G, Corsi, P, Di Giambenedetto, S, Meini, G, Ghisetti, V, Bonora, S, Pecorari, M, Gismondo, Mr, Bagnarelli, P, Carli, T, De Luca, A, Collaborators Giacometti A, ARCA Collaborative G. r. o. u. p., Butini, L, del Gobbo, R, Menzo, S, Tacconi, D, Corbelli, G, Zanussi, S, Maggiolo, F, Callegaro, A, Calza, L, Re, Mc, Raffaele, P, Turconi, P, Mandas, A, Tini, S, Zoncada, A, Paolini, E, Amadio, G, Sighinolfi, L, Zuccati, G, Morfini, M, Manetti, R, Galli, L, Di Pietro, M, Bartalesi, F, Tosti, A, Di Biagio, A, Setti, M, Bruzzone, B, Penco, G, Trezzi, M, Orani, A, Pardelli, R, De Gennaro, M, Chiodera, A, Scalzini, A, Palvarini, L, Almi, P, Todaro, G, Monforte, Ad, Cicconi, P, Rusconi, S, Micheli, V, Biondi, Ml, Gianotti, N, Capetti, A, Meraviglia, P, Boeri, E, Mussini, C, Soria, A, Vecchi, L, Santirocchi, M, Brustia, D, Ravanini, P, Dal Bello, F, Romano, N, Mancuso, S, Calzetti, C, Maserati, R, Filice, G, Baldanti, F, Francisci, D, Parruti, G, Polilli, E, Sacchini, D, Martinelli, C, Consolini, R, Vatteroni, L, Vivarelli, A, Dionisio, D, Nerli, A, Lenzi, L, Magnani, G, Ortolani, P, Andreoni, M, Palamara, G, Fimiani, C, Palmisano, L, Vullo, Vincenzo, Turriziani, O, Montano, M, Cenderello, G, Gonnelli, A, Palumbo, M, Delle Foglie, P, Rossi, C, Poletti, F, Mondino, V, Malena, M, and Lattuada, E.
Published: 2010

18. HIV-1 transmission through breast-milk

Author: De Martino, M., Tovo, P. A., Tozzi, A. E., Pezzotti, P., Galli, L., Liviadotti, S., Caselli, D., Marchisio, P., Giaquinto, G., Fioredda, F., Plebani, A., Gabiano, C., Zuccotti, V. G., Conte, A., Rizzi, M., Mazzoni, P. L., Ibba, P., Ferrarris, G., Benaglia, G., Stegagno, M., Masi, M., Dallacasa, P., Duse, Marzia, Rossi, G., Sciotto, A., Barbanera, M., De Mattia, D., Zaniboni, M., Bezzi, T., Campelli, A., Ciccimarra, F., Bassanetti, F., Consolini, R., Mazza, A., Tarallo, L., Altobelli, R., Castaldo, A., and Fundarò, C.
Subjects: medicine.medical_specialty, Multivariate analysis, business.industry, Immunology, Gestational age, Odds ratio, Logistic regression, medicine.disease, Confidence interval, Surgery, Infectious Diseases, Acquired immunodeficiency syndrome (AIDS), Immunology and Allergy, Medicine, Risk factor, business, Breast feeding, Demography
Abstract: Objectives To estimate the risk of HIV-1 transmission through breast-milk in children born to infected mothers, and to determine the relationship between duration of breast-feeding and risk. Design and methods The study population included 168 breast-fed and 793 bottle-fed children born to seropositive mothers. All subjects were enrolled and followed-up in the Italian Register for HIV Infection in Children; HIV sero-status was defined in all children. Multivariate analysis was performed using a logistic regression model. Independent variables included biological factors (duration of breast-feeding, gestational age, clinical condition of mother at delivery, mode of delivery, birth-weight and sex). Year of birth and age when HIV infection was diagnosed were also considered in the analysis attempting to control for possible selection biases. Results Breast-feeding increased the risk of HIV-1 transmission. The estimated adjusted odds ratio for 1 day of breast- versus bottle-feeding was 1.19 (95% confidence interval, 1.10-1.28). The infection odds ratio of breast- versus bottle-feeding increased with the natural logarithm of the duration of practice. Conclusions These results are the first to provide an appraisal of the additional risk of HIV-1 transmission associated with a seropositive mother breast-feeding her child. Biological significance of this route of transmission was supported by demonstration of a relationship between duration of breast-feeding and risk of HIV-1 transmission.
Published: 1992
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19. Immunoglobulin therapy by intravenous: prospective multicenter surveillance of side effects

Author: Soresina, A., Rondelli, R., Quinti, I., Marzollo, R., Agostini, C., Spadaro, G., Martino, S., Pietrogrande, M. C., Putti, C., Maurizio Arico', Moschese, V., Consolini, R., Plebani, A., Pession, A., Ugazio, A. G., A., Soresina, R., Rondelli, I., Quinti, R., Marzollo, C., Agostini, Spadaro, Giuseppe, S., Martino, M. C., Pietrogrande, C., Putti, M., Arico, V., Moschese, R., Consolini, A., Plebani, A., Pession, and A. G., Ugazio
Subjects: Settore MED/38 - Pediatria Generale e Specialistica
Published: 2008

20. Virologic, immunologic, and clinical benefits from early combined antiretroviral therapy in infants with perinatal HIV-1 infection

Author: Chiappini, E., Galli, L., Atovo, P. i. e. r., Gabiano, C., Castelli Gattinara, G., Guarino, A., Baddato, R., Giaquinto, C., Lisi, C., de Martino, M., Osimani, P., Cordiali, R., De Mattia, D., Manzionna, M., Di Bari, C., Ruggeri, M., Masi, M., Miniaci, A., Specchia, F., Ciccia, M., Lanari, M., Baldi, F., Battisti, L., Fiorino, C., Dessı`, C., Pintor, C., Dedoni, M., Fenu, M. L., Cavallini, R., Anastasio, E., Merolla, F., Sticca, M., Pomero, G., Bezzi, Teresa Maria, Fiumana, Elisa, Bonsignori, F., Gervaso, P., Seini, E., Cecchi, M. T., Cosso, D., Timitilli, A., Stronati, M., Plebani, A., Pinzani, R., Bongianin, I., Vigano`, A., Giacomet, V., Erba, P., Salvini, F., Zuccotti, G. V., Giovannini, M., Ferraris, G., Lipreri, R., Moretti, C., Cellini, M., Cano, M. C., Paolucci, P., Bruzzese, E., De Marco, G., Tarallo, L., Tancredi, F., Pennazzato, M., Rampon, O., Dalle Nogare, E. R., Sanfilippo, A., Romano, A., Saitta, M., Dodi, I., Barone, A., Maccabruni, A., Consolini, R., Legitimo, A., Magnani, C., Falconieri, P., Fundaro`, C., Genovese, O., Panzanella, A., Casadei, A. M., Martino, A., Concato, C., Anzidei, G., Bove, G., Cerilli, S., Catania, S., Ajassa, C., Ganau, A., Cristiano, L., Mazza, A., Di Palma, A., Mignone, F., Riva, C., Scorfaro, C., Portelli, V., Rabusin, M., Pellegatta, A., Molesini, M., Chiappini, E, Galli, L, Tovo, Pa, Gabiano, C, Gattinara, Gc, Guarino, Alfredo, Baddato, R, Giaquinto, C, Lisi, C, and DE MARTINO, M.
Subjects: medicine.medical_specialty, Pediatrics, Anti-HIV Agents, medicine.medical_treatment, Immunology, combined antiretroviral therapy, CD4-CD8 Ratio, HIV Infections, HIV-1 infection, Asymptomatic, Drug Administration Schedule, Acquired immunodeficiency syndrome (AIDS), Immunopathology, Antiretroviral Therapy, Highly Active, Medicine, Immunology and Allergy, Humans, Sida, ART, infants, Chemotherapy, biology, business.industry, Age Factors, Infant, Viral Load, biology.organism_classification, medicine.disease, Infectious Disease Transmission, Vertical, Surgery, CD4 Lymphocyte Count, Infectious Diseases, Treatment Outcome, Child, Preschool, Lentivirus, Disease Progression, HIV-1, Viral disease, medicine.symptom, business, Epidemiologic Methods, Viral load
Abstract: Objective: To investigate the impact of early versus deferred combined antiretroviral treatment (ART) in asymptomatic or moderately symptomatic [Centers for Disease Control and Prevention (CDC) category N, A or B] infants with perinatal HIV-1 infection. Methods: A multi-centre nationwide case-control study was conducted. Data from 30 infants treated with combined ART with three or more drugs before 6 months of age were compared with data from 103 infants starting ART with three or more drugs after 6 months of age. The median follow-up time was 4.1 years (range, 1.0-6.5 years). Results: No difference was evident in the first available viral load and CD4 T-lymphocyte percentage between the two groups of children. Early-treated infants showed significantly lower viral loads than infants receiving deferred treatment at all the follow-up periods. A higher proportion of early-treated infants than infants receiving deferred treatment (73.3% versus 30.1%; P < 0.0001) reached an undetectable viral load. Higher CD4 T-lymphocyte percentages were found in early-treated infants at 13-24 (P < 0.0001), 25-36 (P < 0.0001), and 37-48 (P = 0.003) months of age. No early-treated infant versus 20 of 103 (19.4%) infants receiving deferred ART (P=0.02) showed a CD4 T-lymphocyte percentage of less than 15% at one time point during follow-up. No CDC category A, B or C clinical event occurred in early-treated infants over the follow-up period while 44 of 103 (42.7%) infants receiving deferred treatment presented a decline in the CDC category. Kaplan-Meier analyses revealed significant differences in CDC category A (P = 0.0002), B (P = 0.0003), and C (P = 0.0018) event-free survivals. Conclusion: The data suggest virologic, immunologic, and clinical benefits from early administration of ART.
Published: 2006

21. Evaluation of thrombopoiesis kinetics by measurement of reticulated platelets and CD34(+) cell subsets in patients with solid tumors following high dose chemotherapy and autologous peripheral blood progenitor cell support

Author: Consolini, R., Calleri, A., Bengala, C., Legitimo, A., and PIERFRANCO CONTE
Subjects: Adult, Blood Platelets, Platelet Count, Graft Survival, Hematopoietic Stem Cell Transplantation, Antigens, CD34, Antineoplastic Agents, Middle Aged, Transplantation, Autologous, Hematopoiesis, Kinetics, Neoplasms, thrombopoiesis, solid tumors, chemotherapy, Humans
Abstract: The transplantation of mobilised peripheral progenitor cells has resulted in shortening of neutrophil and platelet engrafment times following high-dose chemotherapy. Since reticulated platelet percentage (PR%) has been established as a measure of bone marrow platelet production, we performed this type of analysis on the thrombopoietic compartment during transplant-related chemotherapy.Kinetics of thrombopoiesis of 19 patients with solid tumors undergoing a single or double autologous peripheral blood progenitor cell transplant was characterized by evaluating the level of RP. The correlation between CD34(+) cell subsets and the time of highest percentage of RP was also evaluated.The percentage of RP increases since day +8 after single transplant reaching the peak (3.4%) at day +10. In the group of patients receiving double transplant, the RP value of peak observed after second transplant is not significantly different from that one observed after the first transplant (3 vs 3.7%). In a subgroup of patients both the number of CD34(+) cells/Kg infused and the percentage of CD34(+) CD61(+) cell subsets correlate with the day of RP peak.These results suggest that RP measurement is an early indicator of engraftment. Additionally, the observation that RP percentage is high at the time of platelet transfusion in 13 out of 20 cases of transfusions (the 7 cases with low RP value being transfused during the period of obligate thrombocytopenia) suggests that the evaluation of this parameter, together with the platelet count, can be used to monitor the need for platelet transfusion.
Published: 2001

22. EPIDEMIOLOGY, CLINICAL FEATURES, AND PROGNOSTIC FACTORS OF PAEDIATRIC HIV INFECTION

Author: Tovo, P. A., de Martino, M., Caramia), G., Armenio, L., Schettini, F., De Mattia, D., Chiodo, F., Masi, M., Trombacco, M. G., Zaniboni, M. G., Duse, Marzia, Vertua, G., Quarta, G., Cao, A., Dessi', C., Di Gregorio, F., Bezzi, T., Cocchi, P., Calabri, G., Vierucci, A., Galli, L., Boeri, E., Jannuzzi, C., Terragna, A., De Maria, A., Sanpietro, F., Barbanera, M., Bardare, M., Plebani, A., Giovannini, M., Magni, L. A., Marchisio, P., Tornaghi, R., Rossi, A., Esposito, L., Guarino, A., Romano, G., Viggiano, D., Zacchello, F., Giaquinto, C., Chieco Bianchi, L., Benaglia, G., Bertolini, P., Arico', M., Caselli, D., Bassanetti, F., Consolini, R., Antonellini, A., Magnani, C., Calvani, M., Falconieri, P., Segni, G., Fundaro', C., Gabiano, C., Palomba, E., Perugini, L., and Negro, F.
Subjects: Hepatitis, Pediatrics, medicine.medical_specialty, Pregnancy, business.industry, Vaginal delivery, Mortality rate, Secondary infection, General Medicine, medicine.disease, Substance abuse, Epidemiology, medicine, Lymphoid interstitial pneumonia, business
Abstract: 486 children born to HIV-positive mothers, 57 children infected by blood products, and 1 child for whom the personal history was not available were studied. Perinatal infection had a more varied clinical picture and a worse outcome compared with infection acquired later in childhood. Severe secondary infections, neurological disorders, and hepatitis (but not lymphoid interstitial pneumonia) were linked to a high mortality rate in perinatally infected children, in whom an early onset of symptoms was also a bad prognostic factor. Perinatal HIV infection occurred in 32·6% of children born to seropositive mothers, with a higher transmission rate in children born by vaginal delivery and then breast-fed. Preterm delivery and low birthweight seemed to be related to drug abuse during pregnancy, not to intrauterine HIV infection. Girls had a higher rate of perinatal infection and, of those infected, had an increased mortality.
Published: 1988
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23. The phenotype and genotype of mevalonate kinase deficiency: A series of 114 cases from the Eurofever Registry

Author: Nm, Ter Haar, Jeyaratnam J, Hj, Lachmann, Simon A, Pa, Brogan, Doglio M, Cattalini M, Anton J, Modesto C, Quartier P, Hoppenreijs E, Martino S, Insalaco A, Luca Cantarini, Lepore L, Alessio M, Calvo Penades I, Boros C, Consolini R, and Rigante D

24. A liver to strike at the heart,Un fegato da colpo al cuore

Author: Vierucci, F., Di Cicco, M. E., Ghione, S., Belcari, F., Marchi, B., Randazzo, E., Gori, M., Palla, G., Consolini, R., Federico, G., and GIUSEPPE MAGGIORE

25. Predictive value of the HIV paediatric classification system for the long-term course of perinatally infected children

Author: Galli, L., Martino, M., Tovo, P. -A, Gabiano, C., Zappa, M., Osimani, P., Mattia, D., Zizzadoro, P., Ruggeri, M., Baldi, F., Ciccia, M., Dallacasa, P., Masi, M., Battisti, L., Bresciani, E., Duse, M., Timpano, S., Chiriacò, P. G., Belloni, M., Corrias, A., Ibba, P., Rossi, G., Anastasio, E., Sabatino, G., Sticca, M., Nasi, C., Bezzi, T., Vierucci, A., Farina, S., Ballotti, S., Bassetti, D., Maria, A., Forni, G. L., Gotta, C., Marazzi, M. G., Mecca, D., Tasso, L., Tondo, U., Micheletti, E., Gambaretto, G., Cellini, M., Altobelli, R., Bucceri, A., Conio, S., Ferraris, G., Giovannini, M., Lipreri, R., Paola Giovanna Marchisio, Massironi, E., Pinzani, R., Plebani, A., Rancilio, L., Riva, E., Salvini, F., Tornaghi, R., Zuccotti, G. V., Guarino, A., Pignata, C., Giaquinto, C., Rampon, O., Ruga, E. M., Romano, A., Benaglia, G., Caselli, D., Maccabruni, A., Bassanetti, F., Consolini, R., Palla, G., Antonellini, A., Metri, A. M., Magnani, C., Cecchi, M. T., Castelli Gattinara, G., Catania, S., Falconieri, P., Fundarò, C., Genovese, O., Krzisztofiak, A., Livadiotti, S., Rendeli, C., Stegagno, M., Timpano, C., Mazza, A., Salvatore, C. M., Palomba, E., Riva, C., Tulisso, S., and Pellegatta, A.

26. Determinants of mother-to-infant human immunodeficiency virus 1 transmission before and after the introduction of zidovudine prophylaxis

Author: Martino, M., Galli, L., Tovo, P. -A, Gabiano, C., Pezzotti, P., Wagner, T. M., Rezza, G., Osimani, P., Mattia, D., Di Bari, C., Ruggeri, M., Baldi, F., Ciccia, M., Lanari, M., Masi, M., Venturi, V., Battisti, L., Duse, M., Chiriacò, P. G., Cavallini, R., Dessí, C., Pintor, C., Anastasio, E., Sabatino, G., Sticca, M., Pomero, G., Bezzi, T., Chiappini, E., Luca, M., Gervaso, P., Cecchi, M. T., Bassetti, D., Gotta, C., Rosso, R., Timitilli, A., Tondo, U., Mussini, P., Bricalli, D., Bucceri, A., Ferraris, G., Giovannini, M., Mosca, F., Lipreri, R., Plebani, A., Riva, E., Riva, S., Viganò, A., Gianvincenzo Zuccotti, Cellini, M., Buffolano, W., Guarino, A., Tarallo, L., D Elia, R., Giaquinto, C., Rampon, O., Dalle Nogare, E. R., Romano, A., Caselli, D., Maccabruni, A., Consolini, R., Benaglia, G., Magnani, C., Anzidei, G., Casadei Pistilli, A. M., Castelli Gattinara, G., Catania, S., Facente, C., Falconieri, P., Fundarò, C., Genovese, O., Rendeli, C., Bionda, S., Cristiano, L., Garetto, S., Riva, C., Palomba, E., Portelli, V., Mazza, A., Salvatore, C., Pellegatta, A., and Molesini, M.

27. Massive calcinosis and severe osteoporosis in paediatric-onset overlap syndrome

Author: Picco, P., Papa, R., Francesca Minoia, Leoni, M., Consolini, R., and Buoncompagni, A.

28. Outcome of patients with initial diagnosis of suspected transitory hypogammaglobulinemia at infancy

Author: Moschese, V., Graziani, S., Chini, L., La Rocca, M., Pignata, C., Soresina, A. R., Consolini, R., Trizzino, A., Martino, S., Bossi, G., Putti, M. C., Bertolini, P., Pietrogrande, M. C., Zecca, M., Marseglia, G. L., Cardinale, F., PAOLO ROSSI, and Plebani, A.
Subjects: Settore MED/38 - Pediatria Generale e Specialistica

29. Mode of delivery and gestational age influence perinatal HIV-1 transmission

Author: Pier Angelo Tovo, Martino, M., Gabiano, C., Galli, L., Cappello, N., Ruga, E., Tulisso, S., Vierucci, A., Loy, A., Zuccotti, G. V., Bucceri, A. M., Plebani, A., Marchisio, P., Caselli, D., Liviadotti, S., Dallacasa, P., Fundaró, C., Stegagno, M., Timpano, C., Ruggeri, M., Duse, M., Belloni, M., Cocchi, P., Risso, S., Forni, G. L., Lipreri, R., Ciccimarra, F., Consolini, R., Benaglia, G., Caramia, G., Santis, U., Chiriacó, R. G., Dessí, C., Ibba, P., Zannino, L., Gregorio, F. D., Sciotto, A., Cecchi, M. T., Boeri, E., Meo, A., Magni, L. A., Altobelli, R., Contardi, I., Gambaretto, G., Esposito, L., Bona, G., Giordano, S., Ragazzini, I., Magnani, C., Bionda, S., and Pellegatta, A.

30. Reduction in mortality with availability of antiretroviral therapy for children with perinatal HIV-1 infection

Author: Martino, M., Tovo, P. -A, Balducci, M., Galli, L., Gabiano, C., Rezza, G., Pezzotti, P., Osimani, P., Di Bari, C., Larovere, D., Ruggeri, M., Masi, M., Specchia, F., Battisti, L., Duse, M., Crispino, P., Carrara, P., Pintor, C., Dedoni, M., Dessì, C., Loriano, D., Anastasio, E., Bezzi, T., Luca, M., Farina, S., Vierucci, A., Bassetti, D., Pontali, E., Boni, S., Marazzi, M. G., Tasso, L., Giovanettoni, C., Salvini, F., Pinzani, R., Marchisio, P., Viganò, A., Tornaghi, R., Gianvincenzo Zuccotti, Riva, E., Giovannini, M., Lipreri, R., Conio, S., Ferraris, G., Cellini, M., Baraldi, C., Guarino, A., Canani, R. B., Tarallo, L., Giaquinto, C., Ruga, E., Rampon, O., Nogare, E. R. D., Sanfilippo, A., Romano, A., Benaglia, G., Dodi, I., Caselli, D., Maccabruni, A., Pacati, I., Consolini, R., Palla, G., Cecchi, M. T., Vecchi, V., Anzidei, G., Cerilli, S., Chiodi, R., Gattinara, G. C., Krzysztofiak, A., Bernardi, S., Fundarò, C., Genovese, O., Colafati, G. S., Catania, S., Ajassa, C., Mazza, A., Garetto, S., Riva, C., and Scolfaro, C.

31. Expression of myeloid markers lacks prognostic impact in children treated for acute lymphoblastic leukemia: Italian experience in AIEOP-ALL 88- 91 studies

Author: Putti, M. C., Rondelli, R., Cocito, M. G., Aricó, M., Sainati, L., Conter, V., Guglielmi, C., Cantú-Rajnoldi, A., Consolini, R., Pession, A., Zanesco, L., Masera, G., Biondi, A., and GIUSEPPE BASSO

32. Clinical relevance of CD10 expression in childhood ALL

Author: Consolini, R., Legitimo, A., Rondelli, R., Guglielmi, C., Barisone, E., Lippi, A., Cantù-Rajnoldi, A., Aricò, M., Conter, V., Cocito, M. G., Putti, M. C., Pession, A., Masera, G., Biondi, A., and GIUSEPPE BASSO

33. Antiretroviral treatment in children with HIV-1 infection: Consensus of the Italian register for HIV infection in children | Trattamento antiretrovirale in bambini con infezione da HIV-1: Consensus del registro Italiano per l'infezione da HIV in pediatria

Author: Martino, M., Pier Angelo Tovo, Giaquinto, C., Rossi, A., Galli, L., Gabiano, C., Floridia, M., Ferraris, G., Ruga, E., Castelli Gattinara, G., Scolfaro, C., Vierucci, A., Viganò, A., Zuccotti, G. V., Fundarò, C., Caselli, D., Maria, A., Duse, M., Plebani, A., Timpano, C., Lanari, M., Stegagno, M., Lipreri, R., Gotta, C., Ruggeri, M., Loriano, D., Osimani, P., Cellini, M., Forni, G. L., Benaglia, G., Antonellini, A., Mattia, D., Pintor, C., Mazza, A., Romano, A., Consolini, R., Pignata, C., Marazzi, M. G., Guarino, A., Cecchi, M. T., Zizzadoro, P., Battisti, L., Bezzi, T., Salvatore, C., Ciccia, M., Bionda, S., Metri, A. M., Anastasio, E., Magnani, C., Sticca, M., Tarallo, L., Masi, M., Gambaretto, G., Catania, S., Micheletti, E., Pellegatta, A., Dessì, C., Baldi, F., Ibba, P., Bresciani, E., Berrino, R., Falconieri, P., Tasso, L., Altobelli, R., Chiriacò, P. G., Ruggeri, C., Magni, L. A., Tondo, U., Contardi, I., Tommasi, D., Di Gregorio, F., Meo, A., Resta, F., Molesini, M., Sabatino, G., and Portelli, V.

34. Diagnostics of Primary Immunodeficiencies through Next-Generation Sequencing

Author: Gallo V, Dotta L, Giardino G, Emilia Cirillo, Lougaris V, D'Assante R, Prandini A, Consolini R, Eg, Farrow, Thiffault I, Cj, Saunders, Leonardi A, Plebani A, Badolato R, and Pignata C

35. Evaluation of minimal residual disease in high risk childhood acute lymphoblastic leukemia using an immunological approach during complete remission

Author: Consolini, R., Scamardella, F., Legitimo, A., Putti, C., Granchi, D., Paolucci, P., Lippi, A., Guazzelli, C., Acquaviva, A., Rosanda, C., GIUSEPPE BASSO, and Macchia, P.
Subjects: acute lymphoblastic leukaemia, children, minimal residual disease

36. Soluble interleukin-2 receptor release during culture of human lymphocytes with human, porcine, or bovine islets and the effect of culture and cryopreservation

Author: Arvia, C., Marchetti, P., Giannarelli, R., Ferdeghini, M., Consolini, R., Concetta Prontera, Legitima, A., Coppelli, A., Carmellini, M., Lorenzetti, M., Mosca, F., and Navalesi, R.

37. A prospective study on 136 patients with agammaglobulinemia X-recessive: results from the italian primary immunodeficiencies network

Author: Soresina, S. A., Rondelli, R., Quinti, I., Azzari, C., Pietro-Grande, M. C., Martino, S., Mattia, D., Martire, M. B., PAOLO ROSSI, Cardinale, C. F., Moschese, V., Masi, M. M., Pignata, P. C., Cazzola, C. G., Consolini, R., Duse, D. M., Stabile, S. A., Locatelli, F., Sciotto, S. A., Di Nardo, D. N. R., Anastasio, A. E., Marseglia, M. G. L., Nespoli, N. L., Putti, C., Trizzino, T. A., Gattorno, G. M., Felici, F. L., Fiorini, F. M., Pession, A., Ugazio, A. G., and Plebani, A.
Subjects: Settore MED/38 - Pediatria Generale e Specialistica

38. Long-term follow-up of HIV-seropositive children

Author: Pier Angelo Tovo, Martino, M., Gabiano, C., Galli, L., Ferraris, G., Giaquinto, C., Castelli Gattinara, G., Garetto, S., Vierucci, A., Marchisio, P., Zuccotti, G. V., Fundarò, C., Duse, M., Caselli, D., Maria, A., Plebani, A., Timpano, C., Lanari, M., Stegagno, M., Ruggeri, M., Gotta, G., Lipreri, L., Cellini, M., Osimani, P., Loriano, D., Benaglia, G., Mattia, D., Forni, G. L., Romano, A., Antonellini, A., Pintor, C., Consolini, R., Mazza, A., Micco, A., Guarino, A., Marazzi, M. G., Cecchi, M. T., Di Bari, C., Dessì, C., Bezzi, T., Bionda, S., Erba, G., Battisti, L., Salvatore, C., Sticca, M., Anastasio, E., Masi, M., Magnani, C., Tarallo, L., Gambaretto, G., Catania, S., Pellegatta, A., Todeschini, A., Baldi, F., Nasi, C., Bresciani, E., Tasso, L., Molesini, M., Chiriacò, P. G., Ruggeri, C., Stucchi, C., Resta, F., Sabatino, G., Delle Nogare, E., Tondo, U., Tommasi, D., Meo, A., Contardi, I., and Portelli, V.

39. AB0579 EVALUATION OF PATIENTS WITH PEDIATRIC BEHÇET’S DISEASE: A TERTIARY CENTER EXPERIENCE

Author: Z. Karali, Ş. Çekiç, I. Çakir, and S. S. Kilic
Subjects: Rheumatology, Immunology, Immunology and Allergy, General Biochemistry, Genetics and Molecular Biology
Abstract: BackgroundBehçet’s disease (BD) is an systemic inflammatory vasculitis characterized by recurrent oral aphthae and genital ulcers. In the course of the disease, skin, eye, musculoskeletal, nervous system and gastrointestinal system involvements can be detected.ObjectivesTo evaluate the clinical, laboratory and radiological findings of pediatric cases diagnosed with BD.MethodsFifty patients (0-20 years old) who were followed up with the diagnosis of BD at the Pediatric Rheumatology outpatient clinic of Uludag University Faculty of Medicine between January 2011 and July 2021 were included in our study. The patients were diagnosed according to the diagnostic criteria of the International BD Study Group.ResultsTwenty-four (48%) of the patients were male and 26 (52%) were female. The mean age at the diagnosis of patients was 9 ±4.55 years (10.75±4.55 years in boys, 12.35±3.65 years in girls). Twenty patients (36.3%) had a family history of Behçet’s Disease. Oral aphthae were present in 96% (n=48) patients, while genital ulcers were in 32% (n=16) (Table 1). Of the nine patients with uveitis, 6 had panuveitis, 2 had anterior uveitis and 1 had posterior uveitis. . There was no difference in the distribution of symptoms according to the gender of the patients. HLA-B51 allel was found in 39 (78%) and ANA was positive in 14 patients (28%). Immunological tests showed that serum immunoglobulins were low in 11 (32.3%) of 34 patients.Low IgG levels were detected in 6 patients, low IgM levels were in 3, and low IgA levels were in 2. Thrombus was presented in three cases (thrombus in the right ventricle in one case, in the intracranial transverse sigmoid sinus and left jugular vein in two cases). The most commonly used drug for aphthae was colchicine (n=45, 82%). The use of biological agents according to patient manifestations is shown in Table 2. In the follow-up, clinical findings improved in 35 patients (70%)Complete improvement was detected only with biological agents in 8 patients with uveitis. One patient was operated due to the development of complicated cataracts secondary to uveitis. Three patients were diagnosed with Covid-19, one of them was followed without treatment, while two of them were treated with favipiravir at home. Three patients with Covid-19 infection were using only colchicine treatment.Table 1.Findings at the time of diagnosisn%Uveitis918Skin findings1836Gastrointestinal tract involvement1938Central nervous system involvement612Vascular involvement36Arthritis1734Table 2.Findings Biological AgentsUveitis (n)Arthritis (n)Venous thrombus (n)Central nervous system involvement (n)Azathioprine2231Methotrexate22--Adalimumab31--Infliximab31--ConclusionBehçet’s disease is rare in childhood. Although it is not common, life-threatening complications can be observed. To reduce morbidity and complications, physicians should be aware of manifestations and rare clinical pictures of the BD.References[1]Hu YC, Chiang BL, Yang YH. Clinical Manifestations and Management of Pediatric Behçet’s Disease. Clin Rev Allergy Immunol. 2021 Oct;61(2):171-180.[2]Costagliola G, Cappelli S, Consolini R. Behçet’s Disease in Children: Diagnostic and Management Challenges. Ther Clin Risk Manag. 2020 Jun 11;16:495-507.[3]Balt J, Jamyanjav B, Jav S, Dandii Z, Ganbold C, Horie Y, Lennikov A, Uehara O, Ohno S, Kitaichi N. Clinical features of Behcet’s disease in Mongolia: a multicenter study. Clin Rheumatol. 2020 Sep;39(9):2697-2706.[4]Muruganandam M, Rolle NA, Sibbitt WL Jr, Cook GB, Emil NS, Fangtham M, Reiter KJ, Bankhurst AD. Characteristics of Behcet’s Disease in the American Southwest. Semin Arthritis Rheum. 2019 Oct;49(2):296-302.Disclosure of InterestsNone declared
Published: 2022
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40. Differentiating PFAPA Syndrome From Monogenic Periodic Fevers

Author: Roberta Caorsi, Joost Frenkel, Rita Consolini, Alberto Martini, Alberto Tommasini, Maria Pia Sormani, Francesco Zulian, Marco Gattorno, Maurizia Baldi, Gabriele Simonini, Elisabetta Cortis, MA Pelagatti, Marco Cattalini, Alessandro Plebani, G Calcagno, Silvia Federici, Isabella Ceccherini, Antonella Meini, Gattorno, M., Caorsi, R., Meini, A., Cattalini, M., Federici, S., Zulian, F., Cortis, E., Calcagno, G., Tommasini, A., Consolini, R., Simonini, G., Pelagatti, M. A., Baldi, M., Ceccherini, I., Plebani, A., Frenkel, J., Sormani, M. P., and Martini, A.
Subjects: Male, Abdominal pain, Familial Mediterranean fever, Receptors, Tumor Necrosis Factor, Cohort Studies, Diagnosis, Receptors, differential diagnosis, Child, Preschool, Cohort Studies, Diagnosi, Mevalonate kinase deficiency, medicine.diagnostic_test, PFAPA, Pharyngitis, Aphthous, Syndrome, MEFV, Child, Child, Familial Mediterranean Fever, Phosphotransferases (Alcohol Group Acceptor), Child, Preschool, Female, Stomatitis, Aphthous, medicine.symptom, Tumor Necrosis Factor, Stomatiti, medicine.medical_specialty, PFAPA syndrome, Aphthous, Syndrome, Fever of Unknown Origin, Diagnosis, Differential, Lymphadenitis, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Preschool, Genetic testing, Preschool, Cohort Studies, Diagnosis, Differential, Familial Mediterranean Fever, Female, Fever of Unknown Origin, Gene Expression Regulation, Genetic Predisposition to Disease, Humans, Lymphadenitis, Male, Mutation, Pharyngitis, Phosphotransferases (Alcohol Group Acceptor), Receptors, Tumor Necrosis Factor, Stomatitis, Stomatitis, business.industry, medicine.disease, Differential, Familial Mediterranean Fever, Female, Fever of Unknown Origin, Gene Expression Regulation, Genetic Predisposition to Disease, Humans, Lymphadenitis, Male, Mutation, Pharyngitis, Phosphotransferases (Alcohol Group Acceptor), Receptor, Gene Expression Regulation, Differential, Mutation, Pediatrics, Perinatology and Child Health, Immunology, Periodic fever, aphthous stomatitis, pharyngitis and adenitis, Tumor Necrosis Factor, business
Abstract: OBJECTIVES: To analyze whether there were clinical differences between genetically positive and negative patients fulfilling periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome criteria and to test the accuracy of the Gaslini diagnostic score for identifying patients with PFAPA syndrome with higher probabilities of carrying relevant mutations in genes associated with periodic fevers. METHODS: Complete clinical and genetic information was available for 393 children with periodic fever; 82 had positive genetic test results, 75 had incomplete genetic test results, and 236 had negative results for MVK, TNFRSF1A, and MEFV mutations. Current diagnostic criteria for PFAPA syndrome were applied. RESULTS: Of 393 children, 210 satisfied PFAPA syndrome criteria; 43 carried diagnostic mutations (mevalonate kinase deficiency: n = 33; tumor necrosis factor receptor-associated periodic syndrome: n = 3; familial Mediterranean fever: n = 7), 37 displayed low-penetrance mutations or incomplete genotypes, and 130 demonstrated negative genetic testing results. Genetically positive patients had higher frequencies of abdominal pain and diarrhea (P < .001), vomiting (P = .006), and cutaneous rash and arthralgia (P = .01). Genetically negative patients had a higher frequency of exudative pharyngitis (P = .010). Genetically undetermined patients showed the same pattern of symptom frequency as genetically negative patients. The Gaslini diagnostic score was able to identify 91% of genetically positive patients correctly, with a global accuracy of 66%. CONCLUSION: The Gaslini diagnostic score represents a useful tool to identify patients meeting PFAPA syndrome criteria and at low risk of carrying relevant mutations in genes associated with periodic fevers.
Published: 2009
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41. Unusual onset of a case of chronic recurrent multifocal osteomyelitis

Author: M. C Caparello, Sergio Crovella, Sonia Vitali, A Paolicchi, Rita Consolini, M Barrani, Eugenio Ciancia, Francesco Massei, Mariagrazia Stefania Scaglione, Barrani, M, Massei, F, Scaglione, MARIAGRAZIA STEFANIA, Paolicchi, A, Vitali, Sonia, Ciancia, E. M, Crovella, Sergio, Caparello, M. C, and Consolini, R.
Subjects: medicine.medical_specialty, Acute painful headache, Chronic recurrent multifocal osteomyelitis, CRMO, Rheumatology, Immunology and Allergy, Pediatrics, Perinatology and Child Health, Case Report, Pediatrics, Diagnosis, Differential, Biopsy, Dyschromia, Orbital Diseases, Medicine, Humans, Pediatrics, Perinatology, and Child Health, Child, medicine.diagnostic_test, business.industry, Osteomyelitis, Headache, Magnetic resonance imaging, Perinatology and Child Health, medicine.disease, Clavicle, Magnetic Resonance Imaging, Surgery, Skull, medicine.anatomical_structure, Chronic recurrent multifocal osteomyelitis, CRMO, Acute painful headache, Female, Radiology, Differential diagnosis, business, Tomography, X-Ray Computed
Abstract: Background: Chronic recurrent multifocal osteomyelitis (CRMO) is a rare condition that commonly affects the clavicle and pelvis. Case presentation: We report here a case a 12 years old girl with CRMO arising with recurrent episodes of left supraorbital headache, followed by the appearance of a periorbital dyschromia. Magnetic resonance imaging (MRI) of the skull and orbits revealed an important subacute inflammatory process. Few months after, the child presented a painful swelling of the left clavicle; the histological examination of the related biopsy allowed to establish the diagnosis of CRMO. Conclusion: CRMO presenting as acute headache involving neurocranium is rare; to our knowledge this is the first recognized case in the world literature. This pathological condition is frequently misdiagnosed as infection or neoplasm and needs a deep investigation for the differential diagnosis. The physical, laboratoristic and instrumental diagnostic investigations of the patient and the treatment employed are described in detail.
Published: 2015

42. Effect of laser micromachining of titanium on viability and responsiveness of osteoblast-like cells

Author: Serena Barachini, Mario Gabriele, Rita Consolini, Filippo Graziani, Silvia Cei, Gilberto Sammartino, Annalisa Legitimo, Letizia Mattii, Cei, S, Legitimo, A, Barachini, S, Consolini, R, Mattii, L, Gabriele, M, Graziani, F, Sammartino, Gilberto, and Graziani, F.
Subjects: Adult, Materials science, Adolescent, Cell Survival, Surface Properties, chemistry.chemical_element, Tetrazolium Salts, Lasers, Solid-State, Culture Media, Serum-Free, law.invention, Young Adult, law, medicine, Cell Adhesion, Humans, Dental Etching, Pseudopodia, Cell shape, Cell Shape, Laser micromachining, Cell survival, Cells, Cultured, Cell Proliferation, Platelet-Derived Growth Factor, Titanium, Osteoblasts, technology, industry, and agriculture, Osteoblast, respiratory system, equipment and supplies, Laser, medicine.anatomical_structure, chemistry, Culture Media, Conditioned, Oral Surgery, Porosity, Biomedical engineering
Abstract: Laser engineering may create hemispherical porosities on titanium surfaces obtaining regular and predetermined rough titanium surfaces. The aim of this study was to assess the viability and the proliferation of primary osteoblast-like cells (OB) to growth factors on titanium surfaces with a different roughness in vitro.OB were obtained from volunteers undergoing wisdom tooth removal following a standardized protocol. OB were allowed to attach on 4 different titanium surfaces: sandblasted titanium (SBT) disks, 5-, 10-, and 20-μm regular laser-engineered micropore titanium disks. A well with no disk was used as control. Cell morphology was evaluated with scanning electron microscopy. Viability was measured with MTT (3[4,5 dimethylthiazol 2yl]2,5 diphenyltetrazolium bromide) assay. Proliferation rate of attached cells was evaluated with Cell Counting Kit-8 48 hours after platelet-released supernatant (PRS) application. Statistical analysiswas performed with analysis of variance test.All surfaces showed OB attachment on scanning electron microscopy. OB appeared more numerous on 20T surfaces. Laser-engineered surfaces showed higher OB viability than SBT (P0.01). In terms of proliferation, viability increase was noted for all groups after platelet-released supernatant application. 20T and SBT disks seemed to trigger the higher cellular proliferation (20T vs 10T, P0.05).Laser-engineered porous titanium surfaces promote viability and proliferation of OB. In particular, hemispherical porosity of 20 μm seems to trigger the higher OB response. Further research is needed to confirm these data.
Published: 2011

43. Long-term nonprogressors among children with perinatal HIV-1 infection

Author: P. A. Tovo, M. de Martino, C. Gabiano, L. Galli, G. Ferraris, P. Marchisio, C. Giaquinto, S. Tulisso, G. V. Zuccotti, A. Loy, A. Vierucci, G. Castelli Gattinara, D. Caselli, A. Plebani, C. fundarò, P. Dallacasa, M. Belloni, P. L. Mazzoni, C. Timpano, M. Ruggeri, R. Consolini, G. L. Forni, G. Benaglia, M. G. Marazzi, M. Cellini, A. Mazza, C. Pignata, V. Portelli, D. De Mattia, A. Corrias, C. Gotta, T. Bezzi, G. Caramia, A. Antonellini, E. Anastasio, G. gambaretto, C. Salvatore, L. Battisti, M. Sticca, M. Masi, P. Ibba, S. Bionda, U. De Sarntis, F. Baldi, C. Magnani, A. Pellegatta, R. Berrino, C. Dessì, L. Tasso, L. A. Magni, L. Tarallo, C. Ajassa, U. Tondo, P. G. Chiriacò, I. Contardi, A. Meo, F. Di Gregorio, P. Paolucci, L. Esposito, E. Boeri, D. Tommasi, GUARINO, ALFREDO, Tovo, P. A., de Martino, M., Gabiano, C., Galli, L., Ferraris, G., Marchisio, P., Giaquinto, C., Tulisso, S., Zuccotti, G. V., Loy, A., Vierucci, A., Castelli Gattinara, G., Caselli, D., Plebani, A., Fundarò, C., Dallacasa, P., Belloni, M., Mazzoni, P. L., Timpano, C., Ruggeri, M., Consolini, R., Forni, G. L., Benaglia, G., Marazzi, M. G., Cellini, M., Mazza, A., Pignata, C., Portelli, V., De Mattia, D., Corrias, A., Guarino, Alfredo, Gotta, C., Bezzi, T., Caramia, G., Antonellini, A., Anastasio, E., Gambaretto, G., Salvatore, C., Battisti, L., Sticca, M., Masi, M., Ibba, P., Bionda, S., De Sarntis, U., Baldi, F., Magnani, C., Pellegatta, A., Berrino, R., Dessì, C., Tasso, L., Magni, L. A., Tarallo, L., Ajassa, C., Tondo, U., Chiriacò, P. G., Contardi, I., Meo, A., Di Gregorio, F., Paolucci, P., Esposito, L., Boeri, E., and Tommasi, D.
Published: 1997

44. A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: Results from the Italian Primary Immunodeficiency Network

Author: Fabio Cardinale, M. Marconi, A Soresina, Marco Zecca, Viviana Moschese, Plinio Rossi, P Bertolini, M.A. Avanzini, Rita Carsetti, Isabella Quinti, Rita Consolini, S Di Cesare, Simona Graziani, Maria Cristina Pietrogrande, A Trizzino, Claudio Pignata, Gian Luigi Marseglia, Alessandro Plebani, M La Rocca, Roberto Rondelli, Loredana Chini, Grazia Bossi, Silvana Martino, Moschese, V., Graziani, S., Avanzini, M. A., Carsetti, R., Marconi, M., LA ROCCA, M., Chini, L., Pignata, Claudio, Soresina, A. R., Consolini, R., Bossi, G., Trizzino, A., Martino, S., Cardinale, F., Bertolini, P., Marseglia, G. L., Zecca, M., DI CESARE, S., Quinti, I., Rondelli, R., Pietrogrande, M. C., Rossi, P., and Plebani, A.
Subjects: Male, Aging, Pediatrics, medicine.medical_specialty, Allergy, Immunology, Immunoglobulins, primary immunodeficiency, transient hypogammaglobulinemia of infancy, Memory B cell subsets, in vitro immunoglobulin production, Hypogammaglobulinemia, Agammaglobulinemia, medicine, Humans, Immunology and Allergy, Prospective Studies, Transient hypogammaglobulinemia of infancy, Prospective cohort study, Memory B cell, Pharmacology, Autoimmune disease, Settore MED/38 - Pediatria Generale e Specialistica, B-Lymphocytes, biology, business.industry, Immunologic Deficiency Syndromes, Infant, medicine.disease, Immunoglobulin A, Treatment Outcome, Immunoglobulin M, Italy, Child, Preschool, Immunoglobulin G, Disease Progression, Primary immunodeficiency, biology.protein, Female, memory b cell subsets, Antibody, business, Immunologic Memory
Abstract: Transient hypogammaglobulinemia of infancy (THI) is a heterogeneous disorder characterized by reduced serum IgG levels in early infancy. A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinemia while a definitive diagnosis of THI can only be made a posteriori in patients with normalization of IgG levels. The aim of this study is to characterize clinical and immunological features of children with an initial diagnosis of THI in correlation to natural outcome, and to assess predictive laboratory parameters of clinical evolution for this disorder. We prospectively analysed clinical and immunological characteristics of 77 THI children at initial diagnosis and of 57 patients at follow-up. Memory B cell subsets and in vitro immunoglobulin production were evaluated. Seventy patients (91 percent) showed clinical symptoms. Patients suffered from infections (91 percent), allergies (47 percent) and autoimmune disease (4 percent). During follow-up 41/57 children (72 percent) normalized IgG values, mostly within 24 months of age (p less than 0.001), allowing the diagnosis of THI. The 16 children who did not normalize their IgG levels showed a higher frequency of severe infections and autoimmune disease (p less than 0.01). Moreover, they expressed a reduced frequency of IgM and switched memory B cells (p less than 0.01) and an inability to produce IgG in vitro (p less than 0.02). We conclude that most patients with an initial diagnosis of THI spontaneously recover within 24 months of age and have a benign clinical course, while a subgroup of children with undefined hypogammaglobulinemia share a clinical and immunological profile with other primary immunodeficiencies. Early recognition of children with hypogammaglobulinemia during infancy who are likely to suffer from permanent immunodeficiencies later in life would allow prompt and appropriate laboratory and clinical interventions.

45. Serum amyloid protein A concentration in cryopyrin-associated periodic syndrome patients treated with interleukin-1 beta antagonist

Author: Pastore, S, Paloni, G, Caorsi, R, Ronfani, L, Taddio, A, Lepore, L, CAPS Italian Register, Alessio, M, Cantarini, L, Cattalini, M, Consolini, Rita, Gattorno, R, Gerloni, V, Insalaco, A, Martini, G, Martini, S, Obici, L, Rigante, D., Pastore, Serena, Paloni, Giulia, Caorsi, Roberta, Ronfani, Luca, Taddio, Andrea, Lepore, Loredana, Pastore, S., Paloni, G., Caorsi, R., Ronfani, L., Taddio, A., Lepore, L., Alessio, M., Cantarini, L., Cattalini, M., Consolini, R., Gattorno, M., Gerloni, V., Insalaco, A., Martini, G., Martino, S., Obici, L., and Rigante, D.
Subjects: Adult, Male, Cryopyrin-associated periodic syndrome, Adolescent, Interleukin-1beta, IL-1β inhibitor, Immunosuppressive Agent, Young Adult, Amyloidosi, Humans, Child, Preschool, Inflammation, Serum Amyloid A Protein, Child, Preschool, Drug Monitoring, Female, Immunosuppressive Agents, Middle Aged, Treatment Outcome, Amyloidosis, Cryopyrin-Associated Periodic Syndromes, IL-1 beta inhibitor, Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA, Serum amyloid protein A, serum amyloid protein A, cryopyrin-associated periodic syndromes, amyloidosis, inflammation, Human
Abstract: Objective: Cryopyrin-associated periodic syndromes (CAPS) are a group of chronic, relapsing autoinflammatory disorders which may be complicated by systemic AA amyloidosis. The aim of our study was to evaluate serum amyloid protein A (SAA) level in CAPS patients treated with Interleukin-1 beta (IL-1β) antagonist and to correlate its level with treatment response. Methods: All patients of CAPS Italian Register treated with IL-1β inhibitor were enrolled. SAA levels before starting therapy, and at last visit were evaluated. Patients were then divided in complete responders and partial responders. Results: Twenty-five patients were enrolled. SAA level before starting therapy was increased (median 118.5 mg/L, IQR 96.4-252.8; normal value < 6.4 mg/L), while at last visit SAA was significantly reduced (median 4.3 mg/L, IQR 2.3-12.7) (p < 0.001). However 12 patients still presented SAA levels beyond normal range, 10/25 patients (40%) showed a complete response to treatment. Conversely, 15 patients presented only a partial response, of which 12 for increased SAA value and 3 for increased CRP value. Patients with partial response had SAA values significantly higher than patients with complete response (median 12.6 mg/L; IQR 8.3-20.0 vs. 2.7 mg/L; IQR 1.6-4.1, p < 0.001). Conclusion: Our results confirm the long term efficacy of anti IL-1β treatment in CAPS and the decrease of SAA levels; however 48% of patients still presented SAA elevation despite treatment. The real risk of these patients in developing amyloidosis is not clear but the persistent increase of SAA needs a close follow-up.

46. La rifondazione degli studi teatrali in Italia dagli anni Sessanta al 1985

Author: Roberta Ferraresi and Roberta Ferraresi
Subjects: Theater--History--20th century.--Italy, Dramatic criticism--History--20th century.--
Abstract: La storia dello spettacolo in Italia è una materia piuttosto nuova, che si forma accademicamente nella temperie politica, culturale e artistica che si snoda fra gli anni Sessanta e gli Ottanta. Ma la sua vicenda è molto più lunga e complessa. Anzitutto, perché poggia su di una tensione storiografica preesistente: per questo, più che di “nascita”, nel nostro Paese si parla di rifondazione degli studi di teatro. E poi in quanto alcune delle domande alla base del nuovo paradigma scientifico – a partire dalla definizione stessa dell'oggetto d'indagine – continuano a riverberare anche in seguito. Incastonato com'è fra passato e futuro, il processo di istituzione della disciplina non rappresenta esclusivamente uno snodo-chiave nella nostra cultura teatrale novecentesca. È anche una tappa, certo dirompente, di una storia di più lunga durata, da un lato in larga misura già in atto rispetto al momento che si è soliti considerare il suo innesco e dall'altro lato per certi versi tuttora ben viva e attiva. Questo libro ha il proposito di ricostruire i primi passi di tale progetto, alla ricerca tanto delle ragioni che a un certo punto, intorno alla metà del XX secolo, hanno spinto una serie di giovani ricercatori a perimetrare il nuovo campo di studio; quanto degli esiti di quei percorsi, che hanno portato a immaginare – e poi a concretizzare – un altro, nuovo modo di pensare e studiare il teatro all'interno dell'università, che a tutt'oggi pone questioni ancora estremamente attuali.
Published: 2019

47. Il laboratorio di Lucio Ridenti Cultura teatrale e mondo dell’arte in Italia attraverso «Il Dramma» (1925-1973)

Author: Petrini Armando,Mazzocchi Federica, and Petrini Armando,Mazzocchi Federica,
Subjects: Dramma (Turin, Italy)--Congresses, Theater--Periodicals--History--20th century, Italian periodicals--History--20th century--, Theater--History--20th century--Italy--Con
Abstract: Bollato spesso dalla nuova critica teatrale come passatista e nostalgico, «Il Dramma» (periodico fondato nel 1925 da Pitigrilli insieme a Lucio Ridenti, che ne fu il vero animatore e il direttore fino al 1973) e il suo archivio, prodotto in decenni di lavoro redazionale “sul campo”, costituiscono oggi una vera e propria riscoperta storica, offrendosi come uno strumento imprescindibile per chiunque voglia penetrare la cultura teatrale del nostro Paese. Esso risente fortemente della poliedrica personalità di Ridenti, già attore, fotografo, consigliere d'eleganza (e dandy egli stesso), giornalista, editorialista, intenditore d'arte.Il convegno di studi “Il laboratorio di Lucio Ridenti. Cultura teatrale e mondo dell'arte in Italia attraverso «Il Dramma» (1925-1973)”, di cui vengono pubblicati in questo volume gli Atti, rappresenta la prima iniziativa di esplorazione sistematica e organica del Fondo Lucio Ridenti, avvalendosi di competenze e sguardi incrociati, nel solco di quel laboratorio di sapere, mestiere e passione che è stato appunto «Il Dramma».
Published: 2017

48. Molecular Diagnostics: Current Research and Applications

Author: Jim Huggett, Justin O'Grady, Jim Huggett, and Justin O'Grady
Subjects: Molecular diagnosis, Cancer--Molecular diagnosis, Communicable diseases--Molecular diagnosis
Abstract: The application of molecular technology in clinical diagnosis is a rapidly developing area and is predicted to greatly improve the speed, efficiency and accuracy of diagnostic medicine.The editors of this book have commissioned an excellent series of chapters representing two key molecular diagnostic areas: cancer and infectious diseases. The cancer section deals with the challenges in identifying genetic, epigenetic and transcriptomic biomarkers. The infectious disease section describes the current clinical applications of molecular diagnostics for the detection of viral, bacterial and fungal pathogens as well as an example of the use of molecular diagnostics outside the clinic environment. A cautionary tale describing what can go wrong when molecular methods are applied incorrectly is also provided and makes fascinating reading. A substantial component of the book is dedicated to the process of translating a preclinical test to the bedside and describes the progress in the near patient point-of-care molecular diagnostics market. This is a fundamental consideration for successful translation of diagnostics tests from bench to bedside and is crucial for molecular diagnostics to have an impact on patient care. The final chapter offers a prediction of future trends in the molecular diagnostics of infectious diseases.This volume is essential reading for anyone involved in the development or application of molecular diagnostics and is recommended for all clinical diagnostics laboratories.
Published: 2014

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