1. Co-infection of intestinal tuberculosis and mucormycosis in a patient with Down syndrome: a unique case report with literature review
- Author
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Bhawana Ashok Badhe, Souradeep Dutta, Ketavath Thirupathaiah, Bishal Pal, Ankit Jain, Abhinaya Reddy, and Vishnu Prasad Nelamangala Ramakrishnaiah
- Subjects
Down syndrome ,medicine.medical_specialty ,Tuberculosis ,business.industry ,Opportunistic infection ,Coinfection ,Mucormycosis ,General Medicine ,medicine.disease ,medicine.disease_cause ,INTESTINAL TUBERCULOSIS ,Dermatology ,Organ transplantation ,Autoimmunity ,Immune system ,Tuberculosis, Gastrointestinal ,medicine ,Diabetes Mellitus ,Humans ,Down Syndrome ,business - Abstract
Mucormycosis represents several unusual opportunistic infection caused by saprophytic aseptate fungi. There is a recent rise in cases of mucormycosis due to an increase in diabetic and immunodeficient patients like patients on long-term steroids, immunomodulators due to organ transplantation, malignancies, mainly haematological malignancies, and autoimmunity. Anatomically, mucormycosis can be localised most commonly as rhino-orbito-cerebral followed by pulmonary, disseminated, cutaneous and gastrointestinal, rarest being small intestinal. Patients with Down syndrome are immunodeficient due to their impaired immune response. Disseminated tuberculosis is also common in immunodeficient patients. We report a rare case of small intestinal mucormycosis in a patient with Down syndrome with coexisting intestinal tuberculosis. Due to the invasiveness of mucormycosis, the patient succumbed to death despite providing aggressive surgical debridement and medical management.
- Published
- 2023