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2. Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study
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Reyes, Luis Felipe, Murthy, Srinivas, Garcia-Gallo, Esteban, Merson, Laura, Ibáñez-Prada, Elsa, Rello, Jordi, Fuentes, Yuli, Martin-Loeches, Ignacio, Bozza, Fernando, Duque, Sara, Taccone, Fabio, Fowler, Robert, Kartsonaki, Christiana, Gonçalves, Bronner, Citarella, Barbara Wanjiru, Aryal, Diptesh, Burhan, Erlina, Cummings, Matthew, Delmas, Christelle, Diaz, Rodrigo, Figueiredo-Mello, Claudia, Hashmi, Madiha, Panda, Prasan Kumar, Jiménez, Miguel Pedrera, Rincon, Diego Fernando Bautista, Thomson, David, Nichol, Alistair, Marshall, John, Olliaro, Piero, Abbas, Ali, Abdukahil, Sheryl Ann, Abe, Ryuzo, Abel, Laurent, Absil, Lara, Acharya, Subhash, Acker, Andrew, Adrião, Diana, Al Ageel, Saleh, Ahmed, Shakeel, Ainscough, Kate, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Al Qasim, Eman, Alalqam, Razi, Al-Dabbous, Tala, Alegesan, Senthilkumar, Alegre, Cynthia, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alfoudri, Huda, Ali, Imran, Shah, Naseem Ali, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qabas, Allavena, Clotilde, Allou, Nathalie, Altaf, Aneela, Alves, João, Alves, João Melo, Alves, Rita, Cabrita, Joana Alves, Amaral, Maria, Ampaw, Phoebe, Andini, Roberto, Andréjak, Claire, Angheben, Andrea, Angoulvant, François, Ansart, Séverine, Antonelli, Massimo, de Brito, Carlos Alexandre Antunes, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Lukas, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Asensio, Angel, Asif, Namra, Asim, Mohammad, Assie, Jean Baptiste, Atique, Anika, Attanyake, A., Auchabie, Johann, Aumaitre, Hugues, Auvet, Adrien, Azemar, Laurène, Azoulay, Cecile, Bach, Benjamin, Bachelet, Delphine, Badr, Claudine, Baig, Nadia, Baillie, J. 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Prebensen, Christian, Preiser, Jean-Charles, Prinssen, Anton, Pritchard, Mark, Priyadarshani, Gamage Dona Dilanthi, Proença, Lucia, Pudota, Sravya, Puéchal, Oriane, Semedi, Bambang Pujo, Pulicken, Mathew, Purcell, Gregory, Quesada, Luisa, Quinones-Cardona, Vilmaris, González, Víctor Quirós, Quist-Paulsen, Else, Quraishi, Mohammed, Rabaud, Christian, Rabindrarajan, Ebenezer, Rafael, Aldo, Rafiq, Marie, Rahutullah, Arsalan, Rainieri, Fernando, Ramachandran, Pratheema, Ramakrishnan, Nagarajan, Ramalho, José, Rammaert, Blandine, Ramos, Grazielle Viana, Rana, Asim, Rangappa, Rajavardhan, Ranjan, Ritika, Rapp, Christophe, Rashan, Aasiyah, Rashan, Thalha, Rasheed, Ghulam, Rasmin, Menaldi, Rätsep, Indrek, Rau, Cornelius, Raza, Ali, Real, Andre, Rebaudet, Stanislas, Redl, Sarah, Reeve, Brenda, Rehman, Attaur, Reid, Liadain, Reikvam, Dag Henrik, Reis, Renato, Remppis, Jonathan, Remy, Martine, Ren, Hongru, Renk, Hanna, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Tiago, Ribeiro, Maria Ines, Richardson, David, Richardson, Denise, Richier, Laurent, Riera, Jordi, Rios, Ana, Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rizer, Nicholas, Robba, Chiara, Roberto, André, Roberts, Stephanie, Robertson, David, Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Abreu, Julia Rodriguez, Roessler, Bernhard, Roger, Pierre-Marie, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque, Roberto, Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossetti, Matteo, Rossignol, Bénédicte, Rossignol, Patrick, Rousset, Stella, Roy, Carine, Roze, Benoît, Rusmawatiningtyas, Desy, Russell, Clark, Ryan, Maeve, Ryan, Maria, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sadaf, Sairah, Sadat, Musharaf, Sahraei, Valla, Saidani, Nadia, Saint-Gilles, Maximilien, Sakiyalak, Pranya, Salahuddin, Nawal, Salazar, Leonardo, Saleem, Jodat, Sales, Gabriele, Sallaberry, Stéphane, Gandonniere, Charlotte Salmon, Salvator, Hélène, Sanchez, Olivier, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-François, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Banheiro, Bruno Sarmento, Sarton, Benjamine, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scott, Janet, Scott-Brown, James, Sedillot, Nicholas, Seitz, Tamara, Selvanayagam, Jaganathan, Semaille, Caroline, Semple, Malcolm, Senneville, Eric, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shamsah, Mohammad, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine, Shaw, Victoria, Sheharyar, Ashraf, Shetty, Rajesh Mohan, Shi, Haixia, Shiekh, Mohiuddin, Shimizu, Keiki, Shrapnel, Sally, Shrestha, Shubha Kalyan, Shrestha, Pramesh Sundar, Shum, Hoi Ping, Mohammed, Nassima Si, Sibiude, Jeanne, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Maria Joao, Silva, Rogério, Sin, Wai Ching, Singh, Budha Charan, Singh, Punam, Sitompul, Pompini Agustina, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnès, Song, Myung Jin, Song, Rima, Song, Tae, Chia, Jack Song, Sotto, Albert, Soum, Edouard, Sousa, Ana Chora, Sousa, Marta, Uva, Maria Sousa, Sperry, Alexandra, Spinuzza, Elisabetta, Darshana, B., Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thomas, Stecher, Stephanie-Susanne, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, Ami, Stuart, David, Suen, Gabriel, Suen, Jacky, Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Surovcová, Magdalena, Svistunov, Andrey, Syrigos, Konstantinos, Sztajnbok, Jaques, Szuldrzynski, Konstanty, Tabrizi, Shirin, Tagherset, Lysa, Taleb, Sara, Talsma, Jelmer, Tampubolon, Maria Lawrensia, Tanaka, Hiroyuki, Taqdees, Huda, Taqi, Arshad, Tardivon, Coralie, Tattevin, Pierre, Taufik, M. Azhari, Tawfik, Hassan, Tedder, Richard, Teixeira, João, Tejada, Sofia, Tellier, Marie-Capucine, Téoulé, François, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicolas, Tessier-Grenier, Hubert, Tey, Adrian, Thakur, Anand, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thompson, Shaun, Thomson, Emma, Thwaites, Ryan, Tierney, Paul, Tieroshyn, Vadim, Timashev, Peter, Timsit, Jean-François, Tissot, Noémie, Toki, Maria, Tonby, Kristian, Torre, Marta, Torres, Antoni, Torres, Margarida, Torres-Zevallos, Hernando, Towers, Michael, Trapani, Tony, Treoux, Théo, Tromeur, Cécile, Trontzas, Ioannis, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turmel, Jean-Marie, Turtle, Lance, Twardowski, Pawel, Uchiyama, Makoto, Udayanga, P., Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Uyeki, Timothy, Vajdovics, Cristinava, Val-Flores, Luís, Valran, Amélie, van de Velde, Stijn, van den Berge, Marcel, van der Palen, Job, van der Valk, Paul, van der Vekens, Nicky, van der Voort, Peter, van der Werf, Sylvie, van Gulik, Laura, van Hattem, Jarne, van Netten, Carolien, van Veen, Ilonka, Vanel, Noémie, Vanoverschelde, Henk, Varghese, Pooja, Vauchy, Charline, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelies, Vickers, James, Vidal, José Ernesto, Vieira, César, Vijayan, Deepak, Villanueva, Joy Ann, Villar, Judit, Villeneuve, Pierre-Marc, Villoldo, Andrea, Visseaux, Benoit, Visser, Hannah, Vitiello, Chiara, Vonkeman, Harald, Vuotto, Fanny, Shukeri, Wan Fadzlina Wan Muhd, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Weil, Katharina, Wesselius, Sanne, West, T. Eoin, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Suzette, Williams, Virginie, Wils, Evert-Jan, Yiu, Ng Wing, Wong, Calvin, Xynogalas, Ioannis, Yamazaki, Masaki, Yazdanpanah, Yazdan, Yelnik, Cécile, Yerkovich, Stephanie, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Yuliarto, Saptadi, Zaaqoq, Akram, Zabbe, Marion, Zahran, Maram, Zambon, Maria, Zanella, Alberto, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, University of Oxford, University of La Sabana = Universitad de la Sabana, ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Institut Pasteur [Paris] (IP), Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work was supported by the UK Foreign, Commonwealth, and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135], CIHR Coronavirus Rapid Research Funding Opportunity OV2170359, Grants from Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 Project 101003589] and European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313], The Imperial NIHR Biomedical Research Centre, The Cambridge NIHR Biomedical Research Centre, and Endorsed by the Irish Critical Care-Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]. This work uses Data/Materials provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision were supported by grants from: the National Institute for Health Research (NIHR, award CO-CIN-01), the Medical Research Council (MRC, Grant MC_PC_19059), and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), (Award 200907), Wellcome Trust [Turtle, Lance-fellowship 205228/Z/16/Z], NIHR HPRU in Respiratory Infections at Imperial College London with PHE (Award 200927), Liverpool Experimental Cancer Medicine Centre (Grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (Award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was possible due to the dedication and hard work of the Norwegian SARS-CoV-2 study team and supported by grants from Research Council of Norway Grant No. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner, The dedication and hard work of the Groote Schuur Hospital Covid ICU Team, and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town, and supported by the COVID clinical management team, AIIMS, Rishikesh, India., European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), Reyes, Luis Felipe, Murthy, Sriniva, Garcia-Gallo, Esteban, Merson, Laura, Ibáñez-Prada, Elsa D., Rello, Jordi, Fuentes, Yuli V., Martin-Loeches, Ignacio, Bozza, Fernando, Duque, Sara, Taccone, Fabio S., Fowler, Robert A., Kartsonaki, Christiana, Gonçalves, Bronner P., Citarella, Barbara Wanjiru, Aryal, Diptesh, Burhan, Erlina, Cummings, Matthew J., Delmas, Christelle, Diaz, Rodrigo, Figueiredo-Mello, Claudia, Hashmi, Madiha, Panda, Prasan Kumar, Jiménez, Miguel Pedrera, Rincon, Diego Fernando Bautista, Thomson, David, Nichol, Alistair, Marshall, John C., Olliaro, Piero L., Abbas, Ali, Abdukahil, Sheryl Ann, Abe, Ryuzo, Abel, Laurent, Absil, Lara, Acharya, Subhash, Acker, Andrew, Adrião, Diana, Al Ageel, Saleh, Ahmed, Shakeel, Ainscough, Kate, Aisa, Tharwat, Hssain, Ali Ait, Tamlihat, Younes Ait, Akimoto, Takako, Akmal, Ernita, Al Qasim, Eman, Alalqam, Razi, Al-dabbous, Tala, Alegesan, Senthilkumar, Alegre, Cynthia, Alessi, Marta, Alex, Beatrice, Alexandre, Kévin, Al-Fares, Abdulrahman, Alfoudri, Huda, Ali, Imran, Shah, Naseem Ali, Alidjnou, Kazali Enagnon, Aliudin, Jeffrey, Alkhafajee, Qaba, Allavena, Clotilde, Allou, Nathalie, Altaf, Aneela, Alves, João, Alves, João Melo, Alves, Rita, Cabrita, Joana Alve, Amaral, Maria, Ampaw, Phoebe, Andini, Roberto, Andréjak, Claire, Angheben, Andrea, Angoulvant, Françoi, Ansart, Séverine, Antonelli, Massimo, de Brito, Carlos Alexandre Antune, Apriyana, Ardiyan, Arabi, Yaseen, Aragao, Irene, Araujo, Carolline, Arcadipane, Antonio, Archambault, Patrick, Arenz, Luka, Arlet, Jean-Benoît, Arnold-Day, Christel, Arora, Lovkesh, Arora, Rakesh, Artaud-Macari, Elise, Asensio, Angel, Asif, Namra, Asim, Mohammad, Assie, Jean Baptiste, Atique, Anika, Attanyake, A. 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Karolina, Kruglova, Oksana, Kumar, Deepali, Kumar, Mukesh, Vijayaraghavan, Bharath Kumar Tirupakuzhi, Vecham, Pavan Kumar, Kuriakose, Dinesh, Kurtzman, Ethan, Kutsogiannis, Demetrio, Kutsyna, Galyna, Kyriakoulis, Konstantino, Lachatre, Marie, Lacoste, Marie, Laffey, John G., Lagrange, Marie, Laine, Fabrice, Lairez, Olivier, Lakhey, Sanjay, Lalueza, Antonio, Lambert, Marc, Lamontagne, Françoi, Langelot-Richard, Marie, Langlois, Vincent, Lantang, Eka Yudha, Lanza, Marina, Laouénan, Cédric, Laribi, Samira, Lariviere, Delphine, Lasry, Stéphane, Latif, Naveed, Launay, Odile, Laureillard, Didier, Lavie-Badie, Yoan, Law, Andrew, Lawrence, Cassie, Lawrence, Teresa, Le, Minh, Le Bihan, Clément, Le Bris, Cyril, Le Falher, George, Le Fevre, Lucie, Le Hingrat, Quentin, Le Maréchal, Marion, Le Mestre, Soizic, Le Moal, Gwenaël, Le Moing, Vincent, Le Nagard, Hervé, Le Turnier, Paul, Leal, Ema, Santos, Marta Leal, Lee, Jame, Lee, Jennifer, Lee, Su Hwan, Lee, Todd C., Leeming, Gary, Lefebvre, 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Hugo, Perrot, Clara Mouton, Moyet, Julien, Mufti, Aisha Kalsoom, Mullaert, Jimmy, Müller, Fredrik, Müller, Karl Erik, Munblit, Daniel, Muneeb, Syed, Munir, Nadeem, Murphy, Aisling, Murphy, Lorna, Murris, Marlène, Musaab, Himed, Muvindi, Himasha, Myrodia, Dimitra Melia, Mohd-Hanafiah, Farah Nadia, Nagpal, Dave, Nagrebetsky, Alex, Narayanan, Nageswaran, Khan, Rashid Nasim, Nazerali-Maitland, Alasdair, Neant, Nadège, Nekliudov, Nikita, Neto, Raul, Neumann, Emily, Ng, Pauline Yeung, Nghi, Anthony, Nguyen, Duc, Choileain, Orna Ni, Leathlobhair, Niamh Ni, Nitayavardhana, Prompak, Nonas, Stephanie, Noret, Marion, Norman, Lisa, Notari, Alessandra, Noursadeghi, Mahdad, Nowinski, Adam, Nseir, Saad, Nunez, Jose I., Nurnaningsih, Nurnaningsih, Nyamankolly, Elsa, Brien, Fionnuala O., Callaghan, Annmarie O., O’Callaghan, Annmarie, Occhipinti, Giovanna, OConnor, Derbrenn, O’Donnell, Max, Ogston, Tawnya, Ogura, Takayuki, O’Halloran, Sophie, O’Hearn, Katie, Oliveira, João, Oliveira, Larissa, Ong, David S. Y., Oosthuyzen, Wilna, Opavsky, Anne, Openshaw, Peter, Orakzai, Saijad, Orozco-Chamorro, Claudia Milena, Ortoleva, Jamel, Osatnik, Javier, O’Shea, Linda, O’Sullivan, Miriam, Ouamara, Nadia, Ouissa, Rachida, Oziol, Eric, Pagadoy, Maïder, Pages, Justine, Palacios, Amanda, Palacios, Mario, Palmarini, Massimo, Panarello, Giovanna, Paneru, Hem, Panigada, Mauro, Pansu, Nathalie, Papadopoulos, Aurélie, Parke, Rachael, Parker, Melissa, Parra, Briseida, Pasha, Taha, Pasquier, Jérémie, Pastene, Bruno, Patauner, Fabian, Patrão, Luí, Patricio, Patricia, Patrier, Juliette, Patterson, Lisa, Pattnaik, Rajyabardhan, Paul, Christelle, Paul, Mical, Paulos, Jorge, Paxton, William A., Payen, Jean-Françoi, Peelman, Florent, Peiffer-Smadja, Nathan, Peigne, Vincent, Pejkovska, Mare, Pelosi, Paolo, Peltan, Ithan D., Pereira, Rui, Perez, Daniel, Periel, Lui, Perpoint, Thoma, Pesenti, Antonio, Pestre, Vincent, Petrou, Lenka, Petrovic, Michele, Petrov-Sanchez, Ventzislava, Pettersen, Frank Olav, Peytavin, Gille, Pharand, Scott, Picard, Walter, Picone, Olivier, Pierobon, Carola, Piersma, Djura, Pimentel, Carlo, Pinto, Raquel, Pires, Catarina, Pironneau, Isabelle, Piroth, Lionel, Pius, Riinu, Plantier, Laurent, Poissy, Julien, Pokeerbux, Ryadh, Poli, Sergio, Pollakis, Georgio, Ponscarme, Diane, Post, Andra-Mari, Postma, Douwe F., Povoa, Pedro, Póvoas, Diana, Powis, Jeff, Prapa, Sofia, Preau, Sébastien, Prebensen, Christian, Preiser, Jean-Charle, Prinssen, Anton, Pritchard, Mark G., Priyadarshani, Gamage Dona Dilanthi, Proença, Lucia, Pudota, Sravya, Puéchal, Oriane, Semedi, Bambang Pujo, Pulicken, Mathew, Purcell, Gregory, Quesada, Luisa, Quinones-Cardona, Vilmari, González, Víctor Quiró, Quist-Paulsen, Else, Quraishi, Mohammed, Rabaud, Christian, Rabindrarajan, Ebenezer, Rafael, Aldo, Rafiq, Marie, Rahutullah, Arsalan, Rainieri, Fernando, Ramachandran, Pratheema, Ramakrishnan, Nagarajan, Ramalho, José, Rammaert, Blandine, Ramos, Grazielle Viana, Rana, Asim, Rangappa, Rajavardhan, Ranjan, Ritika, Rapp, Christophe, Rashan, Aasiyah, Rashan, Thalha, Rasheed, Ghulam, Rasmin, Menaldi, Rätsep, Indrek, Rau, Corneliu, Raza, Ali, Real, Andre, Rebaudet, Stanisla, Redl, Sarah, Reeve, Brenda, Rehman, Attaur, Reid, Liadain, Reikvam, Dag Henrik, Reis, Renato, Remppis, Jonathan, Remy, Martine, Ren, Hongru, Renk, Hanna, Resseguier, Anne-Sophie, Revest, Matthieu, Rewa, Oleksa, Reyes, Tiago, Ribeiro, Maria Ine, Richardson, David, Richardson, Denise, Richier, Laurent, Riera, Jordi, Rios, Ana L., Rishu, Asgar, Rispal, Patrick, Risso, Karine, Rizer, Nichola, Robba, Chiara, Roberto, André, Roberts, Stephanie, Robertson, David L., Robineau, Olivier, Roche-Campo, Ferran, Rodari, Paola, Rodeia, Simão, Abreu, Julia Rodriguez, Roessler, Bernhard, Roger, Pierre-Marie, Rojek, Amanda, Romaru, Juliette, Roncon-Albuquerque, Roberto, Roriz, Mélanie, Rosa-Calatrava, Manuel, Rose, Michael, Rosenberger, Dorothea, Rossanese, Andrea, Rossetti, Matteo, Rossignol, Bénédicte, Rossignol, Patrick, Rousset, Stella, Roy, Carine, Roze, Benoît, Rusmawatiningtyas, Desy, Russell, Clark D., Ryan, Maeve, Ryan, Maria, Ryckaert, Steffi, Holten, Aleksander Rygh, Saba, Isabela, Sadaf, Sairah, Sadat, Musharaf, Sahraei, Valla, Saidani, Nadia, Saint-Gilles, Maximilien, Sakiyalak, Pranya, Salahuddin, Nawal, Salazar, Leonardo, Saleem, Jodat, Sales, Gabriele, Sallaberry, Stéphane, Gandonniere, Charlotte Salmon, Salvator, Hélène, Sanchez, Olivier, Sanchez-Miralles, Angel, Sancho-Shimizu, Vanessa, Sandhu, Gyan, Sandhu, Zulfiqar, Sandrine, Pierre-Françoi, Sandulescu, Oana, Santos, Marlene, Sarfo-Mensah, Shirley, Banheiro, Bruno Sarmento, Sarton, Benjamine, Satyapriya, Sree, Satyawati, Rumaisah, Saviciute, Egle, Schaffer, Justin, Schermer, Tjard, Scherpereel, Arnaud, Schneider, Marion, Schroll, Stephan, Schwameis, Michael, Scott, Janet T., Scott-Brown, Jame, Sedillot, Nichola, Seitz, Tamara, Selvanayagam, Jaganathan, Semaille, Caroline, Semple, Malcolm G., Senneville, Eric, Sequeira, Filipa, Sequeira, Tânia, Neto, Ary Serpa, Balazote, Pablo Serrano, Shadowitz, Ellen, Shamsah, Mohammad, Sharjeel, Shaikh, Sharma, Pratima, Shaw, Catherine A., Shaw, Victoria, Sheharyar, Ashraf, Shetty, Rajesh Mohan, Shi, Haixia, Shiekh, Mohiuddin, Shimizu, Keiki, Shrapnel, Sally, Shrestha, Shubha Kalyan, Shrestha, Pramesh Sundar, Shum, Hoi Ping, Mohammed, Nassima Si, Sibiude, Jeanne, Siddiqui, Atif, Sigfrid, Louise, Sillaots, Piret, Silva, Catarina, Silva, Maria Joao, Silva, Rogério, Sin, Wai Ching, Singh, Budha Charan, Singh, Punam, Sitompul, Pompini Agustina, Skogen, Vegard, Smith, Sue, Smood, Benjamin, Smyth, Coilin, Smyth, Michelle, Snacken, Morgane, So, Dominic, Solomon, Joshua, Solomon, Tom, Somers, Emily, Sommet, Agnè, Song, Myung Jin, Song, Rima, Song, Tae, Chia, Jack Song, Sotto, Albert, Soum, Edouard, Sousa, Ana Chora, Sousa, Marta, Uva, Maria Sousa, Sperry, Alexandra, Spinuzza, Elisabetta, Darshana, B. P. Sanka Ruwan Sri, Sriskandan, Shiranee, Stabler, Sarah, Staudinger, Thoma, Stecher, Stephanie-Susanne, Stienstra, Ymkje, Stiksrud, Birgitte, Stolz, Eva, Stone, Amy, Streinu-Cercel, Adrian, Streinu-Cercel, Anca, Stuart, Ami, Stuart, David, Suen, Gabriel, Suen, Jacky Y., Sultana, Asfia, Summers, Charlotte, Supic, Dubravka, Surovcová, Magdalena, Svistunov, Andrey, Syrigos, Konstantino, Sztajnbok, Jaque, Szuldrzynski, Konstanty, Tabrizi, Shirin, Tagherset, Lysa, Taleb, Sara, Talsma, Jelmer, Tampubolon, Maria Lawrensia, Tanaka, Hiroyuki, Taqdees, Huda, Taqi, Arshad, Tardivon, Coralie, Tattevin, Pierre, Taufik, M. Azhari, Tawfik, Hassan, Tedder, Richard S., Teixeira, João, Tejada, Sofia, Tellier, Marie-Capucine, Téoulé, Françoi, Terpstra, Pleun, Terrier, Olivier, Terzi, Nicola, Tessier-Grenier, Hubert, Tey, Adrian, Thakur, Anand, Thibault, Vincent, Thiberville, Simon-Djamel, Thill, Benoît, Thompson, Shaun, Thomson, Emma C., Thwaites, Ryan S., Tierney, Paul, Tieroshyn, Vadim, Timashev, Peter S., Timsit, Jean-Françoi, Tissot, Noémie, Toki, Maria, Tonby, Kristian, Torre, Marta, Torres, Antoni, Torres, Margarida, Torres-Zevallos, Hernando, Towers, Michael, Trapani, Tony, Treoux, Théo, Tromeur, Cécile, Trontzas, Ioanni, Trouillon, Tiffany, Truong, Jeanne, Tual, Christelle, Tubiana, Sarah, Tuite, Helen, Turmel, Jean-Marie, Turtle, Lance C. W., Twardowski, Pawel, Uchiyama, Makoto, Udayanga, P. G. Ishara, Udy, Andrew, Ullrich, Roman, Uribe, Alberto, Usman, Asad, Uyeki, Timothy M., Vajdovics, Cristinava, Val-Flores, Luí, Valran, Amélie, Van de Velde, Stijn, van den Berge, Marcel, van der Palen, Job, van der Valk, Paul, Van Der Vekens, Nicky, Van der Voort, Peter, Van Der Werf, Sylvie, van Gulik, Laura, Van Hattem, Jarne, van Netten, Carolien, van Veen, Ilonka, Vanel, Noémie, Vanoverschelde, Henk, Varghese, Pooja, Vauchy, Charline, Veislinger, Aurélie, Vencken, Sebastian, Ventura, Sara, Verbon, Annelie, Vickers, Jame, Vidal, José Ernesto, Vieira, César, Vijayan, Deepak, Villanueva, Joy Ann, Villar, Judit, Villeneuve, Pierre-Marc, Villoldo, Andrea, Visseaux, Benoit, Visser, Hannah, Vitiello, Chiara, Vonkeman, Harald, Vuotto, Fanny, Shukeri, Wan Fadzlina Wan Muhd, Wang, Chih-Hsien, Webb, Steve, Wei, Jia, Weil, Katharina, Wesselius, Sanne, West, T. Eoin, Wham, Murray, Whelan, Bryan, White, Nicole, Wicky, Paul Henri, Wiedemann, Aurélie, Wijaya, Surya Otto, Wille, Keith, Willems, Suzette, Williams, Virginie, Wils, Evert-Jan, Yiu, Ng Wing, Wong, Calvin, Xynogalas, Ioanni, Yamazaki, Masaki, Yazdanpanah, Yazdan, Yelnik, Cécile, Yerkovich, Stephanie, Yokoyama, Toshiki, Yonis, Hodane, Yousif, Obada, Yuliarto, Saptadi, Zaaqoq, Akram, Zabbe, Marion, Zahran, Maram, Zambon, Maria, Zanella, Alberto, Zayyad, Hiba, Zoufaly, Alexander, Zucman, David, Group, ISARIC Characterization, Intensive Care Medicine, AII - Amsterdam institute for Infection and Immunity, Medical Microbiology and Infection Prevention, AII - Inflammatory diseases, Ibáñez-Prada, Elsa D, Fuentes, Yuli V, Taccone, Fabio S, Fowler, Robert A, Gonçalves, Bronner P, Cummings, Matthew J, Marshall, John C, Olliaro, Piero L, Institut Català de la Salut, [Reyes LF] Pandemic Sciences Institute, University of Oxford, Oxford, UK. Infectious Diseases Department, Universidad de La Sabana, Chía, Colombia. Critical Care Department, Clínica Universidad de La Sabana, Chía, Colombia. [Murthy S] Department of Pediatrics, University of British Columbia, Vancouver, Canada. [Garcia-Gallo E] Infectious Diseases Department, Universidad de La Sabana, Chía, Colombia. [Merson L] Pandemic Sciences Institute, University of Oxford, Oxford, UK. [Ibáñez-Prada ED] Infectious Diseases Department, Universidad de La Sabana, Chía, Colombia. Critical Care Department, Clínica Universidad de La Sabana, Chía, Colombia. [Rello J] Grup de Recerca Clínica/Innovació en la Pneumònia i Sèpsia (CRIPS), Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus
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enfermedades respiratorias::trastornos respiratorios::insuficiencia respiratoria [ENFERMEDADES] ,COVID-19 ,Critical care ,High flow nasal cannula ,Invasive mechanical ventilation ,Respiració artificial ,Critical Care and Intensive Care Medicine ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,COVID-19 (Malaltia) - Tractament ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Prospective Studies ,SARS-CoV-2 ,Tachypnea ,Respiratory Insufficiency ,virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES] ,Otros calificadores::/terapia [Otros calificadores] ,Insuficiència respiratòria - Tractament ,Therapeutics::Therapeutics::Respiratory Therapy::Respiration, Artificial::Noninvasive Ventilation [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES] ,Other subheadings::/therapy [Other subheadings] ,terapéutica::terapéutica::terapia respiratoria::respiración artificial::ventilación no invasiva [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Respiratory Tract Diseases::Respiration Disorders::Respiratory Insufficiency [DISEASES] ,Prospective Studie ,Human - Abstract
Invasive mechanical ventilation; COVID-19; Critical care Ventilación mecánica invasiva; COVID-19; Cuidado crítico Ventilació mecànica invasiva; COVID-19; Atenció crítica Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. This work was supported by the UK Foreign, Commonwealth, and Development Office and Wellcome [215091/Z/18/Z] and the Bill & Melinda Gates Foundation [OPP1209135]; CIHR Coronavirus Rapid Research Funding Opportunity OV2170359; Grants from Rapid European COVID-19 Emergency Response research (RECOVER) [H2020 Project 101003589] and European Clinical Research Alliance on Infectious Diseases (ECRAID) [965313]; The Imperial NIHR Biomedical Research Centre; The Cambridge NIHR Biomedical Research Centre; and Endorsed by the Irish Critical Care-Clinical Trials Group, co-ordinated in Ireland by the Irish Critical Care-Clinical Trials Network at University College Dublin and funded by the Health Research Board of Ireland [CTN-2014-12]. This work uses Data/Materials provided by patients and collected by the NHS as part of their care and support #DataSavesLives. The Data/materials used for this research were obtained from ISARIC4C. The COVID-19 Clinical Information Network (CO-CIN) data was collated by ISARIC4C Investigators. Data and Material provision were supported by grants from: the National Institute for Health Research (NIHR; award CO-CIN-01), the Medical Research Council (MRC; Grant MC_PC_19059), and the NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections at the University of Liverpool in partnership with Public Health England (PHE), (Award 200907), Wellcome Trust [Turtle, Lance-fellowship 205228/Z/16/Z], NIHR HPRU in Respiratory Infections at Imperial College London with PHE (Award 200927), Liverpool Experimental Cancer Medicine Centre (Grant C18616/A25153), NIHR Biomedical Research Centre at Imperial College London (Award IS-BRC-1215-20013), and NIHR Clinical Research Network providing infrastructure support. This work was possible due to the dedication and hard work of the Norwegian SARS-CoV-2 study team and supported by grants from Research Council of Norway Grant No. 312780 and a philanthropic donation from Vivaldi Invest A/S owned by Jon Stephenson von Tetzchner; The dedication and hard work of the Groote Schuur Hospital Covid ICU Team, and supported by the Groote Schuur nursing and University of Cape Town registrar bodies coordinated by the Division of Critical Care at the University of Cape Town; and supported by the COVID clinical management team, AIIMS, Rishikesh, India.
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- 2022
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3. Additional file 2 of Exploring the barriers and facilitators to non-medical prescribing experienced by pharmacists and physiotherapists, using focus groups
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Graham-Clarke, Emma, Rushton, Alison, and Marriott, John
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Additional file 2. Consolidated criteria for reporting qualitative studies(COREQ): 32-item checklist.
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- 2022
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4. Additional file 1: of Negative pressure wound therapy versus usual care for Surgical Wounds Healing by Secondary Intention (SWHSI trial): study protocol for a randomised controlled pilot trial
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Arundel, Catherine, Buckley, Hannah, Clarke, Emma, Cullum, Nicky, Dixon, Stephen, Dumville, Jo, Fairhurst, Caroline, Firth, Anna, Henderson, Eileen, Lamb, Karen, McGinnis, Elizabeth, Oswald, Angela, Goncalves, Pedro, Soares, Marta, Stubbs, Nikki, Torgerson, David, and Chetter, Ian
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SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 119 kb)
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- 2016
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5. An Exploration into the Desire for Creative and Innovative Methods of Investigative Educative Research Through the Medium of the 'Curated Meal'
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Clarke, Emma
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Other Food Science ,Food Science - Published
- 2014
6. Boom, the 21st century superhero film: the output of Hollywood industrialised culture
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Clarke, Emma Jane
- Abstract
The proliferation of superhero films is entrenched within Hollywood blockbuster cinema. Fundamental to Hollywood production is a complex nexus of cultural, economic, historical, industrial, and legal dynamics. In this thesis, I will explore what “the genius of the [contemporary] system” entails, focusing specifically on how superhero blockbusters exemplify the attitudes, behaviours and practices of Hollywood studios. The superhero film maps a recent movement within the Hollywood system toward conglomeration and consequent domination within the cultural industries. Classical Hollywood established this cultural impetrative to monopolise and continues to structure the practices of Hollywood studios. Superhero blockbusters articulate the capabilities of Hollywood studios for authorship. The implications of the subsumption of DC Comics and Marvel within the corporate structures of Warner and Disney, and the licensing contracts with Sony and 20th Century Fox is that Hollywood studios possess considerable power in moulding superhero films to comply with their tastes, desires and risk-manage their anxieties over unpredictable box office returns. I will further explore what I term the ‘Hollywood’s culture of production’ within contemporary Hollywood. I view this production culture through the lenses of social theory, history, legal structures, and mythologies. Drawing on the work of Bourdieu, Foucault and Althusser will reveal how ideologies shape Hollywood studio practices. An account of the industrial histories of Hollywood and comic books will reveal the particular social, temporal and legal circumstances of the convergence between these two texts and industries. An analysis of the mythologies of the American monomyth and Christianity will illuminate that the culture of production in Hollywood is ingratiated within American commodified culture. Thus, superhero films, often dismissed as escapist mass entertainment, are actually highly socially meaningful commodities that elucidate the complex industrial relationships, the history, and contemporary culture of production in Hollywood.
- Published
- 2014
7. Microalbuminceria and hypertension
- Author
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Graham-Clarke, Emma M.
- Abstract
DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT
- Published
- 1990
- Full Text
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8. Critical care pharmacy workforce: a 2020 re-evaluation of the UK deployment and characteristics
- Author
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Mark Borthwick, Greg Barton, Christopher P. Ioannides, Ruth Forrest, Emma Graham-Clarke, Fraser Hanks, Christie James, David Kean, David Sapsford, Alan Timmins, Mark Tomlin, John Warburton, Richard S. Bourne, Borthwick, Mark [0000-0002-3249-1508], Barton, Greg [0000-0001-8560-1734], Graham-Clarke, Emma [0000-0001-5657-778X], Timmins, Alan [0000-0001-9837-8244], Bourne, Richard S [0000-0003-0893-525X], and Apollo - University of Cambridge Repository
- Subjects
Adult ,Census ,Public Administration ,Critical Care ,Public Health, Environmental and Occupational Health ,COVID-19 ,Pharmacy ,Distribution ,Pharmacists ,United Kingdom ,Hospital ,Planning ,Organisation ,Intensive care ,Workforce ,Humans ,Pharmacy Service, Hospital ,Pandemics - Abstract
Acknowledgements: We would like to thank all critical care pharmacists who responded to the call for information and donated data in pursuance of this project. Our thanks also go to the Critical Care Group of the United Kingdom Clinical Pharmacy Association for facilitating access to this network of pharmacists. We would like to extend special thanks to Dr Sarah Carter of the United Kingdom Clinical Pharmacy Association for her expertise and assistance with the use of the Survey Monkey questionnaire tool., INTRODUCTION: Critical care pharmacists improve the quality and efficiency of medication therapy whilst reducing treatment costs where they are available. UK critical care pharmacist deployment was described in 2015, highlighting a deficit in numbers, experience level, and critical care access to pharmacy services over the 7-day week. Since then, national workforce standards have been emphasised, quality indicators published, and service commissioning documents produced, reinforced by care quality assessments. Whether these initiatives have resulted in further development of the UK critical care pharmacy workforce is unknown. This evaluation provides a 2020 status update. METHODS: The 2015 electronic data entry tool was updated and circulated for completion by UK critical care pharmacists. The tool captured workforce data disposition as it was just prior to the COVID-19 pandemic, at critical care unit level. MAIN FINDINGS: Data were received for 334 critical care units from 203 organisations (96% of UK critical care units). Overall, 98.2% of UK critical care units had specific clinical pharmacist time dedicated to the unit. The median weekday pharmacist input to each level 3 equivalent bed was 0.066 (0.043-0.088) whole time equivalents, a significant increase from the median position in 2015 (+ 0.021, p < 0.0001). Despite this progress, pharmacist availability remains below national minimum standards (0.1/level 3 equivalent bed). Most units (71.9%) had access to prescribing pharmacists. Geographical variation in pharmacist staffing levels were evident, and weekend services remain extremely limited. CONCLUSIONS: Availability of clinical pharmacists in UK adult critical care units is improving. However, national standards are not routinely met despite widely publicised quality indicators, commissioning specifications, and assessments. Additional measures are needed to address persistent deficits and realise gains in organisational and patient-level outcomes. These measures must include promotion of cross-professional collaborative working, adjusted funding models, and a nationally recognised training pathway for critical care pharmacists.
- Published
- 2023
- Full Text
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