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Introduction: Patients greater than 65 years old (yo) represent up to 30% of all Ulcerative colitis (UC) patients. A few studies in this population have shown poor outcomes with higher rates of infection, neoplasm, hospitalization, and mortality. However, no robust data exist on the use of biologics in the elderly population with UC. We present a retrospective analysis from 2010 to 2020 comparing outcomes such as mortality, adverse events, hospitalizations, and remission of moderate to severe UC patients 65 yo or more (≥) to those less than (

Mucormycosis of the gastrointestinal tract is a life threatening infection most commonly seen in patients with severe immunosuppression. A 42-year-old male with history of choriocarcinoma was admitted to the intensive care unit with septic shock. He developed massive hematemesis requiring upper endoscopy which showed multiple deep gastric ulcers. Due to uncontrollable bleeding he underwent an emergent gastrectomy which revealed necrotic ulcers with evidence of angioinvasion in the ulcer bed with mucor organisms. The PCR revealed the mucor to be Mycotypha microspora which is extremely rare. We discuss the challenges involved in the diagnosis and treatment of gastric mucormycosis.

Chitinases are necessary for fungal cell wall remodeling and cell replication. Methylxanthines have been shown to competitively inhibit family 18 chitinases in vitro. We sought to determine the effects of methylxanthines on fungal chitinases. Fungi demonstrated variable chitinase activity and incubation with methylxanthines (0.5–10 mM) resulted in a dose-dependent decrease in this activity. All fungi tested, except for Candida spp., demonstrated growth inhibition in the presence of methylxanthines at a concentration of 10 mM. India ink staining demonstrated impaired budding and decreased cell size for methylxanthine-treated Cryptococcus neoformans. C. neoformans and Aspergillus fumigatus treated with pentoxifylline also exhibited abnormal cell morphology. In addition, pentoxifylline-treated C. neoformans exhibited increased susceptibility to calcofluor and a leaky melanin phenotype consistent with defective cell wall function. Our data suggest that a variety of fungi express chitinases and that methylxanthines have antifungal properties related to their inhibition of fungal chitinases. Our results highlight the potential utility of targeting chitinases in the development of novel antifungal therapies.

RESUMEN El Llanero Solitario ha sido uno de los personajes más emblemáticos de la cultura estadounidense. Su paso por la radio, televisión, cine y cómics marcó toda una época en la que los vaqueros eran héroes nacionales. Uno de los medios que tuvo mayor aceptación por parte del público fue el de la tira cómica o comic strip, que se publicaba diariamente. Escrita por Cary Bates e ilustrado por Russ Heath, esta tira logró llevar a muchos lectores a acompañar al Llanero Solitario y a Tonto en sus aventuras. Se trata de una obra de gran calidad narrativa y visual, en la que Russ Heath expone su talento como dibujante y su capacidad para ordenar, de manera inteligente, cada elemento gráfico del cómic.PALABRAS CLAVES Arte secuencial, cómic, composición, Llanero Solitario, narrativa, Russ Heath.KAWASPA RURASPA PARLASPA IMASAMI RURANKUNA ATUN KAWACHI SAPALLA LLAGTAPI, KAWACHISPA KAI WATAKUNAPI 1981-1984 CHASALLATA RURASKA SUG RUSSEL HEATHSUGLLAPIKaipi kai runa Cary Bates i Russ Heath Parlame Kawachhikame imasami tukuikunata sumaska kai suti alpapi sapalla, llalischiskakuna rimaspa, kawaspa kawachispa tukuikunata kai rurai suti comic strip, kai iskai runakuna kai kilkapi parlanakumi iman paikuna uillankuna. Munankuna tukuinutata kawachinga kankuna ajai iachakuna. Allilla imapas rurangapa Kilkangapa tukuikunata kawachinkuna sumaglla apachikuna.IMA SUTI RIMAI SIMI:Rukaikuna, kunaurramanda, kawachii, alpapi sapalla, parlu, Russ Heath.ANALYSIS OF THE AESTHETIC AND SEQUENTIAL NARRATIVE IN THE LONE RANGER COMIC STRIP, PUBLISHED BETWEEN 1981 AND 1984 AND ILLUSTRATED BY RUSSEL HEATHABSTRACT The Lone Ranger has been one of the most iconic characters in American culture. Its passage through radio, television, film and comics marked an era in which cowboys were national heroes. One medium that was widely accepted by the public was the daily comic strip. Written by Cary Bates and illustrated by Russ Heath, this strip managed to make readers feel that they were joining the Lone Ranger and Tonto on their adventures. This is a unique work of great narrative and visual quality, in which Russ Heath shows his talent as an illustrator and his ability to sort intelligently each graphic element.KEYWORDS Sequential art, comic, layout, Lone Ranger, narrative, Russ Heath.ANALYSE DE L’ESTHETIQUE ET DE LA NARRATIVE SEQUENTIELLE DANS LE COMIC STRIP THE LONE RANGER, PUBLIE ENTRE 1981 ET 1984, ET ILLUSTRE PAR RUSSEL HEATHRÉSUMÉ The Lone Ranger a été l’un des personnages les plus emblématiques de la culture américaine. Son passage à travers la radio, la télévision, le cinéma et la bande dessinée a marqué une époque où les cow-boys étaient des héros nationaux. Un moyen qui a été largement accepté par le public était la bande dessinée quotidienne. Écrite par Cary Bates et illustrée par Russ Heath, cette bande a réussi à rendre les lecteurs les compagnons du Lone Ranger et Tonto dans leurs aventures. Ceci est une œuvre unique de grande qualité narrative et visuelle, dans laquelle Russ Heath montre son talent de dessinateur et sa capacité à trier intelligemment chaque élément graphique.MOTS-CLEFSArt séquentiel, bande dessinée, mise en page, Lone Ranger, narrative, Russ Heath.ANALISES DA ESTÉTICA E DA NARRATIVA SEQUENCIAL DAS TIRINHAS O CAVALHEIRO SOLITÁRIO, PUBLICADA ENTRE 1981 E 1984, E ILUSTRADA POR RUSSEL HEATH.RESUMO O Cavalheiro Solitário tem sido um dos personagens mais emblemáticos da cultura americana (E.U). Seu passo pela rádio, televisão, cinema e os quadrinhos marcou toda uma época na que os boiadeiros eram heróis nacionais. Um dos meios que teve maior aceitação pelo público foi o das tirinhas ou quadrinhos strip, que se publicava diariamente. Escrita por Cary Bates e ilustrado por Russ Heath, estas tirinhas conseguiu levar a muitos leitores acompanhar ao cavalheiro solitário e a Tonto em suas aventuras. Se trata de uma obra de grande qualidade narrativa e visual, na que Russ Heath expõe o seu talento como desenhista e sua capacidade para ordenar, de maneira inteligente, cada elemento gráfico do Gibi.PALAVRAS CHAVES Arte sequencial, tirinhas, composição, Cavalheiro Solitário, narrativa, Russ Heath. Recibido el 04 de julio de 2015 Aceptado el 22 de enero de 2016

Determining the identity of a person has become vital in today’s world. Emphasis on security has become increasingly more common in the last few decades, not only in Information Technology, but across all industries. One of the main principles of security is that a system only be accessed by a legitimate user. According to the ISO 7498/2 document [1] (an international standard which defines an information security system architecture) there are 5 pillars of information security. These are Identification/Authentication, Confidentiality, Authorization, Integrity and Non Repudiation. The very first line of security in a system is identifying and authenticating a user. This ensures that the user is who he/she claims to be, and allows only authorized individuals to access your system. Technologies have been developed that can automatically recognize a person by his unique physical features. This technology, referred to as ‘biometrics’, allows us to quickly, securely and conveniently identify an individual. Biometrics solutions have already been deployed worldwide, and it is rapidly becoming an acceptable method of identification in the eye of the public. As useful and advanced as unimodal (single biometric sample) biometric technologies are, they have their limits. Some of them aren’t completely accurate; others aren’t as secure and can be easily bypassed. Recently it has been reported to the congress of the U.S.A [2] that about 2 percent of the population in their country do not have a clear enough fingerprint for biometric use, and therefore cannot use their fingerprints for enrollment or verification. This same report recommends using a biometric system with dual (multimodal) biometric inputs, especially for large scale systems, such as airports. In this technical paper we will investigate and compare multimodal biometric techniques, in order to determine how much of an advantage lies in using this technology, over its unimodal equivalent.