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Additional file 1: Supplementary Methods and Results.

Additional file 1: Supplemental Table S1. Demographic and clinical characteristics of clinical diagnosis subgroups. Data are presented as means ± standard deviations, unless specified otherwise. A and T classification system, for “A” (based on the value of CSF Aβ1–42), and “T” (based on the value of CSF p-Tau181). The following CSF thresholds were used: 385.822 pg/mL for Aβ1–42, and 41.881 pg/mL for p-Tau181. Supplemental Table S2. Clinical characteristics in validation data set. Data are presented as means ± standard deviation, unless specified otherwise. The following CSF thresholds were used: 385.822 pg/mL for Aβ1–42, and 41.881 pg/mL for p-Tau181. Supplemental Table S3. Partial correlations of Aβ1–42. and t-Tau with neuropsychological scores. Partial correlation was performed controlling for age, sex, education, Korean version of the Mini-Mental State Examination, apolipoprotein genotype, and CSF biomarkers. Supplemental Table S4. Multiple linear regression analysis with stepwise selection. Multiple linear regression was performed controlling for age, sex, education, Korean version of the Mini-Mental State Examination, and apolipoprotein genotype. Supplemental Table S5. Mediation analysis of MRI control regions of interests. Data are presented as effect (BootSE), [BootLLCI, BootULCI]. Supplemental Table S6. AUCs of models A and D in CN, MCI, and AD groups.

Additional file 1: Fig. S1. Increased weight and HAFLD in HFD-fed mice with or without STZ. Fig. S2. Insulin resistance in HFD-fed mice with or without STZ. Fig. S3. TonEBP and LCN2 expression in the hippocampus of HFD-fed mice with or without STZ. Fig. S4. TonEBP (+ / ���) mice show ameliorated HFD/STZ-induced hepatic steatosis and eWAT inflammation. Fig. S5. TonEBP-and LCN2-positive neutrophils are observed in epididymal white adipose tissue of HFD/STZ-induced diabetic mice. Fig. S6. TonEBP-and LCN2-positive neurons are observed in hippocampal CA1 region of HFD/STZ-induced diabetic mice. Fig. S7. The TonEBP binding site in the mouse LCN2 promoter. Table S1. List of primary antibodies. Table S2. List of qRT-PCR primers. Table S3. List of qRT-PCR primer for ChIP assay. Table S4. Clinical characteristics of normal subjects (CTL) and type 2 diabetic patients (DM) with or without mild cognitive impairment (MCI).

Additional file 2:: Supplementary Table 1. Correlation of CSF AD biomarkers and plasma contact factors.