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The repeaters in cascade structure can be used to suppress the cross coupling between the nonadjacent repeaters in multiload inductive power transfer (ML-IPT) system. In this article, the cascade repeaters used in the ML-IPT system work both as power transmitters and load carriers. Based on the cascade scheme, the system models of two ML-IPT systems with single-excitation (SE) scheme for different load position are established and high-order compensations are designed to achieve constant load currents. Referring to the topologies of the two ML-IPT systems with SE scheme, a bilateral-excitation (BE) scheme is further proposed to improve output currents and system reliability, and the comparison of the conventional scheme and the proposed scheme is also presented. Finally, a prototype of ML-IPT system with the proposed BE scheme is built, where the maximum deviation of the output currents is less than 13% and the maximum power transfer efficiency reaches 89.2% for an eight-load case.

The carbon–carbon bond cleavage of 1,2-diols is an important chemical transformation. Although traditional stoichiometric and catalytic oxidation methods have been widely used for this transformation, an efficient and valuable method should be further explored from the views of reusable catalysts, less waste, and convenient procedures. Herein an inorganic-ligand supported iron catalyst (NH4)3[FeMo6O18(OH)6]·7H2O was described as a heterogeneous molecular catalyst in acetic acid for this transformation in which hydrogen peroxide was used as the terminal oxidant. Under the optimized reaction conditions, carbon–carbon bond cleavage of 1,2-diols could be achieved in almost all cases and carboxylic acids or ketones could be afforded with a high conversion rate and high selectivity. Furthermore, the catalytic system was used efficiently to degrade renewable biomass oleic acid. Mechanistic insights based on the observation of the possible intermediates and control experiments are presented.

Background: Novel Coronavirus disease 2019 (COVID-19) was first detected in pneumonia patients in Wuhan, China in December 2019. Based on the current understanding, COVID-19 has become a global issue. Presumably, numerous studies have found that SARS-CoV-2 also transpires in kidney tissue with permanent viral loads. However, it is elusive as to whether SARS-CoV-2 can directly damage the kidney or induce acute renal failure. Hence, to comprehensively understand the impact of COVID-19 on kidney damage, we conducted a retrospective series of case studies to assess kidney functions. Additionally, ACE2 distribution in kidney tissue was analyzed through RNAseq data in open-access databases. Results: According to the findings from transcriptome analysis, we revealed higher ACE2 expression levels in females than males. Similar results were more noticeable in the elderly than in young adults. Furthermore, single-cell RNA sequencing data analysis showed high ACE2 expression in kidney tubule and collecting duct principal cells as well as glomerular parietal epithelial cells. On their admission, the patient's serum creatinine and blood urea nitrogen (BUN) were elevated to between 36.13% and 16.80%, respectively. The estimated glomerular filtration rate (EGFR) of < 60 ml/min per 1.73 m2 was reported in 10.92 % of the patients. Notably, at admission, increased BUN time varied linearly following the generalized additive mixed model. Thus, the hourly-increase of BUN in patients was 0.495 (95%CI: 0.263, 0.726). Conclusion: Based on clinical findings, it was ascertained that COVID-19 can damage renal function, but it seldom causes acute renal failure. Coronavirus may directly bind to ACE2-positive cells and damage kidney tissue in the analysis of scRNA-seq data in kidney tissue. Therefore, this evidence suggests that kidney tissue act as the SARS-CoV-2 infection site and the findings could provide insight into the pathophysiology of kidney damage. Methods: We systematically analyzed ACE2 expression profiles in organs based on open-access datasets for healthy individuals. Meanwhile, single-cell sequencing data for kidney samples were collected and analyzed. Assessments on kidney functions were conducted on 119 selected COVID-19 positive patients admitted from 10th February – 18th March 2020, in hospital in Wuhan City, Hubei Province. Consequently, their clinical records and laboratory findings, such as the estimated glomerular filtration rate (eGFR), Blood Urea Nitrogen (BUN), Creatinine, and Comorbidities, were collected.

Additional file 1: Figure S1. Detection of Staphylococcus aureus in the CSF sample. a. Genome coverage of detected Staphylococcus aureus sequences. A total of 1750 sequences were mapped to Staphylococcus aureus, covering the 2.96% of the whole genome. b. Distribution of the sequencing reads from the CSF sample. c. Distribution of non-human sequencing reads from the CSF sample.

Background: Serum prostate-specific antigen (PSA) is a primary metric for diagnosis and prognosis of prostate cancer (PCa). Exposure to heavy metals, such as lead, cadmium, mercury, and zinc can impact PSA levels in PCa patients. However, it is unclear whether this effect also occurs in men without PCa, which may lead to the overdiagnosis of PCa.Method: Data on a total of 5,089 American men who had never been diagnosed with PCa were obtained from the National Health and Nutrition Examination Survey performed from 2003–2010. The relationship between serum PSA levels (dependent variable) and concentrations of lead (μmol/L), cadmium (nmol/L), and mercury (μmol/L) were investigated with dietary zinc intake being used as a potential modifier or covariate in a weighted linear regression model and a generalized additive model. A series of bootstrapping analyses were performed to evaluate sensitivity and specificity using these models. Results: Regression analyses suggested that, in general, lead, cadmium, or mercury did not show an association with PSA levels, which was consistent with the results of the bootstrapping analyses. However, in a subgroup of participants with a high level of dietary zinc intake (≥14.12 mg/day), a significant positive association between cadmium and serum PSA was identified (1.06, 95% CI, P=0.0268, P for interaction=0.0249).Conclusions: With high-level zinc intake, serum PSA levels may rise in PCa-free men as the exposure to cadmium increases, leading to a potential risk of an overdiagnosis of PCa and unnecessary treatment. Therefore, environmental variables should be factored in the current diagnostic model for PCa that is solely based on PSA measurements. Different criteria for PSA screening are necessary based on geographical variables. Further investigations are needed to uncover the biological and biochemical relationship between zinc, cadmium, and serum PSA levels to more precisely diagnose PCa.

Background Clear cell renal cell carcinoma (ccRCC) is the most prevalent and highly malignant pathological type of kidney cancer. Finding more precise biomarkers is critical for enhancing the prognosis of patients with ccRCC. Multiple studies have suggested that Holliday junction recognition protein (HJURP) promotes tumor progression and predicts poor prognosis in a variety of cancers. However, the role of HJURP in ccRCC remains unclear. Methods The ccRCC dataset was obtained from The Cancer Genome Atlas (TCGA), and the relationship between HJURP expression and ccRCC clinical features was investigated using R software. The effect of HJURP expression on survival was assessed using survival probabilities and Cox regression. Gene set enrichment analysis (GSEA) was used to identify HJURP-related signaling pathways in ccRCC. Finally, Tumor IMmune Estimation Resource (TIMER) and Gene Expression Profiling Interactive Analysis (GEPIA) were used to analyze the correlation between HJURP expression and immunocyte infiltrates in ccRCC. Results HJURP expression was upregulated in ccRCC. Increased HJURP expression was associated with poor pathological features and correlated with poor prognosis in patients with ccRCC. Cox regression further found that HJURP expression was a high-risk factor for ccRCC patients. GSEA revealed that HJURP was closely linked to multiple immune-related signaling pathways. In ccRCC, HJURP expression was closely correlated with infiltration of various immune cells and expression of a wide range of immunocyte gene markers. Conclusion HJURP is a potential independent prognostic marker in ccRCC that plays an essential role in the tumor microenvironment by regulating immunocyte infiltration.

There are many problems such as air inlet hole is easy to be blocked, external salt spray affects component's life and seeping water affects equipment's performance in the module of fast charger by using air-cooling. The advantages and disadvantages of four temperature control schemes such as air-cooling, heat exchanger, air conditioning and liquid cooling were compared and analyzed in this research. Four new temperature control schemes were designed to solve the high heat dissipation and high protection problem of the fast charger. In these schemes, compressor refrigeration is not required and the main power consumption components are fans. Maximizing the energy saving of products is an outstanding characteristic. The research result has certain guiding significance in the engineering design of fast charger with increasingly miniaturization and high power.

To investigate the predictive value of pediatrics end-stage liver disease (PELD) or the model for end-stage liver disease (MELD) in the prognosis of pediatric acute liver failure (PALF) treated with artificial liver support system (ALSS).The clinical data of 47 children with acute liver failure seen from August 2008 to July 2013 treated in Children's Hospital, Fudan University were analyzed. Thirty children were treated with ALSS in addition to conventional comprehensive medical treatment (ALSS group). Seventeen children were treated with only conventional comprehensive medical treatment (control group). The main biochemical parameters and coagulation function parameters before and after treatment were compared in the ALSS group and the mortality rates were compared between the two groups. The patients were graded by PELD or MELD when they were hospitalized and the relationship of PELD or MELD scores and mortalities of child patients with the receiver operating characteristic curve (ROC) were analyzed.There were significant differences in total bilirubin (TB) ((302 ± 208) vs. (161 ± 129) µmol/L); alanine aminotransferase (ALT) ((161 ± 225) vs. (761 ± 834) U/L); aspartate aminotransferase ( AST) (66 (35, 123 ) vs. 447 (184, 1,129 ) U/L) ; international normalized ratio (INR) ((2.6 ± 1.6) vs. (5.1 ± 4.0)); prothrombin time activity percentage (PTA) ((42 ± 25)% vs. (22 ± 13)%); albumin( ALB) ((35 ± 5) vs. (33 ± 6) g/L) in the ALSS group after treatment. Through the ROC curve analysis, the best PELD/MELD threshold was 25 to predict the patients survival after ALSS therapy, with a sensitivity of 92. 3% , and a specificity of 94.1% at the cutoff point. The area under the ROC curve was 0. 912. The mortality of patients with PELD or MELD score below 25 in the ALSS group (1/13) was lower than the control group (3/4) (P = 0.022), and the mortality of patients with PELD or MELD score over 25 (16/17) was higher than that of the control group (10/13) (P = 0.290).PELD or MELD score is a valid index in prognostic evaluation of ALSS therapy, which may provide an evidence for the therapeutic strategies of PALF. Patients with PELD or MELD score below 25 treated with ALSS obtained more benefit.

To synthesize a novel environmental protection urea-formaldehyde resin, urea-formaldehyde resin was modified using keratin through adjusting factors of the mole ratio between formaldehyde and carbamide, adding time and adding amount of keratin.. Experimental results showed that the optimum molar ratio of formaldehyde to carbamide optimum for the keratin-modification resin is 1.3∶1; after adding keratin into urea in the third time and it had better to add the amount to 5% of the quality of urea. By optimizing the synthesis process, finally we get the modified environment-friendly urea-formaldehyde resin. At the same time, as keratin's wide variety of sources, low cost, the cost of the modified urea-formaldehyde resin is reduced.

This paper presents the latest achievements of performance assessment (PA) for high level radioactive waste (HLW) repository in China. The first PA model, taking Beishan granite site as an example, is established with GoldSim and is verified by comparison with Japanese PA model. Then the behaviors of granite repository in Beishan area are simulated. The results from these simulations show that the engineered barrier is the most important part inside the repository, especially its bentonite plays a key role in the retardation of repository after the nuclide is released from the vitrified waste. Five sensitive parameters are identified and two design parameters are optimized. As a result, it has been proved that performance assessment model is a necessary tool to understand the behaviors of repository, to identify sensitive parameters, and to optimize design parameters.Copyright © 2009 by ASME

Reliability of power supply is one of the major indexes for a power supply enterprise to establish an international first-class company and it is discovered via statistics and analysis that defect handling of 10 KV fuse appliance is an important factor that affects the reliability of power supply from distribution network to users. In order to ensure the safe operation of distribution network and to improve power supply reliability, Jinshan Power Supply Branch has developed a technology for exchanging 10 KV closed circuit fuse appliance without power-off and has achieved good result after hard working and actual application for more than one month. This technology has successfully passed the appraisal conducted by the Live Line Work Development Co., Ltd. of Shanghai Municipal Electric Power Company before March 29, 2007 and Jinshan Power Supply Branch becomes the first company possessing such an appraised technology within Shanghai Municipal Electric Power Company.

In this paper, a fast evaluation system for remote real-time health monitoring and evaluation of long bridge structure is proposed. The main idea of this system is to apply the reliability design theory for static structure into the dynamic remote health monitoring and reliability evaluation of bridges. The real-time safety evaluation of bridges includes the following components: (1) dynamic acquisition of optimal statistical parameters through distribution testing of fitting performance; (2) real-time analysis of section dynamic reliability of bridge structure; and (3) evaluation of bridge structure reliability by using PNET method in comparison to the standard reliability index commonly used in highway engineering. This research first realizes the real-time dynamic bridge reliability analysis based on the monitoring data analysis and then evaluates in real time the objective health conditions of bridge. The performance of remote monitoring and evaluation over long bridges demonstrates that the proposed evaluation system can deal with real-time information monitoring, evaluate reliably the bridge safety and promote intelligent development of bridge structures.

Ten alkaloids, 15α-hydroxy-14,15-dihydrovindolinine, 15α-hydroxy-14,15-dihydro-16-epi-vindolinine, vindolinine, epivindolinine, vindolinine N (b)-oxide, epivindolinine N (b)-oxide, kopsinine, 15-hydroxykopsinine, vincadifformine and quebrachamine were isolated from Melodinus morsei . The first two are new compounds, with their structures elucidated by spectroscopic methods.

The fabrication of high quality and low cost microlenses on a glass substrate using a simple, rapid, and precise direct microplotting technique is shown in this paper. The fabrication method is based on the use of a microplotter system, which is significantly different from the existing inkjet, roll-to-roll printing, and reactive ion etching technology and could work with higher viscosity materials. By optimizing the parameters of voltage, dispense time, and concentration of the polymer solution, high quality microlenses with a diameter of 20 μm could be obtained. The geometrical and optical characteristics of the microlenses are analyzed by measurement of the surface profile and the imaging properties in the near-field and far-field zones as well as the diffraction pattern. We think that the fabricated microlenses could be attractive for enhancing the light extraction efficiency of light emitting diodes.

Two new triterpenoids, cyclopholidonol ( 1) and cyclopholidone ( 2) have been isolated from the crude drug “Shi Xian Tao”, PHOLIDOTA CHINENSIS. Their structures have been determined on the basis of chemical and spectral evidence.

A new depside of D-(+)-beta-(3,4-dihydroxyphenyl)-lactic acid and 2-(3,4-dihydroxyphenylethenyl)-caffeic acid, named salvianolic acid A, was isolated from the dried roots of SALVIA MILTIORRHIZA Bunge. Its chemical structure was defined by spectral analysis and chemical degradation.

A new diterpene glucoside has been isolated from the leaves of Andrographis paniculata and its structure elucidated as deoxyandrographolide-19beta-D-glucoside on the basis of chemical and spectral evidence. A detailed proton magnetic resonance study of the diterpene was crucial in the structure determination.

The EEG biofeedback system developed by the author is described. Alpha-component biofeedback training in the normal human EEG is reported. The experiment shows the feasibility of using EEG biofeedback to increase the alpha component. The difficulties in biofeedback research and an effective solution are discussed. >

Isolement de 6 alcaloides indoles des racines d'A. yunnanensis. Hormis la tetrahydroalstonine, les cinq autres alcaloides sont isoles pour la premiere fois d'une Alstonia sp.