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Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen causing health care-infections in the world, especially in burns. The aim of this study was to assess the extent of dissemination of MRSA isolated from burn patients in Burn Intensive Care Unit in Tunisia and to evaluate the frequency of virulence and antibiotics resistance genes. Among the 72 S. aureus isolates analyzed in the study, 54% were MRSA. The majority of MRSA (94.8%) were multidrug resistant and they had a high resistance rates to kanamycin (94.8%), tobramycin (90%), tetracycline (94.8%) and ciprofloxacin and rifampicin (87%, each). The gene aac(6′)-Ie-aph(2″)-Ia conferring resistance to kanamycine and tobtamycin were detected in all isolates and the aph(3′)-Ia gene conferring resistance to gentamicin were detected in 2.8% of resistant isolates. Tetracycline resistance genes tet(M), tet(K) and tet(L) were detected in 100%, 10.8% and 2.8% of the isolates, respectively. The SCCmec type III and the agr type I were the most predominant (69.2% and 90%, respectively). The 27 SCCmecIII-agrI isolates were clustered into two PFGE types A and B. The two representative isolates of PFGE clusters A and B belonged to ST239-t037 and ST241-t037 respectively. As conclusion, our results showed a high prevalence of MRSA in trauma burn intensive care unit belonging to two multidrug resistant clones ST239/ST241-agrI-t037-SCCmecIII MRSA. We also demonstrated that MRSA was disseminated between burn patients.

Background: Acenocoumarol is an anticoagulant with numerous drug reactions. We report here, an unusual interaction between acenocoumarol and azathioprine. Case Presentation: A 35-year-old woman, treated with acenocoumarol for thrombosis of the superior mesenteric vein, was prescribed azathioprine for Crohn’s disease. Three days later, INR values decreased from 2.36 to 1.48. The dose of acenocoumarol had to almost be doubled to reach an INR value of 2.56. The interaction between azathioprine and acenocoumarol was then suspected. Few similar cases of interactions between azathioprine and another coumarin derivative, warfarin, have been reported. To our knowledge, this is the second case of such interaction reported with acenocoumarol in literature. Conclusion: Thus, despite the rarity of this interaction reporting, we draw attention to the importance of close monitoring of INR values in patients treated with acenocoumarol associated with azathioprine.

Purpose Striving for growth since their early stages, many small and medium enterprises (SMEs) are increasingly adopting an entrepreneurial behavior based on a rapid and early international expansion. Although some extant research have been done on the dynamic capabilities of SMEs’ accelerated internationalization–born global (BG) SMEs, no study was, to the best of the authors’ knowledge, carried on the microfoundations underlying this phenomenon. This paper aims to fill this gap in the literature and contribute to the growing theory development of SME’s microfoundations. Design/methodology/approach This paper proposes an integrated conceptual framework to better identify the microfoundations that influence born global SMEs internationalization by integrating individual, structural and processual – the microfoundations approach within the dynamic capabilities of sensing, seizing and reconfiguring. Findings Our propositions argue that born global SMEs are characterized by dynamic capabilities based on a combination of some individual (manager’s human and social capital, such as its personal orientation, experiences, cognition and intuition), process (market learning, technology development) and structural (agility, communication/coordination) factors that helps a lot in the acceleration of the internationalization process. Research limitations/implications Empirical study should be done to enrich the conceptual material. Practical implications To identify some international opportunities, companies should rely on the entrepreneurial orientation of its managers, its experience and network as well as the market-related learning and technological processes. The managerial cognition is important to seize opportunities while the manager’s human capital is needed to reconfigure resources while internationalizing rapidly. Social implications This research shows that individual attributes are important but insufficient to accelerate the internationalization process. Some individual characteristics are more useful in sensing international opportunities rapidly, such as manager’s international entrepreneurial, past experience and network, However, the managerial cognition is important to seize opportunities, whereas the manager’s human capital is needed to reconfigure resources while internationalizing rapidly. Originality/value Born global firms must develop several dynamic capabilities to foster their accelerated early international development. This paper gives insights about the individual, structural and processual of sensing international opportunities, seizing and reconfiguring resources and competencies for born globals.

Sarcoidosis is a systemic disease histologically characterized by the presence of non-caseating granulomas. Granulomas can affect all structures of the body, giving heterogeneous manifestations and making the diagnosis of this disease a real challenge. We report the case of a 72-year-old woman who presented with two rare manifestations of sarcoidosis: an orbital and a pulmonary pseudotumor. The orbital tumor revealed the disease. Clinically, the patient had palpebral swelling. Orbital MRI showed an orbital pseudotumor hypointense on T1, and hyperintense on T2, heterogeneous and enhanced after gadolinium injection. The thoracic localization was asymptomatic, revealed by the chest Computed Tomography (CT) scan. Histological evidence of granuloma was obtained at both locations. The level of angiotensin-converting enzyme was high. All the other systemic granulomatous diseases were eliminated. We started a systemic corticotherapy with good clinical results.

Purpose This paper aims to investigate feedback trading and autocorrelation behavior in the cryptocurrency market. Design/methodology/approach It uses the GJR-GARCH model to investigate feedback trading in the cryptocurrency market. Findings The findings show a negative relationship between trading volume and autocorrelation in the cryptocurrency market. The GJR-GARCH model shows that only the USD Coin and Binance USD show an asymmetric effect or leverage effect. Interestingly, other cryptocurrencies such as Ethereum, Binance Coin, Ripple, Solana, Cardano and Bitcoin Cash show the opposite behavior of the leverage effect. The findings of the GJR-GARCH model also show positive feedback trading for USD Coin, Binance USD, Ripple, Solana and Bitcoin Cash and negative feedback trading for Ethereum and Cardano only. Originality/value This paper contributes to the literature by extending Sentana and Wadhwani (1992) to explore the presence of feedback trading in the cryptocurrency market using a sample of the most active cryptocurrencies other than Bitcoin, namely, Ethereum, USD coin, Binance Coin, Binance USD, Ripple, Cardano, Solana and Bitcoin Cash.

Beech (Fagus sylvatica L.), is one of the most socio-economically valuable and widely distributed broadleaved trees in Europe. European beech favorable edaphic and climatic conditions are sufficient moisture in summer and mild temperatures in winter. This highly competitive species is also known to be drought-sensitive and thus may become more vulnerable to expected increasing number of heat waves and drought spells. A better understanding of beech response to soil drought is therefore crucial for forestry planning and forest management in a future warmer world. In this study, we investigate the water balance and radial growth dynamics of a beech stand in an ICOS site in Belgium (BE-Vielsalm), with a special focus on soil drought impacts, based on about three decades of observations (1996-2020). The continuous decreasing trend of beech radial growth (dendrochronological time series) coupled with recent crown defoliation raised concern about the vitality of this stand. On the basis of this site-specific data set, the calibration and the validation of the model HETEROFOR were performed in order to i) simulate the water balance and fluxes at the stand level; ii) track the occurrence and intensity of soil-induced transpiration deficit during the whole study period; iii) characterize the tree water uptake patterns according to soil depth for contrasted years (dry, intermediate and wet) and iv) evaluate the current and lag effects of spring and summer transpiration deficit on the observed annual radial growth of beech trees obtained from dendrochronological analysis. A good agreement between predicted and observed evapotranspiration and extractable water was obtained and showed the robustness of the model. The predicted transpiration deficit revealed an increasing trend, especially after 2010. We observed a negative effect of the spring transpiration deficit on tree radial growth during the current year as well as a carryover effect (i.e., a negative effect of the summer transpiration deficit of the previous year). This study will enrich the state of knowledge about the ongoing debate on the vulnerability of beech trees to drought in Europe.Keywords: Fagus sylvatica, radial growth, soil water balance, forest evapotranspiration, drought, process-based modeling, eddy covariance.

Adult abdominal cystic lymphangioma was a very rare non yet elucidated pathology. In our case, it was revealed by intraperitoneal hemorrhage. Complete surgical excision allowed complication treatment and relapse avoiding.

Reconstruction modalities after pancreaticoduodenectomy is still debated since pancreatic fistula constituted the main reason for mortality and morbidity. Sometimes, as in our case, this type of reconstruction wasn’t deliberate but implied by a previous Roux-en-Y biliodigestive anastomosis for a main bile duct cystic dilation.

Radiation enteritis could lead to lifethreatening condition needing prompt recognition and adequate treatment. Herein we report a case of surgical treatment for radiation enteritis complicated by invasive candidosis in order to raise awareness of the importance of preventive measures avoiding such complications. A 56-year-old woman had a radical hysterectomy for cervical adenocarcinoma followed by chemotherapy and brachytherapy. She consulted for abdominal distension, vomiting, and weight loss secondary to stenotic radiation enteritis. An ileo-cecal resection was performed with ileo-colic side-to-side anastomosis. She developed systemic candidosis in the postoperative course with a good evolution under antifungal treatment. Histopathological exam of the surgical specimen concluded to lesions consistent with radiation enteritis. No recurrence occurred after a follow-up of three months. Preventive measures before radiotherapy could avoid radiation enteritis, surgical treatment, and lifethreatening invasive candidosis

Assessment of gross motor skills is important for children, youths, and adults and can be beneficial for the study and diagnosis of different health conditions. The classical tools are mainly administered by operators. A computerized system using sensors to assess gross motor skills could enhance these tools, providing consistency of measurement, reduce human error, and automate data collection. As part of a computerized system to measure gross motor skills using the Kinect™, we present the details of algorithms developed to test the “horizontal jump” (HJ). These algorithms were developed by translating the performance criteria into equations for the coordinates of anatomical landmarks, describing the expected kinematic behaviour of relevant body parts. Our test results show that the algorithms successfully evaluated the performance criteria.

This paper presents a comparative study of two translational parallel manipulators (TPMs) with three Degrees of Freedom (3-DOF) based on the orientation errors due to joint clearances. In fact, the kinematic and static models of the manipulators have been used to determine the analytical model of the orientation errors. Then, the maximum and the sensitivity of the orientation errors have been considered as criteria to compare the precision of the DELTA and the RAF manipulators. The maximum orientation error is determined by solving an optimization problem of the previous analytical model. The sensitivity of the orientation errors is divided into two types: one related to the sensitivity of the orientation errors to the geometric parameters and another one related to the sensitivity of the orientation error to the joint clearances. The results show that the RAF robot precision is more sensitive to the joint clearances than the DELTA one. However, this advantage of the DELTA is limited to a portion of the workspace, which is free from singular configurations.

The aim of this study is twofold. First, it aims to show how to overcome some of the shortcomings of the standard risk measurement methods using value-at-risk (VaR) in the context of extreme events and propose an alternative empirical method. Second, it aims to fill the research gap in analysis of risk in the Middle East and North Africa (MENA) region. In this regard, for six daily stock indices in the MENA region, from January 3, 2005 to December 31, 2014, we employ a vine copula-based generalized autoregressive conditional heteroskedastic (GARCH) method and the extreme value theory (EVT) to model the dependence between the marginal distributions of returns and forecast the VaR. Based on backtesting, we assess the efficiency of the standard risk measurement models from the following families—the exponentially weighted moving average, the historical simulation, and the GARCH. By implementing the GARCH-EVT-C-vine method in the MENA region, we find that, empirically, standard methods overestimate (underestimate) the violation ratio, implying an underestimation (overestimation) of the risk, and therefore a misallocation of the capital covering the risk. The method also provides better VaR estimates for the MENA stock markets than that of the standard methods. We also verify that the greater the openness of the capital accounts and the flexibility of the exchange rate regimes, the greater will be the conditional dependence of the MENA countries on the developed markets. Finally, the empirical method we propose has an important implication for the MENA countries in that it can be adopted by these countries to forecast VaR effectively.

The dinuclear compound [Co2(Hatzc)2(H2O)6](NO3)2·4H2O containing the polytopic ligand Hatzc‒ = 3-amino-4H-1,2,4-triazole-5-carboxylate was synthesized and characterized. Single-crystal X-ray diffraction showed that two monoanionic N,O-chelating Hatzc‒ ligands bridge two Co(II) ions in a µ-N1,N2 fashion. Both Co(II) centers are further coordinated by three H2O ligands making up an octahedral coordination. A complex network of intra- and intermolecular O‒H···O and N‒H···O hydrogen bonding interactions characterize the structure. Hirshfeld surface analysis, ATR–FTIR, and FT-Raman spectroscopy in combination with density functional theory (DFT) calculation of vibrational modes confirm this multitude of H bonds. Thermogravimetric and differential thermal analysis experiments under an argon atmosphere in the temperature range of 25–900 °C showed thermal stability till about 100 °C and multi-step decomposition yielding Co2O3 at about 280 °C. The octahedral environment of Co(II) was confirmed by UV–vis absorption spectroscopy, which shows weak absorption bands at around 520 nm assignable to electronic d‒d transitions alongside with π‒π* transitions dominating the 250–350 nm range. Time-dependent DFT calculated excited states agree very well in terms of energy match with the observed transitions. The direct and indirect optical band gap values were determined using the Tauc plot method to 3.33 eV and 2.75 eV, respectively, indicating semiconducting properties.

Introduction: The aim of the study was to report the 30-day mortality (30DM) after renal trauma and identify the risk factors associated with death. Methods: The TRAUMAFUF project was a retrospective multi-institutional study including all patients with renal trauma admitted to 17 French hospitals between 2005 and 2015. The included population focused on patients of all age groups who underwent renal trauma during the study period. The primary outcome was death within 30 days following trauma. The multivariate logistic regression model with a stepwise backward elimination was used to identify predictive factors of 30DM. Results: Data on 1,799 renal trauma were recorded over the 10-year period. There were 59 deaths within 30 days of renal trauma, conferring a 30DM rate of 3.27%. Renal trauma was directly involved in 5 deaths (8.5% of all deaths, 0.3% of all renal trauma). Multivariate stepwise logistic regression analysis revealed that age >40 years (odds ratio [OR] 2.18; 95% confidence interval [CI]: 1.20–3.99; p = 0.01), hemodynamic instability (OR 4.67; 95% CI: 2.49–9; p < 0.001), anemia (OR 3.89; 95% CI: 1.94–8.37; p < 0.001), bilateral renal trauma (OR 6.77; 95% CI: 2.83–15.61; p < 0.001), arterial contrast extravasation (OR 2.09; 95% CI: 1.09–3.96; p = 0.02), and concomitant visceral and bone injuries (OR 6.57; 95% CI: 2.41–23.14; p < 0.001) were independent predictors of 30DM. Conclusion: Our large multi-institutional study supports that the 30DM of 3.27% after renal trauma is due to the high degree of associated injuries and was rarely a consequence of renal trauma alone. Age >40 years, hemodynamic instability, anemia, bilateral renal trauma, arterial contrast extravasation, and concomitant visceral and bone lesions were predictors of death. These results can help clinicians to identify high-risk patients.

Background: Some health care systems have set up referral trauma centers to centralize expertise to improve trauma management. There is scant and controversial evidence regarding the impact of provider’s volume on the outcomes of trauma management. Objective: To evaluate the impact of hospital volume on the outcomes of renal trauma management in a European health care system. Design, setting, and participants: A retrospective multicenter study, including all patients admitted for renal trauma in 17 French hospitals between 2005 and 2015, was conducted. Intervention: Nephrectomy, angioembolization, or nonoperative management. Outcome measurements and statistical analysis: Four quartiles according to the caseload per year: low volume (eight or fewer per year), moderate volume (nine to 13 per year), high volume (14–25/yr), and very high volume (≥26/yr). The primary endpoint was failure of nonoperative management defined as any interventional radiology or surgical procedure needed within the first 30 d after admission. Results and limitations: Of 1771 patients with renal trauma, 1704 were included. Nonoperative management was more prevalent in the very-high- and low-volume centers (p = 0.02). In a univariate analysis, very high hospital volume was associated with a lower risk of nonoperative management failure than low (odds ratio [OR] = 0.54; p = 0.05) and moderate (OR = 0.48; p = 0.02) hospital volume. There were fewer nephrectomies in the high- and very-high-volume groups (p = 0.003). In a multivariate analysis, very high volume remained associated with a lower risk of nonoperative management failure than low (OR = 0.48; p = 0.04) and moderate (OR = 0.42; p = 0.01) volume. Study limitations include all the shortcomings inherent to its retrospective multicenter design. Conclusions: In this multicenter study, management of renal trauma varied according to hospital volume. There were lower rates of nephrectomy and failure of nonoperative management in very-high-volume centers. These results raise the question of centralizing the management of renal trauma, which is currently not the case in our health care system. Patient summary: In this study, management of renal trauma varied according to hospital volume. Very-high-volume centers had lower rates of nephrectomy and failure of nonoperative management.

For narrow tubes, red blood cells concentrate in the core region, leaving an annular zone called cell-free layer. This has an impact on both the tube hematocrit level (Fåhraeus effect) and the apparent blood viscosity (Fåhraeus–Lindqvist effect). Blood flow, mass transfer across the microvessel membrane, and diffusion in the tissue affect the solute concentration profiles. The Krogh tissue cylinder concept, limiting mass transfer to a cylinder around each microvessel, and the marginal zone concept (introduced by Haynes to analyze blood flow dynamics in narrow tubes) are both used to develop a model for solute transfer from blood in microvessels to the surrounding tissues, based on fundamentals. The analysis accounts for advection and diffusion in each zone of the microvessel, solute transport in the microvessel membranes, and diffusion and reaction in the tissues. The present investigation provides an analytical solution. The approach can be extended to treat other kinetic models, while accounting for Fåhraeus and Fåhraeus–Lindqvist effects in blood microvessels. The model is validated against published results for glucose transport from blood to tissue.

Key message Quercus ilex populations from cold habitats display a large lag between seed germination and shoot emergence time, favouring avoidance of late frost events. Populations from mild habitats show the fastest seed germination and shoot emergence rates at moderate temperatures, enabling them to synchronize germination in the late winter-early spring period and a rapid seed-to-seedling transition, during the favourable rainy period. Context Quercus ilex is the most abundant and representative Mediterranean oak species. Identifying and describing intraspecific variation in seed traits is necessary to characterize the germination niche, and to elucidate drivers of species’ range. Aims In order to identify adaptations to local environments that may reflect ecological strategies for stress avoidance and seed survival, we tested under common and optimal conditions whether seed functional traits vary, in Quercus ilex subsp. rotundifolia Lam., along climatic gradients within its distribution range in Tunisia. Methods We have explored variations in seed morphological traits, desiccation sensitivity level, germination and shoot emergence rates under different controlled temperature conditions, among 15 populations of Q. ilex sampled throughout the Tunisian distribution of the species. Results Significant between-populations differences were observed for morphological seed traits but no relationships could be established with the climate of the sampling sites. In contrast, key physiological traits varied significantly with elevation and temperature. Specifically, mild temperatures in lowland regions were associated with higher seed moisture content, fast germination and shoot emergence rates at moderate temperatures (13 °C) for germination. Seeds of Q. ilex populations from cold sites displayed the fastest germination rates at low temperatures (5 °C) as well as the greatest lag between seed germination and shoot emergence time. Conclusion Intraspecific variation in seed physiological traits is significantly associated with local climate. This functional diversity should be considered when evaluating germplasm and predicting suitability for reforestation and assisted migration programs.

We present three multi-scale similarity learning architectures, or DeepSim networks. These models learn pixel-level matching with a contrastive loss and are agnostic to the geometry of the considered scene. We establish a middle ground between hybrid and end-to-end approaches by learning to densely allocate all corresponding pixels of an epipolar pair at once. Our features are learnt on large image tiles to be expressive and capture the scene's wider context. We also demonstrate that curated sample mining can enhance the overall robustness of the predicted similarities and improve the performance on radiometrically homogeneous areas. We run experiments on aerial and satellite datasets. Our DeepSim-Nets outperform the baseline hybrid approaches and generalize better to unseen scene geometries than end-to-end methods. Our flexible architecture can be readily adopted in standard multi-resolution image matching pipelines.

Petroleum hydrocarbons (PHs) are used as raw materials in many industries and primary energy sources. However, excessive PHs act as soil pollutants, posing serious threats to living organisms. Various ex-situ or in-situ chemical and biological methods are applied to restore polluted soil. However, most of the chemical treatment methods are expensive, environmentally unfriendly, and sometimes inefficient. That attracts scientists and researchers to develop and select new strategists to remediate polluted soil through risk-based analysis and eco-friendly manner. This review discusses the sources of PHs, properties, distribution, transport, and fate in the environment, internal and external factors affecting the soil remediation and restoration process, and its effective re-utilization for agriculture. Bioremediation is an eco-friendly method for degrading PHs, specifically by using microorganisms. Next-generation sequencing (NGS) technologies are being used to monitor contaminated sites. Currently, these new technologies have caused a paradigm shift by giving new insights into the microbially mediated biodegradation processes by targeting rRNA are discussed concisely. The recent development of risk-based management for soil contamination and its challenges and future perspectives are also discussed. Furthermore, nanotechnology seems very promising for effective soil remediation, but its success depends on its cost-effectiveness. This review paper suggests using bio-electrochemical systems that utilize electro-chemically active microorganisms to remediate and restore polluted soil with PHs that would be eco-friendlier and help tailor-made effective and sustainable remediation technologies.

Background B cells contribute significantly to the pathogenesis of primary Sjogren's syndrome (pSS). Free light chains (FLCs) are generated during the production of immunoglobulins (Igs) and are surrogates of B cell activity. We hypothesized that salivary FLCs and salivary Igs could represent salivary gland inflammation and therefore, serve as biomarkers in pSS. Methods Patients >18 years old fulfilling the American College of Rheumatology / European League Against Rheumatism (EULAR) 2016 criteria for pSS and age-matched healthy and disease controls (sicca non-pSS, rheumatoid arthritis, systemic lupus erythematosus) were recruited for this cross-sectional study. FLCs in saliva and serum were measured by immunoturbidimetry. Serum and salivary Igs were measured by nephelometry and enzyme-linked immunosorbent assay, respectively. Area under the receiver operator characteristic curve was determined. The factors influencing the serum and salivary FLCs in pSS were determined using backward linear regression. Results A total of 78 patients with pSS, 76 healthy controls and 62 disease controls were recruited. Median EULAR SS disease activity index (interquartile range) was 1 (3.75). Serum FLCκ and FLCλ, salivary FLCλ, serum and salivary IgG, salivary IgM was significantly higher in the pSS group compared to the controls. Areas under the curve for salivary FLCλ, serum FLCκ, serum and salivary IgG were 0.75, 0.72, 0.78 and 0.77, respectively. Regression analysis showed that salivary FLCκ, salivary FLCλ and salivary IgG were associated with positive salivary gland histopathology. Use of immunosuppressants and glucocorticoids was associated with lower values of salivary parameters. Conclusion Salivary FLCλ and salivary IgG were significantly different between pSS and control groups and could be potential non-invasive biomarkers in pSS. These findings should be confirmed in larger longitudinal studies.

Unclassified hepatic hepatocellular adenoma in men is still a challenging entity regarding clinical manifestations, diagnosis, and treatment as in our case. It still need more investigations determining their characteristics, risk of complications and malignant transformation in order to improve their therapeutic care.

Applying the principles of circular economy to agriculture is a very important contemporary issue on the international political and economic agenda. In this context, current knowledge and recent insights on biosurfactant production will be surveyed to apply these novel economic approaches in the field of agricultural waste valorisation. The main objective of the CREIAMO project is to set up a replicable methodology for boosting the transition towards circular economy of the oil and wine production sectors through the creation of new destinations for residues originated, new options for their economic valorisation and new business models to increase the competitiveness of companies. A first pilot application will be run in the Lombardia Region. To achieve this objective, the project operates on different eco-innovation strategies: a. Process and product eco-innovation for the exploitation of agriculture wastes from the production of wine and olive oil for producing eco-friendly biosurfactants. Cost-effective production methods will be implemented to improve its market profitability, resulting in higher yields and purity. In CREAIMO, theses bio value-added products will be, therefore, used to treat contaminated soil, which represents a main environmental issue. b. Systemic eco-innovation through industrial symbiosis (IS), allowing companies to achieve at the same time economic, environmental, and social advantages. This project will represent the first structured attempt of industrial symbiosis implementation in the Lombardia region, aiming at creating a symbiosis network with the active participation of both SMEs and local stakeholders.

By studying the geometric shape of the earth which scientists have proven to have a flat surface at the north pole and south pole and vertigo at the equator, I guess there was a relationship between the geometric shape of a circumference of the earth and the number of days in the lunar year. As we know the geometric shape of the earth was a source of research for several scholars in previous centuries. Most of them realized that it is spherical, then they discovered that the north and south poles are thus flattened with an equatorial vertigo. According to these important results and which are or which present the starting points of my research of which I think that there was a fundamental relation between the secret geometric form of the earth as well as the measures and the angles adopted in its creation and the number of days in the lunar year. Also, I will unveil the secret or where did the ancient Egyptians inspire the geometric shape of the pyramid of Cheops and I will prove that it is related to the relationship between the geometric shape of the earth and another share with the numbers of the days of the lunar year which I named relation between terrestrial pyramid and pyramid of Cheops. Afterwards I will theoretically calculate the flat surface of the poles which are equal and that the result presents the scientific proof of my hypothesis., {"references":["Vincent Deparis.la forme de la terre : plate, oblongue ou aplatie aux pôles? . https://planet-terre.ens-lyon.fr/ressource/histoire-forme-Terre.xml.(12/10/2022)","Sebastian Escalon.Voici le premier modèle physique cohérent sur l'histoire de l'attractionlunaire!.https://lejournal.cnrs.fr/articles/voici-le-premier-modele-physique-coherent-sur-lhistoire-de-lattraction-lunaire.(12/10/2022)","Olivier Dequincey.observation de la lune depuis la terre, orbite et phases de la lune. https://planet-terre.ens-lyon.fr/ressource/observation-cycle-Lune.xml.(12/10/2022)","Nelly Lesage.La lune et la terre ne seraient pas aussi semblables qu'on le pensait. https://www.numerama.com/sciences/610457-la-lune-et-la-terre-ne-seraient-pas-aussi-semblables-quon-le-pensait.html.(12/10/2022)","Nicolas Lambert.la vraie forme de la terre. https://neocarto.hypotheses.org/11547 .(12/10/2022"]}

Introduction. Pure extra-thoracic sarcoidosis is rare and poorly characterized in the literature. Herein we present features of pure extra-thoracic sarcoidosis, in comparison with sarcoidosis with intra-thoracic involvement, in a population from the south of Tunisia. Methods. Retrospective, descriptive and comparative study of the patients presenting systemic sarcoidosis and attending the Department of Internal Medicine at the Hedi Chaker University Hospital, Sfax, Tunisia, for 21 years, from January 1996 to December 2016. Results. Twenty-four patients presented pure extra-thoracic sarcoidosis (30% of the cases of systemic sarcoidosis). There was a female predominance (79%). The mean age was 50 years. The main features were polyadenopathies (10 patients: 41.7%), cutaneous involvement (10 patients: 41.6%), inflammatory polyarthralgia (8 cases: 33.3%), general symptoms (6 patients: 25%), uveitis (6 cases: 25%), cholestasis (3 cases) and kidney involvement (2 cases). Lymphopenia, hypercalcemia, and hypercalciuria were observed each one in 12.5% of the cases, and high angiotensin converting enzyme (ACE) level in 38.5% of the cases. The histological proof was required in all the patients. Statistically significant associations identified were mainly hepatic involvement with general symptoms (p=0.035), peripheral lymphadenopathies (p=0.035) and kidney damage (p=0.022), and cutaneous involvement with articular manifestations (p=0.032). Systemic corticosteroids were used in half of the cases, with a good outcome in 21 cases, and recurrence in two cases. One patient was lost to follow up. The comparison to the form with mediastino-pulmonary involvement showed less lymphadenopathies (p=0.001), less lymphopenia (p=0.006), and less frequent use of corticosteroids (p=0.044). Conclusion. Our series was characterized by the frequency of the pure extra-thoracic form and the diversity of the systemic manifestations.

Evidence suggests that dissatisfaction with body image in women can be enhanced by exposure to media’s idealized images. The theory of social comparison and the avoidance hypothesis offer contradictory explanations of this relationship. We compare these two theories using a haptic virtual reality environment. We ask 42 female participants to interact with one of four types of virtual humans (VH) randomly assigned to them. The interaction task involves giving a virtual hug to a normal weight or overweight male or female VH. We verify the hypothesis that participants’ satisfaction with particular body parts and their anti-fat attitudes will determine the choice of the body area of the VH they will virtually touch. Our results show that: (1) touching VH lower torso is predicted by less anti-fat attitude, and avoidance of the upper torso and upper limb areas, and (2) touching VH shoulder and upper limbs areas is predicted by concerns with own stomach area and avoidance of VH lower torso and stomach waist areas. Our results tend to support the avoidance hypothesis as well as other research findings on anti-fat attitudes.

A novel decavanadate salt Mg(H2O)6(C6H14N2)2V10O28·8H2O is obtained by the reaction of vanadium oxide and 1,4-diazabicyclo [2.2.2] octane (DABCO). The title compound is characterized by infrared (IR) spectroscopy and powder X-ray diffraction (XRD). The spectroscopic characterization confirms the presence of the different groups in the structure. Powder XRD confirms the purity of the phase. Optical properties are recorded at room temperature using UV-Visible spectroscopy in the spectral range of 250-800 nm. According to the single crystal XRD analysis, the structure of the compound is orthorhombic: a = 17.927(6) A, b = 15.798(6) A, c = 15.723(5) A, V = 4452.8(7) A3, and Z = 4. The formula unit of Mg(H2O)6(C6H14N2)2V10O288H2O is formed by a decavanadate group, the $$\text{Mg(}{{\text{H}}_{2}}\text{O)}_{6}^{2+}$$ polyhedron, two organic (C6H14N2)2+ cations, and eight water molecules. In the crystal, molecules are linked by O–H…O and N–H…O hydrogen bonds, forming a three-dimensional network.

This study examines the influence of the COVID-19 pandemic on the stock liquidity of S&P 500 firms. We construct a daily data set for stock liquidity and the numbers of COVID-19 reported cases and deaths for the period from 1 January 2020 to 31 December 2020. The regression results show that there is a significant negative relationship between COVID-19 (as measured by the daily growth in the numbers of cases and deaths) and stock liquidity, implying that the COVID-19 pandemic decreases firm liquidity. Furthermore, our analysis reveals a significant difference in liquidity between sectors. In addition, our results remain robust to the use of an alternative proxy for liquidity and to alternative estimation approaches. The results of this study will allow key players in the stock market to recognize and forecast the behavior of stock liquidity during periods marked by pandemic diseases.