221 results on '"Charles, Andrew"'
Search Results
2. Kienböck Disease
- Author
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Charles Andrew Daly and Alexander Reed Graf
- Subjects
Orthopedics and Sports Medicine ,Surgery - Published
- 2022
3. Cryotherapy versus Laser Does Not Influence Anatomic Success after Vitrectomy for Primary Rhegmatogenous Retinal Detachment Repair
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Justin C. Galvin, Arul Earnest, Jacob Egwunye, Rohan W. Essex, Adrian T. Fung, Rohan Essex, Susannah Ahern, Penny Allen, Fred Chen, Ben Clarke, Stewart Lake, Matthew Simunovic, Robert Charles Andrew Symons, Joel Yap, Jolly Gilhotra, and Weng Chan
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Ophthalmology - Published
- 2022
4. Shifting Mortality Dynamics in the United States During the COVID-19 Pandemic as Measured by Years of Life Lost
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Charles Andrew Czeisler and Mark Czeisler
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Internal Medicine ,General Medicine - Published
- 2023
5. Supplementary Data Set from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma
- Author
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Kwok-Wai Lo, Dolly P. Huang, Joe W. Gray, Wen-Lin Kuo, Charles Andrew van Hasselt, Cleo Nga-Yee Lam, Katherine Wing-Ki Hung, Jonathan Shun-Tong Sham, Xin-Yuen Guan, Ka-Fai To, Raymond King-Yin Tsang, Hirokuni Takano, Yvonne Yan-Yan Or, and Angela Bik-Yu Hui
- Abstract
Array CGH data set
- Published
- 2023
6. Supplementary Figure S1 from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma
- Author
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Kwok-Wai Lo, Dolly P. Huang, Joe W. Gray, Wen-Lin Kuo, Charles Andrew van Hasselt, Cleo Nga-Yee Lam, Katherine Wing-Ki Hung, Jonathan Shun-Tong Sham, Xin-Yuen Guan, Ka-Fai To, Raymond King-Yin Tsang, Hirokuni Takano, Yvonne Yan-Yan Or, and Angela Bik-Yu Hui
- Abstract
Supplementary Figure S1 from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma
- Published
- 2023
7. Data from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma
- Author
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Kwok-Wai Lo, Dolly P. Huang, Joe W. Gray, Wen-Lin Kuo, Charles Andrew van Hasselt, Cleo Nga-Yee Lam, Katherine Wing-Ki Hung, Jonathan Shun-Tong Sham, Xin-Yuen Guan, Ka-Fai To, Raymond King-Yin Tsang, Hirokuni Takano, Yvonne Yan-Yan Or, and Angela Bik-Yu Hui
- Abstract
Nasopharyngeal carcinoma is highly prevalent in Southern China and Southeast Asia. To unveil the molecular basis of this endemic disease, high-resolution comparative genomic hybridization arrays were used for systematic investigation of genomic abnormalities in 26 nasopharyngeal carcinoma samples. A comprehensive picture of genetic lesions associated with tumorigenesis of nasopharyngeal carcinoma was generated. Consistent chromosomal gains were frequently found on 1q, 3q, 8q, 11q, 12p, and 12q. High incidences of nonrandom losses were identified on chromosomes 3p, 9p, 11q, 14q, and 16q. In addition to previously characterized regions, we have identified several novel minimal regions of gains, including 3q27.3-28, 8q21-24, 11q13.1-13.3, and 12q13, which may harbor candidate nasopharyngeal carcinoma–associated oncogenes. In this study, gain of 11q13.1-13.3 was the most frequently detected chromosomal aberration and a 5.3-Mb amplicon was delineated at this region. Within this 11q13 amplicon, concordant amplification and overexpression of cyclin D1 (CCND1) oncogene was found in nasopharyngeal carcinoma cell lines, xenografts, and primary tumors. Knockdown of cyclin D1 by small interfering RNA in nasopharyngeal carcinoma cell lines led to significant decrease of cell proliferation. The findings suggest that cyclin D1 is a target oncogene at 11q13 in nasopharyngeal carcinoma and its activation plays a significant role in nasopharyngeal carcinoma tumorigenesis.
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- 2023
8. Supplementary Tables S1& S2 from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma
- Author
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Kwok-Wai Lo, Dolly P. Huang, Joe W. Gray, Wen-Lin Kuo, Charles Andrew van Hasselt, Cleo Nga-Yee Lam, Katherine Wing-Ki Hung, Jonathan Shun-Tong Sham, Xin-Yuen Guan, Ka-Fai To, Raymond King-Yin Tsang, Hirokuni Takano, Yvonne Yan-Yan Or, and Angela Bik-Yu Hui
- Abstract
Supplementary Tables S1& S2 from Array-Based Comparative Genomic Hybridization Analysis Identified Cyclin D1 as a Target Oncogene at 11q13.3 in Nasopharyngeal Carcinoma
- Published
- 2023
9. Changing plant functional diversity over the last 12,000 years provides perspectives for tracking future changes in vegetation communities
- Author
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Matthew Adesanya Adeleye, Simon Graeme Haberle, Rachael Gallagher, Samuel Charles Andrew, and Annika Herbert
- Subjects
Ecology ,Ecology, Evolution, Behavior and Systematics - Published
- 2023
10. Kienböck Disease: Clinical Presentation, Epidemiology, and Historical Perspective
- Author
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Charles Andrew, Daly and Alexander Reed, Graf
- Subjects
Osteonecrosis ,Humans ,Lunate Bone ,Prospective Studies - Abstract
In the now 110 years that have passed since Kienböck first published his seminal description of lunate osteonecrosis, improvements in imaging technology and surgical technique have provided a better understanding of Kienböck disease pathogenesis and treatment. However, the precise etiology, natural history, and optimal treatment remain controversial. Future studies examining the genetics behind the disease and large-scale prospective studies comparing treatment options represent the next step in improving our understanding of this rare and complex phenomenon.
- Published
- 2022
11. Machine Vision-Based Fall Detection System using MediaPipe Pose with IoT Monitoring and Alarm
- Author
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Charles Andrew Q. Bugarin, Juan Miguel M. Lopez, Scud Gabriel M. Pineda, Ma. Franzeska C. Sambrano, and Pocholo James M. Loresco
- Published
- 2022
12. Years of Life Lost in the United States During the COVID-19 Pandemic, March 2020 to October 2021
- Author
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Charles Andrew Czeisler and Mark Czeisler
- Abstract
BackgroundGiven a downward age shift in COVID-19-involved deaths observed during the COVID-19 pandemic, we sought to estimate years of life lost (YLL) associated with leading causes of US death during the first 20 months of the pandemic.FindingsDespite 4796 fewer COVID-19 deaths in Jan-Oct 2021 than in Mar-Dec 2020, the number of YLL due to COVID-19 increased by 1,159,761, from 4,474,186 to 5,633,947 (a 25.9% increase). YLL per COVID-19 death increased from 12.8 in 2020 to 16.3 in 2021, a 27.7% increase. YLL per death did not change by more than 2.3% for any other cause.InterpretationIncreased YLL per COVID-19 death in 2021 result from younger-age COVID-19 mortality, contributing to a marked increase in YLL from this preventable cause of death at a later stage of the pandemic despite advancements in vaccines in treatments.
- Published
- 2022
13. Contrast Increment and Decrement Processing in Individuals With and Without Diabetes
- Author
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Vanessa Thien Sze Tang, Robert Charles Andrew Symons, Spiros Fourlanos, Daryl Guest, and Allison Maree McKendrick
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General Medicine - Published
- 2023
14. Thumb Opposition Strength in Healthy Adults- A Baseline Study
- Author
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Charles Andrew R Chu-Santos and Precious Grace B Handog
- Subjects
medicine.medical_specialty ,Baseline study ,Physical medicine and rehabilitation ,business.industry ,medicine ,Thumb opposition ,General Medicine ,business - Published
- 2021
15. An overview of optometrists' diabetic retinopathy practice patterns – a cross‐sectional survey
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Vanessa Tang, Daryl Guest, Allison M McKendrick, and Robert Charles Andrew Symons
- Subjects
Optometrists ,Diabetic Retinopathy ,genetic structures ,Referral ,Practice patterns ,business.industry ,Cross-sectional study ,Context (language use) ,Diabetic retinopathy ,Eye care ,medicine.disease ,Sensory Systems ,Ophthalmology ,Cross-Sectional Studies ,Diabetic macular oedema ,Community benefit ,Diabetes Mellitus ,Humans ,Optometry ,Medicine ,Practice Patterns, Physicians' ,business - Abstract
Purpose Contemporary eye care increasingly recommends the use of advanced retinal imaging technology. Anecdotal evidence suggests that this equipment is widely available in primary eye care settings; however, knowledge regarding how optometrists use this equipment in the context of diabetic retinopathy (DR) is limited. This study aimed to obtain a current overview of optometrists' clinical practice behaviours in the detection, screening, diagnosis and management of patients with diabetes. Methods A cross-sectional survey was designed to evaluate optometrists' self-reported clinical practice patterns and perceptions, as well as the availability and impact of retinal imaging equipment specific to DR and diabetic macular oedema (DMO) on optometrists' clinical practice. The survey invited participation from all optometrists practising in Australia. Results One hundred and sixty-seven optometrists participated. Optometrists' self-reported confidence in assessing DR and DMO was high. Optometrists' referral patterns considered the severity of DR and DMO before initiating referral to secondary ophthalmology care. Nearly all optometrists (98.8%) indicated that they had some form of retinal imaging equipment available to them in clinical practice. An optical coherence tomography (OCT) device was available to 75.5% of optometrists. A significant association between having an OCT device in the practice and higher self-reported confidence levels in the assessment of DMO was found. Conclusions Many optometrists are well equipped with sophisticated retinal imaging technology for the provision of high-quality eye care. Enhancing optometric training and education programmes can maximise the community benefit of access to this equipment and improve delivery of eye care in the community.
- Published
- 2021
16. Immediate or delayed breast reconstruction: the aspects of timing, a narrative review
- Author
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Lisbet Rosenkrantz Hölmich, Farah Sayegh, and Charles Andrew Salzberg
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Psychotherapist ,Narrative review ,General Medicine ,Breast reconstruction ,Psychology - Published
- 2023
17. Society as real abstraction: Adorno’s critique of economic nature
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Charles Andrew Prusik
- Published
- 2022
18. Electrophysiological and Behavioral Testing Reveal Aberrant Visual Processing in Syngap1+/- Mice
- Author
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Martin, Charles Andrew
- Subjects
Behavioral Neuroscience ,genetic structures ,90399 Biomedical Engineering not elsewhere classified ,FOS: Medical engineering ,eye diseases ,Neuroscience - Abstract
Syngap1+/- is a mouse mode for intellectual disability and autism spectrum disorder where haploinsufficiency of the Syngap1 gene and therefore downregulation of SynGAP1 leads to early maturation of synapses within the brain within post-natal days fourteen and sixteen instead of at the normal developmental schedule of post-natal day thirty. This early-shifted timeline falls directly before the visual critical where binocular matching between inputs from the two eyes occurs, and during a period where neurons become selective to specific orientations. High-level visual and cognitive issues observed in autism spectrum disorder patients might follow from deficits in basic sensory processing development, but it is not yet understand how Syngap1 haploinsufficiency affects visual development and visual processing. Therefore, to characterize visual processing within the Syngap1+/- mouse model of autism spectrum disorder, acute electrophysiological recordings were performed within the monocular and binocular regions of the mouse visual cortex (V1). Responses to a series of visual stimuli were analyzed to measure and compare receptive field size, orientation selectivity, and binocularity between Syngap1+/- mice and littermate controls. In order to understand how potential deficits in physiology could translate into visual perception, a behavioral training protocol was implemented which isolated visual acuity in mice. In accordance with known developmental timelines in the visual cortex, it was found that the receptive field sizes of V1 neurons in Syngap1+/- mice were unchanged from wild type controls. However, these same neurons had wider tuning curves and lower firing rates than neurons in littermate controls. Ocular dominance was unaltered between Syngap1+/- and wild type mice, but this was possibly due to low sample sizes of neurons from the binocular regions of V1. At the behavioral level, lower visual acuities were discovered in Syngap1+/- mice with a size degree difference compared to littermate controls – a minor but significant difference. These results indicate a reduction in SynGAP1 expression has a perceivable effect on V1 development and function at both physiological and behavioral levels.
- Published
- 2022
- Full Text
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19. The effect of crop rotations on soil
- Author
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Caio Fernandes Zani, Arlete Simões Barneze, Rogério Peres Soratto, and Charles Andrew Francis
- Published
- 2022
20. Is the Vectra 3D Imaging System a Reliable Tool for Predicting Breast Mass?
- Author
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Ilana G Margulies, Kasey Leigh Wood, Jordan Jacobs, Yasmina Zoghbi, Andrew Y Ashikari, and Charles Andrew Salzberg
- Subjects
Correlation coefficient ,Breast Neoplasms ,030230 surgery ,Body Mass Index ,Correlation ,03 medical and health sciences ,symbols.namesake ,Imaging, Three-Dimensional ,0302 clinical medicine ,Humans ,Medicine ,Mastectomy ,Retrospective Studies ,business.industry ,Confounding ,Reproducibility of Results ,Bartlett's test ,Pearson product-moment correlation coefficient ,030220 oncology & carcinogenesis ,symbols ,Surgery ,Underweight ,medicine.symptom ,business ,Nuclear medicine ,Breast reconstruction ,Body mass index - Abstract
BACKGROUND In selecting breast implants for breast reconstruction, current preoperative planning largely relies on 2-dimensional measurements, which are often limited in suboptimal accuracy and objectivity. Although the introduction of 3-dimensional imaging modalities has further improved preoperative planning, they require in-depth analysis of accuracy if they are to be considered as a standardized part of preoperative planning. Thus, the present study analyzes the reliability of the Vectra 3D Imaging System in predicting breast mass and explores potential confounding variables that may limit its accuracy. METHODS A retrospective review of 202 breasts that received direct-to-implant reconstruction by a single surgeon between February 2015 and February 2019 was conducted. Variables recorded included Vectra predicted mass (VPM; in grams), mastectomy mass (MM; in grams), ptosis grade, and body mass index (BMI). Body mass index was classified as follows: underweight (BMI < 20 kg/m), normal (20 kg/m ≤ BMI < 25 kg/m), overweight (25 kg/m ≤ BMI < 30 kg/m), and obese (BMI ≥ 30 kg/m). Cup size was approximated as follows: A and smaller (MM ≤250 g), B (250 g < MM ≤ 450 g), C (450 g < MM ≤ 600 g), and D and larger (MM ≥ 600 g). Correlation between MM and VPM was evaluated using 2-tailed Pearson correlation coefficients (r), and associated formula was derived from a linear model. Equality of variances was assessed with the Bartlett test. Correlation coefficients calculated for ptosis and BMI categories were then compared with the overall correlation coefficient. Significance was set at α = 0.05, and analyses were conducted in R 3.6.0, version 1.70. RESULTS There was a strong correlation between MM and VPM (R = 0.90, P < 0.0001). The following equation was derived to predict MM: [MM] = 0.8 × [VPM] + 32 (adjusted r = 0.81). The Bartlett test indicated that VPM varies significantly across cup sizes (P < 0.0001). Comparison of correlation coefficients for ptosis and BMI categories revealed a significantly reduced correlation coefficient for pseudoptosis (0.90 vs 0.75, P = 0.0425). CONCLUSIONS The present study suggests that the reliability of Vectra in predicting breast mass varies across cup sizes and that there exists a significantly decreased association between VPM and MM among pseudoptotic breasts. These are important considerations when using this technology in surgical planning.
- Published
- 2020
21. In situ tribometry with real-time imaging for assessing durability and wear mechanisms of easy-to-clean coatings on glass for touchscreen substrates
- Author
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Jolanta E. Klemberg-Sapieha, Bill Baloukas, Thomas Schmitt, Jincheng Qian, Charles Andrew Paulson, Null Eric Louis, Carlo Kosik-Williams, James Joseph Price, and Ludvik Martinu
- Subjects
010302 applied physics ,Microscope ,Materials science ,Scanning electron microscope ,engineering.material ,Tribology ,01 natural sciences ,law.invention ,Abrasion (geology) ,010309 optics ,Human-Computer Interaction ,Optical microscope ,Coating ,Hardware and Architecture ,law ,0103 physical sciences ,engineering ,Electrical and Electronic Engineering ,Composite material ,Contact area ,Tribometer - Abstract
Touchscreens are now commonplace around the world, and easy-to-clean (ETC) coatings are integral in ensuring an enhanced usability and interactivity with these devices. In the present work, we evaluate the durability and study the wear mechanisms of a fluorine-containing easy-to-clean coating on glass using an in situ tribometer (TribTik). The TribTik is equipped with a microscope lens and camera system that allows one to image, in real time, the contact area between the glass substrate and the abrading counterpart. Through this unique combination, the instantaneous coefficient of friction and the contact area’s status can be monitored and correlated in situ. The in situ monitoring enables one to stop the abrasion cycles at critical stages of the wear process so that the morphology and composition of the wear tracks can be examined in an effort to understand the wear mechanisms of the ETC. We demonstrate that changes in the instantaneous coefficient of friction (COF) are correlated with changes in the in situ images. Critical stages of wear evolution are also identified via optical microscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and Raman analyses. The evolution of the ETC wear mechanism, from start to finish, was found to be described by the following sequence: (1) generation of unconsolidated debris, (2) formation of a layered tribofilm, (3) cracking of the tribofilm, and (4) general failure of the ETC and subsequent damage to the underlying glass substrate. Our study shows that, TribTik, a tribometry system with real-time imaging capability, is a powerful tool to characterize the tribological properties of coatings on touchscreens and/or display substrates.
- Published
- 2019
22. Created Ecosystems and the Concept of Succession
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Charles Andrew Cole
- Subjects
Geography ,Ecology ,Ecosystem ,Ecological succession ,Nature and Landscape Conservation - Published
- 2019
23. A Case of Glaucoma in Hereditary Spherocytosis
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Robert Charles Andrew Symons, Simon E. Skalicky, Haiying Chen, and Eleni Mayson
- Subjects
Ankyrins ,Male ,Retinal Ganglion Cells ,0301 basic medicine ,Intraocular pressure ,medicine.medical_specialty ,genetic structures ,Spherocytosis ,Visual Acuity ,Glaucoma ,Spherocytosis, Hereditary ,Hereditary spherocytosis ,03 medical and health sciences ,Nerve Fibers ,Ophthalmology ,Normal tension glaucoma ,Retinal Vein Occlusion ,medicine ,Humans ,Low Tension Glaucoma ,Intraocular Pressure ,Aged ,Incidental Findings ,business.industry ,medicine.disease ,eye diseases ,030104 developmental biology ,Optic nerve ,Branch retinal vein occlusion ,sense organs ,business ,Tomography, Optical Coherence - Abstract
Purpose To report a case of glaucoma and the inherited red cell membranopathy hereditary spherocytosis diagnosed simultaneously in 2 individuals in a family. Patient A 66-year-old man with normal pressure glaucoma and hereditary spherocytosis. Results This patient presented with a branch retinal vein occlusion, and normal tension glaucoma that was incidentally detected. Further history revealed that the patient's maternal grandmother also had hereditary spherocytosis and glaucoma. Conclusions We hypothesize that glaucoma and hereditary spherocytosis may be associated. Hereditary spherocytosis may be a potential risk factor for glaucoma by causing impaired blood supply to the optic nerve.
- Published
- 2018
24. The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis
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Peter Hickey, Anne K. Voss, Robert Charles Andrew Symons, Tim Thomas, Daniela Amann-Zalcenstein, Waruni Abeysekera, Sabrina M. Lewis, Leigh Coultas, Zoe L. Grant, Alexandra L. Garnham, Gordon K. Smyth, Lachlan Whitehead, and Tracey M. Baldwin
- Subjects
Endothelium ,Angiogenesis ,Embryonic Development ,Histones ,Histone H3 ,Mice ,Cell Movement ,medicine ,Human Umbilical Vein Endothelial Cells ,Animals ,Humans ,KAT7 ,Molecular Biology ,Cells, Cultured ,Histone Acetyltransferases ,Sprouting angiogenesis ,Mice, Inbred BALB C ,biology ,Neovascularization, Pathologic ,Lysine ,Endothelial Cells ,Acetylation ,Histone acetyltransferase ,Cell biology ,Endothelial stem cell ,Mice, Inbred C57BL ,medicine.anatomical_structure ,biology.protein ,Female ,Developmental Biology - Abstract
Blood vessel growth and remodelling are essential during embryonic development and disease pathogenesis. The diversity of endothelial cells (ECs) is transcriptionally evident and ECs undergo dynamic changes in gene expression during vessel growth and remodelling. Here, we investigated the role of the histone acetyltransferase HBO1 (KAT7), which is important for activating genes during development and for histone H3 lysine 14 acetylation (H3K14ac). Loss of HBO1 and H3K14ac impaired developmental sprouting angiogenesis and reduced pathological EC overgrowth in the retinal endothelium. Single-cell RNA sequencing of retinal ECs revealed an increased abundance of tip cells in Hbo1-deficient retinas, which led to EC overcrowding in the retinal sprouting front and prevented efficient tip cell migration. We found that H3K14ac was highly abundant in the endothelial genome in both intra- and intergenic regions, suggesting that HBO1 acts as a genome organiser that promotes efficient tip cell behaviour necessary for sprouting angiogenesis. This article has an associated ‘The people behind the papers’ interview.
- Published
- 2021
25. Spectacular Logic in Hegel and Debord
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Carl Cassegård, Mathias Nilges, Charles Andrew Prusik, and Eric-John Russell
- Published
- 2021
26. The phosphoinositide 5-phosphatase INPP5K: From gene structure to in vivo functions
- Author
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Bastien Moes, Stéphane Schurmans, Christophe Desmet, and Charles-Andrew Vande Catsyne
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0301 basic medicine ,Cancer Research ,Cytoskeleton organization ,Phosphatase ,biology_other ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Protein Domains ,Genetics ,Animals ,Humans ,Inositol ,Molecular Biology ,Phosphatidylinositol (3,4,5)-trisphosphate ,Endoplasmic reticulum ,Inositol Polyphosphate 5-Phosphatases ,Subcellular localization ,Cell biology ,Protein Transport ,030104 developmental biology ,chemistry ,Phosphatidylinositol 4,5-bisphosphate ,030220 oncology & carcinogenesis ,Mutation ,Unfolded protein response ,Molecular Medicine ,Signal Transduction - Abstract
INPP5K (Inositol Polyphosphate 5-Phosphatase K, or SKIP (for Skeletal muscle and Kidney enriched Inositol Phosphatase) is a member of the phosphoinositide 5-phosphatases family. Its protein structure is comprised of a N-terminal catalytic domain which hydrolyses both PtdIns(4,5)P2 and PtdIns(3,4,5)P3, followed by a SKICH domain at the C-terminus which is responsible for protein-protein interactions and subcellular localization of INPP5K. Strikingly, INPP5K is mostly concentrated in the endoplasmic reticulum, although it is also detected at the plasma membrane, in the cytosol and the nucleus. Recently, mutations in INPP5K have been detected in patients with a rare form of autosomal recessive congenital muscular dystrophy with cataract, short stature and intellectual disability. INPP5K functions extend from control of insulin signaling, endoplasmic reticulum stress response and structural integrity, myoblast differentiation, cytoskeleton organization, cell adhesion and migration, renal osmoregulation, to cancer. The goal of this review is thus to summarize and comment recent and less recent data in the literature on INPP5K, in particular on the structure, expression, intracellular localization, interactions and functions of this specific member of the 5-phosphatases family.
- Published
- 2020
27. The Phosphoinositide 5-Phosphatase inpp5k: From Gene Structure to in Vivo Functions
- Author
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Charles-Andrew Vande Catsyne, Bastien Moes, Stéphane Schurmans, and Christophe Desmet
- Subjects
chemistry.chemical_compound ,chemistry ,Cytoskeleton organization ,Phosphatidylinositol 4,5-bisphosphate ,Phosphatidylinositol (3,4,5)-trisphosphate ,Endoplasmic reticulum ,Phosphatase ,Unfolded protein response ,Inositol ,Subcellular localization ,Cell biology - Abstract
INPP5K (Inositol Polyphosphate 5-Phosphatase K, or SKIP (for Skeletal muscle and Kidney enriched Inositol Phosphatase) is a member of the phosphoinositide 5-phosphatases family. Its protein structure is comprised of a N-terminal catalytic domain which hydrolyses both PtdIns(4,5)P2 and PtdIns(3,4,5)P3, followed by a SKICH domain at the C-terminus which is responsible for protein-protein interactions and subcellular localization of INPP5K. Strikingly, INPP5K is mostly concentrated in the endoplasmic reticulum, although it is also detected at the plasma membrane, in the cytosol and the nucleus. Recently, mutations in INPP5K have been detected in patients with a rare form of autosomal recessive congenital muscular dystrophy with cataract, short stature and intellectual disability. INPP5K functions extend from control of insulin signaling, endoplasmic reticulum stress response and structural integrity, myoblast differentiation, cytoskeleton organization, cell adhesion and migration, renal osmoregulation, to cancer. The goal of this review is thus to summarize and comment recent and less recent data in the literature on INPP5K, in particular on the structure, expression, intracellular localization, interactions and functions of this specific member of the 5-phosphatases family.
- Published
- 2020
28. Industrial-grade anti-reflection coatings with extreme scratch resistance
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Shandon Dee Hart, Carlo Kosik Williams, Alexandre Michel Mayolet, Binwei Zhang, Chang-Gyu Kim, Karl W. Koch, Jeong-Hong Oh, Jaymin Amin, Ananth N Subramanian, Charles Andrew Paulson, Lin Lin, and James Joseph Price
- Subjects
Materials science ,business.industry ,Optical engineering ,02 engineering and technology ,Nanoindentation ,engineering.material ,021001 nanoscience & nanotechnology ,01 natural sciences ,Durability ,Atomic and Molecular Physics, and Optics ,010309 optics ,Optics ,Optical coating ,Coating ,Scratch ,0103 physical sciences ,Transmittance ,engineering ,Optoelectronics ,Electronics ,0210 nano-technology ,business ,computer ,computer.programming_language - Abstract
Anti-reflection coatings are widely used throughout the field of optical technology such as in corrective eyeglasses, camera lenses, and microscope optics, to improve the transmittance and reduce the reflectance of glass and other transparent materials. To date, these coatings have suffered from relatively poor scratch resistance and high scratch visibility compared to standard glasses. This has limited their use in applications requiring high mechanical durability such as on the chemically strengthened glasses widely used in modern touch screen devices. Here extremely scratch-resistant anti-reflection coatings are fabricated using industrially scalable reactive sputtering processes. These coatings provide a combination of surface reflectance below 0.7%, low color shifts, nanoindentation hardness as high as 18 GPa, and levels of scratch resistance which dramatically exceed commercial chemically strengthened glasses. An interdisciplinary opto-mechanical design approach has enabled a significant paradigm shift in the use of high-precision optical coatings for mechanically demanding applications. As a direct outcome of the work reported in this Letter, similar coating designs have been successfully deployed on millions of consumer electronics devices with very robust field performance.
- Published
- 2020
29. Impact of metformin on immunological markers: Implication in its anti-tumor mechanism
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Charles Andrew van Hasselt, Peter Y.M. Woo, George G. Chen, Stephanie C.P. Ng, Danny T.M. Chan, George K.C. Wong, Wai Sang Poon, and Michael C. F. Tong
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0301 basic medicine ,endocrine system diseases ,medicine.medical_treatment ,Antineoplastic Agents ,Energy homeostasis ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Neoplasms ,medicine ,Tumor Microenvironment ,Animals ,Humans ,Pharmacology (medical) ,Pharmacology ,Tumor microenvironment ,business.industry ,Mechanism (biology) ,Macrophages ,Immunotherapy ,Metformin ,Review article ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Cytokines ,business ,Adjuvant ,medicine.drug - Abstract
Metformin, an anti-hyperglycemic drug, has been known to have antitumor properties for around 15 years. Although there are a number of reports attributing the antitumor function of metformin to its impact on energy homeostasis and oxygen re-distribution in tumor microenvironment, detailed mechanisms remain largely unknown. In the past several years, there is an increasing number of publications indicating that metformin can affect various immunological components including lymphocytes, macrophages, cytokines and several key immunological molecules in both human and animal studies. These interesting results appear to be in line with emerging data that suggest associations between immune responses and energy homeostasis/oxygen re-distribution, which may explain effective impacts of metformin on immunotherapies against autoimmune diseases as well as cancers. This review article is to analyse and discuss recent development in the above areas with aim to justify metformin as a new adjuvant for immunotherapy against human cancers. We hope that our summary will help to optimize the application of metformin for various types of human cancers.
- Published
- 2020
30. PARACENTRAL ACUTE MIDDLE MACULOPATHY IN A CASE OF HIGH-FLOW DIRECT CAROTID CAVERNOUS FISTULA
- Author
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Robert Charles Andrew Symons, Chi Yun Doreen Ho, Bernard Yan, and Thomas G Hardy
- Subjects
Male ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Optic nerve function ,Macular Degeneration ,Carotid-Cavernous Sinus Fistula ,Ptosis ,Optical coherence tomography ,Retinal Diseases ,Ophthalmology ,medicine ,Humans ,Fluorescein Angiography ,Carotid-cavernous fistula ,medicine.diagnostic_test ,business.industry ,External ophthalmoplegia ,General Medicine ,Middle Aged ,medicine.disease ,eye diseases ,Maculopathy ,medicine.symptom ,High flow ,business ,Tomography, Optical Coherence - Abstract
PURPOSE: To report a case of paracentral acute middle maculopathy in a patient with high-flow carotid cavernous fistula. METHODS: A case report of a 53-year-old male patient who sustained an iatrogenic high-flow carotid cavernous fistula and secondary paracentral acute middle maculopathy. RESULTS: At review 1-week postembolization of the carotid cavernous fistula, there was no significant improvement in visual acuity, tests of optic nerve function, external ophthalmoplegia, and ptosis. Spectral domain optical coherence tomography was performed, which revealed hyperreflectivity of the parafoveal plexiform layers of the right eye with ill-defined margins straddling the inner nuclear layer. CONCLUSION: We suggest that spectral domain optical coherence tomography be performed in cases of high-flow direct carotid cavernous fistula where the best-corrected visual acuity is reduced out of keeping with other ophthalmic manifestations.
- Published
- 2020
31. Acute undifferentiated leukemia: data on incidence and outcomes from a large population-based database
- Author
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Ayman Qasrawi, Reinhold Munker, V. A. M. Gomes, Ranjana Arora, Charles Andrew Chacko, Reshma Ramlal, Melissa Kesler, Sainan Wei, and Akila Mansour
- Subjects
Male ,Cancer Research ,Myeloid ,Multivariate analysis ,Databases, Factual ,medicine.medical_treatment ,Biopsy ,computer.software_genre ,0302 clinical medicine ,hemic and lymphatic diseases ,Epidemiology ,Child ,Database ,Incidence (epidemiology) ,Incidence ,Myeloid leukemia ,Hematology ,Middle Aged ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Prognosis ,Immunohistochemistry ,Leukemia ,Leukemia, Myeloid, Acute ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Child, Preschool ,Population Surveillance ,Female ,Adult ,medicine.medical_specialty ,Adolescent ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,Acute Undifferentiated Leukemia ,Aged ,Chemotherapy ,business.industry ,Infant, Newborn ,Infant ,medicine.disease ,Survival Analysis ,Patient Outcome Assessment ,Neoplasm Grading ,business ,computer ,030215 immunology ,SEER Program - Abstract
Acute undifferentiated leukemia (AUL) is rare and defined by the absence of bona fide myeloid and lymphoid markers. Little is known about its incidence, survival and optimal management in the recent time period. Based on a case observed in our clinic, we queried the Surveillance, Epidemiology, and End Results database between 2000 and 2016. A total of 1,888 cases of AUL were diagnosed (1.34 per million person-years). The incidence of AUL has significantly decreased over time. Compared to other acute leukemias, patients with AUL have the highest median age (74 years); in contrast to acute myeloid leukemia (AML, 65) and acute lymphoblastic leukemia (ALL, 12). Excluding patients with preexisting malignancies, 1,444 patients with AUL were analyzed for survival. Only 35% of AUL patients had received chemotherapy. Comparatively, 94% of ALL and 71% of AML cases received chemotherapy. Among AUL patients who received chemotherapy, the median survival was 12 months as opposed to 1 month in the group who did not receive chemotherapy (or unknown status). Among adults, AUL patients had the worst prognosis, with a median overall survival (OS) of 9 months, compared to 27 months in ALL and 13 months in AML. Among children, the median OS was superior for all three groups of leukemias, the OS of AUL patients being better than in AML and very similar to ALL. On multivariate analysis, older age and time period were associated with worse outcome. We describe here the largest series of cases with AUL published to date.
- Published
- 2019
32. Erratum: Mechanical properties of graphene and boronitrene [Phys. Rev. B 85 , 125428 (2012)]
- Author
-
Richard Charles Andrew, Aniekan Magnus Ukpong, Refilwe Edwin Mapasha, and Nithaya Chetty
- Subjects
Materials science ,Condensed matter physics ,Graphene ,law ,law.invention - Published
- 2019
33. The Effects of Concussion on Quantity and Quality of Sleep in Football Athletes
- Author
-
Taren Bone, Suzanne M. Konz, William Garrett, and Charles Andrew Gilliland
- Subjects
Neurology (clinical) - Abstract
ObjectiveThe objective was to observe the quantity and quality of sleep of collegiate athletes following a concussion.BackgroundPatients diagnosed with a concussion report a disruption or change in their sleep with 46% of patients still having sleep disturbances 3 months after the event. Research is lacking on the sleep disruption or sleep changes in athletes who have experienced a concussion.Design/MethodsThis IRB-approved convenient cohort study involved athletes from 2 local universities. 27 (20 non-concussed and 7 concussed) male collegiate football players (19.93 ± 1.14 years old, 1.82 ± 0.08 m, and 96.42 ± 21.26 kg) wore a Readiband device for 7–10 days or throughout concussion recovery. Concussed participants completed a symptom score sheet each day. Participants returned the Readiband device and completed the Pittsburgh Sleep Quality Index Questionnaire (PSQIQ) after 7–10 days or on return to play. The sleep parameters, and PSQIQ scores were analyzed using non-parametric & independent t-tests with the alpha level set at 0.05.ResultsThe t-tests indicated a difference between the total minutes in bed at the initial measurement (F = 11.839, df = 1, p = 0.037) between the concussed (353.29 ± 110.48 minutes) and non-concussed (471.5 ± 125.09 minutes) groups. There was also a difference between the total minutes asleep at the initial measurement (F = 12.662, df = 1, p = 0.032) between the concussed (286.43 ± 86.73) and non-concussed groups (383.7 ± 104.86). The last measurement that indicated a difference was the calculated minutes in bed at the initial measurement (F = 11.916, df = 1, p = 0.023) between the concussed (326.4 3 ± 97.01) and non-concussed groups (441.60 ± 110.55).ConclusionsThe study results indicate that concussion affects the quantity of sleep, with concussed athletes spending less time in bed and fewer minutes asleep. Changes in sleep occur post-concussion, which may delay concussion recovery.
- Published
- 2021
34. Bilateral neurosensory retinal detachments secondary to extracellular signal‐regulated kinase inhibitor use for metastatic lung adenocarcinoma
- Author
-
Vivian Kuang and Robert Charles Andrew Symons
- Subjects
Ophthalmology ,Pathology ,medicine.medical_specialty ,chemistry.chemical_compound ,Visual acuity ,chemistry ,business.industry ,Extracellular signal-regulated kinases ,medicine ,Retinal ,medicine.symptom ,business ,Metastatic Lung Adenocarcinoma - Published
- 2018
35. Applying Rasch model analysis in the development of the cantonese tone identification test (CANTIT)
- Author
-
Kathy Y. S. Lee, Kit T. Y. Chan, Michael C. F. Tong, Charles Andrew van Hasselt, and Joffee H. S. Lam
- Subjects
Male ,Linguistics and Language ,medicine.medical_specialty ,Child Behavior ,Sample (statistics) ,Audiology ,Residual ,Speech Acoustics ,Language and Linguistics ,03 medical and health sciences ,Speech and Hearing ,Total variation ,Tone (musical instrument) ,Hearing Aids ,0302 clinical medicine ,Hearing ,Phonetics ,Predictive Value of Tests ,medicine ,Humans ,Attention ,Child ,Hearing Loss ,Pitch Perception ,030223 otorhinolaryngology ,Rasch model ,Two-alternative forced choice ,Age Factors ,Reproducibility of Results ,Auditory Threshold ,Recognition, Psychology ,Test (assessment) ,Identification (information) ,Cochlear Implants ,Persons With Hearing Impairments ,Acoustic Stimulation ,Case-Control Studies ,Child, Preschool ,Speech Perception ,Female ,Audiometry, Speech ,Psychology ,030217 neurology & neurosurgery ,Psychoacoustics - Abstract
Applying Rasch analysis to evaluate the internal structure of a lexical tone perception test known as the Cantonese Tone Identification Test (CANTIT).A 75-item pool (CANTIT-75) with pictures and sound tracks was developed. Respondents were required to make a four-alternative forced choice on each item. A short version of 30 items (CANTIT-30) was developed based on fit statistics, difficulty estimates, and content evaluation. Internal structure was evaluated by fit statistics and Rasch Factor Analysis (RFA).200 children with normal hearing and 141 children with hearing impairment were recruited.For CANTIT-75, all infit and 97% of outfit values were 2.0. RFA revealed 40.1% of total variance was explained by the Rasch measure. The first residual component explained 2.5% of total variance in an eigenvalue of 3.1. For CANTIT-30, all infit and outfit values were 2.0. The Rasch measure explained 38.8% of total variance, the first residual component explained 3.9% of total variance in an eigenvalue of 1.9.The Rasch model provides excellent guidance for the development of short forms. Both CANTIT-75 and CANTIT-30 possess satisfactory internal structure as a construct validity evidence in measuring the lexical tone identification ability of the Cantonese speakers.
- Published
- 2017
36. Rare Earth Interstitials in Ge: A Hybrid Density Functional Theory Study
- Author
-
Walter E. Meyer, Emmanuel Igumbor, and Richard Charles Andrew
- Subjects
010302 applied physics ,Work (thermodynamics) ,Materials science ,Condensed matter physics ,Solid-state physics ,Band gap ,Charge (physics) ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Electronic, Optical and Magnetic Materials ,Hybrid functional ,Metastability ,0103 physical sciences ,Materials Chemistry ,Density functional theory ,Electrical and Electronic Engineering ,0210 nano-technology ,Shallow donor - Abstract
In this work, the results of density functional theory calculations for rare earth (Ce, Pr, Eu, and Er) interstitials in Ge are presented. We employed the hybrid functional of Heyd, Scuseria, and Ernzerhof (HSE06) for all the calculations. We calculated the formation energies and charge state transition levels for the tetrahedral (T) and hexagonal (H) configurations of the Ce, Pr, Eu, and Er interstitials in Ge. While for the T configuration, the charge states of the Ce and Pr did not induce any thermodynamic accessible transition state level within the band gap of Ge, for both the T and H configurations the Eu and Er interstitials in Ge induce deep levels in the band gap. The H configuration of the Ce interstitial in Ge induces a shallow donor level at 0.03 eV below the conduction band. The Eu interstitial exhibits negative-U properties for the (+2/−2) transition level and the Er interstitial displays characteristics of charge state controlled metastability.
- Published
- 2016
37. Wavelength-Selective Coatings on Glass with High Hardness and Damage Resistance
- Author
-
Jung-Keun Oh, Jeong-Hong Oh, Binwei Zhang, Alexandre Michel Mayolet, Chang-Gyu Kim, Karl W. Koch, Lin Lin, Charles Andrew Paulson, Dong-Gun Moon, Carlo Kosik Williams, James Joseph Price, Ananth N Subramanian, Sang-Yoon Oh, and Shandon Dee Hart
- Subjects
Materials science ,interference ,Stopband ,engineering.material ,Chemically strengthened glass ,wavelength ,Coating ,Sputtering ,Indentation ,optical ,Materials Chemistry ,selective ,computer.programming_language ,business.industry ,coating ,Surfaces and Interfaces ,Nanoindentation ,Durability ,hardness ,color ,Surfaces, Coatings and Films ,scratch ,lcsh:TA1-2040 ,Scratch ,engineering ,Optoelectronics ,lcsh:Engineering (General). Civil engineering (General) ,business ,damage ,computer - Abstract
Wavelength-selective coatings are broadly applied across diverse industries such as solar energy management, infrared sensing, telecommunications, laser optics, and eye-protective lenses. These coatings have historically not been optimized for hardness or mechanical durability and typically suffer from higher susceptibility to scratch and damage events than uncoated glass. In this work, we describe a family of wavelength-selective coatings with hardness and scratch resistance that are significantly higher than the chemically strengthened glass substrates on which the coatings are fabricated. The coatings are made using industrially scalable reactive sputtering methods. Wavelength-selective coatings are fabricated with nanoindentation hardness as high as 16&ndash, 20 GPa over indentation depths ranging from 200 to 800 nm, as well as excellent durability in aggressive scratch testing. Tunable visible to near-infrared wavelength selectivity ratios (reflectance of stopband: reflectance of passband) as high as 7:1 are achieved. The feasibility of narrowband hard coating design is also demonstrated, with visible narrowband transmission having a peak FWHM of ~8 nm (~1.6%). A unique &ldquo, buried layers&rdquo, hard coating design strategy is shown to deliver particularly excellent hardness profiles. These designs can be tailored for a variety of different wavelengths and selectivity ratios, enabling new uses of wavelength-selective optics in mechanically demanding applications.
- Published
- 2020
38. A first principle hybrid functional calculation ofTmGe3+-VGedefect complexes in germanium
- Author
-
Walter E. Meyer, Emmanuel Igumbor, Richard Charles Andrew, and Refilwe Edwin Mapasha
- Subjects
Chemistry ,Materials Science (miscellaneous) ,Rare earth ,Foundation (engineering) ,chemistry.chemical_element ,Nanotechnology ,Germanium ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Electronic, Optical and Magnetic Materials ,Hybrid functional ,0103 physical sciences ,Materials Chemistry ,First principle ,010306 general physics ,0210 nano-technology - Abstract
The National Research foundation (NRF) of South Africa (Grant specific unique reference number (UID) 78838).
- Published
- 2016
39. Twitter-Augmented Journal Club
- Author
-
Daniel Moyse, Jeffrey M. Taekman, Ankeet D. Udani, and Charles Andrew Peery
- Subjects
business.industry ,010102 general mathematics ,Educational technology ,Globe ,Library science ,General Medicine ,Public relations ,Crowdsourcing ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,Anesthesiology ,Surveys and Questionnaires ,Humans ,Medicine ,Social media ,030212 general & internal medicine ,InformationSystems_MISCELLANEOUS ,0101 mathematics ,business ,Journal club ,Social Media - Abstract
Social media is a nascent medical educational technology. The benefits of Twitter include (1) easy adoption; (2) access to experts, peers, and patients across the globe; (3) 24/7 connectivity; (4) creation of virtual, education-based communities using hashtags; and (5) crowdsourcing information using retweets. We report on a novel Twitter-augmented journal club for anesthesia residents: its design, implementation, and impact. Our inaugural anesthesia Twitter-augmented journal club succeeded in engaging the anesthesia community and increasing residents' professional use of Twitter. Notably, our experience suggests that anesthesia residents are willing to use social media for their education.
- Published
- 2016
40. Evaluating the Use of Antibody Variable Region (Fv) Charge as a Risk Assessment Tool for Predicting Typical Cynomolgus Monkey Pharmacokinetics
- Author
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Yonglei Shang, Sean B. Joseph, Konnie Urban, Saloumeh K Fischer, Saileta Prabhu, Vikas K. Sharma, Jane L. Grogan, Eugene Y. Chiang, Robert F. Kelley, Charles Andrew Boswell, Yong Ying, Isidro Hötzel, Leslie A. Khawli, Devin Tesar, Sheila Ulufatu, and Daniela Bumbaca Yadav
- Subjects
biology ,medicine.drug_class ,Chemistry ,Immunoglobulin Variable Region ,Enzyme-Linked Immunosorbent Assay ,Cell Biology ,Monoclonal antibody ,Risk Assessment ,Biochemistry ,Antibody variable region ,Bioavailability ,Macaca fascicularis ,Pharmacokinetics ,Protein Structure and Folding ,Immunology ,medicine ,biology.protein ,Animals ,Antibody ,Molecular Biology - Abstract
The pharmacokinetic (PK) behavior of monoclonal antibodies in cynomolgus monkeys (cynos) is generally translatable to that in humans. Unfortunately, about 39% of the antibodies evaluated for PKs in cynos have fast nonspecific (or non-target-mediated) clearance (in-house data). An empirical model relating variable region (Fv) charge and hydrophobicity to cyno nonspecific clearance was developed to gauge the risk an antibody would have for fast nonspecific clearance in the monkey. The purpose of this study was to evaluate the predictability of this empirical model on cyno nonspecific clearance with antibodies specifically engineered to have either high or low Fv charge. These amino acid changes were made in the Fv region of two test antibodies, humAb4D5-8 and anti-lymphotoxin α. The humAb4D5-8 has a typical nonspecific clearance in cynos, and by making it more positively charged, the antibody acquires fast nonspecific clearance, and making it less positively charged did not impact its clearance. Anti-lymphotoxin α has fast nonspecific clearance in cynos, and making it more positively charged caused it to clear even faster, whereas making it less positively charged caused it to clear slower and within the typical range. These trends in clearance were also observed in two other preclinical species, mice and rats. The effect of modifying Fv charge on subcutaneous bioavailability was also examined, and in general bioavailability was inversely related to the direction of the Fv charge change. Thus, modifying Fv charge appears to impact antibody PKs, and the changes tended to correlate with those predicted by the empirical model.
- Published
- 2015
41. Excited state proton transfer in 9-aminoacridine carboxamides in water and in DNA
- Author
-
Charles Andrew Smith
- Published
- 2018
42. 'Could someone else's hand have sawn that trunk and dragged the frame away?': Laudy Audley's Secret as a revision of Homer's Odyssey
- Author
-
Charles Andrew Rybak
- Published
- 2018
43. Effects of estrogen-progesterone treatment on the lactational performance of rats
- Author
-
Charles Andrew Hodson
- Published
- 2018
44. Silicon oxynitride based scratch resistant anti-reflective coatings
- Author
-
Gary A. Hart, Jean Francois Oudard, Charles Andrew Paulson, Jue Wang, Paul A. Sachenik, Jonathan P. Bouchard, and James Joseph Price
- Subjects
Materials science ,Silicon oxynitride ,Reflectivity ,Optical modeling ,chemistry.chemical_compound ,chemistry ,Scratch ,Sputtering ,Composite material ,Layer (electronics) ,computer ,Refractive index ,Anti reflective ,computer.programming_language - Abstract
Scratch resistant anti-reflective (SRAR) coatings were developed on Gorilla Glass substrates. A reactive magnetron sputtering process was employed to enable desired layer hardness and refractive index. Optical modeling was performed to determine the effective hardness of the SRAR coatings, in an effort to reduce reflectance in the visible while maintaining high scratch resistance. Scratch resistance was evaluated by using a nano-indentation test. Broadband AR coatings were realized. Potential applications of the SRAR coatings for AD optics were discussed.
- Published
- 2018
45. IoT solutions for precision agriculture
- Author
-
Richard Charles Andrew, Reza Malekian, and Dijana Capeska Bogatinoska
- Subjects
Irrigation ,Animal health ,business.industry ,Computer science ,020208 electrical & electronic engineering ,010401 analytical chemistry ,02 engineering and technology ,Agricultural engineering ,01 natural sciences ,0104 chemical sciences ,Normal field ,Agriculture ,Proof of concept ,0202 electrical engineering, electronic engineering, information engineering ,Precision agriculture ,business ,Internet of Things ,Productivity - Abstract
In this paper, precision agriculture is set to provide higher productivity and a better use of resources when compared to traditional methods and this will result in lower costs with higher yields. A crucial activity for crop farming is water irrigation while for livestock farming it is the monitoring of animal health. This paper presents two feasibility studies on IoT solutions for automated irrigation and one study for automated animal monitoring. In each, the proof of concept is verified to operate under normal field conditions.
- Published
- 2018
46. Supplementary Table 1 -Supplemental material for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study)
- Author
-
Amaal J Starling, Tepper, Stewart J, Marmura, Michael J, Ejaz A Shamim, Robbins, Matthew S, Hindiyeh, Nada, Charles, Andrew C, Goadsby, Peter J, Lipton, Richard B, Silberstein, Stephen D, Gelfand, Amy A, Chiacchierini, Richard P, and Dodick, David W
- Subjects
FOS: Psychology ,FOS: Clinical medicine ,170199 Psychology not elsewhere classified ,110319 Psychiatry (incl. Psychotherapy) ,110306 Endocrinology ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, Supplementary Table 1 for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study) by Amaal J Starling, Stewart J Tepper, Michael J Marmura, Ejaz A Shamim, Matthew S Robbins, Nada Hindiyeh, Andrew C Charles, Peter J Goadsby, Richard B Lipton, Stephen D Silberstein, Amy A Gelfand, Richard P Chiacchierini and David W Dodick in Cephalalgia
- Published
- 2018
- Full Text
- View/download PDF
47. Contributors
- Author
-
David W. Altchek, Michael Angeline, Jeff Ashton, Jolene Bennett, Allan Besselink, Sanjeev Bhatia, Lori A. Bolgla, S. Brent Brotzman, Jason Brumitt, David S. Butler, R. Matthew Camarillo, Mark M. Casillas, Bridget Clark, Alexander T. Caughran, Michael D’Amato, George J. Davies, Michael Duke, Christopher J. Durall, Todd S. Ellenbecker, Brian K. Farr, Larry D. Field, G. Kelley Fitzgerald, Rachel M. Frank, Tigran Garabekyan, Neil S. Ghodadra, Charles E. Giangarra, Charles Andrew Gilliland, John A. Guido, J. Allen Hardin, Maureen A. Hardy, Timothy E. Hewett, Clayton F. Holmes, Barbara J. Hoogenboom, James J. Irrgang, Margaret Jacobs, R. Jason Jadgchew, David A. James, John J. Jasko, Drew Jenk, W. Ben Kibler, Theresa M. Kidd, Kyle Kiesel, Jonathan Yong Kim, Scott E. Lawrance, Michael Levinson, Sameer Lodha, Janice K. Loudon, Adriaan Louw, Joseph R. Lynch, Robert C. Manske, Matthew J. Matava, Sean Mazloom, John McMullen, Morteza Meftah, Erik P. Meira, Keith Meister, Scott T. Miller, Josef H. Moore, Donald Nguyen, Cullen M. Nigrini, Steven R. Novotny, Michael J. O’Brien, Sinan Emre Ozgur, Mark V. Paterno, Ryan T. Pitts, Marisa Pontillo, Andrew S.T. Porter, Christie C.P. Powell, Daniel Prohaska, Matthew T. Provencher, Emilio 'Louie' Puentedura, Amar S. Ranawat, Anil S. Ranawat, James T. Reagan, Bruce Reider, Michael P. Reiman, Amy G. Resler, Bryan Riemann, Toby Rogers, Anthony A. Romeo, Richard Romeyn, Michael D. Rosenthal, Felix H. Savoie, Suzanne Zadra Schroeder, Aaron Sciascia, K. Donald Shelbourne, Jace R. Smith, Damien Southard, Ken Stephenson, Faustin R. Stevens, Mark Stovak, Timothy F. Tyler, Geoffrey S. Van Thiel, Mark Wagner, Reg B. Wilcox, and Daniel Woods
- Published
- 2018
48. Supplementary Table 2 -Supplemental material for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study)
- Author
-
Amaal J Starling, Tepper, Stewart J, Marmura, Michael J, Ejaz A Shamim, Robbins, Matthew S, Hindiyeh, Nada, Charles, Andrew C, Goadsby, Peter J, Lipton, Richard B, Silberstein, Stephen D, Gelfand, Amy A, Chiacchierini, Richard P, and Dodick, David W
- Subjects
FOS: Psychology ,FOS: Clinical medicine ,170199 Psychology not elsewhere classified ,110319 Psychiatry (incl. Psychotherapy) ,110306 Endocrinology ,111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified ,110904 Neurology and Neuromuscular Diseases ,Neuroscience - Abstract
Supplemental material, Supplementary Table 2 for A multicenter, prospective, single arm, open label, observational study of sTMS for migraine prevention (ESPOUSE Study) by Amaal J Starling, Stewart J Tepper, Michael J Marmura, Ejaz A Shamim, Matthew S Robbins, Nada Hindiyeh, Andrew C Charles, Peter J Goadsby, Richard B Lipton, Stephen D Silberstein, Amy A Gelfand, Richard P Chiacchierini and David W Dodick in Cephalalgia
- Published
- 2018
- Full Text
- View/download PDF
49. Athletic Pubalgia
- Author
-
Charles Andrew Gilliland
- Subjects
business.industry ,Medicine ,business - Published
- 2018
50. The Outcome of a Social Cognitive Training for Mainstream Adolescents with Social Communication Deficits in a Chinese Community
- Author
-
Michael C. F. Tong, Yuen-mai Mark, Charles Andrew van Hasselt, Kathy Y. S. Lee, Pamela J. Crooke, Aster L. Y. Lui, and Peggy P. K. Kan
- Subjects
030506 rehabilitation ,Health (social science) ,05 social sciences ,Socialization ,Cognition ,medicine.disease ,Health Professions (miscellaneous) ,Education ,Developmental psychology ,03 medical and health sciences ,Asperger syndrome ,Social cognition ,Developmental and Educational Psychology ,medicine ,Autism ,0501 psychology and cognitive sciences ,Social competence ,0305 other medical science ,Psychology ,Inclusion (education) ,Social cognitive theory ,050104 developmental & child psychology ,Clinical psychology - Abstract
The use of cognitive-based strategies for improving social communication behaviours for individuals who have solid language and cognition is an important question. This study investigated the outcome of teaching Social Thinking®, a framework based in social-cognition, to Chinese adolescents with social communication deficits. Thirty-nine students (33 with Autism Spectrum Disorders and six without), ranging in age from 12 to 15 years with social communication deficits, participated in a 12-week intervention. Students’ pre- and post-intervention social behaviours were measured by six aspects of the Social Thinking-ILAUGH Scale involving 115 familiar raters. Students showed significant improvement in all the six subscales of the Social Thinking-ILAUGH except humour after training. Agreements on ratings among parents and school personnel were satisfactory. A framework based in social cognitive strategies, with appropriate linguistic and cultural adaptations, appears to be a promising tool for Chinese adolesce...
- Published
- 2015
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