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682,792 results on '"Chang, A."'

20. Deep Learning Based on Enhanced MRI T1 Imaging to Differentiate Small-cell and Non-small-cell Primary Lung Cancers in Patients with Brain Metastases

Author

Xiaoping Yin, Kun Yang, Lianyu Sui, Shilong Chang, LinYan Xue, Jianing Wang, Yu Zhang, and Bu-Lang Gao

Subjects
Radiology, Nuclear Medicine and imaging
Abstract

Objectives: To differentiate the primary small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) for patients with brain metastases (BMs) based on a deep learning (DL) model using contrast-enhanced magnetic resonance imaging (MRI) T1 weighted (T1CE) images. Methods: Out of 711 patients with BMs of lung cancer origin (SCLC 232, NSCLC 479), the MRI datasets of 192 patients (lesions’ widths and heights > 30 pixels) with BMs from lung cancer (73 SCLC and 119 NSCLC) confirmed pathologically were enrolled, retrospectively. A typical convolutional neural network ResNet18 was applied for the automatic classification of BMs lesions from lung cancer based on T1CE images, with training and testing groups randomized per patient to eliminate learning bias. A 5-fold cross-validation was performed to evaluate the classification of the model. The receiver operating characteristic (ROC) curve, accuracy, precision, recall and f1 score were calculated. Results: For a 5-fold cross-validation test, the DL model achieved AUCs of 0.8019 and 0.8024 for SCLC and NSCLC patients with BMs, respectively, and a mean overall accuracy of 0.7515±0.04. The DL model performed well in differentiating the primary SCLC and NSCLC with BMs. Conclusion: The proposed DL model is feasible and effective in differentiating the pathological subtypes of SCLC and NSCLC causing BMs, which may be used as a new tool for oncologists to diagnose noninvasively BMs and guide therapy based on the imaging structure of tumors.

Published
2023

22. Prospective randomized comparison between upgraded ‘2C3L’ vs. PVI approach for catheter ablation of persistent atrial fibrillation: PROMPT-AF trial design

Author

Xiao-Xia Liu, Qiang Liu, Yi-Wei Lai, Qi Guo, Rong Bai, De-Yong Long, Rong-Hui Yu, Ri-Bo Tang, Nian Liu, Chen-Xi Jiang, Wei Wang, Xue-Yuan Guo, Song-Nan Li, Xin Zhao, Song Zuo, Chang-Yi Li, Shang-Ming Song, Shuang-Lun Xie, Wei-Li Ge, Jian-Gang Zou, Xiao-Feng Hou, Ke Chen, Jin-Lin Zhang, He-Sheng Hu, Xin-Hua Wang, Zhao-Jun Wang, Xin Du, Chen-Yang Jiang, Cai-Hua Sang, Jian-Zeng Dong, and Chang-Sheng Ma

Subjects
Cardiology and Cardiovascular Medicine
Published
2023

23. A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch

Author

Zhaowenbin Zhang, Wenbo Li, Di Chang, Ziqin Wei, Endian Wang, Jing Yu, Yuze Xu, Yumei Que, Yanxin Chen, Chen Fan, Bing Ma, Yanling Zhou, Zhiguang Huan, Chen Yang, Feng Guo, and Jiang Chang

Subjects
Biomaterials, Biomedical Engineering, Biotechnology
Abstract

A nanocomposite microneedle (ZCQ/MN) patch containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin (ZCQ) was developed as a combination therapy for androgenic alopecia (AGA). The degradable microneedle gradually dissolves after penetration into the skin and releases the ZCQ nanoparticles. ZCQ nanoparticles release quercetin (Qu), copper (Cu

Published
2023

25. Indobufen versus aspirin in patients with acute ischaemic stroke in China (INSURE): a randomised, double-blind, double-dummy, active control, non-inferiority trial

Author

Yuesong Pan, Xia Meng, Baoshi Yuan, S Claiborne Johnston, Hao Li, Philip M Bath, Qiang Dong, Anding Xu, Jing Jing, Jinxi Lin, Yong Jiang, Xuewei Xie, Aoming Jin, Yue Suo, Hongqin Yang, Yefang Feng, Yanhua Zhou, Qing Liu, Xueli Li, Bin Liu, Hui Zhu, Jinguo Zhao, Xuerong Huang, Haitao Li, Yunyun Xiong, Zixiao Li, Yilong Wang, Xingquan Zhao, Liping Liu, Yongjun Wang, Yanxia Wang, Cunrui Wang, Yazhou Han, Ming Yu, Guoping Zou, Aisheng Wu, Guiru Zhang, Ping Zhang, Mingzong Yan, Jia Zhang, Jingyan Zhao, Huitian Zhang, Qinde Qi, Jianling Zhang, Zhishan Zhu, Wenfeng Fan, Liguo Chang, Lan Tan, Liang Zhao, Yanzhong Xue, Peiru Liu, Xiaohua Ju, Zuowen Zhang, Linwen Li, Feng Wei, Lixia Yang, Xuemei Li, Zhixiong Zheng, Hui Liang, Yan Wei, Ming Zhang, Ting Wang, Jianbo Yang, Panbing Huang, Guojun Tan, Yongming Chen, Jin Zhou, Zhongping An, Chunlei Li, Guohua Chen, Runxiu Zhu, Xin Sun, Yong Liu, Mei Zhang, Yanguang Zhuo, Fanwen Meng, Kebo Li, Wei Zhang, Xiangting Chai, Ke Deng, Jianhua Li, Zhiyou Cai, Hailian Jin, Bo Li, Xiaomei Zhang, Beihai Ge, Wei Hu, Zhen Jiao, Lianmei Zhong, Lijie Ren, Xinyi Li, Songdi Wu, Yinguo Wan, Jinghua Zhang, Xiaoyan Ma, Jizheng Hu, Ge Zhang, Chunling Zheng, Jun Xu, YuAn Zou, Zhihui Duan, Changxin Li, Qingxiu Zhang, Xiaoming Song, Zhengchang Jia, Chun Wang, Peining Shao, Jijun Teng, Hua Bao, Yangkun Chen, Yunfei Wei, Xu Zhang, Xisi Meng, Guangning Li, Pengke Pan, Aixia Zhuang, Xiaofei Chen, Jun Tang, Hongwei An, Shihao You, Yanyan Tang, Guilian Zhang, Hongyan Li, Miao Guo, Chunlei Yu, Ying Li, Haichao Liu, Pengfei Liang, Guangming Kang, Huijie Sun, Yu Che, Juan Tang, Dandan Li, Xiaopeng Feng, Yu Geng, Huibing Wang, Ping Shen, Huaiping Zhu, Farong Li, Lifang Zhang, Minghua Cao, Yong You, Guiyun Cui, Jun Gu, Xiangfeng Zhang, Xiaojun Liu, Houqin Chen, Yuehua Zhang, Hongnian Zhao, Ke Liang, Rui Zhi, Ling Ma, Yuanhua Wu, Yalan Geng, Ping Sun, Bing Zhong, Dongxue Li, Jingya Jiao, Yanlei Hao, Guozhong Li, Shaohua Su, Weiping Ju, Lianqiu Min, Liyan Guo, Yafei Shangguan, Yingdong Tai, Ying Xing, Hongshan Chang, Wenya Chen, Hongtao Tang, Shuchun Huang, Jingxian Fang, Donghui Yu, Hailong Zhao, Lei Xu, Aimei Wu, Hebin Wan, Hongliang Wang, Zhihui Shen, Qing Zhang, and Qian Wang

Subjects
Neurology (clinical)
Published
2023

26. Green Experience: The Effect of Horticultural Activities on Children’s Physical and Mental Health and Dietary Behavior

Author

Tzuhui Angie Tseng, Jui-Jung Chang, and Yun-Chen Chang

Subjects
Horticulture
Abstract

Child obesity is a major global public health issue. This study sought to identify means to improve children’s dietary behaviors through horticultural activities and effectively enhance their health and quality of life. The 129 participants were children in third grade through sixth grade in Hsinchu City, Taiwan. A quasi-experimental design was adopted as an intervention for school horticultural activities. The 68 students in the intervention group engaged in 40-minute horticultural sessions for 6 weeks. The pretest and post-test scores of both groups were measured using the Physical Questionnaire for older Children, the Connection to Nature Index, the Willingness to Taste Fruits and Vegetable Scale, and the Children’s Quality of Life Scale, as well as questionnaire items. The qualitative and quantitative data were analyzed through a parallel mixed-method approach. The findings showed that the intervention group’s physical activity levels, nature connectedness, and overall health were higher than those of the control groups. There were no significant differences in willingness to taste fruits and vegetables. This study demonstrates that engaging in natural school spaces and participating in horticultural activities improved the physical and mental health of children. Natural elements should be incorporated into the campus design, and children should be encouraged to participate in school horticultural activities.

Published
2023

32. Time-to-conception and clinical pregnancy rate with a myo-inositol, probiotics, and micronutrient supplement: secondary outcomes of the NiPPeR randomized trial

Author

Shiao-Yng Chan, Sheila J. Barton, See Ling Loy, Hsin Fang Chang, Philip Titcombe, Jui-Tsung Wong, Marilou Ebreo, Judith Ong, Karen ML. Tan, Heidi Nield, Sarah El-Heis, Timothy Kenealy, Yap-Seng Chong, Philip N. Baker, Wayne S. Cutfield, Keith M. Godfrey, Ben Albert, Shirong Cai, Philip C. Calder, Ryan Carvalho, Julie Ann Guiao Castro, Mary Cavanagh, Jerry KY. Chan, Mei Ling Chang, Claudia Chi, Caroline E. Childs, Mei Kit Choh, Mary FF. Chong, Anne HY. Chu, Cathryn Conlon, Cyrus Cooper Paula Costello, Vanessa Cox, Sevasti Galani, Judith Hammond, Nicholas C. Harvey, Richard Holt, Hazel M. Inskip, Mrunalini Jagtap, Gene Jeon, Neerja Karnani, Chiara Nembrini, Karen A. Lillycrop, Falk Müller-Riemenschneider, Padmapriya Natarajan, Sharon Ng, Adaikalavan Ramasamy, Elizabeth Tham, Mya Thway Tint, Justin M. O’Sullivan, Gernalia Satianegara, Lynette PC. Shek, Irma Silva-Zolezzi, Wendy Sim, Shu E. Soh, Vicky Tay, Rachel Taylor, Salika Theodosia, Clare Wall, Gladys Woon, Mark Vickers, and Wei Ying

Subjects
Reproductive Medicine, Obstetrics and Gynecology
Published
2023

35. Aqueous Extract of Sparganii Rhizoma and Curcumae Rhizoma Induces Apoptosis and Inhibits Migration in Human Oral Squamous Cell Carcinoma

Author

Kai-Wei Chang, Chia-Yu Wu, Ting-Yi Renn, Tsung-Ming Chang, Augusta I-Chin Wei, Yen-Ying Kung, and Ju-Fang Liu

Subjects
Pharmacology, Biophysics, Cell Biology, Food Science
Abstract

Sparganii Rhizoma and Curcumae Rhizoma (SRCR) are natural herbs used in traditional Chinese medicine to treat tumors and activate blood circulation. Previous studies have shown that SRCR possesses notable antitumor activity; however, the mechanism underlying anticancer activity in human oral squamous cell carcinoma (OSCC) has yet to be fully elucidated. The risk factors of OSCC include smoking, alcohol consumption, poor oral hygiene, and human papillomavirus infection. OSCC is highly metastatic and responds poorly to chemotherapy; thus, alternative treatment options are imperative. In this study, we found that SRCR induced death in OSCC cells but not in normal cells (HGF-1 cells). SRCR has also shown to induce the production of reactive oxygen species in OSCC cells, sequentially promoting calcium release and stress in the endoplasmic reticulum, which resulted in mitochondrial dysfunction and subsequent apoptosis. Furthermore, SRCR has shown to inhibit the migration of OSCC cells by reducing matrix metalloproteinase-12 and -13. Our findings demonstrate that SRCR exerts anticancer activities in OSCC by inducing cell apoptosis and suppressing cell migration.

Published
2023

36. Characterization of Mammary Tumors Arising from MMTV-PyVT Transgenic Mice

Author

Chien-Liang Liu, Wen-Chien Huang, Shih-Ping Cheng, Ming-Jen Chen, Chi-Hsin Lin, Shao-Chiang Chang, and Yuan-Ching Chang

Subjects
Microbiology (medical), General Medicine, Molecular Biology, Microbiology
Abstract

Among genetically engineered mouse models of breast cancer, MMTV-PyVT is a mouse strain in which the oncogenic polyoma virus middle T antigen is driven by the mouse mammary tumor virus promoter. The aim of the present study was to perform morphologic and genetic analyses of mammary tumors arising from MMTV-PyVT mice. To this end, mammary tumors were obtained at 6, 9, 12, and 16 weeks of age for histology and whole-mount analyses. We conducted whole-exome sequencing to identify constitutional and tumor-specific mutations, and genetic variants were identified using the GRCm38/mm10 mouse reference genome. Using hematoxylin and eosin analysis and whole-mount carmine alum staining, we demonstrated the progressive proliferation and invasion of mammary tumors. Frameshift insertions/deletions (indels) were noted in the Muc4. Mammary tumors showed small indels and nonsynonymous single-nucleotide variants but no somatic structural alterations or copy number variations. In summary, we validated MMTV-PyVT transgenic mice as a multistage model for mammary carcinoma development and progression. Our characterization may be used as a reference for guidance in future research.

Published
2023

38. A draft human pangenome reference

Author

Wen-Wei Liao, Mobin Asri, Jana Ebler, Daniel Doerr, Marina Haukness, Glenn Hickey, Shuangjia Lu, Julian K. Lucas, Jean Monlong, Haley J. Abel, Silvia Buonaiuto, Xian H. Chang, Haoyu Cheng, Justin Chu, Vincenza Colonna, Jordan M. Eizenga, Xiaowen Feng, Christian Fischer, Robert S. Fulton, Shilpa Garg, Cristian Groza, Andrea Guarracino, William T. Harvey, Simon Heumos, Kerstin Howe, Miten Jain, Tsung-Yu Lu, Charles Markello, Fergal J. Martin, Matthew W. Mitchell, Katherine M. Munson, Moses Njagi Mwaniki, Adam M. Novak, Hugh E. Olsen, Trevor Pesout, David Porubsky, Pjotr Prins, Jonas A. Sibbesen, Jouni Sirén, Chad Tomlinson, Flavia Villani, Mitchell R. Vollger, Lucinda L. Antonacci-Fulton, Gunjan Baid, Carl A. Baker, Anastasiya Belyaeva, Konstantinos Billis, Andrew Carroll, Pi-Chuan Chang, Sarah Cody, Daniel E. Cook, Robert M. Cook-Deegan, Omar E. Cornejo, Mark Diekhans, Peter Ebert, Susan Fairley, Olivier Fedrigo, Adam L. Felsenfeld, Giulio Formenti, Adam Frankish, Yan Gao, Nanibaa’ A. Garrison, Carlos Garcia Giron, Richard E. Green, Leanne Haggerty, Kendra Hoekzema, Thibaut Hourlier, Hanlee P. Ji, Eimear E. Kenny, Barbara A. Koenig, Alexey Kolesnikov, Jan O. Korbel, Jennifer Kordosky, Sergey Koren, HoJoon Lee, Alexandra P. Lewis, Hugo Magalhães, Santiago Marco-Sola, Pierre Marijon, Ann McCartney, Jennifer McDaniel, Jacquelyn Mountcastle, Maria Nattestad, Sergey Nurk, Nathan D. Olson, Alice B. Popejoy, Daniela Puiu, Mikko Rautiainen, Allison A. Regier, Arang Rhie, Samuel Sacco, Ashley D. Sanders, Valerie A. Schneider, Baergen I. Schultz, Kishwar Shafin, Michael W. Smith, Heidi J. Sofia, Ahmad N. Abou Tayoun, Françoise Thibaud-Nissen, Francesca Floriana Tricomi, Justin Wagner, Brian Walenz, Jonathan M. D. Wood, Aleksey V. Zimin, Guillaume Bourque, Mark J. P. Chaisson, Paul Flicek, Adam M. Phillippy, Justin M. Zook, Evan E. Eichler, David Haussler, Ting Wang, Erich D. Jarvis, Karen H. Miga, Erik Garrison, Tobias Marschall, Ira M. Hall, Heng Li, and Benedict Paten

Subjects
Cancer Research, Multidisciplinary
Abstract

Here the Human Pangenome Reference Consortium presents a first draft of the human pangenome reference. The pangenome contains 47 phased, diploid assemblies from a cohort of genetically diverse individuals1. These assemblies cover more than 99% of the expected sequence in each genome and are more than 99% accurate at the structural and base pair levels. Based on alignments of the assemblies, we generate a draft pangenome that captures known variants and haplotypes and reveals new alleles at structurally complex loci. We also add 119 million base pairs of euchromatic polymorphic sequences and 1,115 gene duplications relative to the existing reference GRCh38. Roughly 90 million of the additional base pairs are derived from structural variation. Using our draft pangenome to analyse short-read data reduced small variant discovery errors by 34% and increased the number of structural variants detected per haplotype by 104% compared with GRCh38-based workflows, which enabled the typing of the vast majority of structural variant alleles per sample.

Published
2023

41. Normal ECG standards and percentile charts for infants, children and adolescents

Author

Hung-Chi Lue, Mei-Hwan Wu, Jou-Kou Wang, Ming-Tai Lin, Chun-Wei Lu, Shuenn-Nan Chiu, Chun-An Chen, En-Ting Wu, Ching-Chia Wang, Chun-Min Fu, Wei-Chieh Tseng, Wei-Hsuan Chang, and Meng-Chang Lee

Subjects
Pediatrics, Perinatology and Child Health
Abstract

Normal ECG standards in newborns, infants, children and adolescents have been collected and published by many authors. Only those by Davignon et al., Rijinbeek et al. and our two studies covered all ages from birth to adolescence. The standards reflecting the growth and development of the heart in infants, children and adolescents remained to be studied and explored.We selected from our ECG database, after discussions and consultation, 15 key ECG parameters and analyzed for their age- and sex-specific mean, standard deviation and 2nd to 98th percentiles and their percentile charts were constructed.The ranges and distributions of the normal ECG standards, means and 2nd to 98th percentiles of 15 key parameters were established.A complete set of normal ECG standards of 15 key parameters from birth to adolescents is available for clinicians and researchers.

Published
2023

43. Post-ablation augmentation of skin sympathetic nerve activity predicts a poor outcome of idiopathic ventricular arrhythmias

Author

Wei-Tso, Chen, Cheng-Hung, Li, Yu-Hui, Chou, Wei-Lun, Lin, Yenn-Jiang, Lin, Shih-Lin, Chang, Yu-Feng, Hu, Fa-Po, Chung, Jo-Nan, Liao, Ta-Chuan, Tuan, Tze-Fan, Chao, Chin-Yu, Lin, Ting-Yung, Chang, Ling, Kuo, Chih-Min, Liu, Shin-Huei, Liu, Wen-Han, Cheng, Ton Nukhank, An, Ahmed Moustafa Moustafa, Elimam, Chhay, Chheng, Thien Chuong Khac, Nguyen, Ibrahim, Ahliah, Ming-Ren, Kuo, Pei-Heng, Kao, Shih-Ann, Chen, and Li-Wei, Lo

Subjects
Cardiology and Cardiovascular Medicine
Abstract

The neuromodulation effect after ventricular arrhythmia (VA) ablation is unclear. The study aimed to investigate skin sympathetic nerve activity (SKNA) changes in patients receiving catheter ablations for idiopathic VA.Of 43 patients with drug-refractory symptomatic VA receiving ablation, SKNA was continuously recorded for 10 min during resting from electrocardiogram lead I configuration and bipolar electrodes on the right arm 1 day before and 1 day after ablation.Twenty-two patients with acute procedure success and no recurrence during follow-ups were classified as sustained success group (group 1). Other 21 patients were classified as failed ablation group (group 2). Baseline SKNA showed no significant difference between the two groups. Post-ablation SKNA in group 2 was significantly higher than in group 1. In patients with ablation involved right ventricular outflow tract (RVOT), the post-ablation SKNA was also significantly higher in group 2. In contrast, there was no difference in post-ablation SKNA between groups in patients receiving non-RVOT ablation.The neuromodulation response after RVOT ablation may correspond to the sympathetic nerve distribution at RVOT. Augmentation of sympathetic activity after VA ablation indicates an unsuccessful VA suppression, especially in patients receiving ablation of RVOT VA.

Published
2023

47. Magnitude of Synchronous and Dyssynchronous Inspiratory Efforts during Mechanical Ventilation: A Novel Method

Author

Irene Telias, Matías Madorno, Tài Pham, Thomas Piraino, Rémi Coudroy, Michael C. Sklar, Eumorfia Kondili, Savino Spadaro, Tobias Becher, Chang-Wen Chen, Tommaso Mauri, Lise Piquilloud, Laurent Brochard, Felipe Damiani, Cesar Santis, Michael Sklar, Audery Kim, Megan Abbott, Elena Spinelli, Giacomo Grasselli, Nadia Corcione, Francesca Dalla Corte, Carlo Alberto Volta, Francesco Mojoli, Dimitris Georgopoulos, Stella Soundoulounaki, Norbert Weiler, Dirk Schaedler, Oriol Roca, Manel Santafe, Jordi Mancebo, Nuria Rodriguez, Leo Heunks, Heder de Vries, Chang Wen Chen, Jian-Xin Zhou, Guang-Qiang Chen, Nuttapol Rittayamai, Norberto Tiribelli, Sebastian Fredes, Ricard Artigas Mellado, Carlos Ferrando Ortolá, François Beloncle, Alain Mercat, Jean-Michel Arnal, Jean-Luc Diehl, Romy Younan, Alexandre Demoule, Martin Dres, Quentin Fossé, Sébastien Jochmans, Jonathan Chelly, Nicolas Terzi, Claude Guérin, Elias Baedorf Kassis, Jeremy Beitler, Davide Chiumello, Erica Ferrari Luca Bolgiaghi, Arnaud W. Thille, Laurent Papazian, C. Guervilly, Ewan C. Goligher, and Niall D. Ferguson

Subjects
Pulmonary and Respiratory Medicine, Correspondence, Critical Care and Intensive Care Medicine
Published
2023

50. Subunit vaccines with a saponin-based adjuvant boost humoral and cellular immunity to MERS coronavirus

Author

Chi-Chieh Chang, Abdullah Algaissi, Chia-Chun Lai, Chun-Kai Chang, Jr-Shiuan Lin, Yi-Shiang Wang, Bo-Hau Chang, Yu-Chiuan Chang, Wei-Ting Chen, Yong-Qing Fan, Bi‐Hung Peng, Chih-Yu Chao, Shiou-Ru Tzeng, Pi-Hui Liang, Wang-Chou Sung, Alan Yung-Chih Hu, Shin C. Chang, and Ming-Fu Chang

Subjects
Infectious Diseases, General Veterinary, General Immunology and Microbiology, Public Health, Environmental and Occupational Health, Molecular Medicine
Published
2023

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