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1. Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro–In Vivo Extrapolation

Author

Maria König, Rita Schlichting, Fabian Fischer, Beate I. Escher, Cedric Abele, Marie Mühlenbrink, Nils Klüver, and Luise Henneberger

Subjects
0303 health sciences, Cell signaling, Reporter gene, Chemistry, General Medicine, 010501 environmental sciences, Toxicology, 01 natural sciences, In vitro, Genetically modified organism, Cell biology, 03 medical and health sciences, Cell culture, Potency, In vitro in vivo, Throughput (business), 030304 developmental biology, 0105 earth and related environmental sciences
Abstract

High-throughput in vitro reporter gene assays are increasingly applied to assess the potency of chemicals to alter specific cellular signaling pathways. Genetically modified reporter gene cell line...

Published
2020
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